valproic acid has been researched along with Restless Leg Syndrome in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of severe restless legs syndrome (RLS) that occurred as a side effect of olanzapine therapy." | 7.75 | Refractory restless legs syndrome likely caused by olanzapine. ( Khalid, I; Khalid, TJ; Rana, L; Roehrs, T, 2009) |
| "Twenty patients with idiopathic restless legs syndrome (RLS) were treated with 600 mg slow-release VPA and 200 mg slow-release LD+50mg benserazid in a randomized, placebo-controlled, cross-over, double-blind setting with polysomography (PSG) at the end of each 3-week treatment periods." | 6.71 | Treatment of idiopathic restless legs syndrome (RLS) with slow-release valproic acid compared with slow-release levodopa/benserazid. ( Ehrenberg, BL; Eisensehr, I; Noachtar, S; Rogge Solti, S, 2004) |
| "Risperidone was switched to haloperidol." | 5.31 | Restless legs syndrome probably induced by risperidone treatment. ( Bronisch, T; Brunner, J; Wetter, TC, 2002) |
| "We report a case of severe restless legs syndrome (RLS) that occurred as a side effect of olanzapine therapy." | 3.75 | Refractory restless legs syndrome likely caused by olanzapine. ( Khalid, I; Khalid, TJ; Rana, L; Roehrs, T, 2009) |
| "Valproic acid is used in first case as an antiepileptic; own clinical observance and references from the literature show other indication-fields outside of the group of cerebral fits; so Convulex was employed successfully also in the therapy of perioral dyskinesia of variable etiology and in the medical treatment of therapy-resistant pains within the bounds of Polyneuropathy-Polyneuritis Syndrome." | 3.67 | [Further therapeutic possibilities with valproic acid (Convulex)]. ( Auff, E; Holzner, F; Wessely, P, 1985) |
| "Twenty patients with idiopathic restless legs syndrome (RLS) were treated with 600 mg slow-release VPA and 200 mg slow-release LD+50mg benserazid in a randomized, placebo-controlled, cross-over, double-blind setting with polysomography (PSG) at the end of each 3-week treatment periods." | 2.71 | Treatment of idiopathic restless legs syndrome (RLS) with slow-release valproic acid compared with slow-release levodopa/benserazid. ( Ehrenberg, BL; Eisensehr, I; Noachtar, S; Rogge Solti, S, 2004) |
| "Risperidone was switched to haloperidol." | 1.31 | Restless legs syndrome probably induced by risperidone treatment. ( Bronisch, T; Brunner, J; Wetter, TC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Conti, CF | 1 |
| Oliveira, MM | 1 |
| Valbuza, JS | 1 |
| Prado, LB | 1 |
| Carvalho, LB | 1 |
| Prado, GF | 1 |
| Khalid, I | 1 |
| Rana, L | 1 |
| Khalid, TJ | 1 |
| Roehrs, T | 1 |
| Eisensehr, I | 1 |
| Ehrenberg, BL | 1 |
| Rogge Solti, S | 1 |
| Noachtar, S | 1 |
| Wetter, TC | 1 |
| Brunner, J | 1 |
| Bronisch, T | 1 |
| Auff, E | 1 |
| Holzner, F | 1 |
| Wessely, P | 1 |
1 review available for valproic acid and Restless Leg Syndrome
| Article | Year |
|---|---|
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review.
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Evidence-Based Medicine; Gabape | 2008 |
1 trial available for valproic acid and Restless Leg Syndrome
| Article | Year |
|---|---|
Treatment of idiopathic restless legs syndrome (RLS) with slow-release valproic acid compared with slow-release levodopa/benserazid.
Topics: Adult; Aged; Anticonvulsants; Antiparkinson Agents; Benserazide; Cross-Over Studies; Double-Blind Me | 2004 |
3 other studies available for valproic acid and Restless Leg Syndrome
| Article | Year |
|---|---|
Refractory restless legs syndrome likely caused by olanzapine.
Topics: Anticonvulsants; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Bipolar Disorder; Drug Therapy | 2009 |
Restless legs syndrome probably induced by risperidone treatment.
Topics: Adult; Antipsychotic Agents; Dibenzothiazepines; Female; Humans; Polysomnography; Quetiapine Fumarat | 2002 |
[Further therapeutic possibilities with valproic acid (Convulex)].
Topics: Aged; Blepharospasm; Dyskinesia, Drug-Induced; Female; Foot Diseases; Humans; Male; Middle Aged; Myo | 1985 |