valproic acid has been researched along with Pregnancy in 1154 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purposes of this review were to assess the overall usefulness of the information on the prevention of valproic acid use in women during pregnancy on YouTube™ for patients." | 9.41 | YouTube as a source of information on preventing the use of valproic acid in women during pregnancy. ( Ao, Y; Chen, X; Cui, W; Kang, B; Qu, B; Wang, L, 2023) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 9.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%." | 9.12 | Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. ( Luef, G; Ohman, I; Pittschieler, S; Sabers, A; Tomson, T, 2006) |
| " Previously, we have established a mouse model of ASD based on clinical research, which shows that exposure to valproic acid, an antiepileptic drug, during pregnancy causes an increase in the risk of developing ASD in children." | 9.01 | [Chronic Activation of the Dopaminergic Neuronal Pathway Improves Behavioral Abnormalities in the Prenatal Valproic Acid Exposure Mouse Model of Autism Spectrum Disorder]. ( Hara, Y, 2019) |
| "Lamotrigine is used in pregnancy to control epilepsy and mood disorders." | 8.95 | Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. ( Adams-Webber, T; Barzilay, E; Leibson, T; Nulman, I; Pariente, G; Shulman, T, 2017) |
| "The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited." | 8.86 | Valproic acid monotherapy in pregnancy and major congenital malformations. ( Barisic, I; de Jong-van den Berg, LT; Dolk, H; Garne, E; Jentink, J; Loane, MA; Morris, JK, 2010) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 8.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| "Administration of the antiepileptic drug valproic acid (VPA) during early pregnancy can result in a 1-2% incidence of spina bifida aperta, a closure defect of the posterior neural tube in the human." | 8.78 | Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms. ( Ehlers, K; Hauck, RS; Nau, H, 1991) |
| "In this study, based on the excitatory/inhibitory imbalance theory of autism, the time window of GABA switch, the role of K-Cl co-transporter 2 (KCC2) in adjustment GABA switch, and brain permeability to erythropoietin (EPO), the effects of postnatal -EPO and- nano- erythropoietin (NEPO) have been evaluated in the valproic acid (VPA) rat model of autism." | 8.31 | The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. ( Basiri, M; Darvishzadeh-Mahani, F; Haratizadeh, S; Nozari, M; Ranjbar, M, 2023) |
| "Autism spectrum disorders are complex behavioral disorders that can be caused by exposure to valproic acid (VPA) during pregnancy." | 8.31 | Effects of varied‑intensity endurance exercise training on oxidative and antioxidant factors in the liver of rats with valproic acid‑induced autism. ( Aminzadeh, A; Bashiri, H; Heidari, M; Mirzavandi, F; Moslemizadeh, A; Parizi, AS; Pouya, F; Sabet, N, 2023) |
| " VPA-exposed male pups were administered with two doses of ibudilast (5 and10 mg/kg) and all the groups were evaluated for behavioral parameters like social interaction, spatial memory/learning, anxiety, locomotor activity, and nociceptive threshold." | 8.31 | Phosphodiesterase inhibitor, ibudilast alleviates core behavioral and biochemical deficits in the prenatal valproic acid exposure model of autism spectrum disorder. ( Gautam, V; Kumar, A; Rawat, K; Saha, L; Sandhu, A; Sharma, A, 2023) |
| " Valproic acid (VPA) exposure during pregnancy causes autistic-like traits in offspring." | 8.31 | The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism. ( Aguilar-Hernandez, L; Bringas, ME; Flores, G; Garcés-Ramírez, L; Lima-Castañeda, LÁ; Morales-Medina, JC, 2023) |
| "Prenatal exposure to valproic acid (VPA) may enhance the risk of autism spectrum disorder (ASD) in children." | 8.31 | Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid. ( Aldaghi, MR; Raise-Abdullahi, P; Saadat, M; Sameni, HR; Taherian, AA; Vafaei, AA, 2023) |
| "This study aims to understand the relationship between fecal metabolites and gut microbiota in an adolescent valproic acid-induced rat autism model (VPA-exposed offspring)." | 8.12 | Correlation among gut microbiota, fecal metabolites and autism-like behavior in an adolescent valproic acid-induced rat autism model. ( Gu, Y; Han, Y; Qin, J; Ren, S; Wang, X; Zhang, B; Zhang, S; Zhao, Y, 2022) |
| "We previously demonstrated that prenatal exposure to valproic acid (VPA), an environmental model of autism spectrum disorder (ASD), leads to a hyperexcitable phenotype associated with downregulation of inward-rectifying potassium currents in nucleus accumbens (NAc) medium spiny neurons (MSNs) of adolescent rats." | 8.12 | Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder. ( Costa, A; Curti, L; D'Ambrosio, M; Gerace, E; Iezzi, D; Ilari, A; La Rocca, A; Luceri, C; Mannaioni, G; Masi, A; Ranieri, G; Scardigli, M; Silvestri, L, 2022) |
| "The cilostazol regimen, attenuated prenatal VPA exposure associated hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety." | 8.02 | Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder. ( Kulkarni, GT; Luhach, K; Sharma, B; Singh, VP, 2021) |
| " The present work aimed to detect changes in the AVP numbers and level in a valproic acid (VPA)-induced rat model of autism and the underlying mechanism of its pathogenesis." | 8.02 | Postnatal AVP treatments prevent social deficit in adolescence of valproic acid-induced rat autism model. ( Bai, SZ; Dai, YC; Han, JS; Han, SP; Hu, Y; Lan, XY; Wu, J; Zhang, HF; Zhang, R, 2021) |
| "This study was carried out to determine changes over time in use of folic acid, anti-epileptic drugs (AED), seizures during pregnancy and malformation rate over two decades in women with epilepsy enrolled in the Kerala registry of Epilepsy and Pregnancy (KREP)." | 7.96 | Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. ( A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV, 2020) |
| "Valproic acid (VPA), a widely prescribed antiepileptic drug and an effective treatment for psychiatric disorders, is teratogenic causing neural tube defects (NTDs) and other defects in the exposed embryo." | 7.96 | Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD-1 mouse embryos with neural tube defects. ( Shafique, S; Winn, LM, 2020) |
| " This study examined the effect of metformin on VPA-induced autism spectrum disorders in rats." | 7.96 | Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system. ( Adeyemi, OO; Balogun, AO; Ishola, IO, 2020) |
| "This study was performed to evaluate the effects of prenatal exposure to pregabalin (PGB) on behavioral changes of rat offspring in an animal model of valproic acid (VPA)-induced autism-like symptoms." | 7.96 | Prenatal pregabalin is associated with sex-dependent alterations in some behavioral parameters in valproic acid-induced autism in rat offspring. ( Bashiri, H; Moslemizadeh, A; Sepehri, G; Shamsi Meymandi, M; Vakili Shahrbabaki, S, 2020) |
| " Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy." | 7.91 | Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. ( Mirza, R; Sharma, B, 2019) |
| "To establish an improved mouse model of valproic acid (VPA)-induced autism that better mimics human autism." | 7.91 | [Improvement of a mouse model of valproic acid-induced autism]. ( Chen, D; Hu, Y; Li, Y; Wang, S; Zheng, W, 2019) |
| "Prenatal exposure to valproic acid (VPA) induces behavioral disorders and enhancement of oxido-inflammatory stress in Autism Spectrum Disorders (ASDs)." | 7.88 | Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism. ( Hajizadeh Moghaddam, A; Khalaj, R; Zare, M, 2018) |
| "Considering the potential role of lymphocytes in the pathophysiology of autism spectrum disorder (ASD), we aimed to evaluate possible alterations of T cell pools in the lymphoid organs of an animal model of autism induced by valproic acid (VPA)." | 7.88 | Reduced CD4 T Lymphocytes in Lymph Nodes of the Mouse Model of Autism Induced by Valproic Acid. ( Bambini-Junior, V; Baronio, D; Bauer-Negrini, G; Castro, K; Della-Flora Nunes, G; Gottfried, C; Mendes-da-Cruz, DA; Riesgo, R; Savino, W, 2018) |
| "The aim was to identify the effects of early vitamin D supplementation on autism-like behaviors (ASD) induced by valproic acid (VPA, an anti-convulsant and a mood stabilizer) in rats." | 7.85 | Behavioral improvements in a valproic acid rat model of autism following vitamin D supplementation. ( Du, L; Duan, Z; Li, F; Zhao, G, 2017) |
| "The study was performed using a rodent model of autism by exposing rat fetuses to valproic acid (VPA) on the 12." | 7.85 | Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism. ( Al-Askar, M; Al-Ayadhi, L; Bhat, RS; El-Ansary, A; Selim, M, 2017) |
| " Here, we investigate the impact on the corticostriosomal pathway in the valproic acid (VPA)-induced autism spectrum disorder mouse model." | 7.85 | Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder. ( Kuo, HY; Liu, FC, 2017) |
| "Recent studies have reported that oxytocin ameliorates behavioral abnormalities in both animal models and individuals with autism spectrum disorders (ASD)." | 7.85 | Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Higuchi, M; Matsuda, T; Nakazawa, T; Takuma, K, 2017) |
| "We describe a novel ER+ breast cancer model to study de novo and acquired tamoxifen (TAM) resistance." | 7.85 | Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model. ( Bouker, KB; Clarke, R; Cook, KL; Cruz, MI; de Assis, S; Hilakivi-Clarke, L; Hu, R; Jin, L; Nguyen, N; Wang, X; Wang, Y; Wärri, A; Wehrenberg, B; Xuan, J; Zhang, X; Zwart, A, 2017) |
| "Rodents exposed prenatally to valproic acid (VPA) show autism-related behavioral abnormalities." | 7.83 | Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Katashiba, K; Matsuda, T; Onaka, Y; Takano, E; Takuma, K; Taruta, A, 2016) |
| "Exposure to valproic acid (VPA) during pregnancy has been linked with increased incidence of autism, and has repeatedly been demonstrated as a useful autism mouse model." | 7.83 | Early Behavioral Abnormalities and Perinatal Alterations of PTEN/AKT Pathway in Valproic Acid Autism Model Mice. ( Ahn, S; Kim, HS; Lee, K; Mahmood, U; Yang, EJ, 2016) |
| "Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control and subsequent AED changes in women who underwent attempts to withdraw valproic acid (VPA) during the first trimester of pregnancy." | 7.83 | Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2016) |
| "Components of the mTOR pathway were assayed by Western blotting in postmortem fusiform gyrus samples from 11 subjects with idiopathic autism and 13 controls and in valproic acid versus saline-exposed rat neocortex." | 7.81 | Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid. ( Ahn, Y; Fahnestock, M; Michalski, B; Nicolini, C; Rho, JM, 2015) |
| "Valproic acid (VPA) mouse model of autism spectrum disorder (ASD) has been characterized mostly by impaired ultrasonic vocalization, poor sociability and increased repetitive self-grooming behavior." | 7.81 | Characterization of in utero valproic acid mouse model of autism by local field potential in the hippocampus and the olfactory bulb. ( Bumrungsri, S; Chatpun, S; Cheaha, D; Kumarnsit, E, 2015) |
| "Valproic acid administration during gestational period causes behavior and biochemical deficits similar to those observed in humans with autism spectrum disorder." | 7.81 | Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder. ( Kumar, H; Sharma, B; Sharma, BM, 2015) |
| "Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid (Aβ) degradation enzyme neprilysin (NEP) in primary neurons." | 7.80 | Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin. ( Le, W; Li, J; Li, T; Tang, Y; Wang, Z; Zhang, XJ, 2014) |
| "Human fetal exposure to valproic acid (VPA), a widely-used anti-epileptic and mood-stabilizing drug, leads to an increased incidence of behavioral and intellectual impairments including autism; VPA administration to pregnant rats and mice at gestational days 12." | 7.80 | Increased BDNF expression in fetal brain in the valproic acid model of autism. ( Almeida, LE; Krueger, BK; Roby, CD, 2014) |
| "We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism." | 7.80 | Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. ( Ben-Ari, Y; Brouchoud, C; Burnashev, N; Chazal, G; Eftekhari, S; Ferrari, DC; Khalilov, I; Lemonnier, E; Lozovaya, N; Nardou, R; Shahrokhi, A; Tsintsadze, T; Tsintsadze, V; Tyzio, R, 2014) |
| "We recently showed that prenatal exposure to valproic acid (VPA) in mice causes autism-like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and spatial learning disability, in male offspring." | 7.80 | Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. ( Ago, Y; Hara, Y; Hashimoto, H; Hayata-Takano, A; Kataoka, S; Kawanai, T; Maeda, Y; Matsuda, T; Takano, E; Takuma, K; Watanabe, R, 2014) |
| "Autism spectrum disorders (ASD) involve a complex interplay of both genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA)." | 7.80 | Resveratrol prevents social deficits in animal model of autism induced by valproic acid. ( Bambini-Junior, V; Della Flora Nunes, G; Fontes-Dutra, M; Gottfried, C; Michels, M; Mueller de Melo, G; Nogueira Freire, V; Riesgo, R; Zanatta, G, 2014) |
| "The aim of this work is to evaluate the impact of butyl paraben (BP) in brain of the pups developed for mothers administered BP from early pregnancy till weaning and its effect on studying the behavior, brain neurotransmitters and brain derived neurotrophic factor BDNF via comparing the results with valproic acid (VA) autistic-rat model preparing by a single oral injection dose of VA (800 mg/kg b." | 7.79 | Combined prenatal and postnatal butyl paraben exposure produces autism-like symptoms in offspring: comparison with valproic acid autistic model. ( Ali, EH; Elgoly, AH, 2013) |
| "Maternal use of valproic acid (VPA) during pregnancy has been implicated in the aetiology of autism spectrum disorders in children, and rodents prenatally exposed to VPA showed behavioural alterations similar to those observed in humans with autism." | 7.79 | Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid. ( Ago, Y; Hara, Y; Kataoka, S; Maeda, Y; Matsuda, T; Takuma, K, 2013) |
| " Using the prenatal valproic acid (VPA)-injection model of autism spectrum disorder (ASD) in rats, which produces social impairrment and altered seizure susceptibility as in human ASD patients as well as mild neural tube defects like crooked tail phenotype, we examined whether chronic administration of red ginseng extract may rescue the social impairment and crooked tail phenotype in prenatally VPA-exposed rat offspring." | 7.79 | Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. ( Han, SH; Kim, HJ; Kim, HY; Kim, KC; Kim, P; Kwon, KJ; Lee, JM; Park, JH; Shin, CY, 2013) |
| "This study, in a meaningful number of exposed pregnancies, confirms a low risk for MCM with levetiracetam monotherapy use in pregnancy." | 7.79 | Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. ( Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Liggan, B; Mawhinney, E; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2013) |
| " Administration of valproic acid (VA) during first trimester of pregnancy causes neural tube defects (NTDs)." | 7.78 | Reduction in valproic acid-induced neural tube defects by maternal immune stimulation: role of apoptosis. ( Hrubec, T; Mallela, M, 2012) |
| "Valproic acid (VPA) is a potent inducer of neural tube defects in human and mouse, its teratogenicity is associated with its potential to generation of free radicals and increase oxidative stress." | 7.78 | Spirulina (arthrospira) protects against valproic acid-induced neural tube defects in mice. ( Chamorro-Cevallos, G; Escalona-Cardoso, GN; Paniagua-Castro, N; Pérez-Pastén, R, 2012) |
| "Health care providers reported lamotrigine exposure during pregnancy, and subsequent outcomes, on a voluntary basis." | 7.77 | Final results from 18 years of the International Lamotrigine Pregnancy Registry. ( Cunnington, MC; Ferber, S; Messenheimer, JA; Tennis, P; Weil, JG; Yerby, M, 2011) |
| "Valproic acid is a commonly prescribed antiepileptic agent that causes birth defects including neural tube defects." | 7.77 | Valproic acid-induced DNA damage increases embryonic p27(KIP1) and caspase-3 expression: a mechanism for valproic-acid induced neural tube defects. ( Tung, EW; Winn, LM, 2011) |
| "Exposure to the anticonvulsant valproic acid (VPA) during the first trimester of pregnancy is associated with an increased risk of congenital malformations including heart defects, craniofacial abnormalities, skeletal and limb defects, and, most frequently, neural tube defects (NTDs)." | 7.77 | Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects. ( Tung, EW; Winn, LM, 2011) |
| "Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter." | 7.76 | Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| " In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia." | 7.76 | Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010) |
| "Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)." | 7.74 | Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain. ( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008) |
| "In utero exposure to valproic acid (VPA) during pregnancy is associated with an increased risk of neural tube defects (NTDs)." | 7.73 | Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. ( Dawson, JE; Raymond, AM; Winn, LM, 2006) |
| " Maternal treatment with valproic acid (VPA) during pregnancy induces NTD in susceptible fetuses." | 7.73 | Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. ( Benedict, S; Nagelkerke, N; Padmanabhan, R; Shafiullah, M, 2006) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 7.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 7.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "Neural tube defects (NTDs) are the most common of the major anomalies associated with in utero exposure to valproic acid." | 7.70 | Safe use of valproic acid during pregnancy. ( Kennedy, D; Koren, G, 1999) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 7.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "Neural tube defects were induced dose-dependently by single injections of the anticonvulsant drug valproic acid (VPA) as sodium salt in mice on gestational day 8." | 7.67 | Valproic acid-induced neural tube defects: reduction by folinic acid in the mouse. ( Nau, H; Trotz, M; Wegner, C, 1987) |
| "The teratogenic effects of valproic acid and its 4-propyl-4-pentenoic acid (4-en) metabolite were investigated in three inbred mouse strains that were known to possess differing sensitivity to heat-induced neural tube defects." | 7.67 | Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite. ( Bennett, GD; Finnell, RH; Karras, SB; Mohl, VK, 1988) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 7.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy." | 6.65 | Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981) |
| "Valproic acid (VPA) is an anticonvulsant and mood stabilizer that, when used during the gestational period, increases the risk of ASD in the offspring." | 6.58 | Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid. ( Bambini-Junior, V; Deckmann, I; Fontes-Dutra, M; Gottfried, C; Schwingel, GB, 2018) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 6.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Valproic acid (VPA) is a known human teratogen." | 6.45 | Valproic acid in pregnancy: how much are we endangering the embryo and fetus? ( Ornoy, A, 2009) |
| "When treatment with valproic acid is the most appropriate treatment to achieve optimal seizure control, a number of measures can be implemented to minimise risk to the fetus." | 6.43 | Valproic acid in epilepsy : pregnancy-related issues. ( Genton, P; Semah, F; Trinka, E, 2006) |
| "Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population." | 6.43 | Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006) |
| " The repetitive behaviors were ameliorated relatively in VPA groups with NEPO2000 treatment, and astrogliosis was reduced even when VPA rats were treated with a lower dosage of NEPO." | 5.91 | Astrocyte responses to postnatal erythropoietin and nano-erythropoietin treatments in a valproic acid-induced animal model of autism. ( Basiri, M; Haratizadeh, S; Nozari, M; Ranjbar, M, 2023) |
| "Valproic acid (VPA) is a well-known anti-epileptic drug, but its prenatal exposure to animals causes social impairment, neurotransmitters imbalance, and neuroinflammation with ASD-like phenotypes." | 5.91 | Syringic acid alleviates valproic acid induced autism via activation of p38 mitogen-activated protein kinase: Possible molecular approach. ( Mallan, S; Singh, S, 2023) |
| "The mouse model of autism induced by prenatal exposure to valproic acid (VPA) was used to assess the therapeutic potential of STX209 on autism‑like behaviour in the present study." | 5.72 | The GABAB receptor agonist STX209 reverses the autism‑like behaviour in an animal model of autism induced by prenatal exposure to valproic acid. ( Chang, H; Ding, J; Gao, C; He, M; Jiang, S; Li, W; Sun, T; Sun, Y; Wang, F; Wang, Y; Xiao, L; Zhu, C, 2022) |
| " Pregnant C57BL/6 J mice were intraperitoneally injected with a dosage of 500 mg/kg valproic acid (VPA) on embryonic day 10." | 5.72 | Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism. ( Kwan, KM; Ma, SY, 2022) |
| "Autism spectrum disorder is a neurodevelopmental disorder characterized by sensory abnormalities, social skills impairment and cognitive deficits." | 5.72 | Alterations in the intrinsic discharge activity of CA1 pyramidal neurons associated with possible changes in the NADPH diaphorase activity in a rat model of autism induced by prenatal exposure to valproic acid. ( Behzadi, G; Borjkhani, M; Davoudi, S; Hajisoltani, R; Hosseinmardi, N; Janahmadi, M; Karimi, SA; Khatibi, VA; Rahdar, M, 2022) |
| "Melatonin is an endogenous hormone and can restore gut microbial dysbiosis under various disease conditions." | 5.72 | Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism. ( Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y, 2022) |
| "Valproic acid (VPA) is a drug used to treat epilepsy, bipolar disorders and headaches." | 5.62 | Valproic acid during pregnancy decrease the number of spermatogenic cells and testicular volume in the offspring of mice: Stereological quantification. ( Conei, D; Risopatrón, J; Rojas, M; Santamaría, L, 2021) |
| "Despite the increasing prevalence of autism spectrum disorder (ASD), there is still a deficiency in understanding its exact pathophysiology and treatment, therefore validation of translational ASD animal model is warranted." | 5.62 | Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study. ( Abdelraouf, SM; Aboul-Fotouh, S; Abuelezz, SA; Ahmed, AI; Bahaa, N; Elnahas, EM; Hassan, GA; Ibrahim, EA; Mohamad, MI; Nabil, MM, 2021) |
| "These results showed that VAD in autism might result in cerebellar impairments and be a factor aggravating a subtype of ASD with motor comorbidities." | 5.62 | Vitamin A supplementation ameliorates motor incoordination via modulating RORα in the cerebellum in a valproic acid-treated rat autism model with vitamin A deficiency. ( Cheng, B; Hou, N; Li, L; Li, T; Liu, H; Wang, S; Wu, Q; Yang, T, 2021) |
| "Suramin treatment did not affect VPA-induced upregulation of P2X4 and P2Y2 receptor expression in the hippocampus, and P2X4 receptor expression in the medial prefrontal cortex, but normalized an increased level of interleukin 6 (IL-6)." | 5.56 | Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism. ( Bambini-Junior, V; Bauer-Negrini, G; Brum Schwingel, G; Carello-Collar, G; Castillo, ARG; Corrêa-Velloso, J; Deckmann, I; Fontes-Dutra, M; Gonçalves, MCB; Gottfried, C; Hirsch, MM; Körbes-Rockenbach, M; Naaldijk, Y; Rabelo, B; Santos-Terra, J; Schneider, T; Staevie, GZ; Ulrich, H, 2020) |
| "Quercetin (50 mg/kg) was administered orally to the animals from gestational days 6." | 5.56 | Quercetin prevents alterations of behavioral parameters, delta-aminolevulinic dehydratase activity, and oxidative damage in brain of rats in a prenatal model of autism. ( Baldissarelli, J; de Mattos, BDS; de Souza, AA; Gamaro, GD; Pedra, NS; Soares, MSP; Spanevello, RM; Spohr, L; Stefanello, FM; Teixeira, FC, 2020) |
| "The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients." | 5.56 | Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences. ( Braccagni, G; De Montis, MG; Gambarana, C; Guzzi, F; Parenti, M; Scheggi, S, 2020) |
| "Valproic acid is an established structural and neurodevelopmental teratogen." | 5.51 | The effects of valproic acid on early pregnancy human placentas: Pilot ex vivo analysis in cultured placental villi. ( Eisenberg, I; Eyal, S; Imbar, T; Shmuel, M; Tetro, N; Wohl, D; Yagel, S, 2019) |
| "Focal epilepsy was diagnosed in 244 (69." | 5.51 | Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study. ( Bosak, M; Słowik, A; Turaj, W, 2019) |
| "Autism is characterized by numerous behavioral impairments, such as in communication, socialization and cognition." | 5.48 | Zinc as a therapy in a rat model of autism prenatally induced by valproic acid. ( Bernardi, MM; Cezar, LC; da Fonseca, CCN; de Lima, APN; Felicio, LF; Kirsten, TB, 2018) |
| "Rats of the VPA model of autism showed reduced total reciprocal social interaction, prevented by prenatal treatment with resveratrol (RSV)." | 5.48 | Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA. ( Bambini-Junior, V; Bauer-Negrini, G; Deckmann, I; Della-Flora Nunes, G; Fontes-Dutra, M; Gottfried, C; Hirsch, MM; Margis, R; Nunes, W; Rabelo, B; Riesgo, R, 2018) |
| "The etiology of autism remains unknown and its molecular basis is not yet well understood." | 5.48 | Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism. ( Imai, M; Lwin, TT; Mar, O; Nway, NC; Watanabe, H; Win-Shwe, TT, 2018) |
| "Valproic acid treated animals were treated from 5 days preceding behavioral testing in the Morris water maze at a clinically relevant concentration." | 5.42 | Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy. ( Jellett, AP; Jenks, K; Lucas, M; Scott, RC, 2015) |
| "Valproic acid (600 mg/kg) was administered intraperitoneally to the pregnant mice on gestational day 12." | 5.42 | Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism. ( Al-Amin, MM; Khan, FR; Mahmud Reza, H; Rahman, MM; Zaman, F, 2015) |
| "Previously, autism spectrum disorder (ASD) has been identified mainly by social communication deficits and behavioral symptoms." | 5.42 | Alteration of spontaneous spectral powers and coherences of local field potential in prenatal valproic acid mouse model of autism. ( Cheaha, D; Kumarnsit, E, 2015) |
| "Valproic acid (VPA) is a known teratogenic drug." | 5.40 | Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report. ( Casselman, J; De Kegel, A; Dhooge, I; Janssens, S; Maes, L; Van Houtte, E, 2014) |
| "Autism is characterized by behavioral impairments in three main domains: social interaction; language, communication and imaginative play; and the range of interests and activities." | 5.39 | Increased hippocampal cell density and enhanced spatial memory in the valproic acid rat model of autism. ( Edalatmanesh, MA; Moghadas, M; Nikfarjam, H; Vafaee, F, 2013) |
| "In order to establish the etiology of autism with facial palsy, research into developmental abnormalities of the peripheral facial nerves is necessary." | 5.37 | Morphological abnormalities of embryonic cranial nerves after in utero exposure to valproic acid: implications for the pathogenesis of autism with multiple developmental anomalies. ( Imura, Y; Narita, M; Narita, N; Oyabu, A; Tashiro, Y; Uchida, A, 2011) |
| "Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests." | 5.36 | Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010) |
| "Autism is a severe behavioral disorder characterized by pervasive impairments in social interactions, deficits in verbal and non-verbal communication, and stereotyped behaviors, with a four times higher incidence in boys than in girls." | 5.35 | Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid. ( Basta-Kaim, A; Budziszewska, B; Kubera, M; Przewłocki, R; Roman, A; Schneider, K; Schneider, T, 2008) |
| "Aspirin was shown to increase oxygen affinity of hemoglobin via acetylating lysine residues and its general acetylating activity on proteins such as histones makes it also an interesting candidate to activate fetal hemoglobin." | 5.34 | Medroxyprogesterone - valproic acid - aspirin. MVA regime to reduce transfusion associated mortality in late-term hemoglobinopathies. Hypothesis and rationale. ( Altinoz, MA; Carin, MN; Gedikoglu, G; Ozdilli, K, 2007) |
| "Recently, a new rodent model of autism was created by exposure of rat fetuses to valproic acid (VPA) on the 12." | 5.33 | Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. ( Przewłocki, R; Schneider, T, 2005) |
| "Pregnancy was otherwise uneventful." | 5.32 | Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero. ( Audeoud, F; Bernardin, A; Gaugler, C; Messer, J; Stoll, C, 2003) |
| "Morphologic abnormalities found in autism (e." | 5.31 | Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. ( Kato, M; Miyazaki, K; Narita, M; Narita, N; Okado, N; Tazoe, M, 2002) |
| "Valproic acid is an anticonvulsant widely used for the treatment of epilepsy." | 5.31 | Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( Matsuo, H; Nakano, H; Ohtani, H; Sawada, Y; Takanaga, H; Tsukimori, K; Ushigome, F, 2001) |
| "PTA significantly reduced VPA-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced." | 5.29 | Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). ( Nagao, T; Sato, M; Shirota, M, 1995) |
| "Fetuses were examined for exencephaly, resorption, and fetal weight retardation on day 18 of gestation." | 5.28 | Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice. ( Elmazar, MM; Nau, H, 1992) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 5.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| "Valproic acid (VPA) is a widely used antiepileptic drug not recommended in pregnancy because it is teratogenic." | 5.22 | Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells. ( Gomes, JDA; Kowalski, TW; Lord, VO; Mariath, LM; Recamonde-Mendoza, M; Sgarioni, E; Vianna, FSL, 2022) |
| "Valnoctamide could be an important valproate substitute for women of childbearing age with bipolar disorder who may become pregnant." | 5.14 | Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double-blind, controlled, add-on clinical trial. ( Agam, G; Applebaum, J; Belmaker, RH; Bersudsky, Y; Gaiduk, Y; Mishory, A; Podberezsky, A; Sharony, L, 2010) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 5.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%." | 5.12 | Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. ( Luef, G; Ohman, I; Pittschieler, S; Sabers, A; Tomson, T, 2006) |
| " In the general population, it is well established that periconceptual folic acid reduces the risk of neural tube defects (NTDs) and possibly other congenital abnormalities." | 5.05 | Valproate and folate: Congenital and developmental risks. ( Green, R; Reynolds, EH, 2020) |
| " Previously, we have established a mouse model of ASD based on clinical research, which shows that exposure to valproic acid, an antiepileptic drug, during pregnancy causes an increase in the risk of developing ASD in children." | 5.01 | [Chronic Activation of the Dopaminergic Neuronal Pathway Improves Behavioral Abnormalities in the Prenatal Valproic Acid Exposure Mouse Model of Autism Spectrum Disorder]. ( Hara, Y, 2019) |
| " In particular, exposure to valproic acid (VPA) during pregnancy has been demonstrated to increase the risk of autism in children." | 4.98 | The valproic acid-induced rodent model of autism. ( Fahnestock, M; Nicolini, C, 2018) |
| "Lamotrigine is used in pregnancy to control epilepsy and mood disorders." | 4.95 | Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. ( Adams-Webber, T; Barzilay, E; Leibson, T; Nulman, I; Pariente, G; Shulman, T, 2017) |
| " Oxcarbazepine and lamotrigine were associated with increased occurrence of autism." | 4.95 | Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis. ( Cogo, E; D'Souza, J; Finkelstein, Y; Hemmelgarn, BR; Hutton, B; Kealey, R; MacDonald, H; Reynen, E; Rios, P; Soobiah, C; Straus, SE; Thavorn, K; Tricco, AC; Veroniki, AA; Yazdi, F, 2017) |
| "Orofacial clefting (OFC) has been described in infants exposed to valproic acid (VPA) prenatally, but often no distinction is made between cleft lip and palate (CLP) and isolated cleft palate (ICP)." | 4.93 | In utero exposure to valproate increases the risk of isolated cleft palate. ( Bromley, R; Clayton-Smith, J; Irwin, B; Jackson, A; Morrow, J, 2016) |
| "Valproic acid (VPA) use during pregnancy increases fetal risk of major congenital malformations and cognitive impairment." | 4.93 | Guideline adherence for mentally ill reproductive-aged women on treatment with valproic acid: a retrospective chart review. ( Gotlib, D; Kurlander, J; Muzik, M; Perelstein, E; Riba, M; Zivin, K, 2016) |
| "The developmental quotient (DQ) was lower in children exposed to carbamazepine (CBZ) (n = 50) than in children born to women without epilepsy (n = 79); mean difference (MD) of -5." | 4.90 | Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. ( Adab, N; Bromley, R; Greenhalgh, J; Marson, AG; McKay, AJ; Sanniti, A; Tudur Smith, C; Weston, J, 2014) |
| "The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited." | 4.86 | Valproic acid monotherapy in pregnancy and major congenital malformations. ( Barisic, I; de Jong-van den Berg, LT; Dolk, H; Garne, E; Jentink, J; Loane, MA; Morris, JK, 2010) |
| "Valproic acid (2-n-propylpentanoic acid, VPA) is well-established as a mood-stabilizer for bipolar disorder, in addition to its application as a treatment in neurological disorders such as epilepsy, migraine headaches, and chronic neuropathic pain." | 4.84 | Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review. ( Rasgon, NL; Reynolds, MF; Sisk, EC, 2007) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 4.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| "The acute and chronic pharmacotherapy of bipolar disorder requires an understanding of the pharmacology of very dissimilar compounds--the mood stabilizers (lithium, carbamazepine and valproate) and several classes of antidepressants." | 4.78 | Pharmacological issues in the treatment of bipolar disorder: focus on mood-stabilizing compounds. ( Ketter, TA; Potter, WZ, 1993) |
| "Administration of the antiepileptic drug valproic acid (VPA) during early pregnancy can result in a 1-2% incidence of spina bifida aperta, a closure defect of the posterior neural tube in the human." | 4.78 | Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms. ( Ehlers, K; Hauck, RS; Nau, H, 1991) |
| "Valproic acid use during pregnancy results in an absolute risk for spina bifida of 1-2%." | 4.77 | Teratogen update: valproic acid. ( Lammer, EJ; Oakley, GP; Sever, LE, 1987) |
| "We have evaluated 19 children who were exposed to valproic acid (VPA) in utero to look for manifestations of a fetal valproate syndrome (FVS), as proposed by Di Liberti et al." | 4.77 | Verification of the fetal valproate syndrome phenotype. ( Ardinger, HH; Atkin, JF; Blackston, RD; Clarren, SK; Elsas, LJ; Flannery, DB; Harrod, MJ; Lammer, EJ; Livingstone, S; Pellock, JM, 1988) |
| "To investigate whether children born to mothers who used carbamazepine during pregnancy had worse academic performance in adolescence." | 4.31 | Prenatal Carbamazepine Exposure and Academic Performance in Adolescents: A Population-Based Cohort Study. ( Lee, PMY; Li, F; Li, J; Ren, T, 2023) |
| "In this study, based on the excitatory/inhibitory imbalance theory of autism, the time window of GABA switch, the role of K-Cl co-transporter 2 (KCC2) in adjustment GABA switch, and brain permeability to erythropoietin (EPO), the effects of postnatal -EPO and- nano- erythropoietin (NEPO) have been evaluated in the valproic acid (VPA) rat model of autism." | 4.31 | The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. ( Basiri, M; Darvishzadeh-Mahani, F; Haratizadeh, S; Nozari, M; Ranjbar, M, 2023) |
| "The prenatal valproic acid (VPA) model was used to induce autism-like behaviors in offspring rats." | 4.31 | Inhalation of Cananga odorata essential oil relieves anxiety behaviors in autism-like rats via regulation of serotonin and dopamine metabolism. ( Wang, ST; Yao, L; Zhang, N, 2023) |
| "Microglial dysfunction has been reported in the valproic acid (VPA)-induced autism spectrum disorder (ASD) rat models." | 4.31 | Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. ( Chen, J; Hu, C; Li, T; Luo, L; Wei, H; Wu, Q; Yang, T; Yuan, B, 2023) |
| "Autism spectrum disorder is a developmental disorder that can affect sensory-motor behaviors in the valproic acid (Val) rodent model of autism." | 4.31 | Alteration in social interaction and tactile discrimination of juvenile autistic-like rats following tactile stimulation and whisker deprivation. ( Afarinesh, MR; Ahmadi, BBM; Jafaripour, L; Sheibani, V, 2023) |
| "Findings from this explorative study strengthen the evidence for the warning against the use of valproate in pregnancy and raise concern of risks of specific psychiatric disorders associated with topiramate and levetiracetam." | 4.31 | Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. ( Alvestad, S; Bjørk, MH; Christensen, J; Cohen, JM; Dreier, JW; Furu, K; Gissler, M; Igland, J; Leinonen, MK; Sun, Y; Tomson, T; Zoega, H, 2023) |
| "Autism spectrum disorders are complex behavioral disorders that can be caused by exposure to valproic acid (VPA) during pregnancy." | 4.31 | Effects of varied‑intensity endurance exercise training on oxidative and antioxidant factors in the liver of rats with valproic acid‑induced autism. ( Aminzadeh, A; Bashiri, H; Heidari, M; Mirzavandi, F; Moslemizadeh, A; Parizi, AS; Pouya, F; Sabet, N, 2023) |
| "05) of an increased hazard of fetal malformation associated with exposure to valproate, carbamazepine, topiramate, zonisamide, and with conception after assisted fertilization, but a reduced hazard in the offspring of women who continued to smoke during pregnancy." | 4.31 | Specific fetal malformations following intrauterine exposure to antiseizure medication. ( Eadie, M; Graham, J; Hitchcock, A; Lander, C; O'Brien, T; Perucca, P; Vajda, F, 2023) |
| " Valproic acid (VPA) is an anticonvulsant drug that, when administered during pregnancy, causes various birth defects." | 4.31 | Social deficits in mice prenatally exposed to valproic acid are intergenerationally inherited and rescued by social enrichment. ( Barrios, CD; Depino, AM; Zappala, C, 2023) |
| " VPA-exposed male pups were administered with two doses of ibudilast (5 and10 mg/kg) and all the groups were evaluated for behavioral parameters like social interaction, spatial memory/learning, anxiety, locomotor activity, and nociceptive threshold." | 4.31 | Phosphodiesterase inhibitor, ibudilast alleviates core behavioral and biochemical deficits in the prenatal valproic acid exposure model of autism spectrum disorder. ( Gautam, V; Kumar, A; Rawat, K; Saha, L; Sandhu, A; Sharma, A, 2023) |
| "Valproic acid (VPA) treatment during pregnancy is a risk factor for developing autism spectrum disorder, cognitive deficits, and stress-related disorders in children." | 4.31 | Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and brain cytokines. ( Amouzad Mahdirejei, H; Barzegari, A; Esmaeili, MH; Hanani, M; Salari, AA, 2023) |
| " Valproic acid (VPA) exposure during pregnancy causes autistic-like traits in offspring." | 4.31 | The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism. ( Aguilar-Hernandez, L; Bringas, ME; Flores, G; Garcés-Ramírez, L; Lima-Castañeda, LÁ; Morales-Medina, JC, 2023) |
| "Prenatal exposure to valproic acid (VPA) may enhance the risk of autism spectrum disorder (ASD) in children." | 4.31 | Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid. ( Aldaghi, MR; Raise-Abdullahi, P; Saadat, M; Sameni, HR; Taherian, AA; Vafaei, AA, 2023) |
| "Use of valproate and carbamazepine decreased progressively, use of lamotrigine remained relatively static, and the use of levetiracetam increased progressively, whereas the use of topiramate first increased and then fell again, associated with a temporary increase in malformation-associated pregnancy rate." | 4.31 | Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control. ( Eadie, M; Graham, J; Hitchcock, A; Lander, C; O'Brien, T; Perucca, P; Vajda, F, 2023) |
