valproic acid has been researched along with Proteinuria in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches." | 5.41 | Kidney tubular injury induced by valproic acid: systematic literature review. ( Anguissola, G; Bianchetti, MG; Lava, SAG; Leu, D; Milani, GP; Scoglio, M; Simonetti, BG; Simonetti, GD, 2023) |
| " Intriguingly, this reduction of GM3 and nephrin, as well as albuminuria, were inhibited by administration of valproic acid." | 4.12 | Glycosphingolipid GM3 prevents albuminuria and podocytopathy induced by anti-nephrin antibody. ( Furukawa, JI; Hanamatsu, H; Iwasaki, N; Kawashima, N; Nagane, M; Naito, S; Nakayama, KI; Takeuchi, Y; Yamashita, T, 2022) |
| " The creatinine clearance, serum urea, uric acid, lactate dehydrogenase, potassium, fractional excretion of sodium, and microproteinuria were measured to assess kidney injury." | 3.80 | Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats. ( Arora, S; Brar, R; Kaur, T; Singh, AP; Singh, JP, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Kawashima, N | 1 |
| Naito, S | 1 |
| Hanamatsu, H | 1 |
| Nagane, M | 1 |
| Takeuchi, Y | 1 |
| Furukawa, JI | 1 |
| Iwasaki, N | 1 |
| Yamashita, T | 1 |
| Nakayama, KI | 1 |
| Anguissola, G | 1 |
| Leu, D | 1 |
| Simonetti, GD | 1 |
| Simonetti, BG | 1 |
| Lava, SAG | 1 |
| Milani, GP | 1 |
| Bianchetti, MG | 1 |
| Scoglio, M | 1 |
| Brar, R | 1 |
| Singh, JP | 1 |
| Kaur, T | 1 |
| Arora, S | 1 |
| Singh, AP | 1 |
| Khan, S | 1 |
| Jena, G | 1 |
| Tikoo, K | 1 |
| Kumar, V | 1 |
| Freidkin, I | 1 |
| Herman, M | 1 |
| Tobar, A | 1 |
| Chagnac, A | 1 |
| Ori, Y | 1 |
| Korzets, A | 1 |
| Gafter, U | 1 |
| Van Beneden, K | 1 |
| Geers, C | 1 |
| Pauwels, M | 1 |
| Mannaerts, I | 1 |
| Verbeelen, D | 1 |
| van Grunsven, LA | 1 |
| Van den Branden, C | 1 |
| Hong, SK | 1 |
| Anestis, DK | 1 |
| Brown, PI | 1 |
| Rankin, GO | 1 |
1 review available for valproic acid and Proteinuria
| Article | Year |
|---|---|
Kidney tubular injury induced by valproic acid: systematic literature review.
Topics: Epilepsy; Humans; Kidney; Kidney Tubules, Proximal; Proteinuria; Valproic Acid | 2023 |
6 other studies available for valproic acid and Proteinuria
| Article | Year |
|---|---|
Glycosphingolipid GM3 prevents albuminuria and podocytopathy induced by anti-nephrin antibody.
Topics: Albuminuria; Animals; Glycosphingolipids; Mice; Podocytes; Proteinuria; Valproic Acid | 2022 |
Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Catalase; Creatinine; GABA Agents; Glutathione; Kidney; L-Lactate Dehy | 2014 |
Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat.
Topics: Acetylation; Animals; Apoptosis; Autophagy; Biomarkers; Diabetic Nephropathies; DNA Damage; Enzyme A | 2015 |
Effects of histone deacetylase inhibitors on rat mesangial cells.
Topics: Actins; Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Collagen; Cyclin-Dependent Kinase | 2010 |
Valproic acid attenuates proteinuria and kidney injury.
Topics: Acute Kidney Injury; Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Doxorubicin; Drug | 2011 |
Effect of glucuronidation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats.
Topics: Animals; Biotransformation; Blood Urea Nitrogen; Camphanes; Clofibric Acid; Drinking; Eating; Eugeno | 1999 |