valproic acid has been researched along with Rectal Neoplasms in 1 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Rectal Neoplasms: Tumors or cancer of the RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is an anti-epileptic drug with HDACi and anticancer activity." | 2.79 | Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid--short Radiotherapy--rectum 3rd trial). ( Aloj, L; Avallone, A; Bianco, F; Botti, G; Budillon, A; Caracò, C; Cavalcanti, E; D'Angelo, V; Daniele, G; Delrio, P; Di Gennaro, E; Di Maio, M; Gallo, C; Granata, C; Iaffaioli, VR; Lastoria, S; Maiolino, P; Marone, P; Maurea, N; Montano, M; Muto, P; Pecori, B; Perrone, F; Petrillo, A; Piccirillo, MC; Roca, MS; Romano, G; Silvestro, L; Tatangelo, F; Terranova Barberio, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avallone, A | 1 |
| Piccirillo, MC | 1 |
| Delrio, P | 1 |
| Pecori, B | 1 |
| Di Gennaro, E | 1 |
| Aloj, L | 1 |
| Tatangelo, F | 1 |
| D'Angelo, V | 1 |
| Granata, C | 1 |
| Cavalcanti, E | 1 |
| Maurea, N | 1 |
| Maiolino, P | 1 |
| Bianco, F | 1 |
| Montano, M | 1 |
| Silvestro, L | 1 |
| Terranova Barberio, M | 1 |
| Roca, MS | 1 |
| Di Maio, M | 1 |
| Marone, P | 1 |
| Botti, G | 1 |
| Petrillo, A | 1 |
| Daniele, G | 1 |
| Lastoria, S | 1 |
| Iaffaioli, VR | 1 |
| Romano, G | 1 |
| Caracò, C | 1 |
| Muto, P | 1 |
| Gallo, C | 1 |
| Perrone, F | 1 |
| Budillon, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1/2 Study of Valproic Acid and Short-course Radiotherapy Plus Capecitabine as preoperatIve Treatment in Low-moderate Risk Rectal Cancer[NCT01898104] | Phase 1/Phase 2 | 152 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for valproic acid and Rectal Neoplasms
| Article | Year |
|---|---|
Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid--short Radiotherapy--rectum 3rd trial).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Combined Moda | 2014 |