valproic acid has been researched along with Pulmonary Fibrosis in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pulmonary fibrosis is the major limiting factor for the use of bleomycin." | 1.43 | Amelioration of bleomycin-induced lung fibrosis in rats by valproic acid and butyrate: Role of nuclear factor kappa-B, proinflammatory cytokines and oxidative stress. ( Elmaaboud, MAA; Kabel, AM; Omar, MS, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L | 1 |
| Alam, A | 1 |
| Pac-Soo, A | 1 |
| Chen, Q | 1 |
| Shang, Y | 1 |
| Zhao, H | 1 |
| Yao, S | 1 |
| Ma, D | 1 |
| Kabel, AM | 1 |
| Omar, MS | 1 |
| Elmaaboud, MAA | 1 |
2 other studies available for valproic acid and Pulmonary Fibrosis
| Article | Year |
|---|---|
Pretreatment with valproic acid alleviates pulmonary fibrosis through epithelial-mesenchymal transition inhibition in vitro and in vivo.
Topics: A549 Cells; Animals; Epithelial-Mesenchymal Transition; Humans; Lung; Male; Mice; Mice, Inbred C57BL | 2021 |
Amelioration of bleomycin-induced lung fibrosis in rats by valproic acid and butyrate: Role of nuclear factor kappa-B, proinflammatory cytokines and oxidative stress.
Topics: Animals; Bleomycin; Butyrates; Cytokines; Drug Synergism; Drug Therapy; Drug Therapy, Combination; D | 2016 |