| "This study aims to understand the relationship between fecal metabolites and gut microbiota in an adolescent valproic acid-induced rat autism model (VPA-exposed offspring)." | 4.12 | Correlation among gut microbiota, fecal metabolites and autism-like behavior in an adolescent valproic acid-induced rat autism model. ( Gu, Y; Han, Y; Qin, J; Ren, S; Wang, X; Zhang, B; Zhang, S; Zhao, Y, 2022) |
| " In our case series, lamotrigine proved to be less effective and less controllable than other drugs during pregnancy." | 4.12 | [Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center]. ( Bien, CG; Hagemann, A; Knaak, N; Müffelmann, B, 2022) |
| "To assess knowledge among neurologists in Sweden and Norway on the restrictions issued by the European Medicines Agency (EMA) regarding use of valproic acid (VPA) to female patients of childbearing potential, their use of the pregnancy prevention programme and their VPA prescription habits." | 4.12 | Valproate Restrictions in Sweden and Norway: Online survey suggests implementation deficit. ( Sveberg, L; Taubøll, E; Tomson, T; Zelano, J, 2022) |
| " Valproic acid (VPA) injection during pregnancy elicits autism-like behavior in the offspring, making it a classic animal model of ASD." | 4.12 | iTRAQ-Based Proteomics Analysis of Rat Cerebral Cortex Exposed to Valproic Acid before Delivery. ( Cao, X; Chen, M; Lin, J; Liu, X; Shen, L; Tang, X; Ullah Khan, N; Zhang, H; Zhang, K; Zhao, Y, 2022) |
| " In most Australian women starting therapy for epilepsy initiating treatment with levetiracetam monotherapy may offer the best chance of such a desirable outcome to a future pregnancy, yet to be confirmed." | 4.12 | Achieving neurologically desirable outcomes to pregnancy in women with epilepsy. ( Eadie, MJ; Graham, JE; Hitchcock, AE; Lander, CM; O'Brien, TJ; Perucca, P; Vajda, FJE, 2022) |
| "Maternal exposure to anti-epileptic drug Valproic acid (VPA) during pregnancy increases the risk for the development of autism spectrum disorders (ASD)." | 4.12 | Prenatal exposure to valproic acid alters Reelin, NGF expressing neuron architecture and impairs social interaction in their autistic-like phenotype male offspring. ( Rajan, KE; Sivasangari, K, 2022) |
| "Valproic acid (VPA) is a clinically used antiepileptic drug, but it is associated with a significant risk of a low verbal intelligence quotient (IQ) score, attention-deficit hyperactivity disorder and autism spectrum disorder in children when it is administered during pregnancy." | 4.12 | A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure. ( Honda, T; Ishihara, N; Ishihara, Y; Itoh, K; Namba, K; Taketoshi, M; Tominaga, T; Tominaga, Y; Tsuji, M; Vogel, CFA; Yamazaki, T, 2022) |
| "Chemotherapeutic agents such as methotrexate (MTX), raltitrexed (RTX), 5-fluorouracil (5-FU), hydroxyurea (HU), and retinoic acid (RA), and valproic acid (VPA), an antiepileptic drug, all can cause malformations in the developing central nervous system (CNS), such as neural tube defects (NTDs)." | 4.12 | Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis. ( Guan, Z; Li, S; Liang, Y; Niu, B; Wang, J; Wang, X; Yang, A; Yu, J; Zhu, Z, 2022) |
| "We previously demonstrated that prenatal exposure to valproic acid (VPA), an environmental model of autism spectrum disorder (ASD), leads to a hyperexcitable phenotype associated with downregulation of inward-rectifying potassium currents in nucleus accumbens (NAc) medium spiny neurons (MSNs) of adolescent rats." | 4.12 | Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder. ( Costa, A; Curti, L; D'Ambrosio, M; Gerace, E; Iezzi, D; Ilari, A; La Rocca, A; Luceri, C; Mannaioni, G; Masi, A; Ranieri, G; Scardigli, M; Silvestri, L, 2022) |
| "Valproic acid (VPA), a prescribed drug commonly used for various neurological perturbations, has been implicated in teratogenic inflictions on developing fetuses during pregnancy." | 4.12 | Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses. ( Avramidou, E; Dermitzakis, I; Emmanouil-Nikoloussi, EN; Manthos, K; Manthou, ME; Meditskou, S; Theotokis, P, 2022) |
| "The cilostazol regimen, attenuated prenatal VPA exposure associated hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety." | 4.02 | Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder. ( Kulkarni, GT; Luhach, K; Sharma, B; Singh, VP, 2021) |
| "Prenatal uptake of valproic acid (VPA) was associated with increased risk of fetal cardiac anomalies and autism spectrum disorder (ASD), but uptake of VPA is considered the only effective treatment for epilepsy and other neurological disorders." | 4.02 | Effect of Valproic Acid on Maternal - Fetal Heart Rates and Coupling in Mice on Embryonic day 15.5 (E15.5). ( Fukase, M; Kasahara, Y; Khandoker, A; Kimura, Y; Nakanishi, K; Saito, M; Suzuki, A; Widatalla, N; Yoshida, C, 2021) |
| "Statistical analysis of data from the Raoul Wallenberg Australian Register of Antiepileptic Drugs in Pregnancy involving 2104 folic acid-treated pregnancies in women with epilepsy." | 4.02 | Folic acid dose, valproate, and fetal malformations. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Perucca, P; Vajda, FJE, 2021) |
| " We exploited 2 different animal models of autism, the methyl CpG binding protein 2-null (Mecp2y/-) mouse model of Rett syndrome and mice prenatally exposed to valproic acid, and found increased ATM levels." | 4.02 | The DNA repair protein ATM as a target in autism spectrum disorder. ( Antonucci, F; Bifari, F; Cambria, C; Desiato, G; Ferrara, S; Focchi, E; Landsberger, N; Matteoli, M; Menna, E; Murru, L; Passafaro, M; Pizzamiglio, L; Ponzoni, L; Sala, M, 2021) |
| " The present work aimed to detect changes in the AVP numbers and level in a valproic acid (VPA)-induced rat model of autism and the underlying mechanism of its pathogenesis." | 4.02 | Postnatal AVP treatments prevent social deficit in adolescence of valproic acid-induced rat autism model. ( Bai, SZ; Dai, YC; Han, JS; Han, SP; Hu, Y; Lan, XY; Wu, J; Zhang, HF; Zhang, R, 2021) |
| " Fetal valproate syndrome can be prevented by discontinue of the valproic acid especially during first trimester of pregnancy." | 4.02 | Fetal valproate syndrome with coronary arteriovenous fistula: a case report. ( Baykan, A; Doğan, A; Vural, C, 2021) |
| "Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired postnatal neurodevelopment, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD)." | 4.02 | Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter? ( Anderson, A; Graham, J; Hitchcock, A; Honybun, E; Malpas, CB; O'Brien, TJ; Perucca, P; Rayner, G; Thwaites, R; Vajda, FJE, 2021) |
| " Valproic acid (VPA), an anti-seizure medication, is known to increase markers of oxidation and also increase the risk of neural tube defects (NTDs) when taken during pregnancy." | 4.02 | Spatiotemporal evaluation of the mouse embryonic redox environment and histiotrophic nutrition following treatment with valproic acid and 1,2-dithiole-3-thione during early organogenesis. ( Hansen, JM; Harris, C; Lapehn, S; Piorczynski, TB, 2021) |
| " The present work detected the effects of pregnancy supplementation with folic acid (FA) at different doses on rat models of ASD induced by prenatal exposure to valproic acid (VPA), an anti-epileptic increasing the risk of ASD when administered during pregnancy." | 4.02 | Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid. ( Cheng, Q; Di, Y; Fan, J; Kang, M; Lan, J; Li, J; Li, Z; Ren, W; Tian, Y; Wei, C; Zhai, C; Zheng, Q, 2021) |
| " Exposure to the antiepileptic drug valproic acid (VPA) during pregnancy significantly increases the risk of ASD in humans, and consequently is utilized as a validated animal model of ASD in rodents; however, the precise molecular and cellular mechanisms remain ill-defined." | 4.02 | Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model. ( Chen, D; Hu, Y; Lan, J; Li, Y; Liao, A; Wang, S; Wang, X; Wang, Y; Yang, F; Zheng, W, 2021) |
| "This study was carried out to determine changes over time in use of folic acid, anti-epileptic drugs (AED), seizures during pregnancy and malformation rate over two decades in women with epilepsy enrolled in the Kerala registry of Epilepsy and Pregnancy (KREP)." | 3.96 | Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. ( A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV, 2020) |
| "Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans." | 3.96 | In utero exposure to valproic acid disrupts ascending projections to the central nucleus of the inferior colliculus from the auditory brainstem. ( Fech, T; Kulesza, RJ; Mansour, Y; Smith, A; Zimmerman, R, 2020) |
| "Valproic acid (VPA) administered to mice during the early postnatal period causes social, cognitive, and motor deficits similar to those observed in humans with autism spectrum disorder (ASD)." | 3.96 | Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment. ( Derbaly, A; Gifford, JJ; Kusnecov, AW; Norton, SA; Pawlak, AP; Sherman, SL; Wagner, GC; Zhang, H, 2020) |
| "Valproic acid (VPA), a widely prescribed antiepileptic drug and an effective treatment for psychiatric disorders, is teratogenic causing neural tube defects (NTDs) and other defects in the exposed embryo." | 3.96 | Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD-1 mouse embryos with neural tube defects. ( Shafique, S; Winn, LM, 2020) |
| " This study examined the effect of metformin on VPA-induced autism spectrum disorders in rats." | 3.96 | Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system. ( Adeyemi, OO; Balogun, AO; Ishola, IO, 2020) |
| "The use of valproic acid (VPA), an antiepileptic drug, during pregnancy, is known to increase various fetal risks." | 3.96 | Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period. ( Furugen, A; Iseki, K; Jinno, N; Kanno, Y; Kobayashi, M; Kurosawa, Y; Narumi, K, 2020) |
| "This study was performed to evaluate the effects of prenatal exposure to pregabalin (PGB) on behavioral changes of rat offspring in an animal model of valproic acid (VPA)-induced autism-like symptoms." | 3.96 | Prenatal pregabalin is associated with sex-dependent alterations in some behavioral parameters in valproic acid-induced autism in rat offspring. ( Bashiri, H; Moslemizadeh, A; Sepehri, G; Shamsi Meymandi, M; Vakili Shahrbabaki, S, 2020) |
| "The aim of the study was to assess whether, male patients with epilepsy, switching from valproic acid (VPA) to levetiracetam (LEV) or lamotrigine (LMG) critically improves sperm counts and parameters, increasing chance of patients' female partners to spontaneously conceive." | 3.96 | An open study of valproate in subfertile men with epilepsy. ( Georgiou, I; Kostoulas, C; Markoula, S; Siarava, E; Zikopoulos, A, 2020) |
| " In this study, we examined behavioral and hippocampal neurogenesis alterations in male offspring of rats exposed to valproic acid (VPA) during pregnancy." | 3.91 | Prenatal exposure to valproic acid is associated with altered neurocognitive function and neurogenesis in the dentate gyrus of male offspring rats. ( Arai, H; Bolati, K; Fukuhara, T; Ito, M; Kinjo, T; Seki, T; Suzuki, T, 2019) |
| " Maternal exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug during pregnancy in human, has long been considered a risk factor to contribute to ASD susceptibility in offspring from epidemiological studies in humans." | 3.91 | Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates. ( Guo, X; Jiang, YH; Li, XJ; Tu, Z; Wang, Q; Xu, HJ; Yan, T; Yu, HP; Zhang, Y; Zhang, YQ; Zhao, H; Zhou, H, 2019) |
| "Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans and is used as an animal model of ASD." | 3.91 | Auditory Midbrain Hypoplasia and Dysmorphology after Prenatal Valproic Acid Exposure. ( Chosky, D; Kulesza, RJ; Mangold, S; Mansour, Y, 2019) |
| " Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy." | 3.91 | Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. ( Mirza, R; Sharma, B, 2019) |
| "Abnormally high levels of homocysteine (Hcy) are associated with autism spectrum disorder." | 3.91 | Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism. ( Chen, X; Chen, Z; Cui, C; Huang, F; Jiang, X; Niu, J; Sun, J, 2019) |
| "Valproic acid (VPA) is currently one of the four most often prescribed antiepileptic drugs (AEDs) in pregnancy." | 3.91 | Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2019) |
| "To establish an improved mouse model of valproic acid (VPA)-induced autism that better mimics human autism." | 3.91 | [Improvement of a mouse model of valproic acid-induced autism]. ( Chen, D; Hu, Y; Li, Y; Wang, S; Zheng, W, 2019) |
| " In this study, we examined how exposure to valproic acid (VPA) during pregnancy is associated with an increased incidence of ASD." | 3.88 | Dendritic spine anomalies and PTEN alterations in a mouse model of VPA-induced autism spectrum disorder. ( Ahn, S; Cho, K; Choi, M; Kim, H; Kim, HS; Mahmood, U; Regan, P; Yang, EJ, 2018) |
| "Prenatal exposure to the antiepileptic and mood stabilizer valproic acid (VPA) is an environmental risk factor for autism spectrum disorders (ASD), although recent epidemiological studies show that the public awareness of this association is still limited." | 3.88 | Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid. ( Ascenzi, P; Campolongo, P; di Masi, A; Leboffe, L; Manduca, A; Melancia, F; Palmery, M; Schiavi, S; Servadio, M; Trezza, V, 2018) |
| " This limitation and high risks of neural tube and other major teratogenic effects, especially of valproate, indicate the need for great caution in the use of valproate and carbamazepine to treat bipolar disorder in women of child-bearing age." | 3.88 | Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary. ( Baldessarini, RJ; Patel, N; Viguera, AC, 2018) |
| "In utero exposure to valproic acid (VPA) has been associated with worse pregnancy outcomes compared to all other antiepileptic drugs." | 3.88 | Adverse placental effects of valproic acid: Studies in perfused human placentas. ( Bar, J; Eyal, S; Kovo, M; Rubinchik-Stern, M; Shmuel, M, 2018) |
| "Here, we aimed at determining whether a well-acknowledged animal model of autism spectrum disorders, the valproic acid model, displays motor impairments and whether they may correlate with social deficits and neuronal loss within motor brain areas." | 3.88 | Motor Impairments Correlate with Social Deficits and Restricted Neuronal Loss in an Environmental Model of Autism. ( Al Sagheer, T; Balbous, A; Fernagut, PO; Francheteau, M; Haida, O; Jaber, M; Matas, E, 2018) |
| "Prenatal exposure to valproic acid (VPA) induces behavioral disorders and enhancement of oxido-inflammatory stress in Autism Spectrum Disorders (ASDs)." | 3.88 | Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism. ( Hajizadeh Moghaddam, A; Khalaj, R; Zare, M, 2018) |
| "Considering the potential role of lymphocytes in the pathophysiology of autism spectrum disorder (ASD), we aimed to evaluate possible alterations of T cell pools in the lymphoid organs of an animal model of autism induced by valproic acid (VPA)." | 3.88 | Reduced CD4 T Lymphocytes in Lymph Nodes of the Mouse Model of Autism Induced by Valproic Acid. ( Bambini-Junior, V; Baronio, D; Bauer-Negrini, G; Castro, K; Della-Flora Nunes, G; Gottfried, C; Mendes-da-Cruz, DA; Riesgo, R; Savino, W, 2018) |
| "Valproic acid (VPA) exposure during pregnancy has been proven to contribute to congenital heart disease (CHD)." | 3.88 | Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice. ( Duan, HY; Hua, YM; Li, YF; Wang, C; Wang, T; Zhang, Y; Zhou, KY, 2018) |
| "In utero exposure to therapeutic doses of valproic acid (VPA) during pregnancy can produce physical malformation and CNS abnormalities in the offspring." | 3.88 | Maternal voluntary exercise ameliorates learning deficit in rat pups exposed, in utero, to valproic acid; role of BDNF and VEGF and their receptors. ( Akhavan, MM; Ebrahimi, SA; Kamyab, K; Rahimi, R, 2018) |
| " Hearing loss was associated with valproic acid and low-dose acetylsalicylic acid exposure during pregnancy." | 3.88 | In utero drug exposure and hearing impairment in 2-year-old children A case-control study using the EFEMERIS database. ( Araujo, M; Benevent, J; Damase-Michel, C; Durrieu, G; Foch, C; Lacroix, I; Montastruc, JL; Weckel, A, 2018) |
| "The aim was to identify the effects of early vitamin D supplementation on autism-like behaviors (ASD) induced by valproic acid (VPA, an anti-convulsant and a mood stabilizer) in rats." | 3.85 | Behavioral improvements in a valproic acid rat model of autism following vitamin D supplementation. ( Du, L; Duan, Z; Li, F; Zhao, G, 2017) |
| "The study was performed using a rodent model of autism by exposing rat fetuses to valproic acid (VPA) on the 12." | 3.85 | Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism. ( Al-Askar, M; Al-Ayadhi, L; Bhat, RS; El-Ansary, A; Selim, M, 2017) |
| " Pregnant rats were injected daily with 20 or 100 mg/kg valproic acid (VPA) or saline from day 12 until the end of pregnancy." | 3.85 | Suppressed play behaviour and decreased oxytocin receptor binding in the amygdala after prenatal exposure to low-dose valproic acid. ( Bertelsen, F; Folloni, D; Landau, AM; Møller, A; Scheel-Krüger, J; Winterdahl, M, 2017) |
| " Here, we investigate the impact on the corticostriosomal pathway in the valproic acid (VPA)-induced autism spectrum disorder mouse model." | 3.85 | Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder. ( Kuo, HY; Liu, FC, 2017) |
| "Rodents exposed prenatally to valproic acid (VPA) exhibit autism spectrum disorder (ASD)-like behavioral abnormalities." | 3.85 | Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Kawase, H; Matsuda, T; Nakazawa, T; Takuma, K; Tanabe, W; Taruta, A; Tsukada, S, 2017) |
| "Recent studies have reported that oxytocin ameliorates behavioral abnormalities in both animal models and individuals with autism spectrum disorders (ASD)." | 3.85 | Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Higuchi, M; Matsuda, T; Nakazawa, T; Takuma, K, 2017) |
| " Its etiology is still unknown, but different environmental factors during pregnancy, such as exposure to valproic acid (VPA), are associated with high incidence of ASD in children." | 3.85 | The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid. ( Baronio, D; Castro, K; Gottfried, C; Perry, IS; Riesgo, RDS, 2017) |
| "There have been several reports of congenital malformations in the offspring of mothers who took valproic acid (VPA) during pregnancy as a treatment for epilepsy." | 3.85 | Fetal Valproate Syndrome. ( Bulut, C; Çaksen, H; Mutlu-Albayrak, H, 2017) |
| "We describe a novel ER+ breast cancer model to study de novo and acquired tamoxifen (TAM) resistance." | 3.85 | Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model. ( Bouker, KB; Clarke, R; Cook, KL; Cruz, MI; de Assis, S; Hilakivi-Clarke, L; Hu, R; Jin, L; Nguyen, N; Wang, X; Wang, Y; Wärri, A; Wehrenberg, B; Xuan, J; Zhang, X; Zwart, A, 2017) |
| "Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD)." | 3.85 | Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats. ( Bertelsen, F; Drasbek, KR; Folloni, D; Landau, AM; Møller, A; Scheel-Krüger, J, 2017) |
| "Rodents exposed prenatally to valproic acid (VPA) show autism-related behavioral abnormalities." | 3.83 | Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Katashiba, K; Matsuda, T; Onaka, Y; Takano, E; Takuma, K; Taruta, A, 2016) |
| "Carbamazepine is one of the three most frequently prescribed antiepileptic drugs in pregnancy." | 3.83 | Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2016) |
| "Exposure to valproic acid (VPA) during pregnancy has been linked with increased incidence of autism, and has repeatedly been demonstrated as a useful autism mouse model." | 3.83 | Early Behavioral Abnormalities and Perinatal Alterations of PTEN/AKT Pathway in Valproic Acid Autism Model Mice. ( Ahn, S; Kim, HS; Lee, K; Mahmood, U; Yang, EJ, 2016) |
| " Body weight gain, eye opening, the surface righting reflex (SRR) and tail suspension test (TST) were examined in the offspring at postnatal days 5, 10 and 15." | 3.83 | Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development. ( Filipović, L; Kanazir, S; Martać, L; Pavković, Ž; Pešić, V; Podgorac, J; Sekulić, S, 2016) |
| "Exposure to alcohol and valproic acid (VPA) during pregnancy can lead to fetal alcohol spectrum disorders and fetal valproate syndrome, respectively." | 3.83 | Effects of developmental alcohol and valproic acid exposure on play behavior of ferrets. ( Filgueiras, CC; Krahe, TE; Medina, AE, 2016) |
| "Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control and subsequent AED changes in women who underwent attempts to withdraw valproic acid (VPA) during the first trimester of pregnancy." | 3.83 | Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2016) |
| "Rodents exposed to valproic acid (VPA) in prenatal life exhibit post-natal characteristics analogous to autism spectrum disorder (ASD)." | 3.83 | A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse. ( Cheung, C; Chua, SE; Lam, S; Leung, J; Li, Q; McAlonan, GM; Sham, PC; Wei, R; Zhang, X, 2016) |
| " Children exposed to monotherapy levetiracetam (n = 42), topiramate (n = 27), or valproate (n = 47) and a group of children born to women who had untreated epilepsy (n = 55) were enrolled retrospectively from the UK Epilepsy and Pregnancy Register." | 3.83 | Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate. ( Baker, GA; Bromley, RL; Calderbank, R; Cheyne, CP; Clayton-Smith, J; García-Fiñana, M; Irwin, B; Morrow, JI; Rooney, C; Shallcross, R; Trayner, P, 2016) |
| "Components of the mTOR pathway were assayed by Western blotting in postmortem fusiform gyrus samples from 11 subjects with idiopathic autism and 13 controls and in valproic acid versus saline-exposed rat neocortex." | 3.81 | Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid. ( Ahn, Y; Fahnestock, M; Michalski, B; Nicolini, C; Rho, JM, 2015) |
| "To investigate whether the decreased level of serum polyunsaturated fatty acids (PUFAs) in patients with autism is associated with the expression of related liver metabolic enzymes, we selected rats that were exposed to valproic acid (VPA) on embryonic day 12." | 3.81 | Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism model. ( Cao, Y; Gao, J; Hao, Y; Li, X; Liang, S; Sun, C; Wang, X; Wu, L; Xia, W; Zhao, G, 2015) |
| "Valproic acid (VPA) mouse model of autism spectrum disorder (ASD) has been characterized mostly by impaired ultrasonic vocalization, poor sociability and increased repetitive self-grooming behavior." | 3.81 | Characterization of in utero valproic acid mouse model of autism by local field potential in the hippocampus and the olfactory bulb. ( Bumrungsri, S; Chatpun, S; Cheaha, D; Kumarnsit, E, 2015) |
| "Valproic acid administration during gestational period causes behavior and biochemical deficits similar to those observed in humans with autism spectrum disorder." | 3.81 | Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder. ( Kumar, H; Sharma, B; Sharma, BM, 2015) |
| "Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid (Aβ) degradation enzyme neprilysin (NEP) in primary neurons." | 3.80 | Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin. ( Le, W; Li, J; Li, T; Tang, Y; Wang, Z; Zhang, XJ, 2014) |
| "To compare the cognitive and language development of children born to women with epilepsy (WWE) exposed in utero to levetiracetam (LEV) or sodium valproate (VPA) and control children born to women without epilepsy not taking medication during pregnancy." | 3.80 | In utero exposure to levetiracetam vs valproate: development and language at 3 years of age. ( Baker, GA; Bromley, RL; Cheyne, CP; García-Fiñana, M; Irwin, B; Morrow, J; Shallcross, R, 2014) |
| " Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk of MCMs after monotherapy exposure to valproate, carbamazepine and lamotrigine." | 3.80 | Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. ( Campbell, E; Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Kennedy, F; Liggan, B; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2014) |
| "Human fetal exposure to valproic acid (VPA), a widely-used anti-epileptic and mood-stabilizing drug, leads to an increased incidence of behavioral and intellectual impairments including autism; VPA administration to pregnant rats and mice at gestational days 12." | 3.80 | Increased BDNF expression in fetal brain in the valproic acid model of autism. ( Almeida, LE; Krueger, BK; Roby, CD, 2014) |
| "We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism." | 3.80 | Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. ( Ben-Ari, Y; Brouchoud, C; Burnashev, N; Chazal, G; Eftekhari, S; Ferrari, DC; Khalilov, I; Lemonnier, E; Lozovaya, N; Nardou, R; Shahrokhi, A; Tsintsadze, T; Tsintsadze, V; Tyzio, R, 2014) |
| "Evidence from this and other studies suggests that lamotrigine and levetiracetam have low risk for teratogenesis, but that topiramate exposure early in pregnancy may be associated with dose-related anatomical teratogenesis, as valproate is already known to be." | 3.80 | The teratogenicity of the newer antiepileptic drugs - an update. ( Eadie, MJ; Graham, J; Lander, CM; O'Brien, TJ; Vajda, FJ, 2014) |
| "We recently showed that prenatal exposure to valproic acid (VPA) in mice causes autism-like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and spatial learning disability, in male offspring." | 3.80 | Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. ( Ago, Y; Hara, Y; Hashimoto, H; Hayata-Takano, A; Kataoka, S; Kawanai, T; Maeda, Y; Matsuda, T; Takano, E; Takuma, K; Watanabe, R, 2014) |
| "Autism spectrum disorders (ASD) involve a complex interplay of both genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA)." | 3.80 | Resveratrol prevents social deficits in animal model of autism induced by valproic acid. ( Bambini-Junior, V; Della Flora Nunes, G; Fontes-Dutra, M; Gottfried, C; Michels, M; Mueller de Melo, G; Nogueira Freire, V; Riesgo, R; Zanatta, G, 2014) |
| "Valproic acid (VPA) is a blocker of histone deacetylase widely used to treat epilepsy, bipolar disorders, and migraine; its administration during pregnancy increases the risk of autism spectrum disorder (ASD) in the child." | 3.79 | Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder. ( Atzori, M; Bringas, ME; Carvajal-Flores, FN; Flores, G; López-Ramírez, TA, 2013) |
| "To analyze seizure control, dose adjustments, and other changes of antiepileptic drug (AED) treatment during pregnancy in a large cohort of women with epilepsy entering pregnancy on monotherapy with carbamazepine, lamotrigine, phenobarbital, or valproate." | 3.79 | Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Tomson, T; Vajda, F, 2013) |
| "The aim of this work is to evaluate the impact of butyl paraben (BP) in brain of the pups developed for mothers administered BP from early pregnancy till weaning and its effect on studying the behavior, brain neurotransmitters and brain derived neurotrophic factor BDNF via comparing the results with valproic acid (VA) autistic-rat model preparing by a single oral injection dose of VA (800 mg/kg b." | 3.79 | Combined prenatal and postnatal butyl paraben exposure produces autism-like symptoms in offspring: comparison with valproic acid autistic model. ( Ali, EH; Elgoly, AH, 2013) |
| "Maternal use of valproic acid (VPA) during pregnancy has been implicated in the aetiology of autism spectrum disorders in children, and rodents prenatally exposed to VPA showed behavioural alterations similar to those observed in humans with autism." | 3.79 | Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid. ( Ago, Y; Hara, Y; Kataoka, S; Maeda, Y; Matsuda, T; Takuma, K, 2013) |
| " Using the prenatal valproic acid (VPA)-injection model of autism spectrum disorder (ASD) in rats, which produces social impairrment and altered seizure susceptibility as in human ASD patients as well as mild neural tube defects like crooked tail phenotype, we examined whether chronic administration of red ginseng extract may rescue the social impairment and crooked tail phenotype in prenatally VPA-exposed rat offspring." | 3.79 | Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. ( Han, SH; Kim, HJ; Kim, HY; Kim, KC; Kim, P; Kwon, KJ; Lee, JM; Park, JH; Shin, CY, 2013) |
| "This study, in a meaningful number of exposed pregnancies, confirms a low risk for MCM with levetiracetam monotherapy use in pregnancy." | 3.79 | Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. ( Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Liggan, B; Mawhinney, E; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2013) |
| "Based on epidemiological data it is advised to whenever possible avoid valproic acid during pregnancy." | 3.78 | Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes. ( Boersma, C; de Jong-van den Berg, LT; Jentink, J; Postma, MJ, 2012) |
| "Valproic acid (VPA) has been used clinically as an anticonvulsant medication during pregnancy; however, it poses a neurodevelopmental risk due to its high teratogenicity." | 3.78 | Gestational valproate alters BOLD activation in response to complex social and primary sensory stimuli. ( Febo, M; Felix-Ortiz, AC, 2012) |
| " Administration of valproic acid (VA) during first trimester of pregnancy causes neural tube defects (NTDs)." | 3.78 | Reduction in valproic acid-induced neural tube defects by maternal immune stimulation: role of apoptosis. ( Hrubec, T; Mallela, M, 2012) |
| "Valproic acid (VPA) is a potent inducer of neural tube defects in human and mouse, its teratogenicity is associated with its potential to generation of free radicals and increase oxidative stress." | 3.78 | Spirulina (arthrospira) protects against valproic acid-induced neural tube defects in mice. ( Chamorro-Cevallos, G; Escalona-Cardoso, GN; Paniagua-Castro, N; Pérez-Pastén, R, 2012) |
| "Prenatal exposure to valproic acid (VPA) induces neural tube defects and impairment in social behaviors related to autistic spectrum disorder in newborns, which make it a useful animal model of autism." | 3.77 | The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats. ( Cheong, JH; Choi, CS; Go, HS; Kim, KC; Kim, P; Ko, KH; Shin, CY; Yang, SI, 2011) |
| "Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97)." | 3.77 | Child development following in utero exposure: levetiracetam vs sodium valproate. ( Baker, GA; Bonnett, LJ; Bromley, RL; Irwin, B; Morrow, J; Shallcross, R, 2011) |
| "Health care providers reported lamotrigine exposure during pregnancy, and subsequent outcomes, on a voluntary basis." | 3.77 | Final results from 18 years of the International Lamotrigine Pregnancy Registry. ( Cunnington, MC; Ferber, S; Messenheimer, JA; Tennis, P; Weil, JG; Yerby, M, 2011) |
| "Valproic acid is a commonly prescribed antiepileptic agent that causes birth defects including neural tube defects." | 3.77 | Valproic acid-induced DNA damage increases embryonic p27(KIP1) and caspase-3 expression: a mechanism for valproic-acid induced neural tube defects. ( Tung, EW; Winn, LM, 2011) |
| " To assess the impact of influencing AED prescribing practices on spina bifida and cleft palate we searched the literature for estimates of the association between valproic acid or carbamazepine use during pregnancy and these defects and summarized the associations using meta-analyses." | 3.77 | Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States. ( Boulet, SL; Broussard, CS; Devine, OJ; Duwe, KN; Flak, AL; Gilboa, SM; Honein, MA; Moore, CA; Werler, MM, 2011) |
| "Exposure to the anticonvulsant valproic acid (VPA) during the first trimester of pregnancy is associated with an increased risk of congenital malformations including heart defects, craniofacial abnormalities, skeletal and limb defects, and, most frequently, neural tube defects (NTDs)." | 3.77 | Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects. ( Tung, EW; Winn, LM, 2011) |
| "Valproic acid, which current guidelines suggest should be avoided in pregnancy, was most notable in terms of strength and breadth of its associations." | 3.77 | Use of antiepileptic medications in pregnancy in relation to risks of birth defects. ( Ahrens, KA; Anderka, MT; Bosco, JL; Gilboa, SM; Holmes, LB; Mitchell, AA; Werler, MM, 2011) |
| "Valproic acid (VPA ) is a well-known antiepileptic drug with a significant teratogenic effect when administered during pregnancy." | 3.76 | Valproic acid transfer across human placental cotyledon during dual perfusion in vitro. ( Czuczwar, S; Kwasniewska, A; Semczuk, A; Semczuk, M; Semczuk-Sikora, A, 2010) |
| "Exposure to the anticonvulsant drug valproic acid (VPA) in utero is associated with a 1-2% increase in neural tube defects (NTDs), however the molecular mechanisms by which VPA induces teratogenesis are unknown." | 3.76 | Epigenetic modifications in valproic acid-induced teratogenesis. ( Tung, EW; Winn, LM, 2010) |
| "Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter." | 3.76 | Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| " Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single AED (carbamazepine, lamotrigine, phenytoin, or valproate)." | 3.76 | Effects of breastfeeding in children of women taking antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2010) |
| " In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia." | 3.76 | Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010) |
| "Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom." | 3.75 | Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009) |
| " We point out that during the pregnancy 4 of these 5 women with epilepsy had taken valproates, and the other one--carbamazepine." | 3.75 | [Fetal malformations in women with epilepsy]. ( Bozhinov, P; Bozhinova, C; Markova, C, 2009) |
| "This substudy of the Neurodevelopmental Effects of Antiepileptic Drugs investigation enrolled pregnant women with epilepsy on AED monotherapy (carbamazepine, lamotrigine, and valproate)." | 3.75 | A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy. ( Gaillard, WD; McVearry, KM; Meador, KJ; VanMeter, J, 2009) |
| "(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics." | 3.75 | Valproic acid: long-term effects on children exposed in utero. ( , 2009) |
| "Valproate (VPA) treatment in pregnancy leads to congenital anomalies, possibly by disrupting folate or homocysteine metabolism." | 3.74 | Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. ( Gupta, S; Kruger, WD; Leclerc, D; Roy, M; Rozen, R; Wu, Q, 2008) |
| "Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity." | 3.74 | Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: evaluation of the teratogenic effects of its amide derivatives in NMRI mice. ( Bialer, M; Fujiwara, M; Kaufmann, D; Okada, A; Onishi, Y; Shimshoni, JA; Yagen, B, 2008) |
| "Folic acid supplementation reduces the occurrence of neural tube defects (NTDs); however, it is not clear whether it protects against teratogenic effects of antiepileptic drugs." | 3.74 | Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect. ( Boisson, C; Candito, M; Gaucherand, P; Guéant, JL; Luton, D; Naimi, M; Rudigoz, JC; Van Obberghen, E, 2007) |
| "Offspring of rats exposed to valproic acid (VPA) on gestational day (GD) 12 have been advocated as a rodent model of autism because they show neuron loss in brainstem nuclei and the cerebellum resembling that seen in human autistic cases ." | 3.74 | Discrimination learning and reversal of the conditioned eyeblink reflex in a rodent model of autism. ( Brown, KL; Peloso, E; Rodier, P; Stanton, ME, 2007) |
| " Using rats exposed prenatally to valproic acid (VPA) as an animal model of autism, we examined locomotor activity and feeding under a reversed 12-h light/dark cycle, and found disturbance of the circadian rhythm characterized by frequent arousal during the light/sleep phase." | 3.74 | Abnormality of circadian rhythm accompanied by an increase in frontal cortex serotonin in animal model of autism. ( Arita, H; Nakamura, M; Nakasato, A; Nakatani, Y; Seki, Y; Sugawara, M; Tsujino, N, 2007) |
| " By contrast, offspring of rats exposed to carbamazepine (which at the dose used produced low plasma concentrations) or to generalized convulsive seizures showed no clear-cut evidence of dysplasias." | 3.74 | Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. ( Ben-Ari, Y; Depaulis, A; Jorquera, I; Manent, JB; Mazzucchelli, I; Perucca, E; Represa, A, 2007) |
| "Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation." | 3.74 | Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid. ( Markram, H; Rinaldi, T; Silberberg, G, 2008) |
| "Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)." | 3.74 | Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain. ( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008) |
| "To determine the rate of occurrence of major malformations in infants whose mothers had taken the drug valproic acid (VPA) as monotherapy during the first trimester of pregnancy and had enrolled in the North American Antiepileptic Drug Pregnancy Registry." | 3.73 | Increased rate of major malformations in offspring exposed to valproate during pregnancy. ( Alsdorf, RM; Holmes, LB; Nambisan, M; Smith, CR; Surve, T; Wyszynski, DF, 2005) |
| "In utero exposure to valproic acid (VPA) during pregnancy is associated with an increased risk of neural tube defects (NTDs)." | 3.73 | Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. ( Dawson, JE; Raymond, AM; Winn, LM, 2006) |
| "Structure-activity relationship studies of valproic acid (VPA) derivatives have revealed a quantitative correlation between histone deacetylase (HDAC) inhibition and induction of neural tube defects (NTDs) in the NMRI-exencephaly-mouse model, but this correlation has been, so far, limited to congeners with a carboxylic acid function." | 3.73 | S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates an ( Eikel, D; Hoffmann, K; Lampen, A; Nau, H; Zoll, K, 2006) |
| " Maternal treatment with valproic acid (VPA) during pregnancy induces NTD in susceptible fetuses." | 3.73 | Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. ( Benedict, S; Nagelkerke, N; Padmanabhan, R; Shafiullah, M, 2006) |
| "Valproic acid, a drug commonly used to treat seizures and other psychiatric disorders, causes neural tube defects (NTDs) in exposed fetuses at a rate 20 times higher than in the general population." | 3.73 | Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma. ( Holladay, SD; Hrubec, TC; Salafia, CM; Yan, M; Ye, K, 2006) |
| "Fetal Valproate Syndrome results from prenatal exposure to valproic acid." | 3.73 | Fetal valproate syndrome. ( Kulkarni, ML; Shenoy, N; Vani, HN; Zaheeruddin, M, 2006) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 3.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children of mothers with epilepsy." | 3.72 | Normal intelligence in children with prenatal exposure to carbamazepine. ( Bardy, A; Gaily, E; Granström, ML; Hiilesmaa, V; Isoaho, M; Kaaja, E; Kantola-Sorsa, E; Kotila, M; Matila, R; Nylund, T, 2004) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 3.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "In the current study, we wanted to extend our findings and test the hypothesis that Folbp2(-/-) mice are more susceptible to the teratogenic effects of valproic acid (VPA), a commonly used antiepileptic drug that is known to induce neural tube defects (NTDs) in both humans and laboratory animals." | 3.72 | Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice. ( Finnell, RH; Merriweather, MY; Spiegelstein, O; Wicker, NJ, 2003) |
| "Therapy with the antiepileptic drug valproic acid (2-propylpentanoic acid, VPA) during early pregnancy can cause similar teratogenic effects (neural tube defects) in human and mice." | 3.71 | Prediction of embryotoxic effects of valproic acid-derivatives with molecular in vitro methods. ( Göttlicher, M; Lampen, A; Nau, H, 2001) |
| "we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy." | 3.71 | [Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report]. ( Abraham, R; Assencio-Ferreira, VJ; Santos, KC; Veiga, JC, 2001) |
| "We selected all subjects who enrolled in the California Teratogen Information Service (CTIS) pregnancy outcome study for prenatal exposure to carbamazepine or valproic acid between 1990 and 1997 and who received prenatal care through Kaiser Permanente of Southern California (n = 13)." | 3.71 | Selection bias in Teratology Information Service pregnancy outcome studies. ( Chambers, CD; Johnson, KA; Jones, KL; Weber, PA, 2001) |
| "The use of valproic acid during pregnancy has been associated with adverse fetal outcomes, including major and minor congenital malformations, intrauterine growth retardation (IUGR), hyperbilirubinemia, hepatotoxicity, transient hyperglycemia, and fetal and neonatal distress." | 3.71 | Septo-optic dysplasia as a manifestation of valproic acid embryopathy. ( Braddock, SR; McMahon, CL, 2001) |
| "A pregnant woman with epilepsy receiving VPA and ethosuximide (ESM) was given high-dose multivitamins from 13 to 28 weeks' gestation." | 3.70 | Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report. ( Baggot, PJ; Kalamarides, JA; Shoemaker, JD, 1999) |
| "Neural tube defects (NTDs) are the most common of the major anomalies associated with in utero exposure to valproic acid." | 3.70 | Safe use of valproic acid during pregnancy. ( Kennedy, D; Koren, G, 1999) |
| "A full-term baby was born to an epileptic mother treated with two anti-epileptic drugs, sodium valproate and phenobarbital, throughout the pregnancy." | 3.70 | [A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord]. ( Adachi, M; Ai, Y; Maeda, E, 1999) |
| "Twenty epileptic women were treated with valproate only during pregnancy and two were treated with valproate and carbamazepine." | 3.70 | Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate. ( Ebbesen, F; Holsteen, V; Hoseth, E; Joergensen, A; Kaad, PH; Moeller, M; Rix, M, 2000) |
| "Clinical and epidemiologic studies have indicated that maternal use of valproic acid during early pregnancy causes an increased risk for spina bifida." | 3.70 | Developmental toxicity of valproic acid during embryonic chick vertebral chondrogenesis. ( Basu, A; Wezeman, FH, 2000) |
| "Teratogenic chemicals (2,3,7, 8-tetrachlorodibenzo-p-dioxin [TCDD], ethyl carbamate [urethane], methylnitrosourea [MNU], or valproic acid [VA]) were given to pregnant mice to induce cleft palate (TCDD, urethane), digital defects (urethane, MNU), or exencephaly (VA)." | 3.70 | Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations. ( Blaylock, BL; Gogal, RM; Holladay, SD; Sharova, L; Smith, BJ; Ward, DL, 2000) |
| "We report on a newborn baby, exposed to valproic acid in utero, with the typical dysmorphic features of the fetal valproate syndrome and omphalocele." | 3.69 | Omphalocele in a newborn baby exposed to sodium valproate in utero. ( Berthier, M; Bonneau, D; Boussemart, T; Levard, G; Oriot, D, 1995) |
| "We report a newborn with isolated aplasia cutis congenita of the scalp whose mother was treated with valproic acid during pregnancy." | 3.69 | Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero. ( Berthier, M; Bonneau, D; Couet, D; Hubert, A; Larrègue, M; Oriot, D, 1994) |
| "Ingestion of the anticonvulsant drug valproic acid and of the angiotensin converting enzyme inhibitor captopril during pregnancy has been associated with abnormal fetal outcome in humans." | 3.69 | Evaluation of the rat embryo culture system as a predictive test for human teratogens. ( Buttar, HS; Guest, I; Smith, S; Varma, DR, 1994) |
| "This experiment was carried out with the aims of comparing the embryotoxic potential of valproic acid (VPA) in rats and mice, better defining the malformation pattern in these species, and comparing the embryotoxic effects detectable in mid-pregnancy to those observed in fetuses at term." | 3.69 | Teratogenic effects of sodium valproate in mice and rats at midgestation and at term. ( Broccia, ML; Giavini, E; Menegola, E; Nau, H; Prati, M; Ricolfi, R, 1996) |
| " Among 92 pregnancies with maternal valproic acid use, five (including one concordantly affected monozygotic twin-pair) were terminated because of a spina bifida aperta, all prenatally diagnosed by AFP determination and acetylcholinesterase electrophoresis in amniotic fluid." | 3.68 | Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure. ( Hagenaars, AM; Lindhout, D; Los, FJ; Omtzigt, JG; Sachs, ES; Stewart, PA, 1992) |
| "Studies on teratogenicity and pathology of the cenceptus were conducted in Sprague-Dawley rats treated with 600, 800, and 1,000 mg/kg valproic acid po on day 13 of pregnancy." | 3.68 | Valproic acid-induced placental and teratogenic effects in rats. ( Khera, KS, 1992) |
| "A tentative 3 phase sequence of pathogenesis is proposed for the embryotoxic action of valproic acid (800 mg/kg) administered orally to rats on day 13 of pregnancy." | 3.68 | A morphologic basis postulated for valproic acid's embryotoxic action in rats. ( Khera, KS, 1992) |
| "Prenatal exposure to the antiepileptic drug valproic acid (VPA) has been associated with the formation of spina bifida aperta, meningocele, and meningomyelocele in the human." | 3.68 | Valproic acid-induced spina bifida: a mouse model. ( Ehlers, K; Merker, HJ; Nau, H; Stürje, H, 1992) |
| " Spina bifida aperta has been linked specifically to valproic acid (VPA) (estimated risk, 1 to 2%)." | 3.68 | The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort. ( Brandenburg, H; Gaillard, HL; Grobbee, DE; Jahoda, MG; Los, FJ; Omtzigt, JG; Pijpers, L; Sachs, ES; Stewart, PA; Wladimiroff, JW, 1992) |
| " Before 1000 when the ratios of folate metabolites were stable, the rate of valproic acid-induced neural tube defects was reduced from 49% of living fetuses to 12% by coapplication of folinic acid via subcutaneously implanted minipumps." | 3.68 | Diurnal variation of folate concentrations in mouse embryo and plasma: the protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent. ( Nau, H; Wegner, C, 1991) |
| "The anticonvulsant drug valproic acid (VPA) is suspected to be a developmental toxicant in humans, inducing primarily neural tube defects." | 3.68 | Lack of attenuation of valproic acid-induced effects by folinic acid in rat embryos in vitro. ( Grafton, TF; Hansen, DK, 1991) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy." | 3.68 | Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants. ( Hope, PL; Lindenbaum, RH; Squier, W, 1990) |
| "The mechanism underlying the impaired serum protein binding of valproic acid (VPA) in pregnancy was examined in samples collected from 24 healthy women in the last 3 weeks of gestation and 15 age-matched nonpregnant female controls." | 3.67 | Mechanism of altered drug binding to serum proteins in pregnant women: studies with valproic acid. ( Albani, F; Altomare, M; Baruzzi, A; Contin, M; Merlini, GP; Perucca, E; Riva, R, 1984) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 3.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "A female neonate, whose mother had been treated throughout pregnancy with valproic acid and phenytoin, showed evident signs of liver damage, confirmed by laboratory investigations and biopsy." | 3.67 | Congenital liver damage after treatment of mother with valproic acid and phenytoin? ( Felding, I; Rane, A, 1984) |
| "The effect of valproic acid on the distribution of gavaged 65Zn in maternal and embryonic tissue of Sprague-Dawley rats was examined 24 h after gavaging of the drug on d 13 of pregnancy." | 3.67 | The effect of valproic acid on 65Zn distribution in the pregnant rat. ( Hurley, LS; Keen, CL; Peters, JM, 1989) |
| "To investigate whether treatment with valproic acid in pregnancy decreases adrenocorticotropic hormone and cortisol secretion, we measured their concentrations in maternal and umbilical cord blood from a patient receiving valproic acid." | 3.67 | Effect of treatment with sodium valproate on plasma adrenocorticotropic hormone and cortisol concentrations in pregnancy. ( Hatjis, CG; Pippitt, C; Rose, JC; Swain, M, 1985) |
| "Fetal exposure to valproic acid has recently been associated with an increased incidence of neural tube defects." | 3.67 | Prenatal detection of a neural tube defect after fetal exposure to valproic acid. ( Campbell, WA; Cassidy, SB; Ciarleglio, L; Nochimson, DJ; Vintzileos, AM; Weinbaum, PJ, 1986) |
| "The association of fetal and neonatal distress, birth measurements, major malformations, and minor anomalies was studied prospectively in 14 infants of women with epilepsy who were receiving valproic acid (VPA) monotherapy and in 12 infants of women with epilepsy who were receiving VPA in combination with other anticonvulsant drugs." | 3.67 | Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid. ( Deichl, A; Hartmann, AM; Helge, H; Jäger-Roman, E; Jakob, S; Koch, S; Nau, H; Rating, D; Steldinger, R, 1986) |
| " Administration of doses established as median therapeutic doses in humans of phenobarbital, valproate and clonazepam to pregnant rats during the last third of gestation produced sexually dimorphic alterations in pentylenetetrazol (PTZ)-induced seizures as well as in non-convulsive (spontaneous alternation and cliff avoidance) behaviors in the offspring." | 3.67 | Prenatal antiepileptic drug exposure alters seizure susceptibility in rats. ( Nandedkar, AK; Sobrian, SK, 1986) |
| "Neural tube defects were induced dose-dependently by single injections of the anticonvulsant drug valproic acid (VPA) as sodium salt in mice on gestational day 8." | 3.67 | Valproic acid-induced neural tube defects: reduction by folinic acid in the mouse. ( Nau, H; Trotz, M; Wegner, C, 1987) |
| "Four infants who were exposed to sodium valproate or valproic acid during pregnancy are described." | 3.67 | Fetal valproate syndrome: is there a recognisable phenotype? ( Burn, J; Donnai, D; Tucker, SM; Winter, RM, 1987) |
| "Neural tube, craniofacial, and other congenital abnormalities have been described in infants born to mothers with epilepsy who were treated with valproic acid (VPA) during pregnancy." | 3.67 | Congenital abnormalities in two sibs exposed to valproic acid in utero. ( Anderson, L; Chitayat, D; Farrell, K; Hall, JG, 1988) |
| "The teratogenic effects of valproic acid and its 4-propyl-4-pentenoic acid (4-en) metabolite were investigated in three inbred mouse strains that were known to possess differing sensitivity to heat-induced neural tube defects." | 3.67 | Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite. ( Bennett, GD; Finnell, RH; Karras, SB; Mohl, VK, 1988) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 3.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Epilepsy is a group of neurological diseases characterized by susceptibility to recurrent seizures." | 3.01 | Management of epilepsy during pregnancy and lactation. ( Harris, KM; Hope, OA, 2023) |
| "Valproic acid (VPA) is a broad-spectrum, antiepileptic drug, and it is also a potent teratogen." | 2.72 | Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment. ( Fukunaga, K; Han, F; Lin, W; Meng, F; Naveed, M; Taleb, A; Xu, X; Zhang, G; Zhou, QG, 2021) |
| " In 2009, a review was published providing guidance for the dosing and therapeutic drug monitoring of antiepileptic drugs during pregnancy." | 2.66 | Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy. ( Arfman, IJ; Lambrechts, DA; Ter Horst, PGJ; Touw, DJ; Wammes-van der Heijden, EA; Wegner, I, 2020) |
| "These patients with refractory generalized epilepsy with sleep-related fast activities do not belong to a well-established syndromic category." | 2.66 | Genetic/idiopathic generalized epilepsies: Not so good as that! ( Crespel, A; Gelisse, P; Nilo, A, 2020) |
| "Epilepsy is one of the most common neurological complications in pregnancy; some women continue to use antiepileptic drugs (AEDs) to control seizures." | 2.66 | [Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding]. ( Furugen, A, 2020) |
| "Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy." | 2.65 | Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981) |
| "The term of autism spectrum disorders (ASD) is used to account for the diversity of symptoms that characterize this pathology." | 2.61 | [The valproate model of autism]. ( Bossu, JL; Roux, S, 2019) |
| "Valproic acid (VPA) is an anti-epileptic drug (AED) which is currently being investigated for its potential application in the treatment of several types of cancers, including solid and non-solid tumor." | 2.58 | Teratology of valproic acid: an updated review of the possible mediating mechanisms. ( Ponzano, A; Tiboni, GM, 2018) |
| "Valproic acid (VPA) is an anticonvulsant and mood stabilizer that, when used during the gestational period, increases the risk of ASD in the offspring." | 2.58 | Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid. ( Bambini-Junior, V; Deckmann, I; Fontes-Dutra, M; Gottfried, C; Schwingel, GB, 2018) |
| "Pregnancy was a strong determinant for discontinuation of psychotropic medication." | 2.53 | Risks and benefits of psychotropic medication in pregnancy: cohort studies based on UK electronic primary care health records. ( Cowen, PJ; Evans, SJ; Freemantle, N; McCrea, RL; Nazareth, I; Osborn, DP; Petersen, I; Sammon, CJ, 2016) |
| "Pharmacotherapy for mood disorders during pregnancy is often complicated by pregnancy-related pharmacokinetic changes and the need for dose adjustments." | 2.50 | Pharmacotherapy for mood disorders in pregnancy: a review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring. ( Byatt, N; Deligiannidis, KM; Freeman, MP, 2014) |
| "For patients with migraine, the pregnancy labeling of VPA will be changed from Category "D" to "X." | 2.50 | Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions. ( Gentile, S, 2014) |
| "Full seizure control in the pre-pregnancy year, and adjusting antiepileptic drug doses to maintain plasma drug concentrations throughout pregnancy at values associated with seizure control before pregnancy, have major influences in preserving seizure control during pregnancy." | 2.50 | Treating epilepsy in pregnant women. ( Eadie, MJ, 2014) |
| "Epilepsy is one of the commonest chronic neurological disorders in developing countries." | 2.50 | [Epilepsy, antiepileptic drugs and disorders of reproductive functions of women]. ( Gregoraszczuk, EL; Grzyb, E; Kwiecińska, P, 2014) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 2.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Valproic acid (VPA) is a known human teratogen." | 2.45 | Valproic acid in pregnancy: how much are we endangering the embryo and fetus? ( Ornoy, A, 2009) |
| "Juvenile myoclonic epilepsy is a common idiopathic generalized epileptic syndrome that includes generalized myoclonic seizures and commonly generalized tonic-clonic and generalized absence seizures." | 2.45 | The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? ( Abou-Khalil, B; Montouris, G, 2009) |
| "When treatment with valproic acid is the most appropriate treatment to achieve optimal seizure control, a number of measures can be implemented to minimise risk to the fetus." | 2.43 | Valproic acid in epilepsy : pregnancy-related issues. ( Genton, P; Semah, F; Trinka, E, 2006) |
| "Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population." | 2.43 | Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006) |
| " If a dosage of AEDs in pregnant women with epilepsy is reduced to a reasonable minimum and the monotherapy is preferred, the risk of congenital malformations in their offspring can be minimized." | 2.42 | [Effect of anti-epileptic drugs on human placenta and the fetus]. ( Semczuk, M; Semczuk-Sikora, A, 2004) |
| "Neural tube defects were seen in 3% of the sample." | 2.41 | Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. ( Kozma, C, 2001) |
| " Rates of metabolism in children may be much faster than in nonelderly adults, requiring dosing adjustments to ensure enough medication is used to control seizures." | 2.41 | Treatment of epilepsy in 3 specialized populations. ( Leppik, IE, 2001) |
| " In the foetus the plasma level of valproate and the protein binding are higher than in maternal plasma, and the half-life of valproate following placental transfer is considerably longer than in adults." | 2.38 | Pharmacokinetics of valproate in pregnancy: mother-foetus-newborn. ( Johannessen, SI, 1992) |
| "Valproic acid is a very effective anticonvulsant agent widely used in the management of various forms of epilepsy." | 2.38 | Developmental toxicity of valproic acid. ( Cotariu, D; Zaidman, JL, 1991) |
| "Valproic acid is an anticonvulsant that has been associated with open neural tube defects." | 2.38 | Valproic acid prenatal exposure. Association with lipomyelomeningocele. ( Carter, BS; Stewart, JM, 1989) |
| "Valproic acid has probable teratogenic potential in humans but the number of reported cases is few and the spectrum of anomalies is broad so it is not possible to delineate a definite fetal valproate syndrome." | 2.37 | Congenital malformations associated with maternal use of valproic acid. ( Gauthier, M; Huot, C; Larbrisseau, A; Lebel, M, 1987) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| "Forty patients (39." | 1.91 | Epilepsy and pregnancy. Factors associated with epileptic seizures during pregnancy. ( Barambio, S; Becerra, JL; Chíes, E; Ciurans, J; Codina, M; Fumanal, A; García-Esperón, C; Grau-López, L; Jiménez, M, 2023) |
| "A pregnancy was classified as exposed to VPA in the critical time window if this exposure period overlapped with the first 55 days of pregnancy." | 1.91 | Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida. ( Dathe, K; Haug, U; Kollhorst, B; Onken, M; Schaefer, C; Schink, T; Thöne, K, 2023) |
| "Aripiprazole (APZ) is an atypical antipsychotic that can safeguard mice against autism-like behavior induced by valproic acid (VPA)." | 1.91 | Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice. ( de Andrade, GM; de Barros Viana, GS; de Oliveira Ferreira, E; Lima, FAV; Neves, KRT; Pessoa Gomes, JM, 2023) |
| " The repetitive behaviors were ameliorated relatively in VPA groups with NEPO2000 treatment, and astrogliosis was reduced even when VPA rats were treated with a lower dosage of NEPO." | 1.91 | Astrocyte responses to postnatal erythropoietin and nano-erythropoietin treatments in a valproic acid-induced animal model of autism. ( Basiri, M; Haratizadeh, S; Nozari, M; Ranjbar, M, 2023) |
| "Valproic acid (VPA) is a known drug for treating epilepsy and mood disorders; however, it is not recommended for pregnant women because of its possible teratogenicity." | 1.91 | Neonatal Exposure to Valproate Induces Long-Term Alterations in Steroid Hormone Levels in the Brain Cortex of Prepubertal Rats. ( Cho, SH; Jang, EH; Kim, SA; Lee, J, 2023) |
| "Autism spectrum disorder is characterized by a variety of cellular and molecular abnormalities which leads to autism-associated behaviors." | 1.91 | Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism. ( Roghani, M; Sadr, SS; Sanaeierad, A; Zahedi, E, 2023) |
| "Autism is a neurodevelopmental condition, and it's associated pathophysiology, viz." | 1.91 | Neuroprotective Efficacy of Fisetin Against VPA-Induced Autistic Neurobehavioral Alterations by Targeting Dysregulated Redox Homeostasis. ( Ahsan, AU; Budhwar, M; Chopra, M; Mehra, S; Sharma, M, 2023) |
| "Autism has a strong genetic and heritable component; however, environmental factors including toxins, pesticides, infection and in utero exposure to drugs such as VPA have also been implicated in ASD." | 1.91 | Striatal synaptic changes and behavior in adult mouse upon prenatal exposure to valproic acid. ( Delgado-González, E; Durairaj, RV; Espinosa, F; Hernandez, A; Martínez-Torres, A; Reyes-Haro, D, 2023) |
| "Valproic acid (VPA) is a well-known anti-epileptic drug, but its prenatal exposure to animals causes social impairment, neurotransmitters imbalance, and neuroinflammation with ASD-like phenotypes." | 1.91 | Syringic acid alleviates valproic acid induced autism via activation of p38 mitogen-activated protein kinase: Possible molecular approach. ( Mallan, S; Singh, S, 2023) |
| "Neural tube defects (NTDs), including anencephaly and spina bifida, are common major malformations of fetal development resulting from incomplete closure of the neural tube." | 1.91 | A Shared Pathogenic Mechanism for Valproic Acid and ( Huang, J; Luo, J; Parent, JM; Sexton, JZ; Sudyk, R; Takla, TN; Tidball, AM; Vora, NL; Walker, JC, 2023) |
| "Period of pregnancy was calculated based on birth information in claims data." | 1.91 | Prescribing of valproate and oral antiepileptics for women of childbearing age and during pregnancy in Germany between 2010 and 2020. ( Köster, I; Meyer, I; Scholz, K; Schubert, I; Selke, GW, 2023) |
| "Valproic acid (VPA) was administrated once on gestational day 12." | 1.91 | Sex-related beneficial effects of exercise on cardiac function and rhythm in autistic rats. ( Bashiri, H; Jafari, E; Moslemizadeh, A; Rajizadeh, MA; Rostamzadeh, F; Sabet, N, 2023) |
| "Autism is a neurobehavioral disease that induces cognitive and behavioral alterations, usually accompanied by oxidative stress in the brain." | 1.91 | Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the male offspring rats. ( Abbarin, D; Raise-Abdullahi, P; Rashidy-Pour, A; Sedaghat, K; Seyedinia, SA; Tarahomi, P; Vafaei, AA; Yaribeygi, H, 2023) |
| " We should collaborate with obstetricians and other professionals to help ensure a safe environment for pregnancy and childbirth." | 1.91 | [Safe and Effective Management of Epilepsy in Pregnancy]. ( Iwasaki, M; Kimura, Y, 2023) |
| " We investigated potential transgenerational adverse effects of valproate." | 1.72 | Transgenerational adverse effects of valproate? A patient report from 90 affected families. ( Bewley, S; Braillon, A; Hill, C; MacLennan, AH; Martin, M, 2022) |
| " For developmental toxicity this requires scaling the in vitro observed dose-response characteristics to in vivo fetal exposure, while integrating maternal in vivo kinetics during pregnancy, in particular transplacental transfer." | 1.72 | Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach. ( Fragki, S; Hoogenveen, R; Piersma, AH; Schwillens, P; van Oostrom, C; Zeilmaker, MJ, 2022) |
| "The mouse model of autism induced by prenatal exposure to valproic acid (VPA) was used to assess the therapeutic potential of STX209 on autism‑like behaviour in the present study." | 1.72 | The GABAB receptor agonist STX209 reverses the autism‑like behaviour in an animal model of autism induced by prenatal exposure to valproic acid. ( Chang, H; Ding, J; Gao, C; He, M; Jiang, S; Li, W; Sun, T; Sun, Y; Wang, F; Wang, Y; Xiao, L; Zhu, C, 2022) |
| "Valproic acid (VPA) was administered intraperitoneally at doses of 500 mg/kg to female rats during gestational 12." | 1.72 | Sumac and gallic acid-loaded nanophytosomes ameliorate hippocampal oxidative stress via regulation of Nrf2/Keap1 pathway in autistic rats. ( Abbasalipour, H; Hajizadeh Moghaddam, A; Ranjbar, M, 2022) |
| "Valproate (VPA) is an effective treatment for epilepsy and also used in bipolar disorder." | 1.72 | National compliance with UK wide guidelines for usage of valproate in women of childbearing potential. ( Eriksson, SH; Sisodiya, SM; Tittensor, P, 2022) |
| " Pregnant C57BL/6 J mice were intraperitoneally injected with a dosage of 500 mg/kg valproic acid (VPA) on embryonic day 10." | 1.72 | Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism. ( Kwan, KM; Ma, SY, 2022) |
| " Different models were identified that provided accurate predictions for rat prenatal LELs and conservative estimates of human safe exposure." | 1.72 | Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues. ( Allen, D; Bell, S; Ceger, P; Chang, X; Cook, B; Donley, E; Kleinstreuer, N; Knudsen, TB; Lee, UJ; Lumen, A; Mansouri, K; Palmer, J; Sprankle, C; Wambaugh, J, 2022) |
| "Valproic acid (VPA) is a widely prescribed drug to treat epilepsy, bipolar disorder, and migraine." | 1.72 | Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects. ( Keyes, WM; Klein, A; Knauer-Meyer, T; Plassat, JL; Rhinn, M; Zapata-Bodalo, I, 2022) |
| "Autism spectrum disorder is a developmental disorder that can affect social interactions and sensory-motor behaviors." | 1.72 | Sex difference in cognitive behavioral alterations and barrel cortex neuronal responses in rats exposed prenatally to valproic acid under continuous environmental enrichment. ( Afarinesh, MR; Joushy, S; Mafi, F; Mollashahi, M; Sabzalizadeh, M; Sheibani, V, 2022) |
| "Autism spectrum disorder is a neurodevelopmental disorder characterized by sensory abnormalities, social skills impairment and cognitive deficits." | 1.72 | Alterations in the intrinsic discharge activity of CA1 pyramidal neurons associated with possible changes in the NADPH diaphorase activity in a rat model of autism induced by prenatal exposure to valproic acid. ( Behzadi, G; Borjkhani, M; Davoudi, S; Hajisoltani, R; Hosseinmardi, N; Janahmadi, M; Karimi, SA; Khatibi, VA; Rahdar, M, 2022) |
| "Corneal dermoids may regress spontaneously." | 1.72 | Spontaneous Partial Regression of Bilateral Grade III Corneal Dermoids Associated With Fetal Valproate Spectrum Disorder. ( Colak, D; Kiratli, H; Koç, İ, 2022) |
| " We found that gestational VPA exposure via chronic maternal oral dosing was associated with substantial drug-induced differential gene expression in the pup brains, including dysregulated splicing, and observed that this occurred in the absence of evidence for significant neuronal gain or loss." | 1.72 | Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability. ( Abouzeid, M; Feleke, R; Jazayeri, D; Johnson, MR; Jones, NC; O'Brien, TJ; Powell, KL; Srivastava, PK, 2022) |
| "Planned pregnancy was the only independent factor significantly associated with decreased risk of adverse pregnancy outcomes (OR, 0." | 1.72 | Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China. ( Jiang, W; Jiang, Y; Ma, L; Shi, X; Song, C; Wang, Y; Xia, L; Zhang, Y; Zhao, J, 2022) |
| "Melatonin is an endogenous hormone and can restore gut microbial dysbiosis under various disease conditions." | 1.72 | Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism. ( Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y, 2022) |
| "Valproic acid (VPA) is an antiepileptic drug with a pronounced teratogenic effect associated with a high risk of ASD, and its administration to rats during the gestation is used for autism modeling." | 1.62 | Assessment of behavioral, morphological and electrophysiological changes in prenatal and postnatal valproate induced rat models of autism spectrum disorder. ( Chavushyan, V; Danielyan, M; Fereshetyan, K; Yenkoyan, K, 2021) |
| "Despite the increasing prevalence of autism spectrum disorder (ASD), there is still a deficiency in understanding its exact pathophysiology and treatment, therefore validation of translational ASD animal model is warranted." | 1.62 | Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study. ( Abdelraouf, SM; Aboul-Fotouh, S; Abuelezz, SA; Ahmed, AI; Bahaa, N; Elnahas, EM; Hassan, GA; Ibrahim, EA; Mohamad, MI; Nabil, MM, 2021) |
| " However, women must balance the benefit of treatment against all possible adverse effects." | 1.62 | Active Surveillance of the Safety of Medications Used During Pregnancy. ( Bateman, BT; Hernández-Díaz, S; Huybrechts, KF; Kulldorff, M; Mogun, H; Wang, SV; Zhu, Y, 2021) |
| "Autism spectrum disorder is associated with alterations in GABAergic and glutamatergic neurotransmission." | 1.62 | Brain and plasma amino acid concentration in infant rats prenatally exposed to valproic acid. ( BeltrÁn-Parrazal, L; LÓpez-Meraz, ML; Morgado-Valle, C; Puig-Lagunes, ÁA; Rocha, L, 2021) |
| "Logistic regression analysis showed that maternal age over 31 years, family histories of fetal malformation, and conception after assisted fertility treatment, and also dosage of valproate, carbamazepine, and topiramate, made statistically significant (P<0." | 1.62 | The contribution of non-drug factors to fetal malformation in anti-seizure-medication-treated pregnancy. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJE, 2021) |
| "Neuroinflammation was measured by assessing microglia and astrocyte population in the prefrontal cortex (PFC) and cerebellum (CER) of pups." | 1.62 | Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring. ( Manjeese, W; Mpofana, T; Mvubu, NE; Steyn, AJC, 2021) |
| "These results showed that VAD in autism might result in cerebellar impairments and be a factor aggravating a subtype of ASD with motor comorbidities." | 1.62 | Vitamin A supplementation ameliorates motor incoordination via modulating RORα in the cerebellum in a valproic acid-treated rat autism model with vitamin A deficiency. ( Cheng, B; Hou, N; Li, L; Li, T; Liu, H; Wang, S; Wu, Q; Yang, T, 2021) |
| "Valproic acid (VPA) is a teratogenic antiepileptic, causing alterations in oxidative stress in prenatal development, being altered the development of the male reproductive system." | 1.62 | Protective role of vitamin E in testicular development of mice exposed to valproic acid. ( Conei, D; Risopatrón, J; Rojas, M; Santamaría, L, 2021) |
| "Valproic acid (VPA) is an effective anti-epileptic drug clinically used to treat seizures, bipolar disorders and neuropathic pain in women of reproductive age." | 1.62 | Characterizing the effects of in utero valproic acid exposure on murine fetoplacental development. ( Shafique, S; Winn, LM, 2021) |
| "Suramin treatment did not affect VPA-induced upregulation of P2X4 and P2Y2 receptor expression in the hippocampus, and P2X4 receptor expression in the medial prefrontal cortex, but normalized an increased level of interleukin 6 (IL-6)." | 1.56 | Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism. ( Bambini-Junior, V; Bauer-Negrini, G; Brum Schwingel, G; Carello-Collar, G; Castillo, ARG; Corrêa-Velloso, J; Deckmann, I; Fontes-Dutra, M; Gonçalves, MCB; Gottfried, C; Hirsch, MM; Körbes-Rockenbach, M; Naaldijk, Y; Rabelo, B; Santos-Terra, J; Schneider, T; Staevie, GZ; Ulrich, H, 2020) |
| "Quercetin (50 mg/kg) was administered orally to the animals from gestational days 6." | 1.56 | Quercetin prevents alterations of behavioral parameters, delta-aminolevulinic dehydratase activity, and oxidative damage in brain of rats in a prenatal model of autism. ( Baldissarelli, J; de Mattos, BDS; de Souza, AA; Gamaro, GD; Pedra, NS; Soares, MSP; Spanevello, RM; Spohr, L; Stefanello, FM; Teixeira, FC, 2020) |
| "Prepregnancy reduction in VPA dosage reduced the hazard of fetal malformations, whereas ceasing intake of the drug decreased the hazard to one similar to that which applies in the general population, but at a cost of decreased control of epileptic seizures during the pregnancies studied." | 1.56 | Pregnancy after valproate withdrawal-Fetal malformations and seizure control. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJE, 2020) |
| "The causes of hypertension are complex and involve both genetic and environmental factors." | 1.56 | The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids. ( Byrne, CJ; Khaper, N; Khurana, S; Lamothe, J; Mercier, S; Tai, TC; Tharmalingam, S; Williamson, C, 2020) |
| "9)), with a dose-response relationship." | 1.56 | Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. ( Blotière, PO; Coste, J; Dray-Spira, R; Mahmoud, Z; Mikaeloff, Y; Miranda, S; Peyre, H; Ramus, F; Weill, A, 2020) |
| "Valproic acid (VPA) is a branched short-chain fatty acid primarily used in epilepsy, but is also used in bipolar disorder, migraine, and psychotic disorders." | 1.56 | Heart malformation is an early response to valproic acid in developing zebrafish. ( Anitha, V; Deepan, N; Ganesan, V; Jayaseelan, S; Kalaiselvan, D; Rajesh, V; Sivakumar, P, 2020) |
| "The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients." | 1.56 | Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences. ( Braccagni, G; De Montis, MG; Gambarana, C; Guzzi, F; Parenti, M; Scheggi, S, 2020) |
| "Valproic acid (VPA) is a widely used anti-epileptic drug (AED) of demonstrated efficacy." | 1.56 | Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid. ( Baraldés-Rovira, M; Gallego, Y; Mauri-Capdevila, G; Purroy, F; Quílez, A; Sanahuja, J, 2020) |
| " A dose-response relationship was demonstrated and the risk of NDs was more particularly increased for an exposure to VPA during the second or third trimesters of pregnancy." | 1.56 | Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France. ( Blotiere, PO; Coste, J; Dray-Spira, R; Mikaeloff, Y; Miranda, S; Peyre, H; Ramus, F; Weill, A; Zureik, M, 2020) |
| "To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy." | 1.56 | Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020) |
| "To characterize the effects of VPA on murine heart development, pregnant CD-1 mice were dosed with 400 mg/kg of VPA on gestational day (GD) 9." | 1.51 | Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development. ( Belanger, CL; Maciver, RD; Nikolovska, A; Philbrook, NA; Winn, LM, 2019) |
| "Significant decreases in pregnancy weight gain and the number of live fetuses were observed when VPA was administered at the high dose, whereas the percentage of exencephalic fetuses was significantly increased in VPA treated compared with an equivalent VCD dosage group." | 1.51 | Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice. ( Bialer, M; Cabrera, RM; Finnell, RH; Lin, YL; Wlodarczyk, BJ, 2019) |
| "Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD)." | 1.51 | Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring. ( Brikell, I; Christensen, J; Dalsgaard, S; Dreier, JW; Pedersen, L; Sun, Y, 2019) |
| " Interestingly, regarding VPA dosage, we found that women taking equal or more than 700 mg/day of VPA have lower scores on empowerment in all dimensions compared with women with a VPA dosage lower than 700 mg/day." | 1.51 | Level of empowerment and decision-making style of women with epilepsy in childbirth age. ( Canevini, MP; Cutica, I; Pravettoni, G; Riva, S; Turner, K; Zambrelli, E, 2019) |
| "Treatment with pioglitazone significantly attenuated the prenatal VPA-induced social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity." | 1.51 | Beneficial effects of pioglitazone, a selective peroxisome proliferator-activated receptor-γ agonist in prenatal valproic acid-induced behavioral and biochemical autistic like features in Wistar rats. ( Mirza, R; Sharma, B, 2019) |
| "Focal epilepsy was diagnosed in 244 (69." | 1.51 | Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study. ( Bosak, M; Słowik, A; Turaj, W, 2019) |
| " The purpose of this study was to characterise pharmacokinetic variability of VPA in pregnancy, and discuss use of therapeutic drug monitoring (TDM) as guidance to exposure in women." | 1.48 | Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring. ( Baftiu, A; Burns, ML; Farmen, AH; Johannessen Landmark, C; Johannessen, SI; Lossius, MI; Tomson, T, 2018) |
| "Autism is characterized by numerous behavioral impairments, such as in communication, socialization and cognition." | 1.48 | Zinc as a therapy in a rat model of autism prenatally induced by valproic acid. ( Bernardi, MM; Cezar, LC; da Fonseca, CCN; de Lima, APN; Felicio, LF; Kirsten, TB, 2018) |
| "Rats of the VPA model of autism showed reduced total reciprocal social interaction, prevented by prenatal treatment with resveratrol (RSV)." | 1.48 | Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA. ( Bambini-Junior, V; Bauer-Negrini, G; Deckmann, I; Della-Flora Nunes, G; Fontes-Dutra, M; Gottfried, C; Hirsch, MM; Margis, R; Nunes, W; Rabelo, B; Riesgo, R, 2018) |
| " While women younger than 50 years of age were less likely to be prescribed valproate than men in the same age group, and at a lower dosage, it is unclear to what extent this reflects clinicians' concerns about teratogenicity or is driven by perceptions of the indication for valproate, and the dosage required, for the treatment of different phases of the disorder in men and women." | 1.48 | A UK clinical audit addressing the quality of prescribing of sodium valproate for bipolar disorder in women of childbearing age. ( Barnes, TRE; Bhatti, S; Cookson, J; Fagan, E; Ferrier, IN; Paton, C, 2018) |
| "Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used." | 1.48 | Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018) |
| "The etiology of autism remains unknown and its molecular basis is not yet well understood." | 1.48 | Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism. ( Imai, M; Lwin, TT; Mar, O; Nway, NC; Watanabe, H; Win-Shwe, TT, 2018) |
| "Valproic acid (VPA), which is an anti-epileptic and anti-depressive drug, is one of the teratogens to cause ASD onset." | 1.46 | Downregulation of glutamatergic and GABAergic proteins in valproric acid associated social impairment during adolescence in mice. ( Chan, CW; Chau, DK; Choi, AY; Leung, WN; Yang, W, 2017) |
| "Males are predominantly affected by autism spectrum disorders (ASD) with a prevalence ratio of 5:1." | 1.43 | MeCP2 Modulates Sex Differences in the Postsynaptic Development of the Valproate Animal Model of Autism. ( Cheong, JH; Choi, CS; Han, SH; Kim, JW; Kim, KC; Ryu, JH; Shin, CY, 2016) |
| "Autism is a neurodevelopment disorder." | 1.43 | Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats. ( Kumar, H; Sharma, B, 2016) |
| "Nasoethmoidal meningocele is considered an uncommon type of cephalocele, and congenital cystic adenomatoid malformation (CCAM) is a rare lung disorder characterized by overgrowth of the terminal bronchioles." | 1.43 | Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures? ( Bellé, NL; Betat, Rda S; da Cunha, AC; da Rosa, EB; Dorfman, LE; Matos, IO; Rogatto, SR; Rosa, RF; Silveira, DB; Targa, LV; Tsugami, LG; Villacis, RA; Zen, PR, 2016) |
| "Treatment with memantine has significantly attenuated prenatal valproic acid-induced reduction in social interaction, spontaneous alteration, exploratory activity intestinal motility, serotonin levels and prefrontal cortex mitochondrial complex activity." | 1.43 | Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats. ( Kumar, H; Sharma, B, 2016) |
| "Valproic acid (VPA) is a multi-target drug and an inhibitor of histone deacetylase (HDAC)." | 1.43 | Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation. ( Ago, Y; Hasebe, S; Hashimoto, H; Inoue, A; Kawanai, T; Matsuda, T; Onaka, Y; Takuma, K; Taruta, A; Watanabe, R, 2016) |
| "Valproic acid (VPA) is an anti-epileptic drug with teratogenicity activity that has been related to autism." | 1.43 | Prenatal exposure to sodium valproate alters androgen receptor expression in the developing cerebellum in a region and age specific manner in male and female rats. ( Brug, B; Hernandez, ME; Manzo, J; Miquel, M; Perez-Pouchoulen, M; Saft, P; Toledo, R, 2016) |
| "Autism is a severe neurodevelopmental disorder with a population prevalence of 1 in 68, and dramatically increasing." | 1.42 | Tactile stimulation improves neuroanatomical pathology but not behavior in rats prenatally exposed to valproic acid. ( Gibb, R; Harker, A; Kolb, B; Raza, S; Richards, S, 2015) |
| "Valproic acid treated animals were treated from 5 days preceding behavioral testing in the Morris water maze at a clinically relevant concentration." | 1.42 | Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy. ( Jellett, AP; Jenks, K; Lucas, M; Scott, RC, 2015) |
| "Valproic acid (600 mg/kg) was administered intraperitoneally to the pregnant mice on gestational day 12." | 1.42 | Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism. ( Al-Amin, MM; Khan, FR; Mahmud Reza, H; Rahman, MM; Zaman, F, 2015) |
| "Although animal models of autism have demonstrated that model animals engage less in social interaction or attend less to conspecifics than control animals, no animal model has yet replicated the deficit in recognition of complex social interaction as is seen in humans with autism." | 1.42 | Indifference of marmosets with prenatal valproate exposure to third-party non-reciprocal interactions with otherwise avoided non-reciprocal individuals. ( Banno, T; Ichinohe, N; Kawai, N; Nakagaki, K; Nakagami, A; Yasue, M, 2015) |
| "A major focus of animal models of autism has been to mimic the social deficits of the disorder." | 1.42 | Effects of prenatal exposure to valproic acid on the development of juvenile-typical social play in rats. ( Gibb, R; Harker, A; Himmler, BT; Himmler, SM; Kolb, B; Pellis, SM; Raza, S, 2015) |
| " Maternal levels and dosing information were used for estimating the maternal apparent oral clearance and the paired umbilical cord and maternal levels for estimation of umbilical cord/maternal level ratios." | 1.42 | Serum levels of valproic acid during delivery in mothers and in umbilical cord - correlation with birth length and weight. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2015) |
| "Previously, autism spectrum disorder (ASD) has been identified mainly by social communication deficits and behavioral symptoms." | 1.42 | Alteration of spontaneous spectral powers and coherences of local field potential in prenatal valproic acid mouse model of autism. ( Cheaha, D; Kumarnsit, E, 2015) |
| "The treatment profile for epilepsy, seizure control, and maternal and neonatal outcomes in both groups were compared using Chi-square test or Fisher's exact test and Mann-Whitney U test." | 1.40 | Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes. ( Abe, K; Hamada, H; Minakami, H; Obata-Yasuoka, M; Yamada, T; Yoshikawa, H, 2014) |
| " Our previous studies have demonstrated the social cognition deficits observed in this model, a major core symptom of ASD, to be ameliorated following chronic administration of histone deacetylase (HDAC) inhibitors." | 1.40 | Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders. ( Cassidy, AW; Foley, AG; Regan, CM, 2014) |
| "Valproic acid (VPA) is a commonly prescribed drug for those affected by epilepsy and bipolar disorders." | 1.40 | Brief report novel mechanism for valproate-induced teratogenicity. ( Fathe, K; Finnell, RH; Palacios, A, 2014) |
| "Valproic acid (VPA) is a known teratogenic drug." | 1.40 | Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report. ( Casselman, J; De Kegel, A; Dhooge, I; Janssens, S; Maes, L; Van Houtte, E, 2014) |
| "Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential." | 1.39 | Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. ( Christensen, J; Grønborg, TK; Parner, ET; Pedersen, LH; Schendel, D; Sørensen, MJ; Vestergaard, M, 2013) |
| "Autism is characterized by behavioral impairments in three main domains: social interaction; language, communication and imaginative play; and the range of interests and activities." | 1.39 | Increased hippocampal cell density and enhanced spatial memory in the valproic acid rat model of autism. ( Edalatmanesh, MA; Moghadas, M; Nikfarjam, H; Vafaee, F, 2013) |
| " The overall mean maternal valproate dosage taken by women in the Register decreased over the last 5 years of the study period." | 1.39 | Dose dependence of fetal malformations associated with valproate. ( Eadie, MJ; Graham, JE; Lander, CM; O'Brien, TJ; Vajda, FJ, 2013) |
| " This VPA dosage regimen has been in the past related to a specific pathogenic pathway cascade: (1) VPA in utero exposure, (2) H4 histone hyperacetylation (hAC) at the level of somites, (3) expression of pro-apoptotic factors in somite tissues, (4) apoptosis of somite cells, and (5) axial defects in embryos (abnormal or fused somites) and fetuses (fusions, duplications, respecifications of vertebrae, and/or ribs)." | 1.39 | Methionine pretreatment enhances the effects of valproate on axial development in a CD1 mouse model. ( Di Renzo, F; Giavini, E; Menegola, E, 2013) |
| " The mean dosage of AED for valproate was 498 mg/day and carbamazepine was 555 mg/day." | 1.39 | Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy. ( Begum, S; Sarma, SP; Thomas, SV, 2013) |
| "Epilepsy is one of the most common neurological diseases in the world." | 1.39 | [Valproic acid concentration in the blood serum of pregnant women and umbilical cord blood in relation to the condition of the newborn--case studies]. ( Breborowicz, GH; Chuchracki, M; Florek, E; Hassan-Bartz, M; Krzyścin, M; Kulza, M; Miller, R; Napierała, M; Wachowiak, A; Wozniak, A, 2013) |
| "The biological mechanisms of autism spectrum disorders (ASDs) are largely unknown in spite of extensive research." | 1.39 | Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism. ( Atzori, M; Banerjee, A; Galindo, LC; García-Oscos, F; Hall, S; Kilgard, MP; Roychowdhury, S, 2013) |
| "Valproic acid (VPA), which is a commonly used drug in the treatment of epilepsy, has been reported to have neuroprotective effects against various neuronal insults including ischemic stroke." | 1.39 | Neuroprotective effects of valproic acid against hemin toxicity: possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathway. ( Cheong, JH; Cho, KS; Han, SH; Han, SY; Ignarro, LJ; Jeon, SJ; Kim, HY; Kim, JN; Kim, MK; Kim, SY; Kwon, KJ; Ryu, JH; Shin, CY, 2013) |
| " Neurologists had progressively prescribed valproate less frequently and in lower dosage than other classes of practitioner over the 10-year study period, with a parallel decrease in occurrence of fetal malformations in pregnancies referred to the Register." | 1.38 | The prescribing of antiepileptic drugs for pregnant Australian women. ( Eadie, MJ; Graham, J; Hitchcock, AA; Hollingworth, S; Horgan, D; Lander, CM; O'Brien, TJ; Roten, A; Vajda, FJ, 2012) |
| "monniera on VPA induced autism." | 1.38 | Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats. ( Sandhya, T; Sowjanya, J; Veeresh, B, 2012) |
| "Valproic acid (VPA) is a teratogenic drug used in pregnant women for the treatment of epilepsy and mood disorders." | 1.37 | Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly. ( Cetinkaya, M; Köksal, N; Ozkan, H; Yapici, S, 2011) |
| "In order to establish the etiology of autism with facial palsy, research into developmental abnormalities of the peripheral facial nerves is necessary." | 1.37 | Morphological abnormalities of embryonic cranial nerves after in utero exposure to valproic acid: implications for the pathogenesis of autism with multiple developmental anomalies. ( Imura, Y; Narita, M; Narita, N; Oyabu, A; Tashiro, Y; Uchida, A, 2011) |
| "Despite the prevalence of autism, the neurobiology of this disorder is poorly understood." | 1.37 | Malformation of the superior olivary complex in an animal model of autism. ( Kulesza, RJ; Lukose, R; Murawski, NJ; Schmidt, E; Wolski, TP, 2011) |
| "Autism is characterized by behavioral impairments in three main domains: social interaction; language, communication and imaginative play; and range of interests and activities." | 1.37 | Animal model of autism induced by prenatal exposure to valproate: behavioral changes and liver parameters. ( Bambini-Junior, V; Behr, GA; Gottfried, C; Moreira, JC; Riesgo, R; Rodrigues, L, 2011) |
| " VCU was mainly eliminated by metabolism with a half-life of 2 h." | 1.36 | Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative. ( Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B, 2010) |
| "Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests." | 1.36 | Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010) |
| " dosed on day 8 with VPA 400mg/kg or TSA (16 mg/kg)." | 1.36 | VPA-related axial skeletal defects and apoptosis: a proposed event cascade. ( Broccia, ML; Di Renzo, F; Giavini, E; Menegola, E, 2010) |
| " These changes tended to parallel prescribing trends in the wider community, except for valproate, whose prescribing in the overall community increased as its prescribing, and its dosage prescribed, decreased in pregnancy." | 1.36 | Changing patterns of antiepileptic drug use in pregnant Australian women. ( Eadie, MJ; Graham, J; Hitchcock, AA; Hollingworth, S; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| "Approximately 30% of individuals with autism have normal development up to the age of about 30 months after which they experience behavioral regression and lose previously acquired motor, cognitive and social skills." | 1.36 | Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment. ( Bhattacharya, P; Mirochnitchenko, O; Patti, L; Wagner, GC; Yochum, CL, 2010) |
| "Our cases were spina bifida registrations and all other malformed registrations (excluding folic acid sensitive malformations) were used as controls." | 1.36 | Does folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid? ( Bakker, MK; de Jong-van den Berg, LT; Jentink, J; Nijenhuis, CM; Wilffert, B, 2010) |
| "Antiepileptic drugs (AED) as transplacental agents are known to have adverse effects on fetal development." | 1.36 | Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort. ( Bakulic, TI; Demarin, V; Fucic, A; Gjergja, R; Jazbec, AM; Katic, J; Markovic, D; Miškov, S; Stojković, R; Zeljezic, D, 2010) |
| "Diazepam was the most frequently used anticonvulsant (50." | 1.35 | [Eclampsia at a teaching hospital in Ivory Coast: management, outcome and prognostic factors]. ( Amonkou, AA; Brouh, Y; Ndjeundo, PG; Pete, Y; Tetchi, YD; Yapobi, Y, 2008) |
| "A core feature of autism spectrum disorders is the impairment in social interactions." | 1.35 | Abnormal fear conditioning and amygdala processing in an animal model of autism. ( La Mendola, D; Markram, H; Markram, K; Rinaldi, T; Sandi, C, 2008) |
| "Epilepsy has been associated with poor obstetric outcomes that could be the result of the epilepsy itself or a direct effect of anti-epileptic medication on placentation." | 1.35 | Phenytoin but not valproate directly affected in vitro trophoblast differentiation. ( Anin, S; Bates, MD; Chadwick, D; Neilson, JP; Quenby, SM; Vince, GS, 2008) |
| "The pregnancy was continued and the child is developing well during 16 months of follow-up." | 1.35 | Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature. ( Creemers, JW; Mullaart, RA; Reimer, A; Wortmann, SB, 2008) |
| "Autism is a severe behavioral disorder characterized by pervasive impairments in social interactions, deficits in verbal and non-verbal communication, and stereotyped behaviors, with a four times higher incidence in boys than in girls." | 1.35 | Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid. ( Basta-Kaim, A; Budziszewska, B; Kubera, M; Przewłocki, R; Roman, A; Schneider, K; Schneider, T, 2008) |
| "Aspirin was shown to increase oxygen affinity of hemoglobin via acetylating lysine residues and its general acetylating activity on proteins such as histones makes it also an interesting candidate to activate fetal hemoglobin." | 1.34 | Medroxyprogesterone - valproic acid - aspirin. MVA regime to reduce transfusion associated mortality in late-term hemoglobinopathies. Hypothesis and rationale. ( Altinoz, MA; Carin, MN; Gedikoglu, G; Ozdilli, K, 2007) |
| "Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis." | 1.34 | Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid. ( Antoniello, K; Kulangara, K; Markram, H; Rinaldi, T, 2007) |
| " The supplier group was much more sensitive to these toxic effects." | 1.34 | Valproate-induced developmental neurotoxicity is affected by maternal conditions including shipping stress and environmental change during early pregnancy. ( Hori, Y; Kuwagata, M; Ogawa, T; Shioda, S, 2007) |
| "Recently, a new rodent model of autism was created by exposure of rat fetuses to valproic acid (VPA) on the 12." | 1.33 | Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. ( Przewłocki, R; Schneider, T, 2005) |
| " Unlike the situation for the other drugs, the malformation rate in those exposed to valproate increased with increasing maternal drug dosage (P<0." | 1.33 | Maternal valproate dosage and foetal malformations. ( Eadie, MJ; Vajda, FJ, 2005) |
| "Valproic acid (VPA) is a widely used anticonvulsant medication with well-known teratogenic effects in both humans and in experimental animal model systems." | 1.33 | Valproic acid-induced skeletal malformations: associated gene expression cascades. ( Cabrera, RM; Finnell, RH; Giavini, E; Massa, V; Menegola, E, 2005) |
| "Valproic acid (VPA) is an anticonvulsant drug that is widely used therapeutically for a variety of neurological conditions." | 1.33 | Myo-inositol enhances teratogenicity of valproic acid in the mouse. ( Finnell, RH; Giavini, E; Massa, V; Wlodarczyk, B, 2006) |
| " Principal component analysis (PCA) of the metabonomics data showed clustering of the dosed groups away from the controls for the urine samples." | 1.33 | An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms. ( Beger, RD; Dragan, YP; Edmondson, RD; Fuscoe, JC; Han, T; Hansen, DK; Jones, RC; Schnackenberg, LK; Taylor, JT; Thyparambil, S; Tong, W, 2006) |
| "Women with epilepsy have a higher risk of having dysmorphic child." | 1.33 | A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect. ( Batukan, C; Ceylaner, G; Ceylaner, S; Guven, MA; Uzel, M, 2006) |
| "The incidence of birth defects in relation to specific AEDs was: valproate (16." | 1.32 | The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months. ( Graham, J; Hitchcock, A; Lander, C; O'Brien, TJ; Vajda, FJ, 2003) |
| "Pregnancy was otherwise uneventful." | 1.32 | Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero. ( Audeoud, F; Bernardin, A; Gaugler, C; Messer, J; Stoll, C, 2003) |
| "Valproic acid (VPA) is an effective antiepileptic medication, the use of which in females of childbearing age is complicated by its ability to induce birth defects, including neural tube defects (NTDs), in exposed embryos." | 1.32 | Teratogenicity of valproate conjugates with anticonvulsant activity in mice. ( Alexander, G; Chatterjie, N; Finnell, RH; Spiegelstein, O, 2003) |
| " However, there is no information available on the number of therapeutic abortions, or the different types of epilepsy or drug dosage in the two treatment groups." | 1.32 | Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. ( Källén, B; Wide, K; Winbladh, B, 2004) |
| "Valproic acid (VPA) is an antiepileptic drug used clinically." | 1.32 | Effect of valproic acid on fetal and maternal organs in the mouse: a morphological study. ( Emmanouil-Nikoloussi, EN; Foroglou, NG; Kerameos-Foroglou, CH; Thliveris, JA, 2004) |
| "Morphologic abnormalities found in autism (e." | 1.31 | Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. ( Kato, M; Miyazaki, K; Narita, M; Narita, N; Okado, N; Tazoe, M, 2002) |
| " At each dose, one group of male rats was euthanized after 4-week dosage (4-week dose group) and the other two were mated with untreated females after 4 (7-week dose group) or 7 (10-week dose group) weeks of treatment with valproic acid and their fertility was evaluated." | 1.31 | Effects of valproic acid on fertility and reproductive organs in male rats. ( Nishimura, T; Sakai, M; Yonezawa, H, 2000) |
| " The elimination half-life of the drug was much longer in the newborn (18." | 1.31 | Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance. ( Abbott, FS; Kumar, S; Riggs, KW; Rurak, DW; Wong, H; Yeung, SA, 2000) |
| "The course of epilepsy is more difficult to predict, but failure to respond to the first AED is worrisome." | 1.31 | Prognosis of seizures occurring in the first year. ( Datta, AN; Wirrell, EC, 2000) |
| "Autism has been described in association with a variety of medical and genetic conditions." | 1.31 | Fetal valproate syndrome and autism: additional evidence of an association. ( Cunningham, M; Hersh, JH; Kerr, B; King, J; Stephan, M; Williams, G, 2001) |
| "Valproic acid is an anticonvulsant widely used for the treatment of epilepsy." | 1.31 | Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( Matsuo, H; Nakano, H; Ohtani, H; Sawada, Y; Takanaga, H; Tsukimori, K; Ushigome, F, 2001) |
| "Spina bifida occulta was demonstrated in double-stained fetal skeletons by measuring the distance between the, cartilaginous ends of each vertebral arch." | 1.31 | Valproic acid sodium-induced spina bifida occulta in the rat. ( Ceylan, S; Duru, S, 2001) |
| "Ideally any pregnancy in a woman being treated for epilepsy should be planned, and both an obstetrician and a neurologist should be consulted." | 1.31 | Craniosynostosis and fetal exposure to sodium valproate. ( Barcik, U; Bourgeois, M; El Ghouzzi, V; Lajeunie, E; Renier, D; Thorne, JA, 2001) |
| "Metopic craniosynostosis may be an adverse effect of valproic acid exposed fetus." | 1.31 | [Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment]. ( Bensouda, B; Bruel, H; Chabrolle, JP; Degre, S; Ickowicz, V; Poinsot, J; Simon, A, 2001) |
| "Valproic acid (VPA) is a broad-spectrum anticonvulsant with well-documented teratogenic effects, but whose mechanism of action is largely unknown." | 1.31 | A role for protein kinase C and its substrates in the action of valproic acid in the brain: implications for neural plasticity. ( Lenox, RH; Meyer, EM; Watson, DG; Watterson, JM, 2002) |
| "Valproic acid was used as a prototype developmental toxicant because of its known actions on neural tube closure and on segmentation." | 1.30 | Gene expression domains as markers in developmental toxicity studies using mammalian embryo culture. ( Brown, NA; Mann, FM; Williams, JA, 1997) |
| " In the present work the effects of developmentally toxic doses of 2-ethylhexanoic acid (EHXA), 2-ethylhexanol (EHXO), and valproic acid (VPA) on Zn metabolism were investigated in the pregnant rat." | 1.30 | Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid. ( Bui, LM; Commisso, JF; Faber, WD; Keen, CL; Taubeneck, MW; Uriu-Hare, JY, 1998) |
| " Poor compliance may contribute to the occurrence of status epilepticus, resulting in the need for substantial increases in anticonvulsant dosing to suppress seizures." | 1.30 | Status epilepticus during pregnancy. A case report. ( Licht, EA; Sankar, R, 1999) |
| "Following intravenous administration to dogs of the individual enantiomers, (R)-PID had significantly lower clearance and longer half-life than (S)-PID, however, the volumes of distribution were similar." | 1.30 | Stereoselective pharmacokinetics and pharmacodynamics of propylisopropyl acetamide, a CNS-active chiral amide analog of valproic acid. ( Bennett, GD; Bialer, M; Finnell, RH; Levy, RH; Roeder, M; Schurig, V; Spiegelstein, O; Yagen, B, 1999) |
| "One also had features of infantile autism." | 1.29 | Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994) |
| "Juvenile myoclonic epilepsy is a relatively common, though under diagnosed, form of epilepsy that commences in adolescence." | 1.29 | Juvenile myoclonic epilepsy. ( Buchanan, N, 1995) |
| " On the other hand, the peak concentration and duration of exposure to valproic acid and ethylhexanoic acid were very similar despite a more severe teratologic outcome following valproic acid, which indicated higher intrinsic activity of this latter agent." | 1.29 | Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids. ( Collins, MD; Nau, H; Scott, WJ, 1994) |
| " The frequency of withdrawal symptoms was significantly related to the dose of valproate given to the mothers in the third trimester, and there was a tendency for both the frequency of the minor abnormalities and the major malformations to be related to the valproate dosage in the first trimester." | 1.29 | Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero. ( Ebbesen, F; Thisted, E, 1993) |
| "The toxicity of an agent or the therapeutic effect of a drug may be assessed by a dose-response study." | 1.29 | Exact power computation for dose-response studies. ( Hirji, KF; Tang, ML; Vollset, SE, 1995) |
| "Valproic acid (VPA) is an antiepileptic drug that crosses the placenta freely." | 1.29 | Placental transfer of valproic acid after liposome encapsulation during in vitro human placenta perfusion. ( Algeri, M; Barzago, MM; Bonati, M; Bortolotti, A; Diomede, L; Efrati, S; Salmona, M; Stellari, FF, 1996) |
| "PTA significantly reduced VPA-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced." | 1.29 | Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). ( Nagao, T; Sato, M; Shirota, M, 1995) |
| "The influence of dosing time on embryotoxicity of valproate was investigated in ICR (Institute of Cancer Research, USA) mice under light-dark (12:12) cycle." | 1.29 | Circadian rhythm of embryotoxicity induced by sodium valproate in mice. ( Ogawa, N; Ohdo, S; Sugiyama, T; Watanabe, H; Yoshiyama, Y, 1995) |
| " The disposition of VPA in maternal serum is best described by a biexponential function with a terminal elimination half-life of 2." | 1.29 | The pharmacokinetics of valproic acid in pregnant sheep after maternal and fetal intravenous bolus administration. ( Abbott, FS; Gordon, JD; Hall, C; Kwan, E; Riggs, KW; Rurak, DW, 1995) |
| "Valproic acid (VPA) is an anti-convulsant drug known to cause spina bifida in humans." | 1.29 | Effect of supplemental folic acid on valproic acid-induced embryotoxicity and tissue zinc levels in vivo. ( Dial, SL; Gehring, TA; Grafton, TF; Hansen, DK; Siitonen, PH, 1995) |
| "The influence of dosing time on the embryotoxicity of sodium valproate (valproic acid, VPA) was investigated in ICR mice under a light-dark (12:12) cycle." | 1.29 | Chronotoxicity of sodium valproate in pregnant mouse and embryo. ( Ogawa, N; Ohdo, S; Sugiyama, T; Watanabe, H; Yoshiyama, Y, 1996) |
| "Fetuses were examined for exencephaly, resorption, and fetal weight retardation on day 18 of gestation." | 1.28 | Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice. ( Elmazar, MM; Nau, H, 1992) |
| " Using whole rat embryo cultures, the simultaneous addition of methionine and sodium valproate to the medium provided no protection from neural tube defects, nor did the addition of methionine to a medium of serum obtained from rats previously dosed with sodium valproate." | 1.28 | Methionine decreases the embryotoxicity of sodium valproate in the rat: in vivo and in vitro observations. ( Klein, NW; Nosel, PG, 1992) |
| " It is concluded that 2-EH is not developmentally toxic by the dermal route in the Fischer 344 rat at and below treatment levels which produce maternal toxicity." | 1.28 | The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats. ( Astill, BD; Fisher, LC; Gingell, R; Guest, D; Hodgson, JR; Kubena, MF; Murphy, SR; Tyl, RW; Tyler, TR; Vrbanic, MA, 1992) |
| "Carbamazepine was the antiepileptic drug prescribed most frequently followed by valproic acid." | 1.28 | [The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy]. ( Bülau, P; Fröscher, W; Herrmann, R; Hildenbrand, G; Niesen, M; Penin, H, 1991) |
| " Nulliparous female CD-1 mice were dosed intraperitoneally on day 8 of gestation with 340 mg/kg of sodium valproate." | 1.28 | Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to sodium valproate. ( De Philip, RM; Paulson, RB; Sucheston, ME; Turner, S, 1990) |
| " Two NaVP-filled Alzet osmotic minipumps were implanted subcutaneously on day 5 of gestation for continuous delivery of a total daily dosage of 850 mg/kg for 7 days." | 1.28 | Effects of sodium valproate and oxygen on the craniofacial skeletal pattern in the CD-1 mouse embryo. ( Hayes, TG; Paulson, RB; Sucheston, ME; Weiss, HS, 1989) |
| " Pharmacokinetic interactions between antiepileptic drugs may lead to considerable fluctuation in plasma drug concentration, and monotherapy is often preferable." | 1.27 | Pharmacokinetics of antiepileptic drugs. ( Neuvonen, PJ; Tokola, RA, 1983) |
| "From the analysis of 115 cases of primary generalized epilepsies treated for a mean duration of 43 months with sodium valproate as sole therapy, it appears that: the mean effective daily dosage is 21 mg/kg; the efficacy of valproate proved excellent in 82." | 1.27 | [Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance]. ( Feuerstein, J; Revol, M; Roger, J; Sallou, C; Truelle, JL; Vercelletto, P; Weber, M, 1983) |
| " Depending on its pharmacokinetic parameters, each drug effect has a different onset, intensity, and time course." | 1.27 | Clinical pharmacokinetics of drugs used in the treatment of status epilepticus. ( Baars, AM; van der Dries, A; van der Kleijn, E; Vree, TB, 1983) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 1.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| "The objective of this investigation was to study the teratogenic effects of dosage levels and time of administration of three anticonvulsant drugs (carbamazepine [CMZ], sodium valproate [NaV], and diphenylhydantoin [DPH]) on craniofacial development in the CD-1 mouse fetus." | 1.27 | Teratogenic effects of dosage levels and time of administration of carbamazepine, sodium valproate, and diphenylhydantoin on craniofacial development in the CD-1 mouse fetus. ( Eluma, FO; Hayes, TG; Paulson, RB; Sucheston, ME, 1984) |
| "Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor." | 1.27 | Effects of valproic acid in cultured mammalian neurons. ( Buchhalter, JR; Dichter, MA, 1986) |
| " Maternal pharmacokinetic parameters and plasma metabolites were determined for VPA on the first and last day of dosing for the 10X dose group." | 1.27 | Predicting the human teratogenic potential of the anticonvulsant, valproic acid, from a non-human primate model. ( Cukierski, MA; Hendrickx, AG; Mast, TJ; Nau, H, 1986) |
| "Phenobarbital pretreatment of the dams (previously shown to reduce VPA serum concentrations and induce the omega- and omega-1 oxidation pathways) reduced the embryotoxicity of VPA." | 1.27 | Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen. ( Nau, H, 1986) |
| "Interspecies differences in regard to the teratogenicity of drugs can be the result of differing pharmacokinetic processes that determine the crucial concentration-time relationships in the embryo." | 1.27 | Species differences in pharmacokinetics and drug teratogenesis. ( Nau, H, 1986) |
| "Valproic acid, which is an isomer of 2-EXHA, also produced similar defects, and was approximately twice as potent as 2-EHXA." | 1.27 | Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. ( Randall, JL; Ritter, EJ; Ritter, JM; Scott, WJ, 1987) |
| " The VPA-400 dose was maternally toxic in as much as maternal weight gain was reduced, but no deaths occurred." | 1.27 | Teratogenicity and developmental toxicity of valproic acid in rats. ( Vorhees, CV, 1987) |
| " It was found that both the dosage and timing of VPA administration were crucial in the development of lesions which are similar to human spina bifida aperta." | 1.27 | New animal model for the study of neural tube defects. ( McCollough, D; Michejda, M, 1987) |
| "VPA-induced exencephaly in mice may provide an animal model to further investigate biochemical markers for prenatal diagnosis of neural tube defects." | 1.27 | Amniotic fluid cholinesterase of valproate-induced exencephaly in the mouse: an animal model for prenatal diagnosis of neural tube defects. ( Elmazar, MM; Spielmann, H; Vogel, R, 1988) |
| " Two VA-filled Alzet osmotic minipumps were implanted subcutaneously on gestation day 5 for continuous exposure of a total daily dosage of 850 mg/kg on gestation days 5-12." | 1.27 | Effects of sodium valproate and oxygen on the CD-1 mouse fetus. ( Hayes, TG; Kernan, B; Oca, M; Paulson, RB; Sachs, LA; Sucheston, ME; Weiss, HS; Weiss, S, 1988) |
| " The plasma elimination half-life on GD 8 was 1." | 1.27 | Evaluation of valproic acid (VPA) developmental toxicity and pharmacokinetics in Sprague-Dawley rats. ( Binkerd, PE; Hendrickx, AG; Nau, H; Rowland, JM, 1988) |
| "The effects of pregnancy on seizure excitability as well as antiepileptic drug disposition and efficacy were studied in the mouse during late gestation." | 1.27 | Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse. ( Kuhnz, W; Löscher, W; Nau, H, 1985) |
| " The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding." | 1.27 | Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985) |
| " The incidence of malformations was greater at the higher dosage levels of 340 mg/kg and 560 mg/kg, with a predominance of exencephaly, open eyelids, and gross skeletal defects." | 1.27 | Teratogenic effects of valproate in the CD-1 mouse fetus. ( Hayes, TG; Paulson, GW; Paulson, RB; Sucheston, ME, 1985) |
| "Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy." | 1.27 | Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985) |
| "The incidence of malformations in fetal mice exposed to phenytoin depends on drug dosage and the strain of mice." | 1.26 | Teratogenic effects of anticonvulsants. ( Paulson, GW; Paulson, RB, 1981) |
| " VPA was excreted in the neonates with a mean half-life of 47 +/- 15 hr (n = 8) which is approximately 4 times the mean value found in adult epileptics." | 1.26 | Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers. ( Häuser, I; Helge, H; Koch, S; Nau, H; Rating, D, 1981) |
| " A multicompartment first-order materno-fetal pharmacokinetic model is presented." | 1.26 | Materno-fetal pharmacokinetics and fetal distribution of valproic acid in a pregnant rhesus monkey. ( Cook, MJ; Dickinson, RG; Gerber, N; Kaufman, SN; Lawyer, CH; Lynn, RK; Novy, MJ, 1980) |
| "Only 21% of those with myoclonic astatic epilepsy have become free from seizures." | 1.26 | Sodium valproate: monotherapy and polytherapy. ( Covanis, A; Gupta, AK; Jeavons, PM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 174 (15.08) | 18.7374 |
| 1990's | 130 (11.27) | 18.2507 |
| 2000's | 213 (18.46) | 29.6817 |
| 2010's | 385 (33.36) | 24.3611 |
| 2020's | 252 (21.84) | 2.80 |
| Authors | Studies |
|---|---|
| Luhach, K | 3 |
| Kulkarni, GT | 3 |
| Singh, VP | 3 |
| Sharma, B | 8 |
| Harding, SM | 1 |
| Masters, EC | 1 |
| D'Agata, CM | 1 |
| Agudelo Rivera, AC | 1 |
| Smith, EC | 1 |
| Gu, Y | 1 |
| Han, Y | 1 |
| Ren, S | 1 |
| Zhang, B | 1 |
| Zhao, Y | 3 |
| Wang, X | 9 |
| Zhang, S | 1 |
| Qin, J | 1 |
| Bertels, X | 1 |
| Mehuys, E | 1 |
| Boussery, K | 1 |
| Lahousse, L | 1 |
| Christensen, J | 9 |
| Trabjerg, BB | 1 |
| Sun, Y | 9 |
| Gilhus, NE | 5 |
| Bjørk, MH | 7 |
| Tomson, T | 24 |
| Dreier, JW | 6 |
| Müffelmann, B | 1 |
| Hagemann, A | 1 |
| Knaak, N | 1 |
| Bien, CG | 1 |
| Conei, D | 2 |
| Rojas, M | 2 |
| Santamaría, L | 2 |
| Risopatrón, J | 2 |
| Rakitin, A | 1 |
| Kurvits, K | 1 |
| Laius, O | 1 |
| Uusküla, M | 1 |
| Haldre, S | 1 |
| Martin, M | 2 |
| Hill, C | 1 |
| Bewley, S | 2 |
| MacLennan, AH | 1 |
| Braillon, A | 3 |
| Fragki, S | 1 |
| Hoogenveen, R | 1 |
| van Oostrom, C | 1 |
| Schwillens, P | 1 |
| Piersma, AH | 1 |
| Zeilmaker, MJ | 1 |
| Fereshetyan, K | 1 |
| Chavushyan, V | 1 |
| Danielyan, M | 1 |
| Yenkoyan, K | 1 |
| Widatalla, N | 1 |
| Khandoker, A | 1 |
| Yoshida, C | 2 |
| Nakanishi, K | 2 |
| Fukase, M | 2 |
| Suzuki, A | 2 |
| Kasahara, Y | 2 |
| Saito, M | 1 |
| Kimura, Y | 3 |
| Hansen, JM | 3 |
| Lucas, SM | 1 |
| Ramos, CD | 1 |
| Green, EJ | 1 |
| Nuttall, DJ | 1 |
| Clark, DS | 1 |
| Marchant, ED | 1 |
| Hancock, CR | 1 |
| Piorczynski, TB | 2 |
| Battistoni, M | 4 |
| Bacchetta, R | 1 |
| Di Renzo, F | 9 |
| Metruccio, F | 4 |
| Moretto, A | 4 |
| Menegola, E | 12 |
| Ehlken, B | 1 |
| Nishikawa, C | 1 |
| Kaplan, S | 3 |
| Dresco, I | 1 |
| Granados, D | 1 |
| Toussi, M | 3 |
| Zelano, J | 1 |
| Sveberg, L | 1 |
| Taubøll, E | 3 |
| Gaudio, M | 1 |
| Konstantara, E | 1 |
| Joy, M | 1 |
| van Vlymen, J | 1 |
| de Lusignan, S | 1 |
| Elnahas, EM | 3 |
| Abuelezz, SA | 2 |
| Mohamad, MI | 3 |
| Nabil, MM | 2 |
| Abdelraouf, SM | 2 |
| Bahaa, N | 2 |
| Hassan, GAM | 2 |
| Aboul-Fotouh, S | 4 |
| Lin, J | 1 |
| Zhang, K | 2 |
| Cao, X | 1 |
| Ullah Khan, N | 1 |
| Liu, X | 6 |
| Tang, X | 1 |
| Chen, M | 2 |
| Zhang, H | 2 |
| Shen, L | 1 |
| Vakili Shahrbabaki, SS | 1 |
| Jonaidi, H | 1 |
| Sheibani, V | 4 |
| Bashiri, H | 5 |
| Błaszczyk, B | 1 |
| Miziak, B | 1 |
| Pluta, R | 1 |
| Czuczwar, SJ | 1 |
| Kurt, A | 1 |
| Salihoglu, AK | 1 |
| Ayar, A | 1 |
| Vajda, FJE | 9 |
| O'Brien, TJ | 24 |
| Graham, JE | 7 |
| Hitchcock, AE | 1 |
| Perucca, P | 6 |
| Lander, CM | 16 |
| Eadie, MJ | 21 |
| Bódi, V | 1 |
| Májer, T | 1 |
| Kelemen, V | 1 |
| Világi, I | 1 |
| Szűcs, A | 1 |
| Varró, P | 1 |
| Jiang, S | 1 |
| Xiao, L | 1 |
| He, M | 1 |
| Gao, C | 1 |
| Zhu, C | 1 |
| Chang, H | 1 |
| Ding, J | 1 |
| Li, W | 1 |
| Wang, Y | 5 |
| Sun, T | 1 |
| Wang, F | 1 |
| Santrač, A | 1 |
| Bijelić, D | 1 |
| Stevanović, V | 1 |
| Banićević, M | 1 |
| Aranđelović, J | 1 |
| Batinić, B | 1 |
| Sharmin, D | 1 |
| Cook, JM | 1 |
| Savić, MM | 1 |
| Can Kantarci, B | 1 |
| Sanli, A | 1 |
| Gavas, S | 1 |
| Toplu, A | 1 |
| Nur Turgan Asik, Z | 1 |
| Tugce Cilingir-Kaya, O | 1 |
| Gulcebi Idrizoglu, M | 1 |
| Ercan, F | 1 |
| Onat, F | 1 |
| Abbasalipour, H | 1 |
| Hajizadeh Moghaddam, A | 2 |
| Ranjbar, M | 3 |
| Roberti, R | 1 |
| Rocca, M | 1 |
| Iannone, LF | 1 |
| Gasparini, S | 1 |
| Pascarella, A | 1 |
| Neri, S | 1 |
| Cianci, V | 1 |
| Bilo, L | 2 |
| Russo, E | 1 |
| Quaresima, P | 1 |
| Aguglia, U | 2 |
| Di Carlo, C | 1 |
| Ferlazzo, E | 1 |
| Abhishek, M | 1 |
| Rubal, S | 1 |
| Rohit, K | 1 |
| Rupa, J | 1 |
| Phulen, S | 1 |
| Gurjeet, K | 1 |
| Raj, SA | 1 |
| Manisha, P | 1 |
| Alka, B | 1 |
| Ramprasad, P | 1 |
| Bikash, M | 1 |
| Degremont, A | 1 |
| Kerbrat, S | 1 |
| Balusson, F | 1 |
| Jonville-Bera, AP | 1 |
| Ringa, V | 1 |
| Travers, D | 1 |
| Tillaut, H | 1 |
| Leray, E | 1 |
| Oger, E | 1 |
| Biraben, A | 2 |
| Polard, E | 1 |
| Imam, B | 1 |
| Rahmatinia, M | 1 |
| Shahsavani, A | 1 |
| Khodagholi, F | 1 |
| Hopke, PK | 1 |
| Bazazzpour, S | 1 |
| Hadei, M | 1 |
| Yarahmadi, M | 1 |
| Abdollahifar, MA | 1 |
| Torkmahalleh, MA | 1 |
| Kermani, M | 1 |
| Ilkhani, S | 1 |
| MirBehbahani, SH | 1 |
| Wartman, C | 1 |
| VandenBerg, A | 1 |
| Eriksson, SH | 1 |
| Tittensor, P | 1 |
| Sisodiya, SM | 2 |
| McTaggart, S | 1 |
| MacColl, G | 1 |
| Gronkowski, K | 1 |
| Wood, R | 1 |
| Leach, JP | 1 |
| Bennie, M | 1 |
| Ma, SY | 1 |
| Kwan, KM | 1 |
| Elesawy, RO | 1 |
| El-Deeb, OS | 1 |
| Eltokhy, AK | 1 |
| Arakeep, HM | 1 |
| Ali, DA | 1 |
| Elkholy, SS | 1 |
| Kabel, AM | 1 |
| Mahase, E | 1 |
| Santos-Terra, J | 6 |
| Deckmann, I | 7 |
| Carello-Collar, G | 2 |
| Nunes, GD | 2 |
| Bauer-Negrini, G | 5 |
| Schwingel, GB | 3 |
| Fontes-Dutra, M | 9 |
| Riesgo, R | 8 |
| Gottfried, C | 14 |
| Kikuchi, D | 1 |
| Obara, T | 1 |
| Miura, R | 1 |
| Suzuki, N | 1 |
| Josaka, R | 1 |
| Tokunaga, M | 1 |
| Ouchi, R | 1 |
| Usui, K | 1 |
| Okada, K | 1 |
| Galizio, A | 1 |
| Odum, AL | 1 |
| Seiffe, A | 2 |
| Ramírez, MF | 1 |
| Sempé, L | 1 |
| Depino, AM | 7 |
| Chang, X | 1 |
| Palmer, J | 1 |
| Lumen, A | 1 |
| Lee, UJ | 1 |
| Ceger, P | 1 |
| Mansouri, K | 1 |
| Sprankle, C | 1 |
| Donley, E | 1 |
| Bell, S | 1 |
| Knudsen, TB | 1 |
| Wambaugh, J | 1 |
| Cook, B | 1 |
| Allen, D | 1 |
| Kleinstreuer, N | 1 |
| Taheri, F | 1 |
| Esmaeilpour, K | 1 |
| Sepehri, G | 3 |
| Ur Rehman, N | 1 |
| Maneshian, M | 1 |
| Liu, Z | 2 |
| Wang, J | 4 |
| Xu, Q | 1 |
| Wu, Z | 1 |
| You, L | 1 |
| Hong, Q | 1 |
| Zhu, J | 1 |
| Chi, X | 2 |
| Kowalski, TW | 1 |
| Lord, VO | 1 |
| Sgarioni, E | 1 |
| Gomes, JDA | 1 |
| Mariath, LM | 1 |
| Recamonde-Mendoza, M | 1 |
| Vianna, FSL | 1 |
| Dufour, A | 2 |
| Dumon, C | 2 |
| Gouty-Colomer, LA | 2 |
| Eftekhari, S | 3 |
| Ferrari, DC | 3 |
| Ben-Ari, Y | 4 |
| Zoega, H | 5 |
| Leinonen, MK | 5 |
| Cohen, JM | 5 |
| Furu, K | 5 |
| Gissler, M | 5 |
| Hálfdánarson, Ó | 1 |
| Igland, J | 2 |
| Alvestad, S | 6 |
| Menkes, DB | 3 |
| Goldspink, R | 3 |
| Sivasangari, K | 1 |
| Rajan, KE | 1 |
| Rhinn, M | 1 |
| Zapata-Bodalo, I | 1 |
| Klein, A | 1 |
| Plassat, JL | 1 |
| Knauer-Meyer, T | 1 |
| Keyes, WM | 1 |
| Jian, J | 1 |
| Li, LG | 1 |
| Zhao, PJ | 1 |
| Zheng, RJ | 1 |
| Dong, XW | 1 |
| Zhao, YH | 1 |
| Yin, BQ | 2 |
| Cheng, H | 1 |
| Li, HL | 1 |
| Li, EY | 1 |
| La Neve, A | 2 |
| Falcicchio, G | 1 |
| Trojano, M | 1 |
| Boero, G | 1 |
| Sabzalizadeh, M | 1 |
| Mollashahi, M | 1 |
| Afarinesh, MR | 2 |
| Mafi, F | 1 |
| Joushy, S | 1 |
| Thomas, SV | 9 |
| Jeemon, P | 1 |
| Jose, M | 3 |
| Amrithum, LM | 1 |
| Bhaskar, D | 1 |
| Nair, MKC | 1 |
| George, B | 1 |
| Avolio, E | 1 |
| Olivito, I | 1 |
| Rosina, E | 1 |
| Romano, L | 1 |
| Angelone, T | 1 |
| De Bartolo, A | 1 |
| Scimeca, M | 1 |
| Bellizzi, D | 1 |
| D'Aquila, P | 1 |
| Passarino, G | 1 |
| Alò, R | 1 |
| Facciolo, RM | 1 |
| Bagni, C | 1 |
| De Lorenzo, A | 1 |
| Canonaco, M | 1 |
| Alpay, M | 1 |
| Yucel, F | 1 |
| Rahdar, M | 4 |
| Hajisoltani, R | 3 |
| Davoudi, S | 4 |
| Karimi, SA | 2 |
| Borjkhani, M | 2 |
| Khatibi, VA | 1 |
| Hosseinmardi, N | 4 |
| Behzadi, G | 4 |
| Janahmadi, M | 4 |
| Kalim, A | 1 |
| Reardon, W | 2 |
| Ishihara, Y | 1 |
| Honda, T | 1 |
| Ishihara, N | 1 |
| Namba, K | 1 |
| Taketoshi, M | 1 |
| Tominaga, Y | 1 |
| Tsuji, M | 1 |
| Vogel, CFA | 1 |
| Yamazaki, T | 1 |
| Itoh, K | 1 |
| Tominaga, T | 2 |
| Takayama, K | 1 |
| Tobori, S | 1 |
| Andoh, C | 1 |
| Kakae, M | 1 |
| Hagiwara, M | 1 |
| Nagayasu, K | 1 |
| Shirakawa, H | 1 |
| Ago, Y | 12 |
| Kaneko, S | 5 |
| Gruppuso, PA | 1 |
| Ahmed, R | 1 |
| Adashi, EY | 1 |
| Kiratli, H | 1 |
| Colak, D | 1 |
| Koç, İ | 1 |
| Kim, H | 2 |
| Woo, RS | 1 |
| Yang, EJ | 3 |
| Kim, HB | 1 |
| Jo, EH | 1 |
| Lee, S | 1 |
| Im, H | 1 |
| Kim, S | 4 |
| Kim, HS | 3 |
| Guan, Z | 1 |
| Liang, Y | 1 |
| Zhu, Z | 1 |
| Yang, A | 1 |
| Li, S | 2 |
| Yu, J | 1 |
| Niu, B | 1 |
| Anshu, K | 2 |
| Nair, AK | 2 |
| Srinath, S | 2 |
| Laxmi, TR | 2 |
| Iezzi, D | 1 |
| Curti, L | 1 |
| Ranieri, G | 1 |
| Gerace, E | 1 |
| Costa, A | 1 |
| Ilari, A | 1 |
| La Rocca, A | 1 |
| Luceri, C | 1 |
| D'Ambrosio, M | 1 |
| Silvestri, L | 1 |
| Scardigli, M | 1 |
| Mannaioni, G | 1 |
| Masi, A | 1 |
| Katušić-Bojanac, A | 1 |
| Plazibat, M | 1 |
| Himelreich-Perić, M | 1 |
| Eck-Raković, K | 1 |
| Krasić, J | 1 |
| Sinčić, N | 1 |
| Jurić-Lekić, G | 1 |
| Ježek, D | 1 |
| Bulić-Jakuš, F | 1 |
| Serra, D | 1 |
| Henriques, JF | 1 |
| Sousa, FJ | 1 |
| Laranjo, M | 1 |
| Resende, R | 1 |
| Ferreira-Marques, M | 1 |
| de Freitas, V | 1 |
| Silva, G | 1 |
| Peça, J | 1 |
| Dinis, TCP | 1 |
| Almeida, LM | 1 |
| Imado, E | 1 |
| Sun, S | 2 |
| Abawa, AR | 1 |
| Tahara, T | 1 |
| Kochi, T | 1 |
| Huynh, TNB | 1 |
| Asano, S | 1 |
| Hasebe, S | 7 |
| Nakamura, Y | 1 |
| Hisaoka-Nakashima, K | 1 |
| Kotake, Y | 1 |
| Irifune, M | 1 |
| Tsuga, K | 1 |
| Takuma, K | 12 |
| Morioka, N | 1 |
| Kiguchi, N | 1 |
| Feleke, R | 1 |
| Jazayeri, D | 3 |
| Abouzeid, M | 1 |
| Powell, KL | 2 |
| Srivastava, PK | 1 |
| Jones, NC | 2 |
| Johnson, MR | 1 |
| Shi, X | 2 |
| Zhang, Y | 9 |
| Song, C | 1 |
| Jiang, Y | 1 |
| Zhao, J | 2 |
| Xia, L | 1 |
| Ma, L | 1 |
| Jiang, W | 1 |
| Biosca-Brull, J | 1 |
| Guardia-Escote, L | 1 |
| Blanco, J | 1 |
| Basaure, P | 1 |
| Cabré, M | 1 |
| Sánchez-Santed, F | 2 |
| Domingo, JL | 1 |
| Colomina, MT | 1 |
| Jiménez, M | 1 |
| Grau-López, L | 1 |
| Ciurans, J | 1 |
| García-Esperón, C | 1 |
| Fumanal, A | 1 |
| Barambio, S | 1 |
| Chíes, E | 1 |
| Codina, M | 1 |
| Becerra, JL | 1 |
| Mishra, A | 3 |
| Singla, R | 3 |
| Kumar, R | 1 |
| Sharma, A | 2 |
| Joshi, R | 1 |
| Sarma, P | 1 |
| Kaur, G | 1 |
| Prajapat, M | 1 |
| Bhatia, A | 2 |
| Medhi, B | 3 |
| Samalin, L | 1 |
| Arnould, A | 1 |
| Boudieu, L | 1 |
| Henry, C | 2 |
| Haffen, E | 1 |
| Drapier, D | 1 |
| Anmella, G | 2 |
| Pacchiarotti, I | 2 |
| Vieta, E | 2 |
| Belzeaux, R | 1 |
| Llorca, PM | 1 |
| Meador, KJ | 17 |
| Fauvelle, K | 1 |
| Bigna, JJ | 1 |
| Manthos, K | 1 |
| Theotokis, P | 1 |
| Dermitzakis, I | 1 |
| Avramidou, E | 1 |
| Meditskou, S | 1 |
| Manthou, ME | 1 |
| Emmanouil-Nikoloussi, EN | 2 |
| Ishida, K | 1 |
| Tatsumi, K | 1 |
| Minamigawa, Y | 1 |
| Mori, K | 1 |
| Matsumaru, D | 1 |
| Nagase, H | 1 |
| Kanda, Y | 2 |
| Nakanishi, T | 1 |
| Ren, T | 1 |
| Lee, PMY | 1 |
| Li, F | 2 |
| Li, J | 4 |
| Haug, U | 3 |
| Kollhorst, B | 3 |
| Schink, T | 3 |
| Thöne, K | 3 |
| Dathe, K | 3 |
| Schaefer, C | 4 |
| Onken, M | 3 |
| Cui, Y | 3 |
| Xiang, G | 3 |
| Yu, M | 3 |
| Qiu, B | 3 |
| Li, XG | 3 |
| Liu, W | 3 |
| Zhang, D | 3 |
| Maisterrena, A | 3 |
| Matas, E | 4 |
| Mirfendereski, H | 3 |
| Balbous, A | 4 |
| Marchand, S | 3 |
| Jaber, M | 4 |
| Cesta, CE | 3 |
| Nørgaard, M | 3 |
| Einarsdóttir, K | 3 |
| Engeland, A | 3 |
| Karlstad, Ø | 3 |
| Klungsøyr, K | 3 |
| Odsbu, I | 3 |
| Reutfors, J | 3 |
| Selmer, RM | 3 |
| Ulrichsen, SP | 3 |
| Galineau, L | 3 |
| Arlicot, N | 3 |
| Dupont, AC | 3 |
| Briend, F | 3 |
| Houy-Durand, E | 3 |
| Tauber, C | 3 |
| Gomot, M | 3 |
| Gissot, V | 3 |
| Barantin, L | 3 |
| Lefevre, A | 3 |
| Vercouillie, J | 3 |
| Roussel, C | 3 |
| Roux, S | 4 |
| Nadal, L | 3 |
| Mavel, S | 3 |
| Laumonnier, F | 3 |
| Belzung, C | 4 |
| Chalon, S | 4 |
| Emond, P | 3 |
| Santiago-Ribeiro, MJ | 3 |
| Bonnet-Brilhault, F | 3 |
| Righes Marafiga, J | 2 |
| Brum Schwingel, G | 3 |
| Rabelo, B | 4 |
| Kazmierzak de Moraes, R | 2 |
| Rockenbach, M | 2 |
| Vendramin Pasquetti, M | 2 |
| Calcagnotto, ME | 2 |
| Viana, CE | 2 |
| Bortolotto, VC | 2 |
| Araujo, SM | 2 |
| Dahleh, MMM | 2 |
| Machado, FR | 2 |
| de Souza Pereira, A | 2 |
| Moreira de Oliveira, BP | 2 |
| Leimann, FV | 2 |
| Gonçalves, OH | 2 |
| Prigol, M | 2 |
| Guerra, GP | 2 |
| Kim, UJ | 1 |
| Hong, N | 1 |
| Ahn, JC | 1 |
| Haratizadeh, S | 2 |
| Darvishzadeh-Mahani, F | 1 |
| Basiri, M | 3 |
| Nozari, M | 3 |
| Oliveri, NMB | 1 |
| Almarsdóttir, AB | 1 |
| Jacobsen, R | 1 |
| Zhang, N | 1 |
| Wang, ST | 1 |
| Yao, L | 2 |
| Manière-Guerrero, I | 1 |
| Bonizzoni, E | 6 |
| Battino, D | 11 |
| Clinard, F | 1 |
| Mathieu-Huart, A | 1 |
| Perucca, E | 14 |
| Pouzaud, F | 1 |
| Vajda, F | 12 |
| Rousselle, C | 1 |
| de Oliveira Ferreira, E | 1 |
| Pessoa Gomes, JM | 1 |
| Neves, KRT | 1 |
| Lima, FAV | 1 |
| de Barros Viana, GS | 1 |
| de Andrade, GM | 1 |
| Luo, L | 2 |
| Chen, J | 3 |
| Wu, Q | 3 |
| Yuan, B | 2 |
| Hu, C | 2 |
| Yang, T | 3 |
| Wei, H | 1 |
| Li, T | 5 |
| Zohny, SM | 1 |
| Habib, MZ | 2 |
| Elayat, WM | 1 |
| Elhossiny, RM | 1 |
| El-Salam, MFA | 1 |
| Shahrbabaki, SSV | 1 |
| Moslemizadeh, A | 4 |
| Amiresmaili, S | 1 |
| Tezerji, SS | 1 |
| Juybari, KB | 1 |
| Shamsi Meymandi, M | 2 |
| Pumipi, T | 2 |
| Kim, SA | 1 |
| Jang, EH | 1 |
| Lee, J | 3 |
| Cho, SH | 1 |
| Ahmadi, BBM | 1 |
| Jafaripour, L | 1 |
| Mirzavandi, F | 1 |
| Sabet, N | 2 |
| Aminzadeh, A | 1 |
| Heidari, M | 1 |
| Pouya, F | 1 |
| Parizi, AS | 1 |
| O'Brien, T | 5 |
| Graham, J | 17 |
| Hitchcock, A | 8 |
| Lander, C | 6 |
| Eadie, M | 5 |
| Anggadiredja, K | 1 |
| Kurniati, NF | 1 |
| Kasai, A | 2 |
| Hashimoto, H | 9 |
| Zahedi, E | 2 |
| Sadr, SS | 2 |
| Sanaeierad, A | 2 |
| Roghani, M | 2 |
| Zappala, C | 3 |
| Barrios, CD | 1 |
| Ruyani, SF | 1 |
| Sumarsono, SH | 1 |
| Lin, F | 1 |
| Mehra, S | 1 |
| Ahsan, AU | 1 |
| Sharma, M | 2 |
| Budhwar, M | 1 |
| Chopra, M | 1 |
| Sandhu, A | 1 |
| Rawat, K | 1 |
| Gautam, V | 1 |
| Kumar, A | 1 |
| Saha, L | 1 |
| Abtahi, S | 1 |
| Pajouheshnia, R | 1 |
| Durán, CE | 1 |
| Riera-Arnau, J | 1 |
| Gamba, M | 1 |
| Alsina, E | 1 |
| Hoxhaj, V | 1 |
| Andersen, M | 1 |
| Bartolini, C | 1 |
| Kristiansen, SB | 1 |
| Brown, J | 1 |
| Hallgreen, CE | 1 |
| Garcia-Poza, P | 1 |
| Gardarsdottir, H | 1 |
| Gini, R | 3 |
| Girardi, A | 1 |
| Holthuis, E | 1 |
| Huerta, C | 1 |
| Ibánez, L | 1 |
| Limoncella, G | 1 |
| Martín-Pérez, M | 1 |
| Paoletti, O | 1 |
| Roberto, G | 1 |
| Souverein, P | 1 |
| Swart, KMA | 1 |
| Wing, K | 1 |
| Sturkenboom, M | 1 |
| Klungel, O | 1 |
| Barzegari, A | 1 |
| Amouzad Mahdirejei, H | 1 |
| Hanani, M | 1 |
| Esmaeili, MH | 1 |
| Salari, AA | 1 |
| Hernandez, A | 1 |
| Delgado-González, E | 1 |
| Durairaj, RV | 1 |
| Reyes-Haro, D | 1 |
| Martínez-Torres, A | 1 |
| Espinosa, F | 1 |
| Qu, B | 1 |
| Kang, B | 1 |
| Chen, X | 2 |
| Ao, Y | 1 |
| Wang, L | 3 |
| Cui, W | 4 |
| Pekoz, MT | 1 |
| Aslan-Kara, K | 1 |
| Tekin, B | 1 |
| Gurses, C | 1 |
| Yeni, SN | 1 |
| Bozdemir, H | 1 |
| Keskin-Guler, S | 1 |
| Ataklı, D | 1 |
| Gul, G | 1 |
| Eren, F | 1 |
| Sarı, H | 1 |
| Gul, ZB | 1 |
| Ceyhan-Dirican, A | 1 |
| Genc, F | 1 |
| Bicer-Gomceli, Y | 1 |
| Ozkara, C | 2 |
| Delil, S | 1 |
| Atalar, AC | 1 |
| Bebek, N | 1 |
| Baykan, B | 1 |
| Bora, İ | 1 |
| Bican-Demir, A | 1 |
| Mısırlı, CH | 1 |
| Tutkavul, K | 1 |
| Velioglu, SK | 1 |
| Ilhan-Algin, D | 1 |
| Erdinc, O | 1 |
| Saygi, S | 1 |
| Tezer-Fılık, I | 1 |
| Apaydın-Dogan, E | 1 |
| Akyol, A | 1 |
| Kamisli, O | 1 |
| Yalcın, AD | 1 |
| Cakmak, G | 1 |
| Ersoy, A | 1 |
| Ustun-Ozek, S | 1 |
| Halac, G | 1 |
| Kutlu, G | 1 |
| Tantik-Pak, A | 1 |
| Yücel, SP | 1 |
| Mallan, S | 1 |
| Singh, S | 2 |
| Ohyama, N | 2 |
| Furugen, A | 5 |
| Sawada, R | 1 |
| Aoyagi, R | 1 |
| Nishimura, A | 2 |
| Umazume, T | 1 |
| Narumi, K | 4 |
| Kobayashi, M | 4 |
| Takla, TN | 1 |
| Luo, J | 1 |
| Sudyk, R | 1 |
| Huang, J | 1 |
| Walker, JC | 1 |
| Vora, NL | 1 |
| Sexton, JZ | 1 |
| Parent, JM | 1 |
| Tidball, AM | 1 |
| Aboul-Ela, YM | 1 |
| Ebeid, MA | 1 |
| Tarek, M | 1 |
| Sadek, DR | 1 |
| Negm, EA | 1 |
| Abdelhakam, DA | 1 |
| Lima-Castañeda, LÁ | 1 |
| Bringas, ME | 2 |
| Aguilar-Hernandez, L | 1 |
| Garcés-Ramírez, L | 1 |
| Morales-Medina, JC | 1 |
| Flores, G | 2 |
| Scholz, K | 1 |
| Köster, I | 1 |
| Meyer, I | 1 |
| Selke, GW | 1 |
| Schubert, I | 1 |
| Rostamzadeh, F | 1 |
| Rajizadeh, MA | 1 |
| Jafari, E | 1 |
| Park, G | 1 |
| Jang, WE | 1 |
| Gonzales, EL | 3 |
| Ji, J | 1 |
| Choi, S | 1 |
| Kim, Y | 1 |
| Park, JH | 3 |
| Mohammad, HB | 1 |
| Bang, G | 1 |
| Kang, M | 2 |
| Jeon, SJ | 5 |
| Kim, JY | 1 |
| Kim, KP | 1 |
| Shin, CY | 12 |
| An, JY | 1 |
| Kim, MS | 1 |
| Lee, YS | 1 |
| Seyedinia, SA | 1 |
| Tarahomi, P | 1 |
| Abbarin, D | 1 |
| Sedaghat, K | 1 |
| Rashidy-Pour, A | 1 |
| Yaribeygi, H | 1 |
| Vafaei, AA | 2 |
| Raise-Abdullahi, P | 2 |
| Saadat, M | 1 |
| Taherian, AA | 1 |
| Aldaghi, MR | 1 |
| Sameni, HR | 1 |
| Hope, OA | 1 |
| Harris, KM | 1 |
| Iwasaki, M | 1 |
| D'Antoni, S | 1 |
| Schiavi, S | 5 |
| Buzzelli, V | 1 |
| Giuffrida, S | 1 |
| Feo, A | 1 |
| Ascone, F | 1 |
| Busceti, CL | 1 |
| Nicoletti, F | 1 |
| Trezza, V | 6 |
| Catania, MV | 1 |
| Fantaneanu, TA | 1 |
| Thornton, HF | 1 |
| Zhang, T | 1 |
| Bercovici, E | 1 |
| Hrazdil, C | 1 |
| Ikeda, KM | 1 |
| Kassiri, J | 1 |
| Suller Marti, A | 1 |
| Pana, R | 1 |
| Rezazadeh, A | 1 |
| Kobayashi, E | 1 |
| Bui, E | 1 |
| Nakagami, Y | 1 |
| Nishi, M | 1 |
| Sharma, AR | 2 |
| Batra, G | 2 |
| Dhir, N | 1 |
| Jain, A | 2 |
| Modi, T | 1 |
| Saini, L | 2 |
| Thakur, N | 1 |
| Singh, RS | 2 |
| Singh, A | 2 |
| Prakash, A | 1 |
| Goyal, M | 1 |
| Modi, M | 2 |
| Abid, M | 1 |
| Basit, A | 1 |
| Wu, HF | 1 |
| Lu, TY | 1 |
| Chu, MC | 1 |
| Chen, PS | 6 |
| Lee, CW | 1 |
| Lin, HC | 2 |
| Arafat, EA | 1 |
| Shabaan, DA | 1 |
| Kinjo, T | 2 |
| Ito, M | 2 |
| Seki, T | 2 |
| Fukuhara, T | 1 |
| Bolati, K | 1 |
| Arai, H | 1 |
| Suzuki, T | 2 |
| Charlton, R | 2 |
| Damase-Michel, C | 3 |
| Hurault-Delarue, C | 2 |
| Loane, M | 3 |
| Pierini, A | 2 |
| Puccini, A | 2 |
| Neville, A | 3 |
| Snowball, J | 2 |
| Morris, JK | 4 |
| Jackson, A | 3 |
| Ward, H | 1 |
| Bromley, RL | 8 |
| Deshpande, C | 1 |
| Vasudevan, P | 1 |
| Scurr, I | 1 |
| Dean, J | 2 |
| Shannon, N | 1 |
| Berg, J | 1 |
| Holder, S | 1 |
| Baralle, D | 1 |
| Clayton-Smith, J | 16 |
| Kazlauskas, N | 3 |
| Campolongo, M | 3 |
| Cubała, WJ | 1 |
| Dudek, D | 1 |
| Maina, G | 1 |
| Thomas, P | 1 |
| Mohammadi, S | 1 |
| Asadi-Shekaari, M | 1 |
| Parvan, M | 1 |
| Shabani, M | 1 |
| Sakade, Y | 1 |
| Yamanaka, K | 1 |
| Soumiya, H | 1 |
| Furukawa, S | 1 |
| Fukumitsu, H | 1 |
| Zhao, H | 1 |
| Wang, Q | 1 |
| Yan, T | 1 |
| Xu, HJ | 1 |
| Yu, HP | 1 |
| Tu, Z | 1 |
| Guo, X | 2 |
| Jiang, YH | 1 |
| Li, XJ | 1 |
| Zhou, H | 1 |
| Zhang, YQ | 1 |
| Aykan, DA | 1 |
| Ergün, Y | 1 |
| Philbrook, NA | 1 |
| Nikolovska, A | 1 |
| Maciver, RD | 1 |
| Belanger, CL | 1 |
| Winn, LM | 10 |
| Oakley, GP | 3 |
| Hara, Y | 10 |
| Feng, S | 1 |
| Li, M | 1 |
| Liu, Y | 2 |
| Yan, J | 1 |
| Tang, Y | 2 |
| Du, D | 1 |
| Chen, F | 1 |
| Gandhi, M | 1 |
| Rac, MWF | 1 |
| McKinney, J | 1 |
| Husebye, ESN | 1 |
| Spigset, O | 2 |
| Daltveit, AK | 3 |
| Keni, RR | 1 |
| A S, R | 1 |
| Baishya, J | 1 |
| Sankara Sarma, P | 1 |
| Harris, L | 1 |
| Lowes, O | 1 |
| Angus-Leppan, H | 6 |
| Andrade, FO | 1 |
| Nguyen, NM | 1 |
| Warri, A | 2 |
| Hilakivi-Clarke, L | 2 |
| Hirsch, MM | 3 |
| Staevie, GZ | 1 |
| Körbes-Rockenbach, M | 1 |
| Gonçalves, MCB | 1 |
| Corrêa-Velloso, J | 1 |
| Naaldijk, Y | 1 |
| Castillo, ARG | 1 |
| Schneider, T | 5 |
| Bambini-Junior, V | 10 |
| Ulrich, H | 1 |
| Arfman, IJ | 1 |
| Wammes-van der Heijden, EA | 1 |
| Ter Horst, PGJ | 1 |
| Lambrechts, DA | 1 |
| Wegner, I | 1 |
| Touw, DJ | 1 |
| Hughes, EM | 3 |
| Calcagno, P | 2 |
| Clarke, M | 1 |
| Sanchez, C | 3 |
| Smith, K | 3 |
| Kelly, JP | 3 |
| Finn, DP | 4 |
| Roche, M | 4 |
| Zimmerman, R | 2 |
| Smith, A | 3 |
| Fech, T | 1 |
| Mansour, Y | 2 |
| Kulesza, RJ | 7 |
| Matsuo, K | 1 |
| Yabuki, Y | 1 |
| Fukunaga, K | 3 |
| Moghim, MM | 1 |
| Cock, H | 2 |
| Kinton, L | 1 |
| Synnott Wells, M | 1 |
| Shankar, R | 3 |
| Huber-Mollema, Y | 2 |
| van Iterson, L | 1 |
| Oort, FJ | 2 |
| Lindhout, D | 16 |
| Rodenburg, R | 2 |
| Norton, SA | 2 |
| Gifford, JJ | 2 |
| Pawlak, AP | 1 |
| Derbaly, A | 1 |
| Sherman, SL | 1 |
| Wagner, GC | 4 |
| Kusnecov, AW | 2 |
| Suri, R | 1 |
| Socol, DK | 1 |
| Gitlin, M | 1 |
| Shafique, S | 3 |
| Lebedevs, T | 1 |
| Gan, M | 1 |
| Teoh, SWK | 1 |
| Brown, P | 1 |
| de Mattos, BDS | 1 |
| Soares, MSP | 1 |
| Spohr, L | 1 |
| Pedra, NS | 1 |
| Teixeira, FC | 1 |
| de Souza, AA | 1 |
| Stefanello, FM | 1 |
| Baldissarelli, J | 1 |
| Gamaro, GD | 1 |
| Spanevello, RM | 1 |
| Toledo, M | 1 |
| Mostacci, B | 2 |
| Bosak, M | 2 |
| Jedrzejzak, J | 1 |
| Thomas, RH | 2 |
| Salas-Puig, J | 1 |
| Schmitz, B | 4 |
| Hitchcock, AA | 8 |
| Lamothe, J | 1 |
| Khurana, S | 1 |
| Tharmalingam, S | 1 |
| Williamson, C | 1 |
| Byrne, CJ | 1 |
| Khaper, N | 1 |
| Mercier, S | 1 |
| Tai, TC | 1 |
| Tsuji, C | 2 |
| Fujisaku, T | 2 |
| Tsuji, T | 2 |
| Weinstein-Fudim, L | 3 |
| Ergaz, Z | 3 |
| Szyf, M | 1 |
| Ornoy, A | 7 |
| Reynolds, EH | 1 |
| Green, R | 1 |
| Davies, P | 2 |
| Reuber, M | 1 |
| Grunewald, R | 1 |
| Howell, S | 1 |
| Dickson, J | 1 |
| Dennis, G | 1 |
| Shanmugarajah, P | 1 |
| Tsironis, T | 1 |
| Brockington, A | 1 |
| Ishola, IO | 1 |
| Balogun, AO | 1 |
| Adeyemi, OO | 1 |
| Braine, E | 1 |
| McDonald, S | 1 |
| Dworkin, S | 1 |
| Griggs, K | 1 |
| Nilo, A | 1 |
| Gelisse, P | 2 |
| Crespel, A | 2 |
| Lenart, J | 1 |
| Augustyniak, J | 1 |
| Lazarewicz, JW | 1 |
| Zieminska, E | 1 |
| Jinno, N | 2 |
| Kurosawa, Y | 3 |
| Kanno, Y | 2 |
| Iseki, K | 3 |
| Gąssowska-Dobrowolska, M | 2 |
| Cieślik, M | 2 |
| Czapski, GA | 1 |
| Jęśko, H | 1 |
| Frontczak-Baniewicz, M | 1 |
| Gewartowska, M | 1 |
| Dominiak, A | 2 |
| Polowy, R | 1 |
| Filipkowski, RK | 1 |
| Babiec, L | 1 |
| Adamczyk, A | 2 |
| Chatterjee, M | 1 |
| Singh, P | 1 |
| Xu, J | 1 |
| Lombroso, PJ | 1 |
| Kurup, PK | 1 |
| Becker, M | 1 |
| Blotière, PO | 2 |
| Miranda, S | 2 |
| Weill, A | 2 |
| Mikaeloff, Y | 2 |
| Peyre, H | 2 |
| Ramus, F | 2 |
| Mahmoud, Z | 1 |
| Coste, J | 2 |
| Dray-Spira, R | 2 |
| Morrison, I | 1 |
| Cork, H | 1 |
| Smith, P | 2 |
| Campbell, C | 1 |
| Megan McTiernan, M | 1 |
| White, K | 2 |
| Dey, S | 1 |
| Vakili Shahrbabaki, S | 1 |
| Rajesh, V | 1 |
| Deepan, N | 1 |
| Anitha, V | 1 |
| Kalaiselvan, D | 1 |
| Jayaseelan, S | 1 |
| Sivakumar, P | 1 |
| Ganesan, V | 1 |
| Scheggi, S | 1 |
| Guzzi, F | 1 |
| Braccagni, G | 1 |
| De Montis, MG | 1 |
| Parenti, M | 1 |
| Gambarana, C | 1 |
| Potasiewicz, A | 2 |
| Gzielo, K | 2 |
| Popik, P | 2 |
| Nikiforuk, A | 2 |
| Wu, M | 2 |
| Di, Y | 3 |
| Diao, Z | 1 |
| Qian, Z | 2 |
| Wei, C | 2 |
| Zheng, Q | 2 |
| Han, J | 1 |
| Fan, J | 2 |
| Tian, Y | 4 |
| Ren, W | 3 |
| Thornton, AM | 2 |
| Kerr, DM | 2 |
| Mehta, U | 1 |
| Smith, M | 1 |
| Kalk, E | 1 |
| Hayes, H | 1 |
| Swart, A | 1 |
| Tucker, L | 1 |
| Coetzee, R | 1 |
| Boulle, A | 1 |
| Blockman, M | 1 |
| Morales-Navas, M | 1 |
| Castaño-Castaño, S | 1 |
| Pérez-Fernández, C | 1 |
| Sánchez-Gil, A | 1 |
| Teresa Colomina, M | 1 |
| Leinekugel, X | 1 |
| A-G, N | 1 |
| Am, EB | 1 |
| Eh, R | 1 |
| Ahmed, RG | 1 |
| Hołuj, M | 1 |
| Litwa, E | 1 |
| Quílez, A | 1 |
| Baraldés-Rovira, M | 1 |
| Gallego, Y | 1 |
| Sanahuja, J | 1 |
| Mauri-Capdevila, G | 1 |
| Purroy, F | 1 |
| Robson, J | 1 |
| Moss, N | 1 |
| McGettigan, P | 1 |
| Beardsley, SJ | 1 |
| Lovegrove, E | 1 |
| Dezateux, C | 1 |
| McKinnell, ZE | 2 |
| Maze, T | 1 |
| Ramos, A | 1 |
| Challans, B | 1 |
| Plakke, B | 2 |
| Zureik, M | 1 |
| Dos Santos, ALG | 2 |
| de Leão, ERLP | 2 |
| de Almeida Miranda, D | 1 |
| de Souza, DNC | 2 |
| Picanço Diniz, CW | 1 |
| Diniz, DG | 2 |
| Shlaen, M | 1 |
| Coste, F | 1 |
| de Voogd, H | 2 |
| Dimos, V | 2 |
| Wiggs, KK | 1 |
| Rickert, ME | 1 |
| Sujan, AC | 1 |
| Quinn, PD | 1 |
| Larsson, H | 1 |
| Lichtenstein, P | 1 |
| Oberg, AS | 1 |
| D'Onofrio, BM | 1 |
| de Moura, LVB | 1 |
| da Silveira Júnior, AM | 1 |
| Diniz, CWP | 1 |
| Sosthenes, MCK | 1 |
| Tiboni, GM | 4 |
| Ponzano, A | 3 |
| Ferrone, A | 1 |
| Franceschelli, S | 1 |
| Speranza, L | 1 |
| Patruno, A | 1 |
| Wang, K | 1 |
| Li, N | 1 |
| Xu, M | 1 |
| Huang, M | 1 |
| Huang, F | 2 |
| Daugaard, CA | 2 |
| Pedersen, L | 2 |
| Isabelle, B | 1 |
| Tcherny-Lessenot, S | 1 |
| Hassan, GA | 1 |
| Ibrahim, EA | 1 |
| Ahmed, AI | 1 |
| Yang, JQ | 1 |
| Yang, CH | 1 |
| Pizzamiglio, L | 1 |
| Focchi, E | 1 |
| Cambria, C | 1 |
| Ponzoni, L | 1 |
| Ferrara, S | 1 |
| Bifari, F | 1 |
| Desiato, G | 1 |
| Landsberger, N | 1 |
| Murru, L | 1 |
| Passafaro, M | 1 |
| Sala, M | 1 |
| Matteoli, M | 1 |
| Menna, E | 1 |
| Antonucci, F | 1 |
| Markoula, S | 1 |
| Siarava, E | 1 |
| Kostoulas, C | 1 |
| Zikopoulos, A | 1 |
| Georgiou, I | 1 |
| Ranzato, F | 1 |
| Giuliano, L | 1 |
| Durante, V | 1 |
| Ermio, C | 1 |
| Monti, G | 1 |
| Zambrelli, E | 2 |
| Lodi, MAM | 1 |
| Galimberti, CA | 1 |
| Takeda, K | 1 |
| Watanabe, T | 1 |
| Oyabu, K | 1 |
| Tsukamoto, S | 1 |
| Oba, Y | 1 |
| Nakano, T | 1 |
| Kubota, K | 1 |
| Katsurabayashi, S | 1 |
| Iwasaki, K | 1 |
| Wu, J | 1 |
| Dai, YC | 1 |
| Lan, XY | 1 |
| Zhang, HF | 1 |
| Bai, SZ | 1 |
| Hu, Y | 3 |
| Han, SP | 1 |
| Han, JS | 1 |
| Zhang, R | 2 |
| Huybrechts, KF | 1 |
| Kulldorff, M | 1 |
| Hernández-Díaz, S | 1 |
| Bateman, BT | 1 |
| Zhu, Y | 1 |
| Mogun, H | 1 |
| Wang, SV | 1 |
| Spoendlin, J | 2 |
| Blozik, E | 2 |
| Graber, S | 2 |
| Rauch, M | 2 |
| Marxer, C | 2 |
| Rüegg, S | 2 |
| Meier, C | 2 |
| Winterfeld, U | 2 |
| Panchaud, A | 2 |
| Doğan, A | 1 |
| Baykan, A | 1 |
| Vural, C | 1 |
| Honybun, E | 1 |
| Thwaites, R | 1 |
| Malpas, CB | 1 |
| Rayner, G | 1 |
| Anderson, A | 1 |
| Li, Z | 2 |
| You, M | 1 |
| Che, X | 1 |
| Dai, Y | 2 |
| Xu, Y | 1 |
| Kaplan, YC | 1 |
| Demir, O | 1 |
| von Mandach, U | 1 |
| Hösli, I | 1 |
| Traetta, ME | 2 |
| Codagnone, MG | 3 |
| Uccelli, NA | 3 |
| Ramos, AJ | 1 |
| Zárate, S | 1 |
| Reinés, A | 2 |
| Lapehn, S | 1 |
| Harris, C | 2 |
| Puig-Lagunes, ÁA | 1 |
| Rocha, L | 1 |
| Morgado-Valle, C | 1 |
| BeltrÁn-Parrazal, L | 1 |
| LÓpez-Meraz, ML | 1 |
| Taleb, A | 1 |
| Lin, W | 1 |
| Xu, X | 1 |
| Zhang, G | 1 |
| Zhou, QG | 1 |
| Naveed, M | 1 |
| Meng, F | 1 |
| Han, F | 2 |
| Seshachala, BB | 1 |
| Lathikakumari, AM | 1 |
| Murali, S | 1 |
| Kumar, AS | 1 |
| Kakumoto, M | 1 |
| Shimokawa, K | 1 |
| Ueshima, S | 1 |
| Hira, D | 1 |
| Okano, T | 1 |
| Kolasa-Wołosiuk, A | 1 |
| Friedland, K | 1 |
| Yang, Z | 1 |
| Fang, S | 1 |
| Guo, J | 1 |
| Gou, L | 1 |
| Tetro, N | 3 |
| Moushaev, S | 1 |
| Shmuel, M | 4 |
| Eyal, S | 6 |
| Payne, M | 1 |
| Mali, I | 1 |
| Vangsness, L | 1 |
| Shrestha, TB | 1 |
| Bossmann, SH | 1 |
| Cheng, Q | 1 |
| Zhai, C | 1 |
| Lan, J | 2 |
| Manjeese, W | 1 |
| Mvubu, NE | 1 |
| Steyn, AJC | 1 |
| Mpofana, T | 1 |
| Horie, J | 1 |
| Wang, S | 3 |
| Liu, H | 1 |
| Cheng, B | 1 |
| Li, L | 1 |
| Hou, N | 1 |
| Khodaverdi, M | 1 |
| Tavassoli, Z | 1 |
| Ghasemi, Z | 1 |
| Amini, AE | 1 |
| Hamed, R | 1 |
| Berman, E | 1 |
| Mizutani, R | 1 |
| Minami, K | 1 |
| Furuhara, K | 1 |
| Pinyue, F | 1 |
| Jing, Z | 1 |
| Wang, W | 2 |
| Tang, J | 1 |
| Zhong, M | 1 |
| Hughes, JE | 1 |
| Buckley, N | 1 |
| Looney, Y | 1 |
| Kirwan, G | 1 |
| Curran, S | 1 |
| Doherty, CP | 2 |
| Mullooly, M | 1 |
| Bennett, KE | 1 |
| Levanovich, N | 1 |
| Rosato Siri, MV | 1 |
| Urrutia, L | 2 |
| Falasco, G | 2 |
| Vázquez, S | 1 |
| Pasquini, JM | 1 |
| Reinés, AG | 1 |
| Ajinkya, S | 1 |
| Fox, J | 1 |
| Lekoubou, A | 1 |
| Shin, KO | 1 |
| Crumrine, DA | 1 |
| Lee, Y | 1 |
| Kim, B | 1 |
| Abuabara, K | 1 |
| Park, C | 1 |
| Uchida, Y | 1 |
| Wakefield, JS | 1 |
| Meyer, JM | 1 |
| Jeong, S | 1 |
| Park, BD | 1 |
| Park, K | 2 |
| Elias, PM | 1 |
| Zheng, W | 2 |
| Liao, A | 1 |
| Li, Y | 4 |
| Yang, F | 1 |
| Chen, D | 2 |
| Humphrey, RM | 1 |
| Paz, AVC | 1 |
| Gama, CS | 1 |
| Sharma, S | 2 |
| Bansal, S | 1 |
| Clavenna, A | 2 |
| Campi, R | 2 |
| Putignano, D | 2 |
| Fortino, I | 2 |
| Bonati, M | 3 |
| Zucker, I | 1 |
| Du, L | 1 |
| Zhao, G | 2 |
| Duan, Z | 1 |
| Gobshtis, N | 1 |
| Tfilin, M | 1 |
| Wolfson, M | 1 |
| Fraifeld, VE | 1 |
| Turgeman, G | 1 |
| Olde Loohuis, NFM | 1 |
| Martens, GJM | 1 |
| van Bokhoven, H | 1 |
| Kaplan, BB | 1 |
| Homberg, JR | 1 |
| Aschrafi, A | 1 |
| Bath, KG | 1 |
| Pimentel, T | 1 |
| Pariente, G | 1 |
| Leibson, T | 1 |
| Shulman, T | 1 |
| Adams-Webber, T | 1 |
| Barzilay, E | 1 |
| Nulman, I | 2 |
| Nicolini, C | 2 |
| Fahnestock, M | 2 |
| Al-Askar, M | 1 |
| Bhat, RS | 1 |
| Selim, M | 1 |
| Al-Ayadhi, L | 1 |
| El-Ansary, A | 1 |
| Gooneratne, IK | 1 |
| Wimalaratna, M | 1 |
| Ranaweera, AKP | 1 |
| Wimalaratna, S | 1 |
| Bertelsen, F | 2 |
| Folloni, D | 2 |
| Møller, A | 3 |
| Landau, AM | 2 |
| Scheel-Krüger, J | 3 |
| Winterdahl, M | 1 |
| Acosta, J | 1 |
| Campolongo, MA | 1 |
| Höcht, C | 2 |
| Golombek, DA | 1 |
| Agostino, PV | 1 |
| Stadelmaier, R | 1 |
| Nasri, H | 1 |
| Deutsch, CK | 1 |
| Bauman, M | 1 |
| Hunt, A | 1 |
| Stodgell, CJ | 1 |
| Adams, J | 1 |
| Holmes, LB | 6 |
| Zhou, Y | 1 |
| Peng, L | 1 |
| Yamaguchi, H | 1 |
| Takano, E | 4 |
| Nakazawa, T | 4 |
| Matsuda, T | 9 |
| Kuo, HY | 1 |
| Liu, FC | 1 |
| Casassus, B | 2 |
| Gotlib, D | 2 |
| Ramaswamy, R | 1 |
| Kurlander, JE | 1 |
| DeRiggi, A | 1 |
| Riba, M | 3 |
| Veroniki, AA | 1 |
| Rios, P | 1 |
| Cogo, E | 1 |
| Straus, SE | 1 |
| Finkelstein, Y | 1 |
| Kealey, R | 1 |
| Reynen, E | 1 |
| Soobiah, C | 1 |
| Thavorn, K | 1 |
| Hutton, B | 1 |
| Hemmelgarn, BR | 1 |
| Yazdi, F | 1 |
| D'Souza, J | 1 |
| MacDonald, H | 1 |
| Tricco, AC | 1 |
| Barrett, CE | 1 |
| Hennessey, TM | 1 |
| Gordon, KM | 1 |
| Ryan, SJ | 1 |
| McNair, ML | 1 |
| Ressler, KJ | 1 |
| Rainnie, DG | 1 |
| Taruta, A | 4 |
| Kawase, H | 2 |
| Tanabe, W | 1 |
| Tsukada, S | 2 |
| Dai, X | 2 |
| Yin, Y | 1 |
| Qin, L | 2 |
| Mahmood, U | 3 |
| Ahn, S | 2 |
| Choi, M | 1 |
| Regan, P | 1 |
| Cho, K | 1 |
| Kumaresan, UD | 1 |
| Kutty, BM | 1 |
| Wise, J | 1 |
| Higuchi, M | 2 |
| Womersley, K | 1 |
| Shona, SI | 1 |
| Rizk, AA | 1 |
| El Sadik, AO | 1 |
| Emam, HY | 1 |
| Ali, EN | 1 |
| Wiedemann, K | 1 |
| Stüber, T | 1 |
| Rehn, M | 1 |
| Frieauff, E | 1 |
| Brumback, AC | 1 |
| Ellwood, IT | 1 |
| Kjaerby, C | 1 |
| Iafrati, J | 1 |
| Robinson, S | 1 |
| Lee, AT | 1 |
| Patel, T | 1 |
| Nagaraj, S | 1 |
| Davatolhagh, F | 1 |
| Sohal, VS | 1 |
| Servadio, M | 3 |
| Manduca, A | 1 |
| Melancia, F | 2 |
| Leboffe, L | 1 |
| Campolongo, P | 2 |
| Palmery, M | 2 |
| Ascenzi, P | 1 |
| di Masi, A | 1 |
| Patel, N | 1 |
| Viguera, AC | 1 |
| Baldessarini, RJ | 1 |
| Kirihata, Y | 1 |
| Ban, Y | 1 |
| Nakamori, C | 1 |
| Takagi, H | 1 |
| Hashimoto, T | 1 |
| Tsutsumi, S | 1 |
| Graham, RK | 1 |
| Tavella, G | 1 |
| Parker, GB | 1 |
| Fueta, Y | 1 |
| Sekino, Y | 2 |
| Yoshida, S | 1 |
| Ueno, S | 1 |
| Cartocci, V | 3 |
| Catallo, M | 1 |
| Tempestilli, M | 1 |
| Segatto, M | 1 |
| Pfrieger, FW | 1 |
| Bronzuoli, MR | 1 |
| Scuderi, C | 1 |
| Pallottini, V | 3 |
| Mohd Yunos, H | 1 |
| Green, A | 1 |
| Friedrich, L | 1 |
| Sruk, A | 1 |
| Bielen, I | 1 |
| Zhou, J | 1 |
| Ren, J | 1 |
| Wang, H | 2 |
| An, X | 1 |
| Zhang, J | 2 |
| Shi, M | 1 |
| Qiao, Y | 1 |
| Johannessen Landmark, C | 1 |
| Farmen, AH | 1 |
| Burns, ML | 1 |
| Baftiu, A | 2 |
| Lossius, MI | 1 |
| Johannessen, SI | 2 |
| Pennell, PB | 8 |
| Elkjær, LS | 1 |
| Bech, BH | 2 |
| Laursen, TM | 1 |
| Cezar, LC | 1 |
| Kirsten, TB | 1 |
| da Fonseca, CCN | 1 |
| de Lima, APN | 1 |
| Bernardi, MM | 1 |
| Felicio, LF | 1 |
| Patel, R | 1 |
| Pasos, J | 1 |
| Della-Flora Nunes, G | 3 |
| Nunes, W | 1 |
| Margis, R | 1 |
| Li, K | 1 |
| Gu, J | 1 |
| Gao, T | 1 |
| Li, D | 2 |
| Sgadò, P | 1 |
| Rosa-Salva, O | 1 |
| Versace, E | 1 |
| Vallortigara, G | 1 |
| Paton, C | 1 |
| Cookson, J | 1 |
| Ferrier, IN | 1 |
| Bhatti, S | 1 |
| Fagan, E | 1 |
| Barnes, TRE | 1 |
| Rubinchik-Stern, M | 1 |
| Bar, J | 1 |
| Kovo, M | 1 |
| Liu, RSN | 1 |
| Wieck, A | 2 |
| Jones, S | 1 |
| Craig, J | 9 |
| Sabers, A | 9 |
| Garne, E | 2 |
| Addor, MC | 1 |
| Barisic, I | 2 |
| Bianchi, F | 1 |
| Gatt, M | 1 |
| Lanzoni, M | 1 |
| Lynch, C | 1 |
| Mokoroa, O | 1 |
| Nelen, V | 1 |
| O'Mahony, MT | 1 |
| Randrianaivo-Ranjatoelina, H | 1 |
| Rissmann, A | 1 |
| Tucker, D | 1 |
| de Walle, HEK | 1 |
| Zymak-Zakutnia, N | 1 |
| Rankin, J | 1 |
| Al Sagheer, T | 1 |
| Haida, O | 1 |
| Francheteau, M | 1 |
| Fernagut, PO | 1 |
| Kerr, MP | 1 |
| Macfarlane, A | 1 |
| Greenhalgh, T | 1 |
| Koren, G | 5 |
| Yanai, J | 1 |
| Galappatthy, P | 1 |
| Liyanage, CK | 1 |
| Lucas, MN | 1 |
| Jayasekara, DTLM | 1 |
| Abhayaratna, SA | 1 |
| Weeraratne, C | 1 |
| De Abrew, K | 1 |
| Gunaratne, PS | 1 |
| Gamage, R | 1 |
| Wijeyaratne, CN | 1 |
| Kim, JW | 5 |
| Kang, RJ | 1 |
| Gonzales, ELT | 1 |
| Kim, DG | 1 |
| Oh, HA | 2 |
| Seung, H | 2 |
| Ko, MJ | 2 |
| Kwon, KJ | 5 |
| Kim, KC | 10 |
| Lee, SH | 2 |
| Chung, C | 1 |
| Kälviäinen, R | 4 |
| Straus, S | 1 |
| Dogne, JM | 1 |
| Bakchine, S | 1 |
| Haas, M | 1 |
| Salgueiro, N | 1 |
| Khalaj, R | 1 |
| Zare, M | 1 |
| Barton, S | 1 |
| Nadebaum, C | 1 |
| Anderson, VA | 1 |
| Reutens, DC | 2 |
| Wood, AG | 1 |
| Baronio, D | 3 |
| Castro, K | 3 |
| Mendes-da-Cruz, DA | 1 |
| Savino, W | 1 |
| Duan, HY | 1 |
| Zhou, KY | 1 |
| Wang, T | 1 |
| Li, YF | 1 |
| Hua, YM | 1 |
| Wang, C | 1 |
| Sen, A | 1 |
| Nashef, L | 1 |
| Sher, J | 1 |
| Frank, JW | 1 |
| Doi, L | 1 |
| de Caestecker, L | 1 |
| Rahimi, R | 1 |
| Akhavan, MM | 1 |
| Kamyab, K | 1 |
| Ebrahimi, SA | 1 |
| Foch, C | 1 |
| Araujo, M | 1 |
| Weckel, A | 1 |
| Montastruc, JL | 1 |
| Benevent, J | 1 |
| Durrieu, G | 1 |
| Lacroix, I | 1 |
| Tartaglione, AM | 2 |
| Cipriani, C | 1 |
| Chiarotti, F | 1 |
| Perrone, B | 1 |
| Balestrieri, E | 1 |
| Matteucci, C | 1 |
| Sinibaldi-Vallebona, P | 1 |
| Calamandrei, G | 2 |
| Ricceri, L | 1 |
| Lin, YL | 1 |
| Bialer, M | 10 |
| Cabrera, RM | 3 |
| Finnell, RH | 16 |
| Wlodarczyk, BJ | 2 |
| Tonini, C | 1 |
| Di Pippo, T | 1 |
| Vuono, F | 1 |
| Marino, M | 1 |
| Heneghan, C | 1 |
| Aronson, JK | 1 |
| Win-Shwe, TT | 1 |
| Nway, NC | 1 |
| Imai, M | 1 |
| Lwin, TT | 1 |
| Mar, O | 1 |
| Watanabe, H | 3 |
| Naito, M | 1 |
| Mishina, T | 1 |
| Kouji, H | 1 |
| Mangold, S | 1 |
| Chosky, D | 1 |
| Canevini, MP | 4 |
| Vignoli, A | 2 |
| Beghi, E | 1 |
| Bortolotti, A | 2 |
| Merlino, L | 1 |
| Kotajima-Murakami, H | 1 |
| Kobayashi, T | 2 |
| Kashii, H | 1 |
| Sato, A | 1 |
| Hagino, Y | 1 |
| Tanaka, M | 1 |
| Nishito, Y | 1 |
| Takamatsu, Y | 1 |
| Uchino, S | 1 |
| Ikeda, K | 2 |
| Brikell, I | 1 |
| Dalsgaard, S | 1 |
| Cohen, MJ | 2 |
| May, R | 1 |
| Loblein, H | 1 |
| Conrad, T | 1 |
| Baker, GA | 12 |
| Kalayjian, LA | 5 |
| Kanner, A | 3 |
| Liporace, JD | 4 |
| Privitera, M | 3 |
| Loring, DW | 7 |
| Souza-Nunes, W | 1 |
| Green, L | 1 |
| Cloarec, R | 1 |
| Riffault, B | 1 |
| Rabiei, H | 1 |
| Guimond, D | 1 |
| Bonifazi, P | 1 |
| Lozovaya, N | 2 |
| Olsen, DB | 1 |
| Perera, C | 1 |
| Patterson, S | 1 |
| Bruxner, G | 1 |
| Mirza, R | 2 |
| Sailer, L | 1 |
| Duclot, F | 1 |
| Wang, Z | 4 |
| Kabbaj, M | 1 |
| Jiang, X | 1 |
| Niu, J | 1 |
| Cui, C | 1 |
| Chen, Z | 1 |
| Sun, J | 1 |
| Turner, K | 1 |
| Cutica, I | 1 |
| Riva, S | 1 |
| Pravettoni, G | 1 |
| Richards, N | 1 |
| Reith, D | 1 |
| Stitely, M | 1 |
| Watkins, LV | 1 |
| Cock, HR | 1 |
| Bossu, JL | 1 |
| Bjørnvold, M | 1 |
| Molteberg, E | 1 |
| Lossius, M | 1 |
| Landmark, CJ | 1 |
| Imbar, T | 1 |
| Wohl, D | 1 |
| Eisenberg, I | 1 |
| Yagel, S | 1 |
| Guimarães-Souza, EM | 1 |
| Joselevitch, C | 1 |
| Britto, LRG | 1 |
| Chiavegatto, S | 1 |
| Morgan, S | 1 |
| Raine, J | 1 |
| Hudson, I | 1 |
| Kacirova, I | 3 |
| Grundmann, M | 3 |
| Brozmanova, H | 3 |
| Xiang, Z | 1 |
| Jia, Y | 1 |
| He, X | 1 |
| Gürer, R | 1 |
| Aydın, Ş | 1 |
| Słowik, A | 1 |
| Turaj, W | 1 |
| Bromley, R | 4 |
| Journel, H | 1 |
| Odent, S | 1 |
| Wood, A | 2 |
| Williams, J | 1 |
| Cuthbert, V | 1 |
| Hackett, L | 1 |
| Aslam, N | 1 |
| Malm, H | 2 |
| James, G | 1 |
| Westbom, L | 1 |
| Day, R | 1 |
| Ladusans, E | 1 |
| Bruce, I | 1 |
| Walker, R | 1 |
| Sidhu, S | 1 |
| Dyer, C | 1 |
| Ashworth, J | 1 |
| Hindley, D | 1 |
| Diaz, GA | 1 |
| Rawson, M | 1 |
| Turnpenny, P | 2 |
| Hesemann, J | 1 |
| Lauer, E | 1 |
| Ziska, S | 1 |
| Noonan, K | 1 |
| Nemeth, B | 1 |
| Scott-Schwoerer, J | 1 |
| McCarty, C | 1 |
| Rasmussen, K | 1 |
| Goldberg, JM | 1 |
| Sund, S | 1 |
| Eickhoff, J | 1 |
| Raggio, CL | 1 |
| Giampietro, PF | 1 |
| Vajda, FJ | 16 |
| Wilson, KL | 1 |
| Alexander, JM | 1 |
| Lazic, SE | 1 |
| Essioux, L | 1 |
| Carvajal-Flores, FN | 1 |
| López-Ramírez, TA | 1 |
| Atzori, M | 2 |
| Grønborg, TK | 1 |
| Sørensen, MJ | 1 |
| Schendel, D | 1 |
| Parner, ET | 1 |
| Pedersen, LH | 1 |
| Vestergaard, M | 2 |
| Oguchi-Katayama, A | 1 |
| Monma, A | 1 |
| Moriguchi, T | 1 |
| Sato, K | 1 |
| Miller, MW | 1 |
| Church, CC | 1 |
| Selim, ME | 1 |
| Al-Ayadhi, LY | 1 |
| Kmietowicz, Z | 2 |
| Rihtman, T | 1 |
| Parush, S | 1 |
| Edalatmanesh, MA | 1 |
| Nikfarjam, H | 1 |
| Vafaee, F | 1 |
| Moghadas, M | 1 |
| Malyshev, AV | 1 |
| Razumkina, EV | 1 |
| Dubynin, VA | 1 |
| Myasoedov, NF | 1 |
| Wang, CC | 3 |
| Chan, YH | 1 |
| Gean, PW | 2 |
| Yang, YK | 1 |
| Giavini, E | 8 |
| Lee, DK | 1 |
| Go, HS | 5 |
| Kim, P | 5 |
| Choi, CS | 7 |
| Song, MR | 1 |
| Ali, EH | 2 |
| Elgoly, AH | 2 |
| Onishi, Y | 3 |
| Okada, A | 6 |
| Noyori, H | 2 |
| Okamura, A | 1 |
| Hen, N | 1 |
| Yagen, B | 7 |
| Fujiwara, M | 6 |
| Cohen, OS | 1 |
| Varlinskaya, EI | 2 |
| Wilson, CA | 1 |
| Glatt, SJ | 1 |
| Mooney, SM | 2 |
| Denny, KJ | 1 |
| Jeanes, A | 1 |
| Fathe, K | 2 |
| Taylor, SM | 1 |
| Woodruff, TM | 1 |
| Moldrich, RX | 1 |
| Leanage, G | 1 |
| She, D | 1 |
| Dolan-Evans, E | 1 |
| Nelson, M | 1 |
| Reza, N | 1 |
| Lucchina, L | 2 |
| Begum, S | 1 |
| Sarma, SP | 1 |
| Abe, K | 1 |
| Hamada, H | 1 |
| Yamada, T | 1 |
| Obata-Yasuoka, M | 1 |
| Minakami, H | 1 |
| Yoshikawa, H | 1 |
| Zhang, XJ | 1 |
| Le, W | 1 |
| de Theije, CG | 1 |
| Koelink, PJ | 1 |
| Korte-Bouws, GA | 1 |
| Lopes da Silva, S | 1 |
| Korte, SM | 1 |
| Olivier, B | 1 |
| Garssen, J | 1 |
| Kraneveld, AD | 1 |
| Kang, JW | 1 |
| Lin, T | 1 |
| Lee, JE | 1 |
| Jin, DI | 1 |
| Klein, P | 2 |
| Mathews, GC | 1 |
| Shallcross, R | 5 |
| Cheyne, CP | 3 |
| García-Fiñana, M | 4 |
| Irwin, B | 7 |
| Morrow, J | 8 |
| Campbell, E | 1 |
| Kennedy, F | 1 |
| Russell, A | 3 |
| Smithson, WH | 2 |
| Parsons, L | 3 |
| Morrison, PJ | 2 |
| Liggan, B | 3 |
| Delanty, N | 3 |
| Hunt, SJ | 2 |
| Veiby, G | 2 |
| Engelsen, BA | 2 |
| Nakken, KO | 1 |
| Almeida, LE | 1 |
| Roby, CD | 1 |
| Krueger, BK | 1 |
| Foley, AG | 1 |
| Cassidy, AW | 1 |
| Regan, CM | 1 |
| Kulza, M | 1 |
| Miller, R | 1 |
| Wozniak, A | 1 |
| Napierała, M | 1 |
| Wachowiak, A | 1 |
| Hassan-Bartz, M | 1 |
| Krzyścin, M | 1 |
| Chuchracki, M | 1 |
| Breborowicz, GH | 1 |
| Florek, E | 1 |
| Tyzio, R | 1 |
| Nardou, R | 1 |
| Tsintsadze, T | 1 |
| Shahrokhi, A | 1 |
| Khalilov, I | 1 |
| Tsintsadze, V | 1 |
| Brouchoud, C | 1 |
| Chazal, G | 1 |
| Lemonnier, E | 1 |
| Burnashev, N | 1 |
| Deligiannidis, KM | 1 |
| Byatt, N | 1 |
| Freeman, MP | 1 |
| Gentile, S | 1 |
| Chomiak, T | 1 |
| Hung, J | 1 |
| Cihal, A | 1 |
| Dhaliwal, J | 1 |
| Baghdadwala, MI | 1 |
| Dzwonek, A | 1 |
| Podgorny, P | 1 |
| Hu, B | 1 |
| Smith, V | 1 |
| Brown, N | 1 |
| Verrotti, A | 2 |
| Scaparrotta, A | 1 |
| Cofini, M | 1 |
| Chiarelli, F | 2 |
| Lamparter, C | 1 |
| Baxter, P | 1 |
| Ahn, Y | 2 |
| Narous, M | 1 |
| Tobias, R | 1 |
| Rho, JM | 2 |
| Mychasiuk, R | 2 |
| Palacios, A | 1 |
| Bertelsen, FC | 1 |
| Nyengaard, JR | 1 |
| Wellmann, KA | 1 |
| Lee, EJ | 1 |
| You, JS | 1 |
| Choi, DH | 1 |
| Han, SH | 8 |
| Yang, SM | 2 |
| Cheong, JH | 7 |
| Bahn, GH | 2 |
| Cusmano, DM | 1 |
| Mong, JA | 1 |
| Van Houtte, E | 1 |
| Casselman, J | 1 |
| Janssens, S | 1 |
| De Kegel, A | 1 |
| Maes, L | 1 |
| Dhooge, I | 1 |
| Kataoka, S | 3 |
| Kawanai, T | 2 |
| Maeda, Y | 3 |
| Watanabe, R | 2 |
| Hayata-Takano, A | 1 |
| Zanatta, G | 1 |
| Della Flora Nunes, G | 1 |
| Mueller de Melo, G | 1 |
| Michels, M | 1 |
| Nogueira Freire, V | 1 |
| Weston, J | 1 |
| Adab, N | 4 |
| Greenhalgh, J | 1 |
| Sanniti, A | 1 |
| McKay, AJ | 1 |
| Tudur Smith, C | 1 |
| Marson, AG | 1 |
| Yang, C | 1 |
| Yuan, G | 1 |
| Li, R | 2 |
| Ryu, JH | 4 |
| Hegazy, HG | 1 |
| Briggs, M | 3 |
| Gummery, A | 1 |
| Kneen, R | 2 |
| Mawer, G | 6 |
| Sargar, KM | 1 |
| Herman, TE | 1 |
| Siegel, MJ | 1 |
| Raza, S | 2 |
| Harker, A | 2 |
| Richards, S | 2 |
| Kolb, B | 3 |
| Gibb, R | 3 |
| Gonchoroski, T | 1 |
| de Melo, GM | 1 |
| Jellett, AP | 1 |
| Jenks, K | 1 |
| Lucas, M | 1 |
| Scott, RC | 1 |
| Michalski, B | 1 |
| Štefánik, P | 1 |
| Olexová, L | 1 |
| Kršková, L | 1 |
| Al-Amin, MM | 1 |
| Rahman, MM | 1 |
| Khan, FR | 1 |
| Zaman, F | 1 |
| Mahmud Reza, H | 1 |
| Grzyb, E | 1 |
| Kwiecińska, P | 1 |
| Gregoraszczuk, EL | 1 |
| Marson, A | 1 |
| Boon, P | 1 |
| Covanis, A | 2 |
| Gaily, E | 3 |
| Trinka, E | 2 |
| Podestá, MF | 1 |
| Katashiba, K | 2 |
| Higashino, K | 1 |
| Gao, J | 2 |
| Liang, S | 3 |
| Sun, C | 2 |
| Xia, W | 1 |
| Hao, Y | 1 |
| Li, X | 1 |
| Cao, Y | 2 |
| Wu, L | 2 |
| Cheaha, D | 2 |
| Bumrungsri, S | 1 |
| Chatpun, S | 1 |
| Kumarnsit, E | 2 |
| Tanoshima, M | 1 |
| Tanoshima, R | 1 |
| Beyene, J | 1 |
| Ito, S | 1 |
| Van McCrary, S | 1 |
| Lee, PC | 1 |
| Wildt, DE | 1 |
| Comizzoli, P | 1 |
| Yasue, M | 1 |
| Nakagami, A | 1 |
| Banno, T | 1 |
| Nakagaki, K | 1 |
| Ichinohe, N | 1 |
| Kawai, N | 1 |
| Himmler, BT | 1 |
| Himmler, SM | 1 |
| Pellis, SM | 1 |
| Vlasov, PN | 2 |
| Homberg, V | 1 |
| Ueda, C | 1 |
| Yamada, K | 1 |
| Nakamura, A | 1 |
| Hatsuda, Y | 1 |
| Kawanishi, S | 1 |
| Nishii, S | 1 |
| Ogawa, M | 1 |
| Kumar, P | 1 |
| Mohan, V | 1 |
| Sinha, RA | 1 |
| Chagtoo, M | 1 |
| Godbole, MM | 1 |
| Janszky, J | 1 |
| Kumar, H | 3 |
| Sharma, BM | 1 |
| Dubiel, A | 2 |
| Nuttall, JR | 1 |
| Wang, CY | 1 |
| Cheng, CW | 1 |
| Wang, WH | 1 |
| Tzeng, SF | 1 |
| Juliandi, B | 1 |
| Tanemura, K | 1 |
| Igarashi, K | 1 |
| Furukawa, Y | 1 |
| Otsuka, M | 1 |
| Moriyama, N | 1 |
| Ikegami, D | 1 |
| Abematsu, M | 1 |
| Sanosaka, T | 1 |
| Tsujimura, K | 1 |
| Narita, M | 5 |
| Kanno, J | 1 |
| Nakashima, K | 1 |
| Onaka, Y | 2 |
| Lavi-Blau, T | 1 |
| Ekstein, D | 1 |
| Neufeld, MY | 1 |
| Khan, SJ | 1 |
| Fersh, ME | 1 |
| Ernst, C | 1 |
| Klipstein, K | 1 |
| Albertini, ES | 1 |
| Lusskin, SI | 1 |
| Perry, IS | 1 |
| Riesgo, RDS | 1 |
| Murphy, S | 1 |
| Bennett, K | 1 |
| Banerjee, A | 2 |
| Luong, JA | 1 |
| Ho, A | 1 |
| Saib, AO | 1 |
| Ploski, JE | 1 |
| da Rosa, EB | 1 |
| Silveira, DB | 1 |
| Tsugami, LG | 1 |
| Bellé, NL | 1 |
| Matos, IO | 1 |
| Targa, LV | 1 |
| Betat, Rda S | 1 |
| da Cunha, AC | 1 |
| Villacis, RA | 1 |
| Rogatto, SR | 1 |
| Dorfman, LE | 1 |
| Rosa, RF | 1 |
| Zen, PR | 1 |
| Genton, P | 3 |
| Solignac, I | 1 |
| Arman, D | 1 |
| Sancak, S | 1 |
| Topcuoglu, S | 1 |
| Karatekin, G | 1 |
| Petersen, I | 1 |
| McCrea, RL | 1 |
| Sammon, CJ | 1 |
| Osborn, DP | 1 |
| Evans, SJ | 1 |
| Cowen, PJ | 1 |
| Freemantle, N | 1 |
| Nazareth, I | 1 |
| Morakotsriwan, N | 1 |
| Wattanathorn, J | 1 |
| Kirisattayakul, W | 1 |
| Chaisiwamongkol, K | 1 |
| Vanya, M | 1 |
| Devosa, I | 1 |
| Szok, D | 1 |
| Bártfai, G | 1 |
| Lee, K | 1 |
| Nissen, M | 1 |
| Buehler, SM | 1 |
| Stubbe, M | 1 |
| Gimsa, J | 1 |
| Balon, R | 1 |
| Perelstein, E | 1 |
| Kurlander, J | 1 |
| Zivin, K | 1 |
| Muzik, M | 1 |
| Meir, M | 1 |
| Bishara, A | 1 |
| Mann, A | 1 |
| Udi, S | 1 |
| Portnoy, E | 1 |
| Podgorac, J | 1 |
| Pešić, V | 1 |
| Pavković, Ž | 1 |
| Martać, L | 1 |
| Kanazir, S | 1 |
| Filipović, L | 1 |
| Sekulić, S | 1 |
| Krahe, TE | 1 |
| Filgueiras, CC | 1 |
| Medina, AE | 1 |
| Iijima, Y | 1 |
| Behr, K | 1 |
| Iijima, T | 1 |
| Biemans, B | 1 |
| Bischofberger, J | 1 |
| Scheiffele, P | 1 |
| Inoue, A | 1 |
| Zhang, JX | 1 |
| Zhang, QL | 1 |
| Huang, JY | 1 |
| Wang, HJ | 1 |
| Shen, H | 1 |
| Long, S | 1 |
| Liao, MH | 1 |
| Liu, ZR | 1 |
| Wang, ZM | 1 |
| Tao, RR | 1 |
| Cui, TT | 1 |
| Moriguchi, S | 1 |
| Lu, YM | 1 |
| Mutlu-Albayrak, H | 1 |
| Bulut, C | 1 |
| Çaksen, H | 1 |
| Perez-Pouchoulen, M | 1 |
| Miquel, M | 1 |
| Saft, P | 1 |
| Brug, B | 1 |
| Toledo, R | 1 |
| Hernandez, ME | 1 |
| Manzo, J | 1 |
| Peralta, F | 1 |
| Fuentealba, C | 1 |
| Fiedler, J | 1 |
| Aliaga, E | 1 |
| Wu, H | 1 |
| Wang, P | 1 |
| Sun, H | 1 |
| Wei, R | 1 |
| Li, Q | 1 |
| Lam, S | 1 |
| Leung, J | 1 |
| Cheung, C | 1 |
| Zhang, X | 2 |
| Sham, PC | 1 |
| Chua, SE | 1 |
| McAlonan, GM | 1 |
| Bold, J | 1 |
| Sakata-Haga, H | 1 |
| Fukui, Y | 1 |
| Calderbank, R | 1 |
| Rooney, C | 1 |
| Trayner, P | 1 |
| Morrow, JI | 1 |
| Bouker, KB | 1 |
| Cook, KL | 1 |
| Jin, L | 1 |
| Zwart, A | 1 |
| Nguyen, N | 1 |
| Hu, R | 1 |
| Cruz, MI | 1 |
| de Assis, S | 1 |
| Xuan, J | 1 |
| Wehrenberg, B | 1 |
| Clarke, R | 1 |
| Chau, DK | 1 |
| Choi, AY | 1 |
| Yang, W | 1 |
| Leung, WN | 1 |
| Chan, CW | 1 |
| Ha, S | 1 |
| Park, H | 1 |
| Ra, JC | 1 |
| Suh, YH | 1 |
| Chang, KA | 1 |
| Talwadekar, M | 1 |
| Fernandes, S | 1 |
| Kale, V | 1 |
| Limaye, L | 1 |
| Fujimura, K | 1 |
| Mitsuhashi, T | 1 |
| Shibata, S | 1 |
| Shimozato, S | 1 |
| Takahashi, T | 1 |
| Kikuchi, N | 1 |
| Ohira, S | 1 |
| Asaka, R | 1 |
| Tanaka, K | 1 |
| Takatsu, A | 1 |
| Shiozawa, T | 1 |
| Mabunga, DF | 1 |
| Masson, M | 1 |
| Huberfeld, G | 1 |
| Richa, S | 1 |
| Gaillard, R | 1 |
| Akimova, D | 1 |
| Lin, Y | 1 |
| Ross, ME | 1 |
| Chen, Q | 1 |
| Gross, SS | 1 |
| Hao, N | 1 |
| Yan, B | 1 |
| Zhou, D | 1 |
| Drasbek, KR | 1 |
| Main, SL | 1 |
| Kasradze, S | 1 |
| Gogatishvili, N | 1 |
| Lomidze, G | 1 |
| Ediberidze, T | 1 |
| Lazariashvili, M | 1 |
| Khomeriki, K | 1 |
| Mamukadze, S | 1 |
| Metreveli, M | 1 |
| Gagoshidze, T | 1 |
| Tatishvili, N | 1 |
| Van Twisk, D | 1 |
| Murphy, SP | 1 |
| Thakar, J | 1 |
| Wen, X | 1 |
| Hartzema, A | 1 |
| Delaney, JA | 1 |
| Brumback, B | 1 |
| Egerman, R | 1 |
| Roth, J | 1 |
| Segal, R | 1 |
| Würtz, AM | 1 |
| Rytter, D | 1 |
| Vestergaard, CH | 1 |
| Bromfield, EB | 1 |
| Dworetzky, BA | 1 |
| Wyszynski, DF | 3 |
| Smith, CR | 2 |
| Baldwin, EJ | 1 |
| Brouh, Y | 1 |
| Ndjeundo, PG | 1 |
| Tetchi, YD | 1 |
| Amonkou, AA | 1 |
| Pete, Y | 1 |
| Yapobi, Y | 1 |
| Pearlstein, T | 1 |
| Wu, X | 2 |
| Dallas, S | 1 |
| Wilson, B | 1 |
| Block, ML | 1 |
| Kinyamu, H | 1 |
| Lu, N | 1 |
| Gao, X | 1 |
| Leng, Y | 1 |
| Chuang, DM | 3 |
| Zhang, W | 1 |
| Lu, RB | 2 |
| Hong, JS | 3 |
| Roy, M | 1 |
| Leclerc, D | 1 |
| Gupta, S | 1 |
| Kruger, WD | 1 |
| Rozen, R | 1 |
| Shimshoni, JA | 3 |
| Kaufmann, D | 1 |
| Whitehall, J | 1 |
| Smith, J | 1 |
| Kluger, BM | 1 |
| Domínguez-Fuentes, B | 1 |
| García-Gil, D | 1 |
| Romero-Palacios, A | 1 |
| Sánchez-Crespo, JM | 1 |
| García-Arjona, R | 1 |
| Navarro-Navarro, J | 1 |
| Snow, WM | 1 |
| Hartle, K | 1 |
| Ivanco, TL | 1 |
| Harden, CL | 3 |
| Sethi, NK | 1 |
| Yu, IT | 1 |
| Park, JY | 1 |
| Kim, SH | 1 |
| Lee, JS | 1 |
| Kim, YS | 1 |
| Son, H | 1 |
| Cole, RL | 1 |
| Van Ross, ER | 1 |
| Larsen, K | 1 |
| Blichfeldt, S | 1 |
| Sahlholdt, L | 1 |
| Rasmussen, JO | 1 |
| Seidahmed, MZ | 2 |
| Miqdad, AM | 1 |
| Al-Dohami, HS | 1 |
| Shareefi, OM | 1 |
| Ackers, R | 1 |
| Besag, FM | 1 |
| Wade, A | 1 |
| Murray, ML | 1 |
| Wong, IC | 1 |
| Browning, N | 2 |
| Combs-Cantrell, DT | 2 |
| Cohen, M | 2 |
| Frisch, C | 1 |
| Hüsch, K | 1 |
| Angenstein, F | 1 |
| Kudin, A | 1 |
| Kunz, W | 1 |
| Elger, CE | 1 |
| Helmstaedter, C | 1 |
| Hauser, WA | 2 |
| Gronseth, GS | 2 |
| French, JA | 2 |
| Wiebe, S | 2 |
| Thurman, D | 2 |
| Koppel, BS | 2 |
| Kaplan, PW | 2 |
| Robinson, JN | 2 |
| Hopp, J | 2 |
| Ting, TY | 2 |
| Gidal, B | 2 |
| Hovinga, CA | 2 |
| Wilner, AN | 2 |
| Vazquez, B | 2 |
| Holmes, L | 2 |
| Krumholz, A | 2 |
| Finnell, R | 2 |
| Hirtz, D | 2 |
| Le Guen, C | 2 |
| Kuwagata, M | 2 |
| Ogawa, T | 2 |
| Shioda, S | 2 |
| Nagata, T | 1 |
| Tung, EW | 4 |
| Bozhinov, P | 1 |
| Bozhinova, C | 1 |
| Markova, C | 1 |
| Martínez-Frías, ML | 6 |
| Blanco, O | 1 |
| Leno-Durán, E | 1 |
| Morales, JC | 1 |
| Olivares, EG | 1 |
| Ruiz-Ruiz, C | 1 |
| Kolozsi, E | 1 |
| Mackenzie, RN | 1 |
| Roullet, FI | 2 |
| deCatanzaro, D | 2 |
| Foster, JA | 2 |
| Al-Mendalawi, MD | 1 |
| Liu, YH | 1 |
| Huang, YG | 1 |
| Maccotta, L | 1 |
| Sullivan, JE | 1 |
| Cansu, A | 2 |
| Erdogan, D | 2 |
| Serdaroglu, A | 1 |
| Take, G | 1 |
| Coskun, ZK | 2 |
| Gurgen, SG | 2 |
| Wlodarczyk, B | 3 |
| Schurig, V | 2 |
| Montouris, G | 1 |
| Abou-Khalil, B | 1 |
| Somerville, ER | 1 |
| Cook, MJ | 3 |
| Oyabu, A | 3 |
| Imura, Y | 2 |
| Kamada, N | 1 |
| Yokoyama, T | 1 |
| Tano, K | 1 |
| Uchida, A | 2 |
| Narita, N | 3 |
| Trivedi, A | 1 |
| Halliday, R | 1 |
| Waters, K | 1 |
| Levison, J | 1 |
| Broccia, ML | 5 |
| McVearry, KM | 1 |
| Gaillard, WD | 1 |
| VanMeter, J | 1 |
| Hollingworth, S | 2 |
| Dufour-Rainfray, D | 1 |
| Vourc'h, P | 1 |
| Le Guisquet, AM | 1 |
| Garreau, L | 1 |
| Ternant, D | 1 |
| Bodard, S | 1 |
| Jaumain, E | 1 |
| Gulhan, Z | 1 |
| Andres, CR | 1 |
| Guilloteau, D | 1 |
| Yochum, CL | 1 |
| Bhattacharya, P | 1 |
| Patti, L | 1 |
| Mirochnitchenko, O | 1 |
| Dennig, D | 1 |
| Rating, D | 7 |
| Steinhoff, BJ | 1 |
| Mayer, T | 1 |
| Kini, U | 5 |
| Hurst, JA | 1 |
| Byren, JC | 1 |
| Wall, SA | 1 |
| Johnson, D | 1 |
| Wilkie, AO | 1 |
| Singh, RP | 1 |
| Dhariwal, D | 1 |
| Bhujel, N | 1 |
| Shaikh, Z | 1 |
| Nishikawa, H | 1 |
| Solanki, G | 1 |
| Dover, MS | 1 |
| Kultima, K | 1 |
| Jergil, M | 1 |
| Salter, H | 1 |
| Gustafson, AL | 1 |
| Dencker, L | 2 |
| Stigson, M | 1 |
| Jentink, J | 3 |
| Loane, MA | 1 |
| Dolk, H | 1 |
| de Jong-van den Berg, LT | 3 |
| Wollaston, L | 1 |
| Love, J | 1 |
| Kelly, J | 1 |
| Purdy, L | 1 |
| McEwan, L | 1 |
| Sin, X | 1 |
| Bersudsky, Y | 1 |
| Applebaum, J | 1 |
| Gaiduk, Y | 1 |
| Sharony, L | 1 |
| Mishory, A | 1 |
| Podberezsky, A | 1 |
| Agam, G | 1 |
| Belmaker, RH | 1 |
| Bakker, MK | 1 |
| Nijenhuis, CM | 1 |
| Wilffert, B | 1 |
| Semczuk-Sikora, A | 3 |
| Czuczwar, S | 1 |
| Semczuk, A | 1 |
| Kwasniewska, A | 1 |
| Semczuk, M | 3 |
| Xu, L | 1 |
| Zhu, X | 1 |
| Nishijo, H | 1 |
| Peng, Y | 1 |
| Ji, P | 1 |
| Yeh, V | 1 |
| Ramirez, T | 1 |
| Murata-Hori, M | 1 |
| Lodish, HF | 1 |
| Alessandri, JL | 1 |
| Isidor, B | 1 |
| David, A | 1 |
| Martin-Coignard, D | 1 |
| Ghazouani, J | 1 |
| Ramful, D | 1 |
| Laville, JM | 1 |
| Le Caignec, C | 1 |
| Fucic, A | 1 |
| Stojković, R | 1 |
| Miškov, S | 1 |
| Zeljezic, D | 1 |
| Markovic, D | 1 |
| Gjergja, R | 1 |
| Katic, J | 1 |
| Jazbec, AM | 1 |
| Bakulic, TI | 1 |
| Demarin, V | 1 |
| Gandal, MJ | 2 |
| Edgar, JC | 1 |
| Ehrlichman, RS | 1 |
| Mehta, M | 1 |
| Roberts, TP | 1 |
| Siegel, SJ | 2 |
| Yang, SI | 1 |
| Ko, KH | 3 |
| Bonnett, LJ | 1 |
| Berle, JØ | 1 |
| Solberg, DK | 1 |
| Çoban, D | 1 |
| Kurtoğlu, S | 1 |
| Akın, MA | 1 |
| Akçakuş, M | 1 |
| Güneş, T | 1 |
| Ozkan, H | 1 |
| Cetinkaya, M | 1 |
| Köksal, N | 1 |
| Yapici, S | 1 |
| Cummings, C | 1 |
| Stewart, M | 1 |
| Stevenson, M | 1 |
| Nelson, J | 1 |
| Costa-Borges, N | 1 |
| Gonzalez, S | 1 |
| Santaló, J | 1 |
| Ibáñez, E | 1 |
| Tashiro, Y | 2 |
| Cunnington, MC | 1 |
| Weil, JG | 1 |
| Messenheimer, JA | 1 |
| Ferber, S | 1 |
| Yerby, M | 2 |
| Tennis, P | 1 |
| Lukose, R | 1 |
| Schmidt, E | 1 |
| Wolski, TP | 1 |
| Murawski, NJ | 1 |
| Seo, JE | 1 |
| Han, SM | 1 |
| Kang, YS | 1 |
| Kulaga, S | 1 |
| Sheehy, O | 1 |
| Zargarzadeh, AH | 1 |
| Moussally, K | 1 |
| Bérard, A | 1 |
| Gilboa, SM | 2 |
| Broussard, CS | 1 |
| Devine, OJ | 1 |
| Duwe, KN | 1 |
| Flak, AL | 1 |
| Boulet, SL | 1 |
| Moore, CA | 1 |
| Werler, MM | 2 |
| Honein, MA | 1 |
| Rodrigues, L | 1 |
| Behr, GA | 1 |
| Moreira, JC | 1 |
| Crandall, JE | 1 |
| Goodman, T | 1 |
| McCarthy, DM | 1 |
| Duester, G | 1 |
| Bhide, PG | 1 |
| Dräger, UC | 1 |
| McCaffery, P | 1 |
| Horgan, D | 1 |
| Roten, A | 2 |
| Walcott, EC | 1 |
| Higgins, EA | 1 |
| Desai, NS | 1 |
| Zhang, LL | 1 |
| Zeng, LN | 1 |
| Li, YP | 1 |
| Karén, J | 1 |
| Rodriguez, A | 1 |
| Friman, T | 1 |
| Sundberg, C | 1 |
| Scholz, B | 1 |
| Ahrens, KA | 1 |
| Bosco, JL | 1 |
| Mitchell, AA | 1 |
| Anderka, MT | 1 |
| Mehta, MV | 1 |
| Pinheiro, RM | 1 |
| de Lima, MN | 1 |
| Fries, GR | 1 |
| Garcia, VA | 1 |
| Presti-Torres, J | 1 |
| Hallmenschlager, LH | 1 |
| Alcalde, LA | 1 |
| Roesler, R | 1 |
| Andersen, ML | 1 |
| Quevedo, J | 1 |
| Kapczinski, F | 1 |
| Schröder, N | 1 |
| Morrison, N | 1 |
| Thomas, R | 1 |
| Sandhya, T | 1 |
| Sowjanya, J | 1 |
| Veeresh, B | 1 |
| Sui, L | 1 |
| Mawhinney, E | 2 |
| Campbell, J | 1 |
| Smithson, W | 1 |
| Robertson, I | 1 |
| Morrison, P | 2 |
| Hunt, S | 1 |
| Smith, AK | 1 |
| Conneely, KN | 1 |
| Newport, DJ | 1 |
| Kilaru, V | 1 |
| Schroeder, JW | 1 |
| Knight, BT | 1 |
| Cubells, JC | 1 |
| Stowe, ZN | 1 |
| Brennan, PA | 1 |
| Sangalli, JR | 1 |
| De Bem, TH | 1 |
| Perecin, F | 1 |
| Chiaratti, MR | 1 |
| Oliveira, Lde J | 1 |
| de Araújo, RR | 1 |
| Valim Pimentel, JR | 1 |
| Smith, LC | 1 |
| Meirelles, FV | 1 |
| Boersma, C | 1 |
| Postma, MJ | 1 |
| Felix-Ortiz, AC | 1 |
| Febo, M | 1 |
| Cappelletti, G | 2 |
| Sarkar, S | 1 |
| Sardar, SK | 1 |
| Munian, D | 1 |
| Bhattacharya, S | 1 |
| Majhi, B | 1 |
| Mallela, M | 1 |
| Hrubec, T | 1 |
| Kim, CH | 1 |
| Nakahashi, A | 1 |
| Paradis, FH | 1 |
| Hales, BF | 1 |
| Moschidou, D | 1 |
| Mukherjee, S | 1 |
| Blundell, MP | 1 |
| Jones, GN | 1 |
| Atala, AJ | 1 |
| Thrasher, AJ | 1 |
| Fisk, NM | 1 |
| De Coppi, P | 1 |
| Guillot, PV | 1 |
| Kim, HJ | 2 |
| Lee, JM | 1 |
| Kim, HY | 2 |
| Kozhokaru, AB | 1 |
| Karlov, VA | 3 |
| Zhidkova, IA | 1 |
| Serkina, AV | 1 |
| Escalona-Cardoso, GN | 1 |
| Paniagua-Castro, N | 1 |
| Pérez-Pastén, R | 1 |
| Chamorro-Cevallos, G | 1 |
| Kang, JD | 1 |
| Lu, Y | 1 |
| Jin, JX | 1 |
| Hong, Y | 1 |
| Yan, CG | 1 |
| Yin, XJ | 1 |
| Bristot Silvestrin, R | 1 |
| Galland, F | 1 |
| Daniele Bobermim, L | 1 |
| Quincozes-Santos, A | 1 |
| Torres Abib, R | 1 |
| Zanotto, C | 1 |
| Batassini, C | 1 |
| Brolese, G | 1 |
| Gonçalves, CA | 1 |
| García-Oscos, F | 1 |
| Roychowdhury, S | 1 |
| Galindo, LC | 1 |
| Hall, S | 1 |
| Kilgard, MP | 1 |
| Kim, JN | 1 |
| Kim, MK | 1 |
| Kim, SY | 1 |
| Cho, KS | 1 |
| Han, SY | 1 |
| Ignarro, LJ | 1 |
| Koo, J | 1 |
| Zavras, A | 1 |
| Dela Pena, IC | 1 |
| Mawer, GE | 1 |
| Cheyne, C | 1 |
| Lucas, SB | 1 |
| Crawford, P | 1 |
| Polifka, JE | 1 |
| Friedman, JM | 1 |
| Kajantie, E | 1 |
| Kivirikko, S | 1 |
| Kääriäinen, H | 1 |
| Peippo, M | 1 |
| Somer, M | 1 |
| Smyth, MD | 1 |
| Barbaro, NM | 1 |
| Baraban, SC | 1 |
| Witters, I | 1 |
| Van Assche, F | 1 |
| Fryns, JP | 1 |
| Davidson, DL | 1 |
| Kato, M | 1 |
| Tazoe, M | 1 |
| Miyazaki, K | 1 |
| Okado, N | 1 |
| Coyle, H | 2 |
| Ozkinay, F | 1 |
| Cogulu, O | 1 |
| Gunduz, C | 1 |
| Yilmaz, D | 1 |
| Kultursay, N | 1 |
| Kaaja, E | 2 |
| Kaaja, R | 1 |
| Hiilesmaa, V | 2 |
| Hornby, SJ | 1 |
| Welham, RA | 1 |
| Biernacki, B | 2 |
| Minta, M | 2 |
| Zmudzki, J | 1 |
| Gosakan, R | 1 |
| von Knorring, N | 1 |
| Stewart, P | 1 |
| Servillo, G | 1 |
| Striano, P | 1 |
| Striano, S | 1 |
| Tortora, F | 1 |
| Boccella, P | 1 |
| De Robertis, E | 1 |
| Rossano, F | 1 |
| Briganti, F | 1 |
| Tufano, R | 1 |
| Yerby, MS | 6 |
| Houge, G | 1 |
| Fiskerstrand, T | 1 |
| Øyen, N | 1 |
| Anoop, P | 1 |
| Sasidharan, CK | 1 |
| Rogowska, W | 1 |
| Gagliardi, JP | 1 |
| Krishnan, KR | 1 |
| Stoll, C | 1 |
| Audeoud, F | 1 |
| Gaugler, C | 1 |
| Bernardin, A | 1 |
| Messer, J | 2 |
| Gjerstad, L | 1 |
| Henriksen, T | 1 |
| Husby, H | 1 |
| Zhang, MM | 1 |
| Yu, K | 1 |
| Xiao, C | 1 |
| Ruan, DY | 1 |
| Kawanishi, CY | 1 |
| Hartig, P | 1 |
| Bobseine, KL | 1 |
| Schmid, J | 1 |
| Cardon, M | 1 |
| Massenburg, G | 1 |
| Chernoff, N | 1 |
| Duchowny, M | 1 |
| Kantola-Sorsa, E | 1 |
| Isoaho, M | 1 |
| Matila, R | 1 |
| Kotila, M | 1 |
| Nylund, T | 1 |
| Bardy, A | 1 |
| Granström, ML | 2 |
| Källén, B | 4 |
| Spiegelstein, O | 3 |
| Merriweather, MY | 1 |
| Wicker, NJ | 1 |
| Burt, VK | 1 |
| Rasgon, N | 1 |
| Wu, SP | 1 |
| Shyu, MK | 1 |
| Liou, HH | 1 |
| Gau, CS | 1 |
| Lin, CJ | 1 |
| Chatterjie, N | 1 |
| Alexander, G | 1 |
| Wu, S | 1 |
| Legido, A | 1 |
| De Luca, F | 1 |
| Wide, K | 1 |
| Winbladh, B | 1 |
| Yonkers, KA | 1 |
| Wisner, KL | 3 |
| Stowe, Z | 1 |
| Leibenluft, E | 2 |
| Cohen, L | 1 |
| Miller, L | 1 |
| Manber, R | 1 |
| Viguera, A | 1 |
| Suppes, T | 1 |
| Altshuler, L | 1 |
| Ge, Y | 1 |
| Belcher, SM | 1 |
| Pierce, DR | 1 |
| Light, KE | 1 |
| Sheen, VL | 1 |
| Basel-Vanagaite, L | 1 |
| Goodman, JR | 1 |
| Scheffer, IE | 1 |
| Bodell, A | 1 |
| Ganesh, VS | 1 |
| Ravenscroft, R | 1 |
| Hill, RS | 1 |
| Cherry, TJ | 1 |
| Shugart, YY | 1 |
| Barkovich, J | 1 |
| Straussberg, R | 1 |
| Walsh, CA | 1 |
| Lundberg, YW | 1 |
| Greer, KA | 1 |
| Garg, R | 1 |
| Merks, JH | 1 |
| Ceelie, N | 1 |
| Caron, HN | 1 |
| Hennekam, RC | 1 |
| Foroglou, NG | 1 |
| Kerameos-Foroglou, CH | 1 |
| Thliveris, JA | 1 |
| Przewłocki, R | 4 |
| Hanusa, BH | 1 |
| Peindl, KS | 2 |
| Perel, JM | 1 |
| Shorvon, SD | 1 |
| Vinten, J | 3 |
| Ayres, J | 1 |
| Baker, G | 1 |
| Fryer, A | 2 |
| Gorry, J | 2 |
| Gregg, J | 2 |
| Nicolaides, P | 1 |
| Pickering, L | 1 |
| Tunnicliffe, L | 1 |
| Chadwick, DW | 1 |
| Solinas, C | 2 |
| Cook, M | 2 |
| Aoki, Y | 3 |
| Kushima, K | 2 |
| Kurihara, H | 1 |
| Carney, EW | 1 |
| Scialli, AR | 1 |
| Watson, RE | 1 |
| DeSesso, JM | 1 |
| ten Berg, K | 1 |
| van Oppen, AC | 1 |
| Nikkels, PG | 1 |
| Gittenberger-de Groot, AC | 1 |
| van der Voet, GB | 1 |
| Brilstra, EH | 1 |
| de Oliveira, RS | 1 |
| Lajeunie, E | 3 |
| Arnaud, E | 2 |
| Greensmith, A | 1 |
| Renier, D | 4 |
| Curtis, V | 1 |
| Penovich, P | 1 |
| Nambisan, M | 1 |
| Surve, T | 1 |
| Alsdorf, RM | 1 |
| Santos de Oliveira, R | 1 |
| Peng, GS | 2 |
| Li, G | 1 |
| Tzeng, NS | 1 |
| Hsu, YD | 1 |
| Yang, S | 1 |
| Alsdorf, R | 1 |
| O'Brien, MD | 1 |
| Gilmour-White, SK | 1 |
| Bailey, DN | 1 |
| Briggs, JR | 1 |
| Turczak, J | 1 |
| Artama, M | 2 |
| Auvinen, A | 2 |
| Raudaskoski, T | 1 |
| Isojärvi, I | 1 |
| Isojärvi, J | 1 |
| Sukumaran, S | 1 |
| Krishnamoorthy, T | 1 |
| Eriksson, K | 2 |
| Viinikainen, K | 2 |
| Mönkkönen, A | 2 |
| Aikiä, M | 2 |
| Nieminen, P | 2 |
| Heinonen, S | 2 |
| Dawson, JE | 1 |
| Raymond, AM | 1 |
| Peterson, GM | 1 |
| Naunton, M | 1 |
| Prudenziati, M | 1 |
| Minucci, S | 1 |
| Massa, V | 3 |
| Eikel, D | 1 |
| Hoffmann, K | 1 |
| Zoll, K | 1 |
| Lampen, A | 2 |
| Nau, H | 43 |
| Semah, F | 1 |
| Baran, OP | 1 |
| Kervancioglu, P | 1 |
| Akkus, M | 1 |
| Nergiz, Y | 2 |
| Baran, O | 1 |
| Tuncer, MC | 1 |
| Schnackenberg, LK | 1 |
| Jones, RC | 1 |
| Thyparambil, S | 1 |
| Taylor, JT | 1 |
| Han, T | 1 |
| Tong, W | 1 |
| Hansen, DK | 3 |
| Fuscoe, JC | 1 |
| Edmondson, RD | 1 |
| Beger, RD | 1 |
| Dragan, YP | 1 |
| Reuhl, KR | 1 |
| Cheh, M | 1 |
| McRae, P | 1 |
| Halladay, AK | 1 |
| Tana, M | 1 |
| Pelliccia, P | 1 |
| Latini, G | 1 |
| Nava-Ocampo, AA | 1 |
| Moretti, ME | 1 |
| Sussman, R | 1 |
| Krämer, G | 1 |
| Helmstädter, C | 1 |
| Jokeit, H | 1 |
| Koch, S | 6 |
| Luef, G | 2 |
| Guven, MA | 1 |
| Batukan, C | 1 |
| Ceylaner, S | 1 |
| Ceylaner, G | 1 |
| Uzel, M | 1 |
| Padmanabhan, R | 1 |
| Shafiullah, M | 1 |
| Benedict, S | 1 |
| Nagelkerke, N | 1 |
| Isojärvi, JI | 1 |
| Sobol, E | 1 |
| Ben-Menachem, E | 1 |
| Smith, JC | 1 |
| Wolff, MC | 1 |
| Vorbrodt, AW | 1 |
| Dobrogowska, DH | 1 |
| Kozlowski, PB | 1 |
| Rabe, A | 1 |
| Tarnawski, M | 1 |
| Lee, MH | 1 |
| Pittschieler, S | 1 |
| Ohman, I | 1 |
| Hrubec, TC | 1 |
| Yan, M | 1 |
| Ye, K | 1 |
| Salafia, CM | 1 |
| Holladay, SD | 2 |
| Kulkarni, ML | 1 |
| Zaheeruddin, M | 1 |
| Shenoy, N | 1 |
| Vani, HN | 1 |
| Candito, M | 1 |
| Naimi, M | 1 |
| Boisson, C | 3 |
| Rudigoz, JC | 1 |
| Gaucherand, P | 1 |
| Guéant, JL | 1 |
| Luton, D | 2 |
| Van Obberghen, E | 1 |
| Stanton, ME | 1 |
| Peloso, E | 1 |
| Brown, KL | 1 |
| Rodier, P | 1 |
| Tsujino, N | 1 |
| Nakatani, Y | 1 |
| Seki, Y | 1 |
| Nakasato, A | 1 |
| Nakamura, M | 1 |
| Sugawara, M | 1 |
| Arita, H | 1 |
| Altinoz, MA | 1 |
| Ozdilli, K | 1 |
| Carin, MN | 1 |
| Gedikoglu, G | 1 |
| Chakravarty, A | 1 |
| Mukherjee, A | 1 |
| Roy, D | 1 |
| Duncan, S | 2 |
| Rao, S | 1 |
| Sein, K | 1 |
| Haddad, PM | 1 |
| Manent, JB | 1 |
| Jorquera, I | 1 |
| Mazzucchelli, I | 1 |
| Depaulis, A | 1 |
| Represa, A | 1 |
| Ziòłkowska, B | 1 |
| Gieryk, A | 1 |
| Tyminska, A | 1 |
| Markram, K | 1 |
| Rinaldi, T | 3 |
| La Mendola, D | 1 |
| Sandi, C | 1 |
| Markram, H | 3 |
| Quenby, SM | 1 |
| Anin, S | 1 |
| Bates, MD | 1 |
| Chadwick, D | 3 |
| Vince, GS | 1 |
| Neilson, JP | 1 |
| Silberberg, G | 1 |
| Kulangara, K | 1 |
| Antoniello, K | 1 |
| Wortmann, SB | 1 |
| Reimer, A | 1 |
| Creemers, JW | 1 |
| Mullaart, RA | 1 |
| Carrim, ZI | 1 |
| McKay, L | 1 |
| Sidiki, SS | 1 |
| Lavy, TE | 1 |
| Bortner, CD | 1 |
| Pang, H | 1 |
| Hori, Y | 1 |
| Reynolds, MF | 1 |
| Sisk, EC | 1 |
| Rasgon, NL | 1 |
| Valentin, M | 1 |
| Ducarme, G | 1 |
| Yver, C | 1 |
| Vuillard, E | 1 |
| Belarbi, N | 1 |
| Rowley, C | 1 |
| Onslow, J | 1 |
| Murphy, R | 1 |
| Daugherty, J | 1 |
| Houry, D | 1 |
| Rodríguez-Vázquez, M | 1 |
| Carrascosa-Romero, MC | 1 |
| Pardal-Fernández, JM | 1 |
| Iniesta, I | 1 |
| Diav-Citrin, O | 1 |
| Shechtman, S | 1 |
| Bar-Oz, B | 1 |
| Cantrell, D | 1 |
| Arnon, J | 1 |
| Roman, A | 1 |
| Basta-Kaim, A | 1 |
| Kubera, M | 1 |
| Budziszewska, B | 1 |
| Schneider, K | 1 |
| Yuan, Z | 1 |
| Liu, B | 1 |
| Sailhamer, EA | 1 |
| Shults, C | 1 |
| Velmahos, GC | 1 |
| Demoya, M | 1 |
| Alam, HB | 1 |
| Moynihan, AT | 1 |
| Hehir, MP | 1 |
| Sharkey, AM | 1 |
| Robson, SC | 1 |
| Europe-Finner, GN | 1 |
| Morrison, JJ | 1 |
| Rodríguez-Pinilla, E | 2 |
| Mejías, C | 1 |
| Prieto-Merino, D | 1 |
| Fernández, P | 1 |
| Brown, NA | 4 |
| Kao, J | 1 |
| Fabro, S | 1 |
| Hiilesmaa, VK | 1 |
| Bardy, AH | 1 |
| Teramo, KA | 1 |
| Robert, E | 11 |
| Guibaud, P | 2 |
| Bjerkedal, T | 1 |
| Czeizel, A | 1 |
| Goujard, J | 2 |
| Mastroiacova, P | 1 |
| Nevin, N | 1 |
| Oakley, G | 1 |
| Hurd, RW | 1 |
| Wilder, BJ | 1 |
| Van Rinsvelt, HA | 1 |
| Spielmann, H | 3 |
| Castilla, E | 1 |
| Rosa, F | 1 |
| Tokola, RA | 1 |
| Neuvonen, PJ | 1 |
| Meinardi, H | 3 |
| Löfkvist, E | 1 |
| Mauguiere, F | 1 |
| Feuerstein, J | 1 |
| Revol, M | 1 |
| Roger, J | 1 |
| Sallou, C | 1 |
| Truelle, JL | 1 |
| Vercelletto, P | 1 |
| Weber, M | 1 |
| Bruguerolle, B | 1 |
| Jadot, G | 1 |
| Valli, M | 1 |
| Bouyard, P | 1 |
| Bailey, CJ | 1 |
| Pool, RW | 1 |
| Poskitt, EM | 1 |
| Harris, F | 1 |
| Göpfert-Geyer, I | 1 |
| Jäger-Roman, E | 5 |
| Jakob, S | 2 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Helge, H | 7 |
| van der Kleijn, E | 1 |
| Baars, AM | 1 |
| Vree, TB | 1 |
| van der Dries, A | 1 |
| Curran, AC | 1 |
| Frew, J | 1 |
| ten Kate, LP | 1 |
| Swagemakers, ML | 1 |
| Weemhoff, RA | 1 |
| van Eck, JH | 1 |
| Bruckner, A | 1 |
| Lee, YJ | 1 |
| O'Shea, KS | 1 |
| Henneberry, RC | 1 |
| Otani, K | 4 |
| Fukushima, Y | 4 |
| Sato, T | 2 |
| Nomura, Y | 2 |
| Ogawa, Y | 2 |
| Leck, I | 1 |
| Cordero, JF | 1 |
| Philbert, A | 4 |
| Pedersen, B | 3 |
| Friis, ML | 1 |
| Fukuda, T | 1 |
| Kuroki, Y | 1 |
| Sonawane, BR | 1 |
| Yaffe, SJ | 1 |
| Robert, JM | 2 |
| Lapras, C | 1 |
| Melis, GB | 1 |
| Fruzzetti, F | 1 |
| Paoletti, AM | 1 |
| Mais, V | 1 |
| Kemeny, A | 1 |
| Strigini, F | 1 |
| Boldrini, A | 1 |
| Fioretti, P | 1 |
| Schmidt, D | 2 |
| Löscher, W | 4 |
| Schäfer, H | 2 |
| Bruni, J | 1 |
| Albright, PS | 1 |
| Froescher, W | 1 |
| Gugler, R | 1 |
| Niesen, M | 2 |
| Hoffmann, F | 1 |
| Luck, W | 1 |
| Riva, R | 2 |
| Albani, F | 2 |
| Contin, M | 2 |
| Baruzzi, A | 2 |
| Altomare, M | 2 |
| Merlini, GP | 2 |
| Keränen, T | 1 |
| Sivenius, J | 1 |
| Berlin, CM | 1 |
| Jeavons, PM | 2 |
| Bantz, EW | 1 |
| Marescaux, C | 1 |
| Vergnes, M | 1 |
| Kuhnz, W | 2 |
| Felding, I | 1 |
| Rane, A | 3 |
| Eluma, FO | 2 |
| Sucheston, ME | 6 |
| Hayes, TG | 5 |
| Paulson, RB | 6 |
| DiLiberti, JH | 1 |
| Farndon, PA | 1 |
| Dennis, NR | 1 |
| Curry, CJ | 1 |
| Niermeijer, MF | 1 |
| Haug, M | 1 |
| Simler, S | 1 |
| Kim, L | 1 |
| Mandel, P | 1 |
| Dalens, B | 1 |
| Raynaud, EJ | 1 |
| Gaulme, J | 1 |
| Morselli, PL | 1 |
| Franco-Morselli, R | 1 |
| Paulson, GW | 2 |
| Shakir, RA | 1 |
| Johnson, RH | 1 |
| Lambie, DG | 1 |
| Melville, ID | 1 |
| Nanda, RN | 1 |
| Gomez, MR | 1 |
| Aminoff, MJ | 1 |
| Ruprah, M | 1 |
| Richens, A | 1 |
| Dam, M | 4 |
| Clay, SA | 1 |
| McVie, R | 1 |
| Chen, H | 1 |
| Häuser, I | 1 |
| Cairney, P | 1 |
| Hornabrook, RW | 1 |
| Ainsworth, JW | 1 |
| Zierer, R | 1 |
| Neubert, D | 2 |
| Gansau, C | 1 |
| Dickinson, RG | 4 |
| Lawyer, CH | 1 |
| Kaufman, SN | 2 |
| Lynn, RK | 3 |
| Gerber, N | 3 |
| Novy, MJ | 2 |
| Ishizaki, T | 2 |
| Yokochi, K | 1 |
| Chiba, K | 2 |
| Tabuchi, T | 2 |
| Wagatsuma, T | 2 |
| Patsalos, PN | 1 |
| Wiggins, RC | 1 |
| Andrew, M | 1 |
| Barr, RD | 1 |
| Nakazawa, Y | 1 |
| Gupta, AK | 1 |
| Pedersen, A | 1 |
| Graf, WD | 1 |
| Pippenger, CE | 1 |
| Shurtleff, DB | 1 |
| Christianson, AL | 1 |
| Chesler, N | 1 |
| Kromberg, JG | 1 |
| Buchanan, N | 1 |
| Laegreid, L | 1 |
| Kyllerman, M | 1 |
| Hedner, T | 1 |
| Hagberg, B | 1 |
| Viggedahl, G | 1 |
| Scott, WJ | 6 |
| Collins, MD | 5 |
| Fisher, JE | 1 |
| Acuff-Smith, KD | 2 |
| Schilling, MA | 1 |
| Vorhees, CV | 4 |
| Boussemart, T | 1 |
| Bonneau, D | 2 |
| Levard, G | 1 |
| Berthier, M | 2 |
| Oriot, D | 2 |
| Nieto Barrera, M | 1 |
| Rufo Campos, M | 1 |
| Silieström Ribed, ML | 1 |
| Andrews, JE | 1 |
| Ebron-McCoy, M | 1 |
| Bojic, U | 1 |
| Kavlock, RJ | 2 |
| Bavoux, F | 1 |
| Fournier-Perhilou, AI | 1 |
| Wood, C | 1 |
| Francoual, C | 1 |
| Boccara, JF | 1 |
| van Kempen, TA | 1 |
| Odle, J | 1 |
| Oakeshott, P | 4 |
| Hunt, G | 1 |
| Scollo-Lavizzari, G | 1 |
| Proeckl, D | 1 |
| Hubert, A | 1 |
| Couet, D | 1 |
| Larrègue, M | 1 |
| Narotsky, MG | 1 |
| Francis, EZ | 1 |
| Guest, I | 1 |
| Buttar, HS | 1 |
| Smith, S | 1 |
| Varma, DR | 1 |
| Ylagan, LR | 1 |
| Budorick, NE | 1 |
| Martin, PJ | 1 |
| Millac, PA | 1 |
| Sonoda, T | 3 |
| Ohdo, S | 4 |
| Ohba, K | 2 |
| Okishima, T | 2 |
| Hayakawa, K | 2 |
| Thisted, E | 1 |
| Ebbesen, F | 2 |
| Kondo, T | 3 |
| Kan, R | 1 |
| Takeda, A | 2 |
| Nakane, Y | 1 |
| Guibaud, S | 4 |
| Simplot, A | 2 |
| Francannet, C | 1 |
| Patouraux, MH | 1 |
| Sharony, R | 1 |
| Garber, A | 1 |
| Viskochil, D | 1 |
| Schreck, R | 1 |
| Platt, LD | 1 |
| Ward, R | 1 |
| Buehler, BA | 1 |
| Graham, JM | 1 |
| Thurston, JH | 1 |
| Hauhart, RE | 1 |
| Gunatilake, SB | 1 |
| Van den Berg, RJ | 1 |
| Kok, P | 1 |
| Voskuyl, RA | 1 |
| Van Waes, M | 1 |
| Bennett, GD | 4 |
| Eberwine, JH | 1 |
| Potter, WZ | 1 |
| Ketter, TA | 1 |
| Donnai, D | 2 |
| Tang, ML | 1 |
| Hirji, KF | 1 |
| Vollset, SE | 1 |
| Finnerty, M | 1 |
| Levin, Z | 1 |
| Miller, LJ | 1 |
| Tonn, GR | 1 |
| Doroudian, A | 1 |
| Gordon, JG | 1 |
| Rurak, DW | 4 |
| Riggs, KW | 4 |
| Abbott, FS | 4 |
| Axelson, JE | 1 |
| Barzago, MM | 1 |
| Stellari, FF | 1 |
| Diomede, L | 1 |
| Algeri, M | 1 |
| Efrati, S | 1 |
| Salmona, M | 1 |
| Sato, M | 1 |
| Shirota, M | 1 |
| Nagao, T | 1 |
| Ogawa, N | 2 |
| Yoshiyama, Y | 2 |
| Sugiyama, T | 2 |
| Gordon, JD | 1 |
| Kwan, E | 1 |
| Hall, C | 1 |
| Sachs, GS | 1 |
| Lösche, G | 1 |
| Grafton, TF | 2 |
| Dial, SL | 1 |
| Gehring, TA | 1 |
| Siitonen, PH | 1 |
| Briner, W | 1 |
| Lieske, R | 1 |
| Michaud, L | 1 |
| Gottrand, F | 1 |
| Turck, D | 1 |
| Poher, M | 1 |
| Lecomte-Houcke, M | 1 |
| Farriaux, JP | 2 |
| Wood, BP | 1 |
| Prati, M | 2 |
| Ricolfi, R | 1 |
| Espinasse, M | 1 |
| Manouvrier, S | 1 |
| Boute, O | 1 |
| Ubeda, N | 1 |
| Alonso, E | 1 |
| Martín-Rodríguez, JC | 1 |
| Varela-Moreiras, G | 1 |
| Puerta, J | 1 |
| Pérez-Miguelsanz, J | 1 |
| Johnson, EM | 1 |
| Hockey, A | 1 |
| Bower, C | 1 |
| Goldblatt, J | 1 |
| Knowles, S | 1 |
| Chabrolle, JP | 3 |
| Poinsot, J | 3 |
| Bruel, H | 3 |
| Amussini, P | 1 |
| Williams, JA | 1 |
| Mann, FM | 1 |
| Van Maele-Fabry, G | 1 |
| Clotman, F | 1 |
| Gofflot, F | 1 |
| Bosschaert, J | 1 |
| Picard, JJ | 1 |
| Hall, JL | 1 |
| Harris, MJ | 1 |
| Juriloff, DM | 1 |
| Williams, PG | 1 |
| Hersh, JH | 2 |
| Jacobs, HS | 1 |
| Janas, MS | 1 |
| Arrøe, M | 1 |
| Hansen, SH | 1 |
| Graem, N | 1 |
| Radatz, M | 1 |
| Ehlers, K | 3 |
| Bui, LM | 1 |
| Taubeneck, MW | 1 |
| Commisso, JF | 1 |
| Uriu-Hare, JY | 1 |
| Faber, WD | 1 |
| Keen, CL | 2 |
| Tueth, MJ | 1 |
| Murphy, TK | 1 |
| Evans, DL | 1 |
| Bradaï, R | 1 |
| Hishida, R | 1 |
| Kennedy, D | 2 |
| Dardennes, R | 1 |
| Even, C | 1 |
| Mo, CN | 1 |
| Ladusans, EJ | 1 |
| Landy, SH | 1 |
| McGinnis, J | 1 |
| Baggot, PJ | 1 |
| Kalamarides, JA | 1 |
| Shoemaker, JD | 1 |
| Licht, EA | 1 |
| Sankar, R | 1 |
| Prieto, L | 1 |
| Patterson, V | 1 |
| Canger, R | 1 |
| Fumarola, C | 1 |
| Guidolin, L | 1 |
| Mamoli, D | 1 |
| Palmieri, C | 1 |
| Molteni, F | 1 |
| Granata, T | 1 |
| Hassibi, P | 1 |
| Zamperini, P | 1 |
| Pardi, G | 1 |
| Avanzini, G | 1 |
| Khabibova, AO | 1 |
| Levy, RH | 3 |
| Roeder, M | 1 |
| Adachi, M | 1 |
| Ai, Y | 1 |
| Maeda, E | 1 |
| Faiella, A | 1 |
| Wernig, M | 1 |
| Consalez, GG | 1 |
| Hostick, U | 1 |
| Hofmann, C | 1 |
| Hustert, E | 1 |
| Boncinelli, E | 1 |
| Balling, R | 1 |
| Nadeau, JH | 1 |
| Davis, LL | 1 |
| Ryan, W | 1 |
| Adinoff, B | 1 |
| Petty, F | 1 |
| Gigantelli, JW | 1 |
| Braddock, SR | 2 |
| Johnson, LN | 1 |
| Utoguchi, N | 1 |
| Audus, KL | 1 |
| Arroyo, I | 1 |
| Fondevilla, J | 1 |
| García, MJ | 1 |
| Craig, JC | 1 |
| Miranda, RC | 1 |
| Mackler, SA | 1 |
| Sharief, N | 1 |
| Adams, T | 1 |
| Butler, L | 1 |
| Gnanaratnam, J | 1 |
| Chaudron, LH | 1 |
| Jefferson, JW | 1 |
| Piontek, CM | 1 |
| Baab, S | 1 |
| Pandya, NA | 1 |
| Jani, BR | 1 |
| Nishimura, T | 1 |
| Sakai, M | 1 |
| Yonezawa, H | 1 |
| Kumar, S | 2 |
| Wong, H | 2 |
| Yeung, SA | 2 |
| Moore, SJ | 1 |
| Quinn, A | 1 |
| Glover, S | 1 |
| Lloyd, DJ | 1 |
| Montgomery, T | 1 |
| Dean, JC | 1 |
| Datta, AN | 1 |
| Wirrell, EC | 1 |
| Fraser, CM | 1 |
| Sills, GJ | 1 |
| Butler, E | 1 |
| Thompson, GG | 1 |
| Lindsay, K | 1 |
| Duncan, R | 1 |
| Howatson, A | 1 |
| Brodie, MJ | 1 |
| Joergensen, A | 1 |
| Hoseth, E | 1 |
| Kaad, PH | 1 |
| Moeller, M | 1 |
| Holsteen, V | 1 |
| Rix, M | 1 |
| Basu, A | 1 |
| Wezeman, FH | 1 |
| Fairgrieve, SD | 1 |
| Jackson, M | 1 |
| Jonas, P | 1 |
| Walshaw, D | 1 |
| Montgomery, TL | 1 |
| Burn, J | 2 |
| Lynch, SA | 1 |
| Griswold, KS | 1 |
| Pessar, LF | 1 |
| Al Deeb, S | 1 |
| Al Moutaery, K | 1 |
| Arshaduddin, M | 1 |
| Tariq, M | 1 |
| Sharova, L | 1 |
| Smith, BJ | 1 |
| Gogal, RM | 1 |
| Ward, DL | 1 |
| Blaylock, BL | 1 |
| Kozma, C | 1 |
| Williams, G | 1 |
| King, J | 1 |
| Cunningham, M | 1 |
| Stephan, M | 1 |
| Kerr, B | 1 |
| Iqbal, MM | 2 |
| Gundlapalli, SP | 1 |
| Ryan, WG | 1 |
| Ryals, T | 1 |
| Passman, TE | 1 |
| Harvey, EA | 1 |
| Coull, BA | 1 |
| Huntington, KB | 1 |
| Khoshbin, S | 1 |
| Hayes, AM | 1 |
| Ryan, LM | 1 |
| Ushigome, F | 2 |
| Takanaga, H | 1 |
| Matsuo, H | 1 |
| Tsukimori, K | 2 |
| Nakano, H | 2 |
| Ohtani, H | 2 |
| Sawada, Y | 2 |
| Amusini, P | 1 |
| Levesque, L | 1 |
| Iskandar, K | 1 |
| Ceylan, S | 2 |
| Duru, S | 1 |
| Göttlicher, M | 1 |
| Mercho, S | 1 |
| Lopes-Cendes, I | 1 |
| Seni, MH | 1 |
| Benjamin, A | 1 |
| Dubeau, F | 1 |
| Andermann, F | 1 |
| Andermann, E | 1 |
| Assencio-Ferreira, VJ | 1 |
| Abraham, R | 1 |
| Veiga, JC | 1 |
| Santos, KC | 1 |
| Johnson, KA | 1 |
| Weber, PA | 1 |
| Jones, KL | 1 |
| Chambers, CD | 1 |
| McMahon, CL | 1 |
| Nagai, T | 1 |
| Leppik, IE | 1 |
| Sohhan, T | 1 |
| Mahmud, SZ | 1 |
| Barcik, U | 1 |
| Thorne, JA | 1 |
| El Ghouzzi, V | 1 |
| Bourgeois, M | 1 |
| Boyle, NJ | 1 |
| Clarke, MP | 1 |
| Figueiredo, F | 1 |
| Sodhi, P | 1 |
| Poddar, B | 1 |
| Parmar, V | 1 |
| Bescoby-Chambers, N | 1 |
| Forster, P | 1 |
| Bates, G | 1 |
| Waes, JG | 1 |
| Eudy, JD | 1 |
| Rosenquist, TH | 1 |
| Bensouda, B | 1 |
| Simon, A | 1 |
| Ickowicz, V | 1 |
| Degre, S | 1 |
| Włodarczyk, B | 1 |
| Nakamura, H | 1 |
| Koyabu, N | 1 |
| Satoh, S | 1 |
| Watterson, JM | 1 |
| Watson, DG | 1 |
| Meyer, EM | 1 |
| Lenox, RH | 1 |
| Laskowska, M | 1 |
| Leszczyńska-Gorzelak, B | 1 |
| Oleszczuk, J | 1 |
| Iezzi, S | 1 |
| Cossu, G | 1 |
| Nervi, C | 1 |
| Sartorelli, V | 1 |
| Puri, PL | 1 |
| Similä, S | 1 |
| von Wendt, L | 1 |
| Hartikainen-Sorri, AL | 2 |
| Kääpä, P | 1 |
| Saukkonen, AL | 1 |
| Poser, W | 1 |
| Poser, S | 1 |
| Ritter, G | 1 |
| Conomy, JP | 1 |
| Alexander, FW | 1 |
| Harland, RC | 1 |
| Smith, WB | 1 |
| Reith, H | 1 |
| Pinder, RM | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Hvidberg, EF | 1 |
| Omtzigt, JG | 4 |
| Los, FJ | 3 |
| Hagenaars, AM | 1 |
| Stewart, PA | 3 |
| Sachs, ES | 3 |
| Khera, KS | 2 |
| Elmazar, MM | 4 |
| Almuna, R | 1 |
| Tohá, D | 1 |
| Campos, G | 1 |
| del Río, S | 1 |
| Stürje, H | 1 |
| Merker, HJ | 4 |
| Pijpers, L | 2 |
| Nosel, PG | 1 |
| Klein, NW | 1 |
| Buntinx, IM | 1 |
| Tyl, RW | 1 |
| Fisher, LC | 1 |
| Kubena, MF | 1 |
| Vrbanic, MA | 1 |
| Gingell, R | 1 |
| Guest, D | 1 |
| Hodgson, JR | 1 |
| Murphy, SR | 1 |
| Tyler, TR | 1 |
| Astill, BD | 1 |
| Cornel, MC | 1 |
| Grobbee, DE | 1 |
| Jahoda, MG | 1 |
| Brandenburg, H | 1 |
| Gaillard, HL | 1 |
| Wladimiroff, JW | 2 |
| Friel, PN | 1 |
| McCormick, K | 2 |
| Leavitt, A | 1 |
| Erickson, DM | 1 |
| McCormick, KB | 1 |
| Loewenson, RB | 1 |
| Sells, CJ | 1 |
| Benedetti, TJ | 1 |
| Wegner, C | 4 |
| Dravet, C | 1 |
| Julian, C | 1 |
| Legras, C | 1 |
| Magaudda, A | 1 |
| Guerrini, R | 1 |
| Soulayrol, S | 1 |
| Giraud, N | 1 |
| Mesdjian, E | 1 |
| Trentin, G | 1 |
| Meijer, JW | 1 |
| Thiel, R | 1 |
| Drews, E | 1 |
| Fröscher, W | 1 |
| Herrmann, R | 1 |
| Bülau, P | 1 |
| Penin, H | 1 |
| Hildenbrand, G | 1 |
| Hauck, RS | 3 |
| Walling, KM | 1 |
| Resnick, E | 1 |
| Clarke, DO | 1 |
| McCarthy, A | 1 |
| Agrawal, P | 1 |
| Orrell, RW | 1 |
| Weisenburger, WP | 1 |
| Minck, DR | 1 |
| Berry, JS | 1 |
| Setchell, KD | 1 |
| Tanaka, H | 1 |
| Izumi, M | 1 |
| Okada, H | 1 |
| Ishikawa, S | 1 |
| Palea, KM | 1 |
| Cotariu, D | 1 |
| Zaidman, JL | 1 |
| Anai, T | 1 |
| Hirota, Y | 1 |
| Oga, M | 1 |
| Yoshimatsu, J | 1 |
| Miyakawa, I | 1 |
| Srivastava, M | 1 |
| Wittfoht, W | 1 |
| Klug, S | 1 |
| Lewandowski, C | 1 |
| Zappel, F | 1 |
| Cohen, LS | 1 |
| Heller, VL | 1 |
| Kobayashi, S | 1 |
| Takai, K | 1 |
| Iga, T | 1 |
| Hanano, M | 1 |
| Verloes, A | 1 |
| Frikiche, A | 1 |
| Gremillet, C | 1 |
| Paquay, T | 1 |
| Decortis, T | 1 |
| Rigo, J | 1 |
| Senterre, J | 1 |
| Fradkin, R | 1 |
| Turner, S | 1 |
| De Philip, RM | 1 |
| Squier, W | 1 |
| Hope, PL | 1 |
| Lindenbaum, RH | 1 |
| Minematsu, S | 1 |
| Taki, M | 1 |
| Watanabe, M | 1 |
| Takahashi, M | 1 |
| Wakui, Y | 1 |
| Ishihara, K | 1 |
| Takeda, S | 1 |
| Fujii, Y | 1 |
| Markovitz, PJ | 1 |
| Calabrese, JR | 1 |
| Pison, H | 1 |
| Carter, BS | 1 |
| Stewart, JM | 1 |
| Robinek, F | 1 |
| Czeizel, E | 1 |
| Peters, JM | 1 |
| Hurley, LS | 1 |
| Fowler, DW | 1 |
| Haddad, J | 1 |
| Willard, D | 1 |
| Koerner, M | 1 |
| Friel, P | 1 |
| Pacifici, GM | 2 |
| Temellini, A | 1 |
| Giuliani, L | 1 |
| Thomas, H | 1 |
| Oesch, F | 1 |
| Serville, F | 1 |
| Carles, D | 1 |
| Dallay, D | 1 |
| Hunt, GM | 1 |
| Chevallier, B | 1 |
| Nègre, V | 1 |
| Bidat, E | 1 |
| Lagardère, B | 1 |
| Weiss, HS | 2 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Staunton, H | 1 |
| Kerr, BM | 1 |
| Gossrau, R | 3 |
| Graf, R | 3 |
| Bertilsson, L | 1 |
| Kola, I | 2 |
| Folb, PI | 1 |
| Legius, E | 1 |
| Jaeken, J | 1 |
| Eggermont, E | 1 |
| Günther, T | 2 |
| Vormann, J | 2 |
| Coraggio, F | 1 |
| Angiulli, B | 1 |
| Carbone, M | 1 |
| Catalano, A | 1 |
| Costa, MR | 1 |
| Gargiulo, L | 1 |
| Gentile, B | 1 |
| Masetto, O | 1 |
| Pomponio, N | 1 |
| Scarpato, P | 1 |
| Hatjis, CG | 1 |
| Rose, JC | 1 |
| Pippitt, C | 1 |
| Swain, M | 1 |
| Buchhalter, JR | 1 |
| Dichter, MA | 1 |
| Weinbaum, PJ | 1 |
| Cassidy, SB | 1 |
| Vintzileos, AM | 1 |
| Campbell, WA | 1 |
| Ciarleglio, L | 1 |
| Nochimson, DJ | 1 |
| Heikkinen, J | 1 |
| Nikiforow, R | 1 |
| Coakley, ME | 1 |
| Krauer, B | 1 |
| Mast, TJ | 1 |
| Cukierski, MA | 1 |
| Hendrickx, AG | 2 |
| Deichl, A | 1 |
| Hartmann, AM | 1 |
| Steldinger, R | 1 |
| Sobrian, SK | 1 |
| Nandedkar, AK | 1 |
| Larsson, OM | 1 |
| Gram, L | 2 |
| Schousboe, I | 1 |
| Schousboe, A | 1 |
| Petrere, JA | 1 |
| Anderson, JA | 1 |
| Sakowski, R | 1 |
| Fitzgerald, JE | 1 |
| de la Iglesia, FA | 1 |
| Shinnar, S | 1 |
| Durá, T | 1 |
| Moya, M | 1 |
| Muñoz, M | 1 |
| Juste, M | 1 |
| Castaño, C | 1 |
| Ritter, EJ | 1 |
| Randall, JL | 1 |
| Ritter, JM | 1 |
| Di Carlo, FJ | 1 |
| Bickart, P | 1 |
| Auer, CM | 1 |
| Brown, EG | 1 |
| Trotz, M | 1 |
| Chapman, JB | 1 |
| Cutler, MG | 1 |
| Bertollini, R | 2 |
| Mastroiacovo, P | 2 |
| Massa, G | 1 |
| Lecoutere, D | 1 |
| Casaer, P | 1 |
| Lammer, EJ | 2 |
| Sever, LE | 1 |
| Hirano, T | 2 |
| Huot, C | 1 |
| Gauthier, M | 1 |
| Lebel, M | 1 |
| Larbrisseau, A | 1 |
| Curran, MA | 1 |
| Winter, RM | 1 |
| Tucker, SM | 1 |
| Michejda, M | 1 |
| McCollough, D | 1 |
| Ardinger, HH | 1 |
| Atkin, JF | 1 |
| Blackston, RD | 1 |
| Elsas, LJ | 1 |
| Clarren, SK | 1 |
| Livingstone, S | 1 |
| Flannery, DB | 1 |
| Pellock, JM | 1 |
| Harrod, MJ | 1 |
| Tsuru, N | 1 |
| Maeda, T | 1 |
| Tsuruoka, M | 1 |
| Stark, KL | 1 |
| Juchau, MR | 1 |
| Naruse, I | 1 |
| Vogel, R | 1 |
| Sachs, LA | 1 |
| Oca, M | 1 |
| Kernan, B | 1 |
| Weiss, S | 1 |
| Reuss, A | 1 |
| van Swaay, E | 1 |
| Binkerd, PE | 1 |
| Rowland, JM | 1 |
| Chitayat, D | 1 |
| Farrell, K | 1 |
| Anderson, L | 1 |
| Hall, JG | 1 |
| Wellesley, D | 1 |
| Karras, SB | 1 |
| Mohl, VK | 1 |
| Stahlmann, R | 1 |
| Tein, I | 1 |
| MacGregor, DL | 1 |
| Garden, AS | 1 |
| Benzie, RJ | 1 |
| Hutton, EM | 1 |
| Gare, DJ | 1 |
| Jallon, P | 1 |
| Loiseau, P | 1 |
| Pillans, PI | 1 |
| Bentsen, K | 1 |
| Wolf, H | 1 |
| Leschot, NJ | 1 |
| Segni, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PSG in Valproate-induced Nocturnal Enuresis in Children[NCT04191863] | 260 participants (Actual) | Observational | 2018-09-01 | Completed | |||
| A 12-weeks, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Related Mechanism of Sulforaphane in Treatment of Autism Spectrum Disorder[NCT02879110] | 110 participants (Actual) | Interventional | 2016-08-31 | Completed | |||
| A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641] | 20 participants (Anticipated) | Observational | 2018-12-03 | Recruiting | |||
| Homeopathic Treatment in Pregnant Women With Overweight and Mental Disorder: a Double Blinded Controlled Clinical Trial[NCT00942097] | Phase 2/Phase 3 | 134 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| Rett Syndrome, MECP2 Duplication, and Rett-Related Disorders Consortium, Rare Disease Clinical Research Network: Neurophysiologic Correlates[NCT03077308] | 185 participants (Actual) | Observational | 2017-01-02 | Completed | |||
| Lamotrigine Pregnancy Registry (LAM05)[NCT01064297] | 3,416 participants (Actual) | Observational | 2001-11-30 | Completed | |||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Effects and Consequences for Mother and Child From Treatment for Depression, A Prospective Randomized, Placebo- Controlled, Trial With Internet-based Cognitive Behavior Therapy and Sertraline or Placebo for Moderate Depression in Pregnancy[NCT02185547] | Phase 4 | 17 participants (Actual) | Interventional | 2016-02-21 | Terminated (stopped due to Difficulties in recruiting participants.) | ||
| Medication Safety and Contraceptive Counseling for Reproductive Aged Women With Psychiatric Conditions[NCT02292056] | 50 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | |||
| A Phase II Multiple Site, Randomized, Placebo-Controlled Trial of Oral Valproic Acid for Autosomal Dominant Retinitis Pigmentosa[NCT01233609] | Phase 2 | 90 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| A Study of Divalproex Sodium in Children With Autism Spectrum Disorder and Epileptiform EEG[NCT01170325] | Phase 2 | 0 participants (Actual) | Interventional | 2010-06-30 | Withdrawn | ||
| Neurodevelopmental Effects of Antiepileptic Drugs II: the NEAD Study[NCT00021866] | 331 participants (Actual) | Observational | 2000-09-30 | Completed | |||
| Prophylactic Use of Immediate Postpartum Sertraline to Prevent Postpartum Depression: A Double Blind Randomized Placebo Controlled Trial[NCT02235064] | 2 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Low recruitment, completion of funding cycle) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The number of infants with major congenital malformations were counted and are presented by earliest trimester of exposure to lamotrigine polytherapy with valproate. (NCT01064297)
Timeframe: Although reports and diagnoses of MCMs are accepted up to six years after the birth, the majority of malformations are reported following assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) |
|---|---|
| First Exposure During First Trimester | 14 |
| First Exposure During Second Trimester | 1 |
| First Exposure During Third Trimester | 0 |
| Unspecified Trimester of Exposure | 0 |
| All Trimesters | 1 |
The number of infants with major congenital malformations were counted and are presented by earliest trimester of exposure to lamotrigine polytherapy without valproate. (NCT01064297)
Timeframe: Although reports and diagnoses of MCMs are accepted up to six years after the birth, the majority of malformations are reported following assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) |
|---|---|
| First Exposure During First Trimester | 12 |
| First Exposure During Second Trimester | 0 |
| First Exposure During Third Trimester | 1 |
| All Trimesters | 13 |
Among lamotrigine monotherapy exposures: live births, fetal deaths, induced abortions with birth defects, and live births without defects. Due to the likelihood of inconsistent identification of birth defects among spontaneous losses, fetal deaths, and induced abortions without reported birth defects, these offspring were not included in analyses. (NCT01064297)
Timeframe: Although reports and diagnoses of MCMs are accepted up to six years after the birth, the majority of malformations are reported after assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) |
|---|---|
| First Exposure During First Trimester | 35 |
| First Exposure During Second Trimester | 4 |
| First Exposure During Third Trimester | 1 |
| Unspecified Trimester of Exposure | 0 |
| All Trimesters | 40 |
The number of live births, fetal deaths, induced abortions, and spontaneous pregnancy losses were recorded according to the time at which women were first exposed to lamotrigine monotherapy. Due to inconsistent identification of major congenital malformations (MCMs) among spontaneous losses, no comment is made concerning the presence or absence of MCMs. (NCT01064297)
Timeframe: Although reports and diagnoses of major congenital malformations are accepted up to six years after the birth, the majority of malformations are reported after assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Live Birth (Birth Defects Reported) | Fetal Death (Birth Defects Reported) | Induced Abortion (Birth Defects Reported) | Live Birth (No Birth Defects Reported) | Fetal Death (No Birth Defects Reported) | Induced Abortion (No Birth Defects Reported) | Spontaneous Pregnancy Loss | |
| First Exposure During First Trimester | 31 | 1 | 3 | 1523 | 10 | 33 | 98 |
| First Exposure During Second Trimester | 4 | 0 | 0 | 91 | 0 | 0 | 0 |
| First Exposure During Third Trimester | 1 | 0 | 0 | 17 | 0 | 0 | 0 |
| Unspecified Trimester of Exposure | 0 | 0 | 0 | 5 | 0 | 0 | 0 |
The number of live births, fetal deaths, induced abortions, and spontaneous pregnancy losses were recorded according to the time at which women were first exposed to lamotrigine polytherapy with valproate. Due to inconsistent identification of major congenital malformations (MCMs) among spontaneous losses, no comment is made concerning the presence or absence of MCMs. (NCT01064297)
Timeframe: Although reports and diagnoses of MCMs are accepted up to six years after the birth, the majority of malformations are reported following assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Live Birth (Birth Defects Reported) | Fetal Death (Birth Defects Reported) | Induced Abortion (Birth Defects Reported) | Live Birth (No Birth Defects Reported) | Fetal Death (No Birth Defects Reported) | Induced Abortion (No Birth Defects Reported) | Spontaneous Pregnancy Loss | |
| First Exposure During First Trimester | 14 | 0 | 2 | 134 | 1 | 4 | 6 |
| First Exposure During Second Trimester | 1 | 0 | 0 | 6 | 1 | 0 | 0 |
| First Exposure During Third Trimester | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
| Unspecified Trimester of Exposure | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The number of live births, fetal deaths with pregnancy loss occurring >=20 weeks gestation, induced abortions, and spontaneous pregnancy losses were recorded according to the time at which women were first exposed to lamotrigine polytherapy without valproate. Due to inconsistent identification of major congenital malformations (MCMs) among spontaneous losses, no comment is made concerning the presence or absence of MCMs. Although birth defects may not have been reported, they cannot be ruled out. (NCT01064297)
Timeframe: Although reports and diagnoses of MCMs are accepted up to six years after the birth, the majority of malformations are reported following assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Live Birth (Birth Defects Reported) | Fetal Death (Birth Defects Reported) | Induced Abortion (Birth Defects Reported) | Live Birth (No Birth Defects Reported) | Fetal Death (No Birth Defects Reported) | Induced Abortion (No Birth Defects Reported) | Spontaneous Pregnancy Loss | |
| First Exposure During First Trimester | 11 | 0 | 1 | 418 | 3 | 19 | 22 |
| First Exposure During Second Trimester | 0 | 0 | 0 | 25 | 0 | 0 | 0 |
| First Exposure During Third Trimester | 1 | 0 | 0 | 2 | 0 | 0 | 0 |
The number of infants with the reported MCM following first trimester exposure to lamotrigine polytherapy with valproate were counted. (NCT01064297)
Timeframe: Although reports and diagnoses of MCMs are accepted up to six years after the birth, the majority of malformations are reported after assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hydrocephalus/spina bifida | Meningomyelocele | Microcephaly | Orofacial clefts | Cardiac septal defects | Transposition of great vessels | Ventricular hypoplasia | Pulmonary stenosis | Pyloric stenosis | Gastroschisis | Club foot | Polydactyly | |
| Doses Lower Than Prescribed | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 |
| Prescribed Doses | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The number of infants with the reported MCM following first trimester exposure to lamotrigine polytherapy without valproate were counted. (NCT01064297)
Timeframe: Although reports and diagnoses of MCMs are accepted up to six years after the birth, the majority of malformations are reported after assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Neural tube defect | Cardiac septal defect/murmur | Coarctation of aorta | Tetralogy of Fallot | Esophageal defects | Hypospadias | Hydroencephalopathy | Omphalocele | Extra digit | Skin tags on ear | |
| Doses Higher Than Prescribed | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
| Doses Lower Than Prescribed | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| Prescribed Doses | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
The number of infants with the reported MCM following first trimester lamotrigine monotherapy exposure were counted. Registry personnel contacted the enrolling physician to obtain information on the pregnancy outcome, lamotrigine dosing and duration of exposure, and use of concomitant antiepileptic drugs during pregnancy. (NCT01064297)
Timeframe: Although reports and diagnoses of MCMs are accepted up to six years after the birth, the majority of malformations are reported after assessments made in the delivery room or shortly after birth
| Intervention | infants (Number) | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Anencephaly | Orofacial clefts | Hypoplastic left heart/left ventricle hypoplasia | Transposition of great vessels | Ventricular septal defects | Minor heart defect, unspecified | Pulmonary stenosis | Hydronephrosis | Renal defect (absent, polysystic, fluid on kidney) | Cortical dysplasis | Hypospadias | Pyloric stenosis | Diaphragmatic hernia | Congenital atresia of anus | Hip dislocation | Club feet | Polydactyly | Epidermolysis bullosa | Light spot across entire abdomen | |
| Dose Higher Than Prescribed | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
| Doses Lower Than Prescribed | 2 | 2 | 1 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 |
| Prescribed Doses | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
| Unknown Maximal Dose in Exposed Trimester | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mean change in best corrected visual acuity as assessed by ETDRS (Early Treatment Diabetic Retinopathy Study) method from baseline to week 52 (NCT01233609)
Timeframe: baseline to week 52
| Intervention | letters read correctly (Mean) |
|---|---|
| Valproic Acid -- Right Eye | -1.4 |
| Valproic Acid--Left Eye | 0.0 |
| Placebo --Right Eye | 0.2 |
| Placebo --Left Eye | 1.3 |
Mean change in visual field area from baseline to 52 weeks. Visual field area is measured with semi-automated kinetic perimetry (SKP) using the Octopus 900 (Haag-Streit) with the I4e target size for each eye and done at least twice to ensure reliable sessions; the visual field area measurements are averaged over the two sessions. Analysis performed with linear mixed model (NCT01233609)
Timeframe: baseline to week 52
| Intervention | Visual field area (degrees squared) (Mean) |
|---|---|
| Placebo--Right Eye | 80.9 |
| Placebo--Left Eye | 115.7 |
| Valproic Acid--Right Eye | 5.3 |
| Valproic Acid--Left Eye | 19.5 |
Mean change in visual field area from baseline to 52 weeks. Visual field area is measured with semi-automated kinetic perimetry (SKP) using the Octopus 900 (Haag-Streit) with the III4e target size for each eye and done at least twice to ensure reliable sessions; the visual field area measurements are averaged over the two sessions. Analysis performed with linear mixed model (NCT01233609)
Timeframe: baseline to week 52
| Intervention | Visual field area (degrees squared) (Mean) |
|---|---|
| Placebo--Right Eye | -122.9 |
| Placebo--Left Eye | -112.0 |
| Valproic Acid--Right Eye | -293.7 |
| Valproic Acid--Left Eye | -237.1 |
Mean change from baseline at week 52 for Full field Hill of Vision (Static perimetry) (NCT01233609)
Timeframe: baseline to week 52
| Intervention | db-steridians (Mean) |
|---|---|
| Placebo--Right Eye | -0.3 |
| Placebo--Left Eye | -1.4 |
| Valproic Acid--Right Eye | -0.2 |
| Valproic Acid--Left Eye | -0.6 |
Mean Change from baseline to week 52 for Static Perimetry Volume --30 Degree Hill of Vision. Full field static perimetry protocol was followed using the Octopus 900 (Haag-Streit) for a single session for each eye. (NCT01233609)
Timeframe: baseline to week 52
| Intervention | db-steridans (Mean) |
|---|---|
| Placebo--Right Eye | -0.3 |
| Placebo--Left Eye | -0.3 |
| Valproic Acid--Right Eye | -0.2 |
| Valproic Acid--Left Eye | -0.2 |
The Antidepressant Side-Effect Checklist (ASEC) was employed to detect any adverse reaction to treatment regimens (NCT02235064)
Timeframe: Discharge from hospital to 12 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 1 |
"Patients met with single psychiatrist (co-investigator), blinded to group assignment, who evaluated the patient using Edinburgh Postpartum Depression Screen, Hamilton Depression Rating Scale, Global Assessment of Functioning Scale, and clinical assessment~0 = No postpartum depression up to 12 weeks following discharge from hospital~1 = Postpartum depression up to 12 weeks following discharge from hospital" (NCT02235064)
Timeframe: Discharge from hospital to 12 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 12 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 4 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 8 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 12 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 4 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 8 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 12 weeks postpartum
| Intervention | Grams (Mean) |
|---|---|
| Sertraline | 5301 |
| Placebo | 4734 |
(NCT02235064)
Timeframe: 4 weeks postpartum
| Intervention | Grams (Mean) |
|---|---|
| Sertraline | 3033 |
| Placebo | 2750 |
(NCT02235064)
Timeframe: 8 weeks postpartum
| Intervention | Grams (Mean) |
|---|---|
| Sertraline | 5301 |
| Placebo | 3685 |
137 reviews available for valproic acid and Pregnancy
| Article | Year |
|---|---|
Epilepsy in Pregnancy-Management Principles and Focus on Valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism | 2022 |
Status epilepticus in pregnancy: a literature review and a protocol proposal.
Topics: Anticonvulsants; Female; Humans; Levetiracetam; Phenytoin; Pregnancy; Review Literature as Topic; St | 2022 |
Valproate: Not All Boxed Warnings Are Created Equal.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Labeling; Drug-Related Side Effects an | 2022 |
Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells.
Topics: Anticonvulsants; Epilepsy; Female; Human Embryonic Stem Cells; Humans; Pregnancy; Transcriptome; Val | 2022 |
Effects of Maternal Use of Antiseizure Medications on Child Development.
Topics: Anticonvulsants; Child; Child Development; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Pregnanc | 2022 |
YouTube as a source of information on preventing the use of valproic acid in women during pregnancy.
Topics: Emotions; Female; Humans; Information Sources; Pregnancy; Social Media; Valproic Acid; Video Recordi | 2023 |
Management of epilepsy during pregnancy and lactation.
Topics: Breast Feeding; Epilepsy; Female; Humans; Lactation; Pregnancy; Prospective Studies; Seizures; Valpr | 2023 |
Expert advice on the management of valproate in women with bipolar disorder at childbearing age.
Topics: Age Factors; Bipolar Disorder; Female; Guidelines as Topic; Humans; Pregnancy; Valproic Acid | 2019 |
[Chronic Activation of the Dopaminergic Neuronal Pathway Improves Behavioral Abnormalities in the Prenatal Valproic Acid Exposure Mouse Model of Autism Spectrum Disorder].
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Autism Spectrum Disorder; Behavior; Disease Models, | 2019 |
Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy.
Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Postpartum Period; Pregnancy; Pregnancy | 2020 |
Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.
Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Generalized; Female; Humans; Pregnancy; Pregnancy Compli | 2021 |
Valproate and folate: Congenital and developmental risks.
Topics: Anticonvulsants; Brain; Female; Folic Acid; Humans; Nervous System Malformations; Neural Tube Defect | 2020 |
Genetic/idiopathic generalized epilepsies: Not so good as that!
Topics: Abnormalities, Drug-Induced; Adult; Comorbidity; Contraindications, Drug; Death, Sudden; Epilepsy, G | 2020 |
Topics: Animals; Autism Spectrum Disorder; Epigenesis, Genetic; Female; Humans; Methionine; Nervous System; | 2020 |
[Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding].
Topics: Anticonvulsants; Benzodiazepines; Biological Transport; Breast Feeding; Cell Line; Epilepsy; Female; | 2020 |
Alternatives to valproate in girls and women of childbearing potential with Idiopathic Generalized Epilepsies: state of the art and guidance for the clinician proposed by the Epilepsy and Gender Commission of the Italian League Against Epilepsy (LICE).
Topics: Animals; Anticonvulsants; Child; Epilepsy, Generalized; Female; Humans; Italy; Phthiraptera; Pregnan | 2021 |
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2021 |
Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Female; Humans; Neurotoxicity Syndromes; Pregnan | 2021 |
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Food Preservati | 2022 |
Risk mitigation for children exposed to drugs during gestation: A critical role for animal preclinical behavioral testing.
Topics: Analgesics; Animals; Behavior, Animal; Child; Cognition Disorders; Female; Humans; Pregnancy; Prenat | 2017 |
Teratology of valproic acid: an updated review of the possible mediating mechanisms.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antineoplastic Agents; Female; Humans; Neopla | 2018 |
Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 2017 |
The valproic acid-induced rodent model of autism.
Topics: Adult; Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; | 2018 |
Valproic Acid in Women and Girls of Childbearing Age.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Antimanic Agents; Europe; Female; H | 2017 |
Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Autistic Disorder; Bayes Theorem; Breast Feeding; Carbamazepine; Child; Epilepsy; F | 2017 |
Is there consensus across international evidence-based guidelines for the psychotropic drug management of bipolar disorder during the perinatal period?
Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Bre | 2018 |
Valproate: life-saving, life-changing.
Topics: Anticonvulsants; England; Epilepsy; Female; Humans; Maternal Exposure; Practice Guidelines as Topic; | 2018 |
Sodium valproate in pregnancy: what are the risks and should we use a shared decision-making approach?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Decision Making; E | 2018 |
Is post exposure prevention of teratogenic damage possible: Studies on diabetes, valproic acid, alcohol and anti folates in pregnancy: Animal studies with reflection to human.
Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; Diabetes, Gestational; Ethanol; Ethyl Ethers; Fe | 2018 |
Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Mice; Neuroim | 2018 |
Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Female; Mice; Pregnancy; Prenatal Exposure Delay | 2019 |
'Conceivably Neglected' - Are prescribers sufficiently aware of the risks of prescribing sodium valproate to women with mental illness?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Epilepsy; Female; | 2019 |
[The valproate model of autism].
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Humans; Mice; | 2019 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
Improving basic and translational science by accounting for litter-to-litter variation in animal models.
Topics: Animals; Animals, Newborn; Antimanic Agents; Databases, Factual; Disease Models, Animal; Female; Mic | 2013 |
Arrhenius thermodynamics and birth defects: chemical teratogen synergy. Untested, testable, and projected relevance.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Drug Synergism; Female; Fever; Human | 2013 |
Neural tube defects, folate, and immune modulation.
Topics: Anticonvulsants; Autoantibodies; Chemokine CCL2; Complement System Proteins; Female; Folate Receptor | 2013 |
Pharmacotherapy for mood disorders in pregnancy: a review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring.
Topics: Antidepressive Agents; Carbamazepine; Drug Monitoring; Female; Humans; Lamotrigine; Mood Disorders; | 2014 |
Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bipolar Di | 2014 |
Treating epilepsy in pregnant women.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; Intellectual Disability; Matern | 2014 |
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili | 2014 |
Prediction of the hazard of foetal malformation in pregnant women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2014 |
Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child.
Topics: Age Factors; Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Epilepsy; Female; Hu | 2014 |
Prevention of migraine attacks. First-choice treatments.
Topics: Adrenergic beta-Antagonists; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tric | 2015 |
[Epilepsy, antiepileptic drugs and disorders of reproductive functions of women].
Topics: Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infertility, Female; Polycystic Ovary Syn | 2014 |
Valproate in the treatment of epilepsy in girls and women of childbearing potential.
Topics: Age Factors; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects | 2015 |
Risks of congenital malformations in offspring exposed to valproic acid in utero: A systematic review and cumulative meta-analysis.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Humans; Maternal Exposure; Odds Ratio; Pregnan | 2015 |
[Algorithms of using valproic acid drugs in women].
Topics: Algorithms; Anticonvulsants; Contraindications; Epilepsy; Female; Humans; Pregnancy; Pregnancy Compl | 2015 |
In utero exposure to valproate increases the risk of isolated cleft palate.
Topics: Anticonvulsants; Cleft Palate; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregn | 2016 |
Is carbamazepine a human teratogen?
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Carbamazepine; Epilepsy; Female; Fet | 2016 |
The plausibility of maternal toxicant exposure and nutritional status as contributing factors to the risk of autism spectrum disorders.
Topics: Animals; Autism Spectrum Disorder; Benzhydryl Compounds; Brain; Diethylhexyl Phthalate; Disease Mode | 2017 |
Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure | 2016 |
Bipolar Disorder in Pregnancy and Postpartum: Principles of Management.
Topics: Antipsychotic Agents; Bipolar Disorder; Electroconvulsive Therapy; Female; Humans; Lactation; Lamotr | 2016 |
Risks and benefits of psychotropic medication in pregnancy: cohort studies based on UK electronic primary care health records.
Topics: Adult; Antipsychotic Agents; Drug Utilization; Electronic Health Records; Female; Humans; Infant, Ne | 2016 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps | 2016 |
Guideline adherence for mentally ill reproductive-aged women on treatment with valproic acid: a retrospective chart review.
Topics: Abnormalities, Drug-Induced; Contraception Behavior; Female; Folic Acid; Guideline Adherence; Humans | 2016 |
Genetic and non-genetic animal models for autism spectrum disorders (ASD).
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Epigenesis, Genetic; Fe | 2016 |
Perinatal depression: treatment options and dilemmas.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Case-Control Studies; Cyclohexan | 2008 |
Teratogenicity of antiepileptic medications.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy | 2008 |
Epileptic disorders in pregnancy: an overview.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Hemorrhag | 2008 |
Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Cognition Disorders; Contraindications; | 2009 |
Valproic acid in pregnancy: how much are we endangering the embryo and fetus?
Topics: Abnormalities, Drug-Induced; Adolescent; Animals; Anticonvulsants; Autistic Disorder; Child; Child D | 2009 |
Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurolo
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Cognition Disorders; Contraindications; | 2009 |
The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
Topics: Anticonvulsants; Congenital Abnormalities; Delayed-Action Preparations; Drug Design; Epilepsy, Gener | 2009 |
The teratogenic risk of antiepileptic drug polytherapy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Drug Therapy, Combination; Female; Fetal Di | 2010 |
Valproic acid monotherapy in pregnancy and major congenital malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Case-Control Studies; Cohort Studies; Female; Humans; | 2010 |
[Treatment of bipolar disorder during pregnancy and in the postpartum period].
Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Contraindications; Female; Humans; Lactati | 2011 |
Side effects of phenobarbital in epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data | 2011 |
Epilepsy and pregnancy.
Topics: Anticonvulsants; Embryonic and Fetal Development; Epilepsy; Female; Fetal Diseases; Folic Acid; Huma | 2002 |
Medical genetics: 1. Clinical teratology in the age of genomics.
Topics: Adult; Alcohol Drinking; Anticonvulsants; Environmental Exposure; Epilepsy; Female; Genetic Counseli | 2002 |
Teratogen-induced limb defects.
Topics: Chorionic Villi Sampling; Female; Humans; Limb Deformities, Congenital; Male; Misoprostol; Phenytoin | 2002 |
Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Aci | 2003 |
Special considerations in treating bipolar disorder in women.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Breast Feeding; Contraceptives, Oral; Drug Inte | 2004 |
Management of bipolar disorder during pregnancy and the postpartum period.
Topics: Adolescent; Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbam | 2004 |
[Effect of anti-epileptic drugs on human placenta and the fetus].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Embryonic and Fetal Development; Epilepsy; Female; Fet | 2004 |
[Therapy of epilepsy: current strategy and tactics].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; | 2004 |
Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison.
Topics: Animals; Biological Transport; Carbamazepine; Embryonic Development; Female; Humans; Maternal-Fetal | 2004 |
Women are not the same as men: specific clinical issues for female patients with bipolar disorder.
Topics: Anticonvulsants; Antidepressive Agents; Benzodiazepines; Bipolar Disorder; Counseling; Dibenzothiaze | 2005 |
Teratogenicity of sodium valproate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Cleft Lip; | 2005 |
Management of epilepsy in women.
Topics: Anticonvulsants; Child; Contraceptives, Oral, Combined; Contraindications; Developmental Disabilitie | 2005 |
Valproate: a simple chemical with so much to offer.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Epilepsy; Female; History, 20th Century; Hu | 2005 |
Valproic acid in epilepsy : pregnancy-related issues.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Autistic Disorder; Epilepsy; Female; Humans; Infant, N | 2006 |
Recent advances on neural tube defects with special reference to Valproic Acid.
Topics: Adult; Animals; Anticonvulsants; Epilepsy; Epoxide Hydrolases; Female; Folic Acid; Folic Acid Defici | 2006 |
Major malformations with valproic acid.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antimanic Agents; Developmental Disabilities; Dose-Res | 2006 |
[Neuropsychological outcome following intrauterine exposure to valproate].
Topics: Female; Germany; Humans; Intellectual Disability; Mental Disorders; Practice Guidelines as Topic; Pr | 2006 |
Role of valproate across the ages. Treatment of epilepsy in adults.
Topics: Adult; Age Factors; Anticonvulsants; Child; Developmental Disabilities; Epilepsy; Female; Fertility; | 2006 |
Teratogenesis of sodium valproate.
Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans; Infant, Newborn; Intellectual | 2007 |
Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Contraceptives, Oral; Epilepsy; Female; Hormone | 2007 |
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 2008 |
ACOG Practice Bulletin: Clinical management guidelines for obstetrician-gynecologists number 92, April 2008 (replaces practice bulletin number 87, November 2007). Use of psychiatric medications during pregnancy and lactation.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety Disorders; Bipolar Disorder; Breast Feed | 2008 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; | 1983 |
The clinical pharmacology of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Hal | 1984 |
Advances in pediatric pharmacology and toxicology.
Topics: Animals; Anti-Bacterial Agents; Aspirin; Attention Deficit Disorder with Hyperactivity; Biological A | 1983 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
Increased platelet destruction in infancy and childhood.
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic; Animals; Autoimmune Diseases; Blood Platelets; Child; Ch | 1982 |
Pregnancy, teratogenesis, and epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb | 1994 |
[Sodium valproate--still a current antiepileptic agent?].
Topics: Aging; Drug Interactions; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Milk, Hum | 1994 |
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure.
Topics: Female; Humans; Pregnancy; Pregnancy Trimester, First; Prenatal Diagnosis; Spina Bifida Cystica; Val | 1993 |
Pharmacological issues in the treatment of bipolar disorder: focus on mood-stabilizing compounds.
Topics: Anticonvulsants; Antidepressive Agents; Bipolar Disorder; Carbamazepine; Drug Interactions; Female; | 1993 |
New approaches for drug and kinetic analysis in the maternal-fetal unit.
Topics: Animals; Diphenhydramine; Female; Fetus; Labetalol; Metoclopramide; Pregnancy; Pregnancy, Animal; Sh | 1995 |
Bipolar mood disorder: practical strategies for acute and maintenance phase treatment.
Topics: Acute Disease; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Clinical T | 1996 |
Issues in the treatment of women with bipolar illness.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bipolar Disorder; Buprop | 1997 |
Special considerations: use of lithium in children, adolescents, and elderly populations.
Topics: Abnormalities, Drug-Induced; Acetates; Adolescent; Adult; Age Factors; Aged; Amines; Anticonvulsants | 1998 |
Valproic acid use in psychiatry: issues in treating women of reproductive age.
Topics: Adult; Animals; Antimanic Agents; Female; Humans; Pregnancy; Pregnancy Complications; Teratogens; Va | 1998 |
[Current trends in the therapeutic use of thymic regulators].
Topics: Anticonvulsants; Antidepressive Agents; Depressive Disorder; Female; Humans; Lithium; Mood Disorders | 1998 |
Divalproex sodium--review of prophylactic migraine efficacy, safety and dosage, with recommendations.
Topics: Child; Female; Humans; Male; Migraine Disorders; Pregnancy; Valproic Acid | 1999 |
Comprehensive review of the psychiatric uses of valproate.
Topics: Anticonvulsants; Antimanic Agents; Anxiety Disorders; Bipolar Disorder; Depressive Disorder, Major; | 2000 |
Mood stabilizers during breastfeeding: a review.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Breast Feeding; Carbamazepine; Cyclohexanecarbo | 2000 |
Management of bipolar disorder.
Topics: Adolescent; Adult; Age Distribution; Antimanic Agents; Bipolar Disorder; Carbamazepine; Child, Presc | 2000 |
[Fetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema | 2000 |
Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Face; Female | 2001 |
Effects of antimanic mood-stabilizing drugs on fetuses, neonates, and nursing infants.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Antimanic Agents; Benzodiazepines; Breast Feed | 2001 |
[Fetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Fetal Diseases; Humans; Infant, Newborn; Pregn | 2001 |
Treatment of epilepsy in 3 specialized populations.
Topics: Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Human | 2001 |
The effects of lithium, valproic acid, and carbamazepine during pregnancy and lactation.
Topics: Adult; Anticonvulsants; Antimanic Agents; Carbamazepine; Female; Humans; Lactation; Lithium; Pregnan | 2001 |
Molecular basis of environmentally induced birth defects.
Topics: Abnormalities, Drug-Induced; Animals; Embryonic and Fetal Development; Female; Gene Expression Regul | 2002 |
[Antiepileptics during pregnancy and lactation. Pharmacokinetic data].
Topics: Anticonvulsants; Bromides; Carbamazepine; Clonazepam; Diazepam; Ethosuximide; Female; Fetus; Humans; | 1979 |
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Tr | 1977 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
[Valproic acid and pregnancy: an unresolved problem. A clinical case].
Topics: Abnormalities, Drug-Induced; Adolescent; Cesarean Section; Epilepsy; Female; Humans; Infant, Newborn | 1992 |
Pharmacokinetics of valproate in pregnancy: mother-foetus-newborn.
Topics: Anticonvulsants; Drug Interactions; Drug Monitoring; Female; Fetus; Humans; Infant, Newborn; Materna | 1992 |
Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Humans; Maternal-Fetal Exchang | 1991 |
Valproic acid.
Topics: Dosage Forms; Drug Administration Schedule; Drug Interactions; Female; Humans; Infant, Newborn; Milk | 1991 |
Developmental toxicity of valproic acid.
Topics: Animals; Dose-Response Relationship, Drug; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Speci | 1991 |
Sodium valproate and spina bifida.
Topics: Female; Humans; Pregnancy; Spinal Dysraphism; Valproic Acid | 1990 |
Valproic acid prenatal exposure. Association with lipomyelomeningocele.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Cleft Palate; Female; | 1989 |
[Fetal disease caused by sodium valproate. Apropos of a case].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1989 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
[Acute hepatic steatosis. Description of a clinical case of sodium valproate-induced acute hepatic steatosis].
Topics: Acute Disease; Adult; Biopsy; Child; Child, Preschool; Diagnosis, Differential; Fatty Liver; Fatty L | 1988 |
Antiepileptic drugs in adolescents.
Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru | 1987 |
Structure-metabolism relationships (SMR) for the prediction of health hazards by the Environmental Protection Agency. II. Application to teratogenicity and other toxic effects caused by aliphatic acids.
Topics: Animals; Female; Humans; Pregnancy; Structure-Activity Relationship; Teratogens; United States; Unit | 1986 |
Teratogen update: valproic acid.
Topics: Abnormalities, Drug-Induced; Animals; Epidemiologic Methods; Epilepsy; Female; Humans; Infant, Newbo | 1987 |
Congenital malformations associated with maternal use of valproic acid.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Epilepsy; Facial Bones; Female | 1987 |
Verification of the fetal valproate syndrome phenotype.
Topics: Abnormalities, Drug-Induced; Facial Bones; Female; Growth Disorders; Humans; Infant; Infant, Newborn | 1988 |
[Pharmacokinetic principles of the teratogenicity of drugs].
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Species Sp | 1988 |
Three cases of delivery under sodium valproate--placental transfer, milk transfer and probable teratogenicity of sodium valproate.
Topics: Abnormalities, Drug-Induced; Adult; Epilepsy; Female; Fingers; Humans; Infant, Newborn; Male; Matern | 1988 |
13 trials available for valproic acid and Pregnancy
| Article | Year |
|---|---|
Effects of in utero exposure to valproate or levetiracetam on the seizures and newborn histopathology of genetic absence epilepsy rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Female; | 2022 |
Cross-sectional evaluation of prescription of valproate and other antiepileptic drugs to pregnant women.
Topics: Anticonvulsants; Cross-Sectional Studies; Drug Prescriptions; Epilepsy; Female; Humans; Infant, Newb | 2021 |
Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double-blind, controlled, add-on clinical trial.
Topics: Adult; Amides; Animals; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Double-Blind Method | 2010 |
Treatment of nuclear-donor cells or cloned zygotes with chromatin-modifying agents increases histone acetylation but does not improve full-term development of cloned cattle.
Topics: Acetylation; Animals; Azacitidine; Cattle; Cell Nucleus; Cells, Cultured; Chromatin Assembly and Dis | 2012 |
Prevention of postpartum episodes in women with bipolar disorder.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Depression, Postpartum; Female; Follow-Up Studies; Humans | 2004 |
In utero antiepileptic drug exposure: fetal death and malformations.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Cognition; Female; Fetal Death; | 2006 |
Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives.
Topics: Anticonvulsants; Contraceptives, Oral; Drug Combinations; Epilepsy; Female; Humans; Kinetics; Lamotr | 2006 |
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy.
Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pregnancy; T | 1981 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
[Depakin 300 and Depakin-chrono in the therapy of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Electroencephalography; Epilepsy; Female; Human | 1999 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Tr | 1977 |
1005 other studies available for valproic acid and Pregnancy
| Article | Year |
|---|---|
Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Biomarkers; Brain; Ci | 2021 |
Prenatal exposure to valproic acid and treatment with intranasal oxytocin have sex-specific effects on behavior in Long Evans rats.
Topics: Administration, Intranasal; Animals; Anti-Anxiety Agents; Anticonvulsants; Autism Spectrum Disorder; | 2021 |
Correlation among gut microbiota, fecal metabolites and autism-like behavior in an adolescent valproic acid-induced rat autism model.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Feces; Female; Gastrointestinal Microbiome; Groo | 2022 |
The implementation of risk minimization measures to prevent teratogenic pregnancy outcomes related to oral retinoid and valproate use in Belgium.
Topics: Belgium; Cross-Sectional Studies; Female; Humans; Pregnancy; Pregnancy Outcome; Retinoids; Teratogen | 2022 |
Prenatal exposure to valproate and risk of congenital malformations-Could we have known earlier?-A population-based cohort study.
Topics: Anticonvulsants; Child; Cohort Studies; Denmark; Female; Humans; Male; Pregnancy; Pregnancy Complica | 2021 |
[Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center].
Topics: Anticonvulsants; Counseling; Epilepsy; Female; Folic Acid; Humans; Lamotrigine; Levetiracetam; Outpa | 2022 |
Valproic acid during pregnancy decrease the number of spermatogenic cells and testicular volume in the offspring of mice: Stereological quantification.
Topics: Animals; Anticonvulsants; Female; Leydig Cells; Male; Mice; Mice, Inbred BALB C; Models, Animal; Pre | 2021 |
Pre-pregnancy counseling for women with epilepsy: Can we do better?
Topics: Anticonvulsants; Counseling; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Teratogen | 2021 |
Transgenerational adverse effects of valproate? A patient report from 90 affected families.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cleft Lip; Cleft Palate; Drug-Related Side Ef | 2022 |
Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach.
Topics: Animals; Biological Transport; Biomarkers; Caproates; Cell Line; Dose-Response Relationship, Drug; F | 2022 |
Assessment of behavioral, morphological and electrophysiological changes in prenatal and postnatal valproate induced rat models of autism spectrum disorder.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Brain; Dise | 2021 |
Effect of Valproic Acid on Maternal - Fetal Heart Rates and Coupling in Mice on Embryonic day 15.5 (E15.5).
Topics: Animals; Autism Spectrum Disorder; Epilepsy; Female; Fetus; Heart Rate, Fetal; Mice; Pregnancy; Valp | 2021 |
Valproic acid promotes SOD2 acetylation: a potential mechanism of valproic acid-induced oxidative stress in developing systems.
Topics: Acetylation; Antioxidants; Female; Glutathione; Glutathione Disulfide; Humans; Neural Tube Defects; | 2021 |
Modified Xenopus laevis approach (R-FETAX) as an alternative test for the evaluation of foetal valproate spectrum disorder.
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Disease Models, Animal; Embryo, Nonmammalian | 2022 |
Effectiveness of risk minimization measures for valproate: a drug utilization study based on implementation of a risk minimization programme in Europe, analysis of data from the UK.
Topics: Anticonvulsants; Cohort Studies; Drug Utilization; Europe; Female; Humans; Male; Pregnancy; United K | 2022 |
Valproate Restrictions in Sweden and Norway: Online survey suggests implementation deficit.
Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Norway; Pregnancy; Sweden; Valproic Aci | 2022 |
Valproate prescription to women of childbearing age in English primary care: repeated cross-sectional analyses and retrospective cohort study.
Topics: Adolescent; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Cohort Studies; Contraceptio | 2022 |
Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
iTRAQ-Based Proteomics Analysis of Rat Cerebral Cortex Exposed to Valproic Acid before Delivery.
Topics: Animals; Autism Spectrum Disorder; Cerebral Cortex; Disease Models, Animal; Female; Pregnancy; Prena | 2022 |
Early postnatal handling alters social behavior, learning, and memory of pre- and postnatal VPA-induced rat models of autism in a context-based manner.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
An in vitro Study on the Contractility of Epileptic Myometrium and Effects of Antiepileptic Agents on Oxytocin-Induced Contractions of Myometrium Isolated from Absence Epileptic WAG/Rij Rats.
Topics: Animals; Anticonvulsants; Antifibrotic Agents; Dose-Response Relationship, Drug; Female; In Vitro Te | 2022 |
Achieving neurologically desirable outcomes to pregnancy in women with epilepsy.
Topics: Anticonvulsants; Australia; Epilepsy; Female; Humans; Levetiracetam; Pregnancy; Pregnancy Complicati | 2022 |
Alterations of the Hippocampal Networks in Valproic Acid-Induced Rat Autism Model.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Hippocampus; M | 2022 |
The GABAB receptor agonist STX209 reverses the autism‑like behaviour in an animal model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Postweaning positive modulation of α5GABAA receptors improves autism-like features in prenatal valproate rat model in a sex-specific manner.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Calcium; Disease Models, Ani | 2022 |
Sumac and gallic acid-loaded nanophytosomes ameliorate hippocampal oxidative stress via regulation of Nrf2/Keap1 pathway in autistic rats.
Topics: Animals; Antioxidants; Autistic Disorder; Female; Gallic Acid; Glutathione; Glutathione Peroxidase; | 2022 |
Neuroprotective effect of the standardised extract of Bacopa monnieri (BacoMind) in valproic acid model of autism spectrum disorder in rats.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Bacopa; Catalase; Disease Models, Animal; Female; H | 2022 |
Prescribing Trends for Valproate Among Pregnant Women: A Cross-sectional Study in 2013 and 2016 Using the French Health Insurance Database.
Topics: Anticonvulsants; Cross-Sectional Studies; Female; Humans; Insurance, Health; Pregnancy; Pregnant Wom | 2022 |
Autism-like symptoms by exposure to air pollution and valproic acid-induced in male rats.
Topics: Air Pollutants; Air Pollution; Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Anima | 2022 |
National compliance with UK wide guidelines for usage of valproate in women of childbearing potential.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Female; Humans; Infant; Pregnancy; United Kingdom; V | 2022 |
Impact of regulatory safety notices on valproate prescribing and pregnancy outcome among women of child-bearing potential in Scotland: a population-based cohort study.
Topics: Abortion, Spontaneous; Cohort Studies; Female; Humans; Male; Pregnancy; Pregnancy Outcome; Scotland; | 2022 |
Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Cerebellum; Disease Models, Animal; Female; ga | 2022 |
Postnatal baicalin ameliorates behavioral and neurochemical alterations in valproic acid-induced rodent model of autism: The possible implication of sirtuin-1/mitofusin-2/ Bcl-2 pathway.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models | 2022 |
Sodium valproate continues to be prescribed in hundreds of pregnancies, data show.
Topics: Anticonvulsants; Bipolar Disorder; Female; Humans; Pregnancy; Valproic Acid | 2022 |
Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Interneurons; | 2022 |
Trends in the prescription of anti-seizure medicines for pregnant women outpatients with epilepsy during 2016-2020 in Japan.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Japan; Lamotrigine; Levetiracetam; Outpatients; Pregnancy | 2022 |
Reinforced behavioral variability in the valproate rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Humans; Pregnancy; Prenatal Expos | 2022 |
Juvenile handling rescues autism-related effects of prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues.
Topics: Animals; Female; Humans; Induced Pluripotent Stem Cells; Pregnancy; Rats; Teratogens; Valproic Acid | 2022 |
Histamine H3 receptor antagonist, ciproxifan, alleviates cognition and synaptic plasticity alterations in a valproic acid-induced animal model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Cognition; Disease Models, Animal; Female; His | 2022 |
Vitamin A supplementation ameliorates prenatal valproic acid-induced autism-like behaviors in rats.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Models, Animal; F | 2022 |
Prenatal reduction of E14.5 embryonically fate-mapped pyramidal neurons in a mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Humans; Mice; | 2022 |
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.
Topics: Anticonvulsants; Autism Spectrum Disorder; Autistic Disorder; Carbamazepine; Child; Cohort Studies; | 2022 |
Comprehensive strategy required to eliminate valproate prescribing in pregnancy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2022 |
Prenatal exposure to valproic acid alters Reelin, NGF expressing neuron architecture and impairs social interaction in their autistic-like phenotype male offspring.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Caspase 3; Disease Models, A | 2022 |
Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects.
Topics: Animals; Autism Spectrum Disorder; Cellular Senescence; Female; Mice; Microcephaly; Neural Tube Defe | 2022 |
TCHis mitigate oxidative stress and improve abnormal behavior in a prenatal valproic acid-exposed rat model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; Hydroxyethylru | 2022 |
Seizure medication and planned pregnancy: balancing the risks and outcomes.
Topics: Anticonvulsants; Epilepsy; Family Planning Services; Female; Humans; Pregnancy; Pregnancy Complicati | 2022 |
Sex difference in cognitive behavioral alterations and barrel cortex neuronal responses in rats exposed prenatally to valproic acid under continuous environmental enrichment.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cognition; Disease Models, Animal; Female; Huma | 2022 |
Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Infant; Phenobarbital; Pregnancy; Prenatal Exposur | 2022 |
Modifications of Behavior and Inflammation in Mice Following Transplant with Fecal Microbiota from Children with Autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Child; Disease Models, Animal; Female; Humans; | 2022 |
Changes of cerebellar cortex in a valproic acid-induced rat model of autism.
Topics: Animals; Autistic Disorder; Cerebellar Cortex; Cerebellum; Disease Models, Animal; Female; Humans; M | 2022 |
Alterations in the intrinsic discharge activity of CA1 pyramidal neurons associated with possible changes in the NADPH diaphorase activity in a rat model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; NADPH Dehydrog | 2022 |
Establishing or Excluding a Diagnosis of Fetal Valproate Spectrum Disorder is a Multi-layered Process.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Humans; Pregnancy; Valproic Acid | 2021 |
A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Maraviroc; Mice | 2022 |
Autism Spectrum Disorder Model Mice Induced by Prenatal Exposure to Valproic Acid Exhibit Enhanced Empathy-Like Behavior via Oxytocinergic Signaling.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Empathy; Female; Humans | 2022 |
Valproate Teratogenicity: A Moving Target.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 2022 |
Spontaneous Partial Regression of Bilateral Grade III Corneal Dermoids Associated With Fetal Valproate Spectrum Disorder.
Topics: Abnormalities, Drug-Induced; Child; Choristoma; Corneal Diseases; Dermoid Cyst; Female; Growth Disor | 2022 |
Transcriptomic analysis in the striatum reveals the involvement of Nurr1 in the social behavior of prenatally valproic acid-exposed male mice.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; Male; M | 2022 |
Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Class I Phosphatidylinositol 3-Kinases; ErbB Recept | 2022 |
Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; Male; P | 2023 |
Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Male; Neurons; | 2022 |
Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro.
Topics: Acetylation; Animals; Female; Gastrulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Hu | 2022 |
Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota-Gut-Brain Axis Modulation in a Valproic Acid Mouse Model.
Topics: Animals; Anthocyanins; Autism Spectrum Disorder; Autistic Disorder; Blueberry Plants; Brain-Gut Axis | 2022 |
Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation.
Topics: Animals; Autism Spectrum Disorder; Calcium; Disease Models, Animal; Female; Humans; Hyperalgesia; Ma | 2022 |
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Epilepsy, Absence; Female; Genomics; Humans; Mal | 2022 |
Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Male; Phenobarbital; Pregnanc | 2022 |
Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner.
Topics: Animals; Behavior, Animal; Chlorpyrifos; Corn Oil; Female; gamma-Aminobutyric Acid; Humans; Male; Mi | 2022 |
Epilepsy and pregnancy. Factors associated with epileptic seizures during pregnancy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Pregnancy; Seizures; V | 2023 |
Granulocyte Colony-Stimulating Factor Improved Core Symptoms of Autism Spectrum Disorder via Modulating Glutamatergic Receptors in the Prefrontal Cortex and Hippocampus of Rat Brains.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autism Spectrum Disorder; Brain; | 2022 |
[French Expert advice on the management of valproate in childbearing and pregnant women with bipolar disorder].
Topics: Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Child; Female; Humans; Pregnancy; Pregnant | 2022 |
Compliance with Prescribing and Dispensing Conditions for Valproate and Related Substances in Girls and Women of Childbearing Potential: A Survey of Community Pharmacists in France.
Topics: Drug Prescriptions; Female; Humans; Pharmacists; Pregnancy; Prenatal Exposure Delayed Effects; Surve | 2023 |
Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses.
Topics: Animals; Apoptosis; Female; Fetus; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Pregnancy; | 2022 |
Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity.
Topics: Animals; Cell Line; Female; Mammals; Mice; Neurons; Neurotoxicity Syndromes; Pregnancy; Rats; Valpro | 2022 |
Prenatal Carbamazepine Exposure and Academic Performance in Adolescents: A Population-Based Cohort Study.
Topics: Academic Performance; Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Cohort Stu | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Pregnancy; Pren | 2023 |
GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Pregnancy; Pren | 2023 |
GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Pregnancy; Pren | 2023 |
GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Pregnancy; Pren | 2023 |
Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Biomarkers; Female; Humans; Lutein; Nanoparticles; Oxi | 2023 |
Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Biomarkers; Female; Humans; Lutein; Nanoparticles; Oxi | 2023 |
Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Biomarkers; Female; Humans; Lutein; Nanoparticles; Oxi | 2023 |
Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Biomarkers; Female; Humans; Lutein; Nanoparticles; Oxi | 2023 |
Photobiomodulation Attenuated Cognitive Dysfunction and Neuroinflammation in a Prenatal Valproic Acid-Induced Autism Spectrum Disorder Mouse Model.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; | 2022 |
The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Erythropoietin; Female; gamma- | 2023 |
The Awareness and Adherence of the Valproate Pregnancy Prevention Program: A Questionnaire Survey among Healthcare Professionals, Pharmacists, and Patients in Denmark.
Topics: Attitude of Health Personnel; Denmark; Female; General Practitioners; Humans; Pharmacists; Pregnancy | 2023 |
Inhalation of Cananga odorata essential oil relieves anxiety behaviors in autism-like rats via regulation of serotonin and dopamine metabolism.
Topics: Animals; Anxiety; Autistic Disorder; Cananga; Disease Models, Animal; Dopamine; Female; Oils, Volati | 2023 |
Proposal for reference values for the developmental effects of valproate based on human data using a benchmark dose approach.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benchmarking; Female; Humans; Pregnancy; Pregnancy Com | 2023 |
Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice.
Topics: Animals; Anticonvulsants; Aripiprazole; Autism Spectrum Disorder; Behavior, Animal; Disease Models, | 2023 |
Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Down | 2023 |
Astrocyte responses to postnatal erythropoietin and nano-erythropoietin treatments in a valproic acid-induced animal model of autism.
Topics: Animals; Astrocytes; Autistic Disorder; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, A | 2023 |
Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis.
Topics: Animals; Aripiprazole; Autism Spectrum Disorder; Autistic Disorder; Brain-Derived Neurotrophic Facto | 2023 |
Ameliorating age-dependent effects of resveratrol on VPA-induced social impairments and anxiety-like behaviors in a rat model of neurodevelopmental disorder.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans | 2023 |
Brief intervention reduces prescription of sodium valproate in women of childbearing age.
Topics: Anticonvulsants; Bipolar Disorder; Crisis Intervention; Female; Humans; Pregnancy; Prescriptions; Te | 2023 |
Neonatal Exposure to Valproate Induces Long-Term Alterations in Steroid Hormone Levels in the Brain Cortex of Prepubertal Rats.
Topics: Animals; Autism Spectrum Disorder; Brain; Cerebral Cortex; Disease Models, Animal; Estradiol; Female | 2023 |
Alteration in social interaction and tactile discrimination of juvenile autistic-like rats following tactile stimulation and whisker deprivation.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Female; Male; Pregnancy; Rats; Social Interact | 2023 |
Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders.
Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Ch | 2023 |
Effects of varied‑intensity endurance exercise training on oxidative and antioxidant factors in the liver of rats with valproic acid‑induced autism.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Catalase; Female; Humans; Liver; | 2023 |
Specific fetal malformations following intrauterine exposure to antiseizure medication.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Carbamazepine; Female; Humans; Male; Pregna | 2023 |
[Comment on: "French Expert advice on the management of valproate in childbearing and pregnant women with bipolar disorder"].
Topics: Anticonvulsants; Bipolar Disorder; Female; Humans; Pregnancy; Pregnant Women; Valproic Acid | 2023 |
Decreased Expression of EP3 Receptor mRNA in the Brain of Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Female; Mice; MicroRNAs; Neuroinfl | 2023 |
Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism.
Topics: Acetylcarnitine; Animals; Autism Spectrum Disorder; Autistic Disorder; Encephalitis; Female; Microbi | 2023 |
Valproate-induced murine autism spectrum disorder is associated with dysfunction of amygdala parvalbumin interneurons and downregulation of AMPK/SIRT1/PGC1α signaling.
Topics: AMP-Activated Protein Kinases; Amygdala; Animals; Autism Spectrum Disorder; Behavior, Animal; Caspas | 2023 |
Social deficits in mice prenatally exposed to valproic acid are intergenerationally inherited and rescued by social enrichment.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female | 2023 |
Exposure to Valproic acid (VPA) resulted in alterations in the expression of angiogenic genes (NRP-1, VEGFA, VEGFR-2 and sFlt1) and histological modifications in the placenta of mice (Mus musculus).
Topics: Animals; Female; Mice; Neuropilin-1; Placenta; Pregnancy; Valproic Acid; Vascular Endothelial Growth | 2023 |
Retinoic acid supplementation ameliorates motor incoordination via RARα-CBLN2 in the cerebellum of a prenatal valproic acid-exposed rat autism model.
Topics: Animals; Ataxia; Autism Spectrum Disorder; Autistic Disorder; Cerebellum; Dietary Supplements; Disea | 2023 |
Neuroprotective Efficacy of Fisetin Against VPA-Induced Autistic Neurobehavioral Alterations by Targeting Dysregulated Redox Homeostasis.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Female; Humans; Oxidation-Reduction; Pregnancy; | 2023 |
Phosphodiesterase inhibitor, ibudilast alleviates core behavioral and biochemical deficits in the prenatal valproic acid exposure model of autism spectrum disorder.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Disease Models, Animal; Female; Inflammation Mediators; | 2023 |
Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study.
Topics: Contraception; Europe; Female; Humans; Interrupted Time Series Analysis; Italy; Pregnancy; Valproic | 2023 |
Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and brain cytokines.
Topics: Anhedonia; Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Cognition; Cytokines; Disease | 2023 |
Striatal synaptic changes and behavior in adult mouse upon prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2023 |
Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Türkiye.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant; Infant, Newborn; Lamotrigine; Preg | 2023 |
Syringic acid alleviates valproic acid induced autism via activation of p38 mitogen-activated protein kinase: Possible molecular approach.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models | 2023 |
Effects of valproic acid on syncytialization in human placental trophoblast cell lines.
Topics: Amino Acid Transport System ASC; Anticonvulsants; ATP-Binding Cassette Transporters; Cell Line; Fema | 2023 |
Chronic inhibition of astrocytic aquaporin-4 induces autistic-like behavior in control rat offspring similar to maternal exposure to valproic acid.
Topics: Animals; Aquaporins; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, | 2023 |
A Shared Pathogenic Mechanism for Valproic Acid and
Topics: Anencephaly; Animals; Brain; Female; Glycogen Synthase Kinase 3 beta; Humans; Mice; Mice, Knockout; | 2023 |
Risperidone impedes glutamate excitotoxicity in a valproic acid rat model of autism: Role of ADAR2 in AMPA GluA2 RNA editing.
Topics: Adenosine Deaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autism Spect | 2023 |
The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism.
Topics: Animals; Antipsychotic Agents; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Diseas | 2023 |
Prescribing of valproate and oral antiepileptics for women of childbearing age and during pregnancy in Germany between 2010 and 2020.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Middle Aged; Pregnancy; Presc | 2023 |
Sex-related beneficial effects of exercise on cardiac function and rhythm in autistic rats.
Topics: Animals; Autistic Disorder; Female; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 2023 |
Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Mice; Pregnancy; Proteomics; Ubiq | 2023 |
Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the male offspring rats.
Topics: Animals; Autistic Disorder; Brain; Crocus; Disease Models, Animal; Female; Glutathione; Humans; Male | 2023 |
Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Child; Disease | 2023 |
[Safe and Effective Management of Epilepsy in Pregnancy].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Levetiracetam; Pregnancy; Seizures; Valproic Acid | 2023 |
Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid.
Topics: Adolescent; Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Hum | 2023 |
Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control.
Topics: Anticonvulsants; Australia; Epilepsy; Female; Humans; Lamotrigine; Pregnancy; Pregnancy Complication | 2023 |
Real-world practices for the care of women with epilepsy during pregnancy: A Canadian perspective.
Topics: Adult; Anticonvulsants; Canada; Epilepsy; Epilepsy, Generalized; Female; Humans; Pregnancy; Pregnanc | 2023 |
MA-5 ameliorates autism-like behavior in mice prenatally exposed to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2023 |
"Comparative evaluation of different chemical agents induced Autism Spectrum Disorder in experimental Wistar rats".
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Chlorpyrifos; Cytokines; Dioxins; Disease Model | 2024 |
The Valproic Acid Dilemma: Safe Alternatives For Pregnant Women And Women Of Childbearing Age With Epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnant Women; Valproic Acid | 2023 |
Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Carbamates; Disea | 2020 |
The possible neuroprotective role of grape seed extract on the histopathological changes of the cerebellar cortex of rats prenatally exposed to Valproic Acid: animal model of autism.
Topics: Animals; Autistic Disorder; Cerebellar Cortex; Disease Models, Animal; Female; Neuroprotective Agent | 2019 |
Prenatal exposure to valproic acid is associated with altered neurocognitive function and neurogenesis in the dentate gyrus of male offspring rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Behavior, Animal; | 2019 |
Did advice on the prescription of sodium valproate reduce prescriptions to women? An observational study in three European countries between 2007 and 2016.
Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Child; Cohort Studies; Databases, Factual; Epi | 2019 |
Exome sequencing in patients with antiepileptic drug exposure and complex phenotypes.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E | 2020 |
Prescription of antiepileptic medicines including valproate in pregnant women: A study in three European countries.
Topics: Adolescent; Adult; Anticonvulsants; Child; Databases, Factual; Female; France; Humans; Italy; Middle | 2019 |
Sex-specific effects of prenatal valproic acid exposure on sociability and neuroinflammation: Relevance for susceptibility and resilience in autism.
Topics: Animals; Animals, Outbred Strains; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Anima | 2019 |
Improvement of autistic-like behaviors in adult rats prenatally exposed to valproic acid through early suppression of NMDA receptor function.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Dizocilpine Maleate; Excitatory Am | 2020 |
Exposure to valproic acid during middle to late-stage corticogenesis induces learning and social behavioral abnormalities with attention deficit/hyperactivity in adult mice.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Cerebral Cortex; Female; M | 2019 |
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Disease Susceptibility; | 2019 |
Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development.
Topics: Acetylation; Animals; Cell Differentiation; Embryonic Development; Female; Fetal Development; Fetal | 2019 |
Classifying by cause and preventing the many causes of spina bifida and anencephaly.
Topics: Anencephaly; Anticonvulsants; Diabetes Mellitus; Female; Folic Acid; Folic Acid Deficiency; Food, Fo | 2020 |
Increased Expression of Kv10.2 in the Hippocampus Attenuates Valproic Acid-Induced Autism-Like Behaviors in Rats.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Biological Therapy; Ether-A-Go-Go Potassium C | 2019 |
Radial Ray Malformation.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Amniocentesis; Amniotic Band Syndrome; Anal Ca | 2019 |
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cohort Studies; Epilepsy; Female; Humans; L | 2020 |
Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Folic Acid; Humans; India; Lamotrigine; Levetiracetam | 2020 |
Treatment decisions in women of childbearing age on valproate.
Topics: Adult; Anticonvulsants; Decision Making; Epilepsy; Female; Humans; Informed Consent; Patient Educati | 2020 |
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Topics: Animals; Cell Transformation, Neoplastic; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Diet, | 2019 |
Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism.
Topics: Animals; Anticonvulsants; Autistic Disorder; Brain; Disease Models, Animal; Female; Locomotion; Male | 2020 |
Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats.
Topics: Animals; Behavior, Animal; Brain; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; | 2020 |
In utero exposure to valproic acid disrupts ascending projections to the central nucleus of the inferior colliculus from the auditory brainstem.
Topics: Animals; Auditory Pathways; Autism Spectrum Disorder; Brain Stem; Disease Models, Animal; Female; In | 2020 |
5-aminolevulinic acid inhibits oxidative stress and ameliorates autistic-like behaviors in prenatal valproic acid-exposed rats.
Topics: Aminolevulinic Acid; Animals; Anticonvulsants; Autistic Disorder; Dose-Response Relationship, Drug; | 2020 |
Valproate risk form-Surveying 215 clinicians involving 4775 encounters.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Physicians | 2020 |
Neurocognition after prenatal levetiracetam, lamotrigine, carbamazepine or valproate exposure.
Topics: Anticonvulsants; Carbamazepine; Child; Child Development; Cognitive Dysfunction; Female; Humans; Lam | 2020 |
Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Male; Mice; Pregnancy; Prenatal E | 2020 |
Standard of Care: Reasonable But Not Perfect.
Topics: Abnormalities, Drug-Induced; Adult; Arnold-Chiari Malformation; Female; Humans; Hydrocephalus; Infan | 2020 |
Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD-1 mouse embryos with neural tube defects.
Topics: Animals; Female; Mice; Neural Tube Defects; Neurulation; Pregnancy; STAT3 Transcription Factor; Tera | 2020 |
Analysis of Perinatal Women Attending a Mother and Baby Unit Taking Sodium Valproate or Lithium with a Diagnosis of Bipolar Affective Disorder.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Breast Feeding; Female; Follow-Up Studies; Humans; Lithiu | 2020 |
Valproic acid induces nuclear factor erythroid 2-related factor 2 expression in fetal and neonatal brains but not in adult brain: evidence of the gamma-aminobutyric acid-shift hypothesis.
Topics: Age Factors; Animals; Brain; Female; GABA Agents; gamma-Aminobutyric Acid; Mice; NF-E2-Related Facto | 2020 |
Quercetin prevents alterations of behavioral parameters, delta-aminolevulinic dehydratase activity, and oxidative damage in brain of rats in a prenatal model of autism.
Topics: Animals; Anticonvulsants; Autistic Disorder; Brain Chemistry; Female; Motor Activity; Neuroprotectiv | 2020 |
Pregnancy after valproate withdrawal-Fetal malformations and seizure control.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2020 |
The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids.
Topics: Animals; Blood Pressure; Decitabine; Dexamethasone; DNA (Cytosine-5-)-Methyltransferases; Epigenesis | 2020 |
Oxytocin ameliorates maternal separation-induced ultrasonic vocalisation calls in mouse pups prenatally exposed to valproic acid.
Topics: ADP-ribosyl Cyclase 1; Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Maternal D | 2020 |
Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA).
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; Brain; Epigenesis, Genetic; Female; Gene Expres | 2020 |
The impact and challenges of the 2018 MHRA statement on the use of sodium valproate in women of childbearing age during the first year of implementation, in a UK epilepsy centre.
Topics: Adolescent; Adult; Anticonvulsants; Contraception; Contraindications, Drug; Cross-Sectional Studies; | 2020 |
Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system.
Topics: Animals; Anticonvulsants; Antioxidants; Autism Spectrum Disorder; Disease Models, Animal; Female; Hy | 2020 |
A rat model of valproate teratogenicity from chronic oral treatment during pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; | 2020 |
Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: A screening test.
Topics: Animals; Autistic Disorder; Cerebellum; Cerebral Cortex; Female; GABA Agents; gamma-Aminobutyric Aci | 2020 |
Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period.
Topics: Animals; Anticonvulsants; Female; Gene Expression; Gestational Age; Male; Membrane Transport Protein | 2020 |
Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Brain; Female; Inflammation; M | 2020 |
Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Expl | 2020 |
Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study.
Topics: Anticonvulsants; Child; Child Development Disorders, Pervasive; Child, Preschool; Cohort Studies; Da | 2020 |
Is the Medicines and Healthcare products Regulator Agency (MHRA) guidance on sodium valproate acceptable to women of childbearing age?
Topics: Anticonvulsants; Delivery of Health Care; Epilepsy; Female; Government Agencies; Humans; Pregnancy; | 2020 |
Sodium valproate prescription to women of childbearing age in a New Zealand inpatient psychiatric unit.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Clinical Audit; | 2020 |
Prenatal pregabalin is associated with sex-dependent alterations in some behavioral parameters in valproic acid-induced autism in rat offspring.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Choice Behavior; Disease Models, Animal; Fema | 2020 |
Heart malformation is an early response to valproic acid in developing zebrafish.
Topics: Animals; Anticonvulsants; Embryonic Development; Female; Heart; Heart Rate; Male; Pregnancy; Prenata | 2020 |
Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Biomarkers; Disease Models, Animal; Female; F | 2020 |
Effects of prenatal exposure to valproic acid or poly(I:C) on ultrasonic vocalizations in rat pups: The role of social cues.
Topics: Animals; Autism Spectrum Disorder; Cues; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; | 2020 |
Abnormal reinforcement learning in a mice model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Conditioning, Psychological; Disease Models, Animal; Female; Lear | 2020 |
Kappa Opioid Receptor-mediated Modulation of Social Responding in Adolescent Rats and in Rats Prenatally Exposed to Valproic Acid.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Female; Male; Pregnancy; Prenatal Exposu | 2020 |
Understanding and Responding to Prescribing Patterns of Sodium Valproate-Containing Medicines in Pregnant Women and Women of Childbearing Age in Western Cape, South Africa.
Topics: Epilepsy; Female; Humans; Practice Patterns, Physicians'; Pregnancy; Pregnant Women; South Africa; V | 2021 |
Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats.
Topics: Animals; Autism Spectrum Disorder; Chlorpyrifos; Disease Models, Animal; Enzyme Inhibitors; Female; | 2020 |
Maternal Sodium Valproate Exposure Alters Neuroendocrine-Cytokines and Oxido-inflammatory Axes in Neonatal Albino Rats.
Topics: Animals; Animals, Newborn; Cytokines; Female; Inflammation; Maternal Exposure; Neurosecretory System | 2021 |
Valproic acid exposure impairs ultrasonic communication in infant, adolescent and adult rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Communication; Female; Male; Pregnancy; Pre | 2020 |
Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Middle Aged; Pregnancy; Risk Assessmen | 2020 |
First do no harm: valproate and medicines safety in pregnancy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid | 2020 |
Valproic acid treated female Long-Evans rats are impaired on attentional set-shifting.
Topics: Animals; Attention; Autism Spectrum Disorder; Behavior, Animal; Cognitive Dysfunction; Disease Model | 2021 |
Alterations in the autonomic nerve activities of prenatal autism model mice treated with valproic acid at different developmental stages.
Topics: Animals; Anticonvulsants; Autistic Disorder; Autonomic Pathways; Behavior, Animal; Disease Models, A | 2020 |
Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France.
Topics: Adult; Anticonvulsants; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Epilepsy | 2020 |
BALB/c female subjected to valproic acid during gestational period exhibited greater microglial and behavioral changes than male mice: A significant contra intuitive result.
Topics: Animals; Anticonvulsants; Behavior, Animal; Calcium-Binding Proteins; Environment; Exploratory Behav | 2021 |
Effectiveness of risk minimisation measures for valproate: A drug utilisation study in Europe.
Topics: Cohort Studies; Drug Utilization; Europe; Female; Humans; Pregnancy; Spain; Valproic Acid | 2021 |
Antiseizure medication use during pregnancy and risk of ASD and ADHD in children.
Topics: Adolescent; Adult; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum D | 2020 |
Attenuation of neurobehavioural abnormalities by papaverine in prenatal valproic acid rat model of ASD.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Dose-Response Relationship, Drug; Doublecortin P | 2021 |
Lateral septum microglial changes and behavioral abnormalities of mice exposed to valproic acid during the prenatal period.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; GABA Agents; Mi | 2021 |
Valproic acid alters nitric oxide status in neurulating mouse embryos.
Topics: Animals; Anticonvulsants; Antimanic Agents; Catalase; Embryo, Mammalian; Female; Glutathione; Matern | 2021 |
Glyoxalase 1 Inhibitor Alleviates Autism-like Phenotype in a Prenatal Valproic Acid-Induced Mouse Model.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2020 |
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen | 2020 |
Effectiveness of risk minimisation measures for valproate: A cross-sectional survey among physicians in Europe.
Topics: Anticonvulsants; Cross-Sectional Studies; Europe; Female; Humans; Physicians; Pregnancy; Valproic Ac | 2021 |
Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study.
Topics: Animals; Animals, Newborn; Apoptosis; Autistic Disorder; Brain Chemistry; Cytokines; Disease Models, | 2021 |
Folic acid dose, valproate, and fetal malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Female; Folic Acid; Humans; Pregnancy; Preg | 2021 |
Combined the GABA-A and GABA-B receptor agonists attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Drug T | 2021 |
The DNA repair protein ATM as a target in autism spectrum disorder.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Autism Spectrum Disorder; Behavior, Animal; Disease | 2021 |
An open study of valproate in subfertile men with epilepsy.
Topics: Adult; Anticonvulsants; Drug Substitution; Epilepsy; Female; Greece; Humans; Infertility, Male; Lamo | 2020 |
Valproic acid-exposed astrocytes impair inhibitory synapse formation and function.
Topics: Animals; Anticonvulsants; Astrocytes; Cells, Cultured; Coculture Techniques; Female; GABAergic Neuro | 2021 |
Postnatal AVP treatments prevent social deficit in adolescence of valproic acid-induced rat autism model.
Topics: Adolescent; Animals; Arginine Vasopressin; Autistic Disorder; Behavior, Animal; Disease Models, Anim | 2021 |
Active Surveillance of the Safety of Medications Used During Pregnancy.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Cohort Studies; Data Mining; Databases, Factual; Fe | 2021 |
Use of valproate in pregnancy and in women of childbearing age between 2014 and 2018 in Switzerland: a retrospective analysis of Swiss healthcare claims data.
Topics: Adolescent; Adult; Anticonvulsants; Delivery of Health Care; Female; Humans; Middle Aged; Pregnancy; | 2021 |
Fetal valproate syndrome with coronary arteriovenous fistula: a case report.
Topics: Abnormalities, Drug-Induced; Arteriovenous Fistula; Female; Humans; Pregnancy; Pregnancy Trimester, | 2021 |
Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter?
Topics: Anticonvulsants; Autism Spectrum Disorder; Case-Control Studies; Child; Child, Preschool; Dose-Respo | 2021 |
Perinatal exposure to BDE-47 exacerbated autistic-like behaviors and impairments of dendritic development in a valproic acid-induced rat model of autism.
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; Dendrites; Disease Models, Animal; Environmenta | 2021 |
Valproate in pregnancy: comment from the SAPP.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Female; Humans; Pregnancy; Valproic Acid | 2021 |
Valproate in pregnancy: authors' reply.
Topics: Female; Humans; Pregnancy; Valproic Acid | 2021 |
Hippocampal neurons isolated from rats subjected to the valproic acid model mimic in vivo synaptic pattern: evidence of neuronal priming during early development in autism spectrum disorders.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Cells, Cultured; Disease Model | 2021 |
Spatiotemporal evaluation of the mouse embryonic redox environment and histiotrophic nutrition following treatment with valproic acid and 1,2-dithiole-3-thione during early organogenesis.
Topics: Amino Acids; Animals; Anticonvulsants; Antineoplastic Agents; Cysteine; Embryo, Mammalian; Female; G | 2021 |
Brain and plasma amino acid concentration in infant rats prenatally exposed to valproic acid.
Topics: Amino Acids; Animals; Autism Spectrum Disorder; Brain; Female; Male; Plasma; Pregnancy; Prenatal Exp | 2021 |
Gestational valproic acid exposure induces epigenetic modifications in murine decidua.
Topics: Animals; Decidua; Epigenesis, Genetic; Female; Histones; Mice; Pregnancy; Valproic Acid | 2021 |
Valproate usage in pregnancy: An audit from the Kerala Registry of Epilepsy and Pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; India; Pregnancy; Pre | 2021 |
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Human | 2021 |
Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid.
Topics: Animals; Autistic Disorder; Biomarkers; Brain; Disease Susceptibility; Enzyme Activation; Female; Im | 2021 |
The contribution of non-drug factors to fetal malformation in anti-seizure-medication-treated pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2021 |
Declining Levels of Specialized Synaptic Surface Proteins in nNOS-Expressing Interneurons in Mice Treated Prenatally with Valproic Acid.
Topics: Animals; Female; Interneurons; Male; Membrane Proteins; Mice; Nitric Oxide Synthase Type I; Pregnanc | 2021 |
Antiseizure medications and fetal nutrients: Effects on choline transporters in a human placental cell line.
Topics: Adult; Anticonvulsants; Antigens, CD; Cell Line; Choline; Female; Fetus; Folic Acid; Gene Expression | 2021 |
Increased volumes of lobule VI in a valproic acid model of autism are associated with worse set-shifting performance in male Long-Evan rats.
Topics: Animals; Attention; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Brain; Cerebellum | 2021 |
Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Dietary Supplements; Disease | 2021 |
Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring.
Topics: Adult; Animals; Astrocytes; Autism Spectrum Disorder; Blood-Brain Barrier; Cell Count; Cerebellum; F | 2021 |
The long-term prognosis of hippocampal neurogenesis and behavioral changes of offspring from rats exposed to valproic acid during pregnancy.
Topics: Animals; Female; Hippocampus; Humans; Neurogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Pr | 2021 |
Vitamin A supplementation ameliorates motor incoordination via modulating RORα in the cerebellum in a valproic acid-treated rat autism model with vitamin A deficiency.
Topics: Animals; Autistic Disorder; Cerebellum; Female; Male; Nuclear Receptor Subfamily 1, Group F, Member | 2021 |
5-HT7 receptor activation rescues impaired synaptic plasticity in an autistic-like rat model induced by prenatal VPA exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal | 2021 |
Effects of antiseizure medications on placental cells: Focus on heterodimeric placental carriers.
Topics: Anticonvulsants; Female; Humans; Lamotrigine; Levetiracetam; Placenta; Pregnancy; Valproic Acid | 2021 |
Oxytocin administration modulates the complex type of ultrasonic vocalisation of mice pups prenatally exposed to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Communication; Disease Models, Animal; Female; Humans; Male; Mate | 2021 |
HIF-1 α may play a role in late pregnancy hypoxia-induced autism-like behaviors in offspring rats.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Hypoxia; Hypoxia-Inducible Factor | 2021 |
Awareness, knowledge and practice of healthcare professionals following implementation of a Pregnancy Prevention Program for sodium valproate in Ireland: a multi-stakeholder cross-sectional study.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cross-Sectional Studies; Female; General Practitioners | 2021 |
Neurobiological substrates underlying corpus callosum hypoconnectivity and brain metabolic patterns in the valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Brain; Corpus Callosum; Exploratory Behavior; Female; Male; Nerve | 2021 |
Contemporary trends in antiepileptic drug treatment among women of childbearing age with epilepsy in the United States: 2004-2015.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy | 2021 |
Protective role of vitamin E in testicular development of mice exposed to valproic acid.
Topics: Animals; Anticonvulsants; Female; Male; Mice; Oxidative Stress; Pregnancy; Testis; Valproic Acid; Vi | 2021 |
Phenotypic overlap between atopic dermatitis and autism.
Topics: Animals; Anticonvulsants; Autistic Disorder; Dermatitis, Atopic; Female; Inflammation Mediators; Maz | 2021 |
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Topics: Animals; Anticonvulsants; Apoptosis; Autism Spectrum Disorder; Behavior, Animal; Brain; Disease Mode | 2021 |
Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Female; Gene Expression; Genes, fos; Genes, Immediate- | 2021 |
Increasing Endocannabinoid Tone Alters Anxiety-Like and Stress Coping Behaviour in Female Rats Prenatally Exposed to Valproic Acid.
Topics: Animals; Anxiety; Anxiety Disorders; Autistic Disorder; Behavior, Animal; Disease Models, Animal; En | 2021 |
Effects of valproate, an HDAC inhibitor, on the expression of folate carriers and folate metabolism-related genes in the placenta of rats.
Topics: Animals; Anticonvulsants; Female; Folic Acid; Histone Deacetylase Inhibitors; Membrane Transport Pro | 2021 |
Resveratrol prevents long-term structural hippocampal alterations and modulates interneuron organization in an animal model of ASD.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Hippocampus; In | 2021 |
Characterizing the effects of in utero valproic acid exposure on murine fetoplacental development.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Female; Fetal Development; Fetus; Male; Mater | 2021 |
Vinpocetine amended prenatal valproic acid induced features of ASD possibly by altering markers of neuronal function, inflammation, and oxidative stress.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Biomarkers; Disease Models, Animal; Doublecorti | 2021 |
Changes in antiepileptic drug prescriptions over a decade in childbearing women in Lombardy region, Italy.
Topics: Anticonvulsants; Drug Prescriptions; Female; Humans; Infant; Lamotrigine; Levetiracetam; Male; Pregn | 2022 |
Behavioral improvements in a valproic acid rat model of autism following vitamin D supplementation.
Topics: Animals; Antimanic Agents; Autistic Disorder; Behavior, Animal; Dietary Supplements; Disease Models, | 2017 |
Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Doublecortin Protein; Female; GABA Agents; Hi | 2017 |
Altered expression of circadian rhythm and extracellular matrix genes in the medial prefrontal cortex of a valproic acid rat model of autism.
Topics: Animals; Autism Spectrum Disorder; Circadian Rhythm; Disease Models, Animal; Extracellular Matrix; F | 2017 |
Effect of early postnatal exposure to valproate on neurobehavioral development and regional BDNF expression in two strains of mice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Fa | 2017 |
Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism.
Topics: Animals; Anticonvulsants; Autistic Disorder; Brain; Curcumin; Dietary Supplements; Disease Models, A | 2017 |
Contraception advice for women with epilepsy.
Topics: Adult; Contraception Behavior; Contraceptive Agents; Counseling; Drug Interactions; Epilepsy; Family | 2017 |
Suppressed play behaviour and decreased oxytocin receptor binding in the amygdala after prenatal exposure to low-dose valproic acid.
Topics: Amygdala; Animals; Behavior, Animal; Brain; Female; Male; Oxytocin; Play and Playthings; Pregnancy; | 2017 |
Deficits in temporal processing in mice prenatally exposed to Valproic Acid.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Dopamine; Female; GABA | 2018 |
Exposure to Sodium Valproate during Pregnancy: Facial Features and Signs of Autism.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Autism Spectrum Disorder; Autistic | 2017 |
Reduced protein expressions of cytomembrane GABA
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; | 2017 |
Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice.
Topics: Animals; Anticonvulsants; Autistic Disorder; Brain; Brain-Derived Neurotrophic Factor; Dendritic Spi | 2017 |
Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Bromodeoxyuridine; Corpus Striatum; Disease Models, Animal; Femal | 2017 |
France bans sodium valproate use in case of pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Bipolar Disorder; Female; France; Humans; Pregnancy; P | 2017 |
Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally.
Topics: Amygdala; Animals; Autism Spectrum Disorder; Behavior, Animal; Emotions; Female; Humans; Male; Pregn | 2017 |
Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice.
Topics: Animals; Aripiprazole; Autism Spectrum Disorder; Dendritic Spines; Disease Models, Animal; Dopamine; | 2017 |
Valproic acid exposure decreases the mRNA stability of Bcl-2 via up-regulating miR-34a in the cerebellum of rat.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Cell Line; Cerebellar Cortex; | 2017 |
Dendritic spine anomalies and PTEN alterations in a mouse model of VPA-induced autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cerebral Cortex; Dendritic Spines; Disease Mode | 2018 |
Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder.
Topics: Animals; Attention; Autism Spectrum Disorder; Disease Models, Animal; Female; Male; Pregnancy; Prena | 2017 |
Women still not being told about pregnancy risks of valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans; | 2017 |
Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; Hippocampus; Interpers | 2017 |
Prescription of Sodium Valproate as a Mood Stabiliser in Pregnancy.
Topics: Bipolar Disorder; Female; Humans; Pregnancy; Pregnancy Complications; Psychotic Disorders; Valproic | 2017 |
Effect of valproic acid administration during pregnancy on postnatal development of cerebellar cortex and the possible protective role of folic acid.
Topics: Animals; Anticonvulsants; Cerebellar Cortex; Female; Folic Acid; Maternal Exposure; Pregnancy; Purki | 2018 |
Fetal Valproate Syndrome - Still a Problem Today!
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cesarean Section; Drug Therapy, Combination; Ep | 2017 |
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior.
Topics: Action Potentials; Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease M | 2018 |
Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid.
Topics: Animals; Anxiety; Autistic Disorder; Disease Models, Animal; DNA Damage; DNA Repair; Dose-Response R | 2018 |
Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Dietary Supplements; Female; Fol | 2018 |
Evaluation of the effects of antiepileptic drugs on folic acid uptake by human placental choriocarcinoma cells.
Topics: Adult; Anticonvulsants; Cell Line, Tumor; Cell Survival; Choriocarcinoma; Female; Folate Receptor 1; | 2018 |
Repairability of skeletal alterations induced by sodium valproate in rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Alcian Blue; Animals; Animals, Newborn; Anthraqui | 2018 |
Prenatal exposure to valproic acid alters the development of excitability in the postnatal rat hippocampus.
Topics: Action Potentials; Aging; Animals; Bicuculline; CA1 Region, Hippocampal; Excitatory Postsynaptic Pot | 2018 |
Altered Brain Cholesterol/Isoprenoid Metabolism in a Rat Model of Autism Spectrum Disorders.
Topics: Adenylate Kinase; Animals; Autism Spectrum Disorder; Brain; Cholesterol; Disease Models, Animal; Fem | 2018 |
Fetal valproate syndrome: the Irish experience.
Topics: Abnormalities, Drug-Induced; Female; Humans; Ireland; Male; Pregnancy; Retrospective Studies; Syndro | 2018 |
Women with epilepsy in childbearing age: Pregnancy-related knowledge, information sources, and antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Counseling; Croatia; Epilepsy; Female; Health Knowledge, Attitud | 2018 |
Transcriptional and splicing dysregulation in the prefrontal cortex in valproic acid rat model of autism.
Topics: Alternative Splicing; Animals; Anticonvulsants; Autistic Disorder; Behavior, Animal; Disease Models, | 2018 |
Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Monitoring; Epilepsy; Female; Humans; | 2018 |
Antiepileptic Drugs in Pregnancy-Quick Decisions With Long-term Consequences.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Language; Mathematics; Pregnancy; Pregnancy Compli | 2018 |
Association Between Prenatal Valproate Exposure and Performance on Standardized Language and Mathematics Tests in School-aged Children.
Topics: Academic Performance; Anticonvulsants; Child; Cohort Studies; Denmark; Female; Humans; Language; Mal | 2018 |
Outcomes of pregnancies in women taking antiepileptic drugs for non-epilepsy indications.
Topics: Abnormalities, Drug-Induced; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Outcome Ass | 2018 |
Zinc as a therapy in a rat model of autism prenatally induced by valproic acid.
Topics: Animals; Autistic Disorder; Corpus Striatum; Disease Models, Animal; Female; Male; Neuroprotective A | 2018 |
Repeated Prenatal Exposure to Valproic Acid Results in Auditory Brainstem Hypoplasia and Reduced Calcium Binding Protein Immunolabeling.
Topics: Animals; Anticonvulsants; Auditory Pathways; Autism Spectrum Disorder; Brain Stem; Calcium-Binding P | 2018 |
Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA.
Topics: Adolescent; Animals; Anticonvulsants; Antioxidants; Autistic Disorder; Behavior, Animal; Child; Chil | 2018 |
The protective effect of polyunsaturated fatty acid intake during pregnancy against embryotoxicity of sodium valproate in mice.
Topics: Animals; Anticonvulsants; Embryonic Development; Fatty Acids, Omega-3; Female; Fetal Diseases; Folic | 2018 |
Embryonic Exposure to Valproic Acid Impairs Social Predispositions of Newly-Hatched Chicks.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Chickens; Disease Models, Animal; Embryonic Deve | 2018 |
A UK clinical audit addressing the quality of prescribing of sodium valproate for bipolar disorder in women of childbearing age.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Antimanic Agents; Bipolar Disorder; Cli | 2018 |
Adverse placental effects of valproic acid: Studies in perfused human placentas.
Topics: Adult; Anticonvulsants; Female; Glucose Transport Proteins, Facilitative; Humans; Organ Culture Tech | 2018 |
Weighing the risks of valproate in women who could become pregnant.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Contraindications, Drug; Developmental Disabilities; E | 2018 |
Dangers of valproate in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 2018 |
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2018 |
Valproate and childbearing potential: new regulations.
Topics: Anticonvulsants; Female; Humans; Pregnancy; Pregnancy Outcome; Prenatal Exposure Delayed Effects; Va | 2018 |
Prevalence of valproate syndrome in Europe from 2005 to 2014: A registry based multi-centre study.
Topics: Adult; Anticonvulsants; Cognitive Dysfunction; Congenital Abnormalities; Epilepsy; Europe; Female; H | 2018 |
Motor Impairments Correlate with Social Deficits and Restricted Neuronal Loss in an Environmental Model of Autism.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Female; Gait; Male; Mice, Inbred C | 2018 |
Guidance is needed on valproate in pregnancy for those without capacity.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2018 |
Prescribing in pregnancy shows the weaknesses in pharmacovigilance.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pharmacovigilance; Pregnancy; Pregnancy Complications; Va | 2018 |
Obstetric outcomes and effects on babies born to women treated for epilepsy during pregnancy in a resource limited setting: a comparative cohort study.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anticonvulsants; Body Height; Body Weight; Carbamazepine; | 2018 |
Pharmacological modulation of AMPA receptor rescues social impairments in animal models of autism.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Disease Models, Animal; Excitatory Amino | 2019 |
Reducing valproate use in women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Drug Utilization; Epilepsy; Female; | 2018 |
Sociability deficits after prenatal exposure to valproic acid are rescued by early social enrichment.
Topics: Animals; Autism Spectrum Disorder; Brain; Female; Male; Mice; Pregnancy; Prenatal Exposure Delayed E | 2018 |
Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism.
Topics: Animals; Anticonvulsants; Antioxidants; Autistic Disorder; Birth Weight; Brain Chemistry; Cytokines; | 2018 |
Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Autistic Disorder; Behavior, Animal; Endocannabinoids; | 2018 |
Memory dysfunction in school-aged children exposed prenatally to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Hu | 2018 |
Valproate-associated foetal malformations-Rates of occurrence, risks in attempted avoidance.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2019 |
Reduced CD4 T Lymphocytes in Lymph Nodes of the Mouse Model of Autism Induced by Valproic Acid.
Topics: Animals; Autistic Disorder; CD4-Positive T-Lymphocytes; Disease Models, Animal; Enzyme Inhibitors; F | 2018 |
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Topics: Animals; Cell Polarity; Enzyme Inhibitors; Female; Fetal Heart; Heart Defects, Congenital; Histone D | 2018 |
New regulations to cut valproate-exposed pregnancies.
Topics: Anticonvulsants; Epilepsy; Female; Government Regulation; Humans; Pregnancy; Pregnancy Complications | 2018 |
Failures in reproductive health policy: overcoming the consequences and causes of inaction.
Topics: Female; Fetal Alcohol Spectrum Disorders; Flour; Folic Acid; Food, Fortified; Health Policy; Humans; | 2019 |
Maternal voluntary exercise ameliorates learning deficit in rat pups exposed, in utero, to valproic acid; role of BDNF and VEGF and their receptors.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cognition; Female; Learning; Male; Maz | 2018 |
Valproate, women, and exceptional circumstances.
Topics: Anticonvulsants; Drug Prescriptions; Drug Utilization; Epilepsy; Female; Humans; Pregnancy; Teratoge | 2018 |
In utero drug exposure and hearing impairment in 2-year-old children A case-control study using the EFEMERIS database.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Aspirin; Case-Control Studies; Child, Pres | 2018 |
Early Behavioral Alterations and Increased Expression of Endogenous Retroviruses Are Inherited Across Generations in Mice Prenatally Exposed to Valproic Acid.
Topics: Animals; Behavior, Animal; Brain; Endogenous Retroviruses; Female; Inheritance Patterns; Male; Mice; | 2019 |
Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Female; Fetal Death; Fetus; Mice; Neu | 2019 |
Prenatal exposure to valproate induces sex-, age-, and tissue-dependent alterations of cholesterol metabolism: Potential implications on autism.
Topics: Age Factors; Animals; Anticonvulsants; Autistic Disorder; Brain; Cholesterol; Female; Liver; Male; M | 2019 |
Sodium valproate: who knew what and when? Cumulative meta-analysis gives extra insights.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Meta-Analysis as Topic; Preg | 2019 |
Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Adhesion Molec | 2018 |
mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.
Topics: Animals; Autistic Disorder; Behavior, Animal; Dendritic Spines; Disease Models, Animal; Female; Hete | 2019 |
Auditory Midbrain Hypoplasia and Dysmorphology after Prenatal Valproic Acid Exposure.
Topics: Animals; Auditory Pathways; Autism Spectrum Disorder; Calbindins; Cell Count; Dopaminergic Neurons; | 2019 |
Hyperexcitability of hippocampal CA1 pyramidal neurons in male offspring of a rat model of autism spectrum disorder (ASD) induced by prenatal exposure to valproic acid: A possible involvement of Ih channel current.
Topics: Action Potentials; Animals; Autism Spectrum Disorder; CA1 Region, Hippocampal; Disease Models, Anima | 2019 |
Perinatal outcome and healthcare resource utilization in the first year of life after antiepileptic exposure during pregnancy.
Topics: Adult; Anticonvulsants; Databases, Factual; Epilepsy; Female; Health Resources; Humans; Infant; Infa | 2019 |
Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero.
Topics: Animals; Body Weight; Female; Gene Expression Regulation, Developmental; Gene Regulatory Networks; I | 2019 |
Fetal Valproate Exposure and Attention-Deficit/Hyperactivity Disorder.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Female; Humans; Pregnancy; Prenatal | 2019 |
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Cohort Studies; Denmark; Epil | 2019 |
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor | 2019 |
Abnormal empathy-like pro-social behaviour in the valproic acid model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Empathy; Female; Interpersonal Relations; | 2019 |
Pyramidal neuron growth and increased hippocampal volume during labor and birth in autism.
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; Bumetanide; Dendrites; Disease Models, Animal; | 2019 |
Valproate is contraindicated in pregnancy.
Topics: Anticonvulsants; Contraindications, Drug; Epilepsy; Female; Humans; Neurodevelopmental Disorders; Pr | 2019 |
Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Br | 2019 |
Consequences of prenatal exposure to valproic acid in the socially monogamous prairie voles.
Topics: Aggression; Animals; Anxiety; Arvicolinae; Behavior, Animal; Female; Gene Expression Regulation, Dev | 2019 |
Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism.
Topics: Animals; Antimanic Agents; Autism Spectrum Disorder; Behavior, Animal; Betaine; Disease Models, Anim | 2019 |
Level of empowerment and decision-making style of women with epilepsy in childbirth age.
Topics: Adolescent; Adult; Anticonvulsants; Decision Making; Empowerment; Epilepsy; Female; Humans; Middle A | 2019 |
Developmental outcomes at age four following maternal antiepileptic drug use.
Topics: Adult; Anticonvulsants; Carbamazepine; Child Development; Child, Preschool; Cohort Studies; Epilepsy | 2019 |
Valproate and the Pregnancy Prevention Programme: exceptional circumstances.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug and Narcotic Control; Europe; Female; Humans; Pre | 2019 |
Continued importance of valproate for women with generalised epilepsy.
Topics: Anticonvulsants; Epilepsy, Generalized; Female; Humans; Pregnancy; Valproic Acid | 2019 |
The effects of valproic acid on early pregnancy human placentas: Pilot ex vivo analysis in cultured placental villi.
Topics: Adult; Amino Acids; Carrier Proteins; Chorionic Villi; Fatty Acids; Female; Folic Acid Transporters; | 2019 |
Retinal alterations in a pre-clinical model of an autism spectrum disorder.
Topics: Action Potentials; Animals; Autism Spectrum Disorder; Endophenotypes; Female; Fragile X Mental Retar | 2019 |
Valproate and the Pregnancy Prevention Programme.
Topics: Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid | 2019 |
Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy.
Topics: Adult; Animals; Anticonvulsants; Breast Feeding; Drug Therapy, Combination; Epilepsy; Female; Humans | 2019 |
The Notch signaling pathway inhibitor Dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism.
Topics: Animals; Atrophy; Autistic Disorder; Autophagy; Beclin-1; Behavior, Animal; Cerebellum; Dendritic Sp | 2019 |
Beneficial effects of pioglitazone, a selective peroxisome proliferator-activated receptor-γ agonist in prenatal valproic acid-induced behavioral and biochemical autistic like features in Wistar rats.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Brain Chemistry; Cytokines; Exploratory | 2019 |
Behavioral problems in children of mothers with epilepsy prenatally exposed to valproate, carbamazepine, lamotrigine, or levetiracetam monotherapy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child Behavior Disorders; Epilepsy; Female; Humans; La | 2019 |
Outcomes of low-dose valproic acid treatment in patients with juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Dose-Response Relationship, Drug; Femal | 2019 |
[Improvement of a mouse model of valproic acid-induced autism].
Topics: Animals; Autistic Disorder; Disease Models, Animal; Female; Mice; Pregnancy; Prenatal Exposure Delay | 2019 |
Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; H | 2019 |
Use of antiepileptic drugs in women of fertile age.
Topics: Adolescent; Adult; Anticonvulsants; Denmark; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Leve | 2019 |
Diagnosis and management of individuals with Fetal Valproate Spectrum Disorder; a consensus statement from the European Reference Network for Congenital Malformations and Intellectual Disability.
Topics: Anticonvulsants; Consensus; Female; Humans; Intellectual Disability; Pregnancy; Pregnancy Complicati | 2019 |
Analysis of maternal risk factors associated with congenital vertebral malformations.
Topics: Abnormalities, Multiple; Adolescent; Adult; Alcohol Drinking; Child; Clomiphene; Diabetes Mellitus, | 2013 |
Associations between particular types of fetal malformation and antiepileptic drug exposure in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Epilepsy; Female; Fetal Diseases; Fructose; | 2013 |
Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder.
Topics: Animals; Child Development Disorders, Pervasive; Dendrites; Disease Models, Animal; Exploratory Beha | 2013 |
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Child; Child Development Disorders, Pervasive | 2013 |
Risks of in utero exposure to valproate.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
Valproate in pregnancy linked to autism in children.
Topics: Anticonvulsants; Autistic Disorder; Denmark; Epilepsy; Female; Humans; Incidence; Infant, Newborn; P | 2013 |
Comparative gene expression analysis of the amygdala in autistic rat models produced by pre- and post-natal exposures to valproic acid.
Topics: Amygdala; Animals; Animals, Newborn; Anxiety; Autistic Disorder; Behavior, Animal; Disease Models, A | 2013 |
Possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Suckling; Autistic Disorder; Autoantib | 2013 |
More drug studies need to include pregnant women, says bulletin.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Industry; Female; Humans; Hypnotics and Sedatives; M | 2013 |
Developmental outcomes at preschool age after fetal exposure to valproic acid and lamotrigine: cognitive, motor, sensory and behavioral function.
Topics: Anticonvulsants; Attention; Behavior; Child; Child, Preschool; Cognition; Faculty; Female; Humans; L | 2013 |
Increased hippocampal cell density and enhanced spatial memory in the valproic acid rat model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; GABA Agents; Hippocamp | 2013 |
Semax corrects brain dysfunction caused by prenatal introduction of valproic acid.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Anticonvulsants; Brain Diseases; Female; Mal | 2013 |
5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Autistic Disorder; Behavior, Animal; Cina | 2013 |
Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Lamotrigine; Phenobarbital; Pregnancy; Pregnancy Com | 2013 |
Comment: valproate dose effects differ across congenital malformations.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Female; Humans; Nervous System Malformations; Pre | 2013 |
Dose dependence of fetal malformations associated with valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Austria; Dose-Response Relationship, Drug; Epilepsy; F | 2013 |
Prenatal valproate exposure is associated with autism spectrum disorder and childhood autism.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
Methionine pretreatment enhances the effects of valproate on axial development in a CD1 mouse model.
Topics: Acetylation; Animals; Blotting, Western; Disease Models, Animal; Embryonic Development; Female; Fetu | 2013 |
Prenatal exposure to sodium valproate is associated with increased risk of childhood autism and autistic spectrum disorder.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2014 |
Valproate use during pregnancy was linked to autism spectrum disorder and childhood autism in offspring.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring.
Topics: Animals; Autistic Disorder; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Eye Proteins; Fe | 2014 |
Combined prenatal and postnatal butyl paraben exposure produces autism-like symptoms in offspring: comparison with valproic acid autistic model.
Topics: Animals; Autistic Disorder; Female; Male; Maternal Exposure; Models, Theoretical; Parabens; Pregnanc | 2013 |
Teratology study of amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide in NMRI mice.
Topics: Animals; Body Weight; Bone and Bones; Carboxylic Acids; Congenital Abnormalities; Embryo, Mammalian; | 2013 |
Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Female; Gene Expressi | 2013 |
Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice.
Topics: Animals; Animals, Newborn; Embryo, Mammalian; Female; Histone Deacetylase Inhibitors; Histone Deacet | 2013 |
Altered peripheral and central inflammatory responses in a mouse model of autism.
Topics: Animals; Cerebellum; Child Development Disorders, Pervasive; Corticosterone; Cytokines; Female; Hipp | 2014 |
[Valproic acid during pregnancy lowers IQ in children].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Intellectual Disability; Maternal-Fetal Exchange; Nervous | 2013 |
Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; India; Pregna | 2013 |
Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy | 2014 |
Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin.
Topics: Amyloid beta-Protein Precursor; Animals; Chromatin Immunoprecipitation; Down-Regulation; Female; Hum | 2014 |
Intestinal inflammation in a murine model of autism spectrum disorders.
Topics: Animals; Brain; Child Development Disorders, Pervasive; Disease Models, Animal; Female; Ileitis; Ile | 2014 |
Teratogenic potential of antiepileptic drugs in the zebrafish model.
Topics: Acetamides; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Ethosuximide; Female; F | 2013 |
Antiepileptic drugs and neurocognitive development.
Topics: Anticonvulsants; Child Development; Female; Humans; Language Development; Levetiracetam; Male; Pirac | 2014 |
In utero exposure to levetiracetam vs valproate: development and language at 3 years of age.
Topics: Adult; Anticonvulsants; Child Development; Child, Preschool; Epilepsy; Female; Humans; Language Deve | 2014 |
Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2014 |
Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Cohort Studies; Epilepsy; Female; | 2014 |
[Valproate should be avoided in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure | 2014 |
Increased BDNF expression in fetal brain in the valproic acid model of autism.
Topics: Animals; Autistic Disorder; Brain; Brain-Derived Neurotrophic Factor; Female; Fetus; Maternal-Fetal | 2014 |
Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders.
Topics: Acetylation; Animals; Behavior, Animal; Cerebellar Cortex; Child Development Disorders, Pervasive; C | 2014 |
[Valproic acid concentration in the blood serum of pregnant women and umbilical cord blood in relation to the condition of the newborn--case studies].
Topics: Adult; Anticonvulsants; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Pregnancy; Pregnancy | 2013 |
Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring.
Topics: Animals; Autistic Disorder; Behavior, Animal; Bumetanide; Chlorides; Cytoprotection; Disease Models, | 2014 |
Auditory-cued sensorimotor task reveals disengagement deficits in rats exposed to the autism-associated teratogen valproic acid.
Topics: Acoustic Stimulation; Animals; Anticipation, Psychological; Attention; Behavior, Animal; Child Devel | 2014 |
In brief: warning against use of valproate for migraine prevention during pregnancy.
Topics: Anticonvulsants; Child; Child Development; Child, Preschool; Female; Humans; Intelligence; Intellige | 2013 |
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2014 |
Tissue-specific effects of valproic acid on DNA repair genes and apoptosis in postimplantation mouse embryos.
Topics: Animals; Apoptosis; Blotting, Western; DNA Repair; Embryo, Mammalian; Embryonic Development; Female; | 2014 |
Valproate and folic acid in pregnancy: associations with autism.
Topics: Autistic Disorder; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Prenatal Exposure Delayed Effect | 2014 |
The ketogenic diet modifies social and metabolic alterations identified in the prenatal valproic acid model of autism spectrum disorder.
Topics: Animals; Behavior, Animal; Child Development Disorders, Pervasive; Diet, Ketogenic; Disease Models, | 2014 |
The teratogenicity of the newer antiepileptic drugs - an update.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Fetus; Fructose; Humans; Lamo | 2014 |
Brief report novel mechanism for valproate-induced teratogenicity.
Topics: Abnormalities, Drug-Induced; Biological Availability; Cell Line; Embryonic Development; Female; Fola | 2014 |
Long-term valproic acid exposure increases the number of neocortical neurons in the developing rat brain. A possible new animal model of autism.
Topics: Animals; Anticonvulsants; Autistic Disorder; Cell Count; Disease Models, Animal; Female; Lactation; | 2014 |
D-Cycloserine ameliorates social alterations that result from prenatal exposure to valproic acid.
Topics: Animals; Cycloserine; Female; Male; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Ra | 2014 |
Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism.
Topics: Acetylcholinesterase; Animals; Autistic Disorder; Behavior, Animal; Blotting, Western; Cells, Cultur | 2014 |
In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism.
Topics: Aging; Animals; Arousal; Child Development Disorders, Pervasive; Circadian Rhythm; Disease Models, A | 2014 |
Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil | 2014 |
Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism.
Topics: Acetylation; Animals; Autistic Disorder; Butyric Acid; CA1 Region, Hippocampal; Dendritic Spines; Di | 2014 |
Resveratrol prevents social deficits in animal model of autism induced by valproic acid.
Topics: Animals; Anti-Inflammatory Agents; Autistic Disorder; Female; Male; Maternal Exposure; Molecular Dyn | 2014 |
Sulindac attenuates valproic acid-induced oxidative stress levels in primary cultured cortical neurons and ameliorates repetitive/stereotypic-like movement disorders in Wistar rats prenatally exposed to valproic acid.
Topics: Animals; beta Catenin; Cells, Cultured; Disease Models, Animal; Female; Glycogen Synthase Kinase 3; | 2015 |
MeCP2 Modulates Sex Differences in the Postsynaptic Development of the Valproate Animal Model of Autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; Methyl-CpG-Binding Pro | 2016 |
Interplay between pro-inflammatory cytokines and brain oxidative stress biomarkers: evidence of parallels between butyl paraben intoxication and the valproic acid brain physiopathology in autism rat model.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Autistic Disorder; Biomarkers; Brain; Brai | 2015 |
IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child Development; Epilepsy; Female; Humans; Intellige | 2015 |
Fine-tuning risk assessment with antiepileptic drug use in pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Lamotrigi | 2015 |
Valproate fetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnostic Imaging; Epilepsy; Female; Fetal Di | 2015 |
Tactile stimulation improves neuroanatomical pathology but not behavior in rats prenatally exposed to valproic acid.
Topics: Amygdala; Animals; Autistic Disorder; Behavior, Animal; Dendrites; Dendritic Spines; Disease Models, | 2015 |
Effects of an H3R antagonist on the animal model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; Histamine Antagonists; | 2015 |
Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cognition; Cognition Disorders; Disease Models, Animal; | 2015 |
Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Autistic Disorder; Child; Child, Preschool; Disease Mod | 2015 |
Valproate and pregnancy: think again.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Lamotrigi | 2015 |
Increased sociability and gene expression of oxytocin and its receptor in the brains of rats affected prenatally by valproic acid.
Topics: Animals; Female; Gene Expression; Hypothalamus; Male; Oxytocin; Paraventricular Hypothalamic Nucleus | 2015 |
Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism.
Topics: Animals; Anxiety; Autistic Disorder; Brain; Catalase; Disease Models, Animal; Female; Glutathione; L | 2015 |
Prevention of valproic acid-induced neural tube defects by sildenafil citrate.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Disease Models, Animal; Dose-Response Relation | 2015 |
Differential Local Connectivity and Neuroinflammation Profiles in the Medial Prefrontal Cortex and Hippocampus in the Valproic Acid Rat Model of Autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Exploratory Behavior; Female; | 2015 |
Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model.
Topics: Animals; Autistic Disorder; Biogenic Monoamines; Corpus Striatum; Disease Models, Animal; Dopamine; | 2015 |
Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism model.
Topics: Acetyltransferases; Animals; Anticonvulsants; Autistic Disorder; bcl-2-Associated X Protein; Caspase | 2015 |
Characterization of in utero valproic acid mouse model of autism by local field potential in the hippocampus and the olfactory bulb.
Topics: Animals; Anticonvulsants; Autistic Disorder; CA1 Region, Hippocampal; Exploratory Behavior; Female; | 2015 |
Commentary: Valproate in the treatment of epilepsy in women and girls: The need for recommendations.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2015 |
Commentary: Revised recommendation from CMDh on use of valproate in women is ethically incomplete and neglects the interests of women.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2015 |
Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; D | 2015 |
Nucleolar Translocation of Histone Deacetylase 2 Is Involved in Regulation of Transcriptional Silencing in the Cat Germinal Vesicle.
Topics: Animals; Cats; Cell Nucleolus; Chromatin; Female; Germinal Center; Histone Deacetylase 2; Histone De | 2015 |
Indifference of marmosets with prenatal valproate exposure to third-party non-reciprocal interactions with otherwise avoided non-reciprocal individuals.
Topics: Animals; Autistic Disorder; Behavior, Animal; Callithrix; Disease Models, Animal; Female; Humans; In | 2015 |
Valproate still has a place in women with epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2015 |
Effects of prenatal exposure to valproic acid on the development of juvenile-typical social play in rats.
Topics: Animals; Autistic Disorder; Behavior, Animal; Communication; Disease Models, Animal; Female; Male; P | 2015 |
[Effect of sulindac on improving autistic behaviors in rats].
Topics: Animals; Autistic Disorder; beta Catenin; Disease Models, Animal; Down-Regulation; Female; Glycogen | 2015 |
[Valproic acid responsible for low IQ].
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Male; Pre | 2015 |
Carrier-mediated placental transport of cimetidine and valproic acid across differentiating JEG-3 cell layers.
Topics: Adult; Algorithms; Anticonvulsants; Carrier Proteins; Cell Line, Tumor; Chromatography, High Pressur | 2015 |
Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cerebellum; Co-Repressor Proteins; Dis | 2015 |
[Position Statement of Hungarian Epilepsy League: The use of valproate preparations for epilepsy in pregnancy and in women of childbearing age].
Topics: Adolescent; Adult; Anticonvulsants; Cognition; Contraception; Dose-Response Relationship, Drug; Drug | 2015 |
Fine-tuning risk assessment with antiepileptic drug use in pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Male; Pre | 2015 |
Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder.
Topics: Acetamides; Animals; Anticonvulsants; Autism Spectrum Disorder; Blood-Brain Barrier; Exploratory Beh | 2015 |
Prenatal valproic acid exposure disrupts tonotopic c-Fos expression in the rat brainstem.
Topics: Acoustic Stimulation; Animals; Auditory Perception; Autism Spectrum Disorder; Brain Stem; Disease Mo | 2015 |
Serum levels of valproic acid during delivery in mothers and in umbilical cord - correlation with birth length and weight.
Topics: Anticonvulsants; Biomarkers; Body Height; Body Weight; Delivery, Obstetric; Dose-Response Relationsh | 2015 |
Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats.
Topics: Animals; Autistic Disorder; Blood-Brain Barrier; Brain; Capillary Permeability; Central Nervous Syst | 2016 |
Valproic acid: reducing the risks of prenatal exposure.
Topics: Anticonvulsants; Brain; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Risk; Valproic | 2016 |
Postnatal Stress Induced by Injection with Valproate Leads to Developing Emotional Disorders Along with Molecular and Cellular Changes in the Hippocampus and Amygdala.
Topics: Amygdala; Animals; Anxiety; Astrocytes; Cell Count; Cell Differentiation; Cell Proliferation; Cell S | 2016 |
Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid.
Topics: Animals; Anticonvulsants; Cognition Disorders; Female; Gene Expression Regulation, Developmental; Hi | 2015 |
Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism.
Topics: Animals; Atomoxetine Hydrochloride; Autistic Disorder; Behavior, Animal; Dendritic Spines; Disease M | 2016 |
Use of antiepileptic drugs during pregnancy and lactation: Type of information provided by searching Google.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans | 2016 |
The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Diet, Ketogenic; Dise | 2017 |
Prescribing trends for sodium valproate in Ireland.
Topics: Adolescent; Adult; Anticonvulsants; Drug Prescriptions; Epilepsy; Female; Folic Acid; Humans; Irelan | 2016 |
Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment.
Topics: Acoustic Stimulation; Animals; Autism Spectrum Disorder; Basolateral Nuclear Complex; Carrier Protei | 2016 |
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures?
Topics: Adolescent; ATPases Associated with Diverse Cellular Activities; Cystic Adenomatoid Malformation of | 2016 |
Is there a difference between various presentations of valproate for cognitive outcome after in utero exposure?
Topics: Anticonvulsants; Cognition; Cognition Disorders; Dose-Response Relationship, Drug; Female; Humans; P | 2016 |
[A girl with foetal valproate syndrome and autism spectrum disorder].
Topics: Anticonvulsants; Autistic Disorder; Child; Child Development Disorders, Pervasive; Epilepsy; Female; | 2016 |
Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Dose-Response Relationsh | 2016 |
Alteration of spontaneous spectral powers and coherences of local field potential in prenatal valproic acid mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Expl | 2015 |
New findings in fetal valproate syndrome: hiatal hernia, gastric volvulus and ectopic kidney.
Topics: Abnormalities, Drug-Induced; Adult; Female; Hernia, Hiatal; Humans; Infant, Newborn; Kidney; Male; P | 2016 |
France steps up warning measures for valproate drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug and Narcotic Control; Drug Information Services; | 2016 |
Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats.
Topics: Animals; Autistic Disorder; Blood-Brain Barrier; Brain; Disease Models, Animal; Excitatory Amino Aci | 2016 |
Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae.
Topics: Animals; Autistic Disorder; Behavior, Animal; Bombyx; Cerebellum; Complex Mixtures; Disease Models, | 2016 |
Early Behavioral Abnormalities and Perinatal Alterations of PTEN/AKT Pathway in Valproic Acid Autism Model Mice.
Topics: Animals; Autistic Disorder; Behavior, Animal; Dendritic Spines; Disease Models, Animal; Female; Hipp | 2016 |
Neuronal in vitro activity is more sensitive to valproate than intracellular ATP: Considerations on conversion problems of IC50 in vitro data for animal replacement.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Cerebral Cortex; Cytoplasm; Dose-Response Relation | 2016 |
Prenatal valproic acid exposure disrupts tonotopic c-Fos expression in the rat brainstem.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Auditory Perception; Autism Spectrum Disorder; Brain | 2016 |
Should women of childbearing potential be prescribed valproate? a call to action.
Topics: Abnormalities, Drug-Induced; Bipolar Disorder; Contraception Behavior; Epilepsy; Female; Humans; Inf | 2016 |
Effects of valproic acid on the placental barrier in the pregnant mouse: Optical imaging and transporter expression studies.
Topics: Age Factors; Animals; Anticonvulsants; Female; Fetus; Gene Expression Regulation; Gestational Age; I | 2016 |
Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development.
Topics: Analysis of Variance; Animals; Anticonvulsants; Body Weight; Developmental Disabilities; Dose-Respon | 2016 |
Effects of developmental alcohol and valproic acid exposure on play behavior of ferrets.
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Ethanol | 2016 |
Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.
Topics: Animals; Anticonvulsants; Female; Mice; Mice, Inbred ICR; Neocortex; Nerve Tissue Proteins; Neurons; | 2016 |
Antiepileptic drug combinations not involving valproate and the risk of fetal malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cohort Studies; Dose-Response Relationship, Drug; Drug | 2016 |
Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation.
Topics: Animals; Autistic Disorder; Female; Gene Expression Regulation, Developmental; Histone Deacetylase I | 2016 |
Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP.
Topics: Adolescent; Adult; Anticonvulsants; Bayes Theorem; Cohort Studies; Epilepsy; Female; Humans; Interna | 2016 |
PI3K/AKT/mTOR-mediated autophagy in the development of autism spectrum disorder.
Topics: Age Factors; Animals; Animals, Newborn; Autism Spectrum Disorder; Autophagy; Cytokines; Disease Mode | 2016 |
Functional Genomic Analyses Identify Pathways Dysregulated in Animal Model of Autism.
Topics: Animals; Animals, Newborn; Autistic Disorder; Disease Models, Animal; Environment; Enzyme Inhibitors | 2016 |
Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid.
Topics: Animals; Astrocytes; Behavior, Animal; Brain; Cell Count; Female; GABA Agents; Maternal Behavior; Mi | 2016 |
Fetal Valproate Syndrome.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Craniofacial Abnormalities; Cryptorc | 2017 |
Prenatal exposure to sodium valproate alters androgen receptor expression in the developing cerebellum in a region and age specific manner in male and female rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Cerebellum; Densitome | 2016 |
Prenatal valproate treatment produces autistic-like behavior and increases metabotropic glutamate receptor 1A-immunoreactivity in the hippocampus of juvenile rats.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cognition; Disease Models, Animal; Female; GABA | 2016 |
Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid.
Topics: Animals; Anticonvulsants; Behavior, Animal; CA1 Region, Hippocampal; Dietary Supplements; Docosahexa | 2016 |
A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Glutamate Decar | 2016 |
Spinal nerve defects in mouse embryos prenatally exposed to valproic acid.
Topics: Animals; Anticonvulsants; Female; Gestational Age; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred | 2018 |
Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate.
Topics: Adult; Anticonvulsants; Child; Cognition Disorders; Cross-Sectional Studies; Epilepsy; Female; Follo | 2016 |
Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenovirus E1A Proteins; Animals; Antineoplastic Combined Chemothe | 2017 |
Downregulation of glutamatergic and GABAergic proteins in valproric acid associated social impairment during adolescence in mice.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Down-Regulation; Elec | 2017 |
Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in a VPA-induced autism mouse model.
Topics: Adipose Tissue; Animals; Animals, Newborn; Anxiety; Autistic Disorder; Cumulative Trauma Disorders; | 2017 |
Valproic acid enhances the neural differentiation of human placenta derived-mesenchymal stem cells in vitro.
Topics: Antigens, Differentiation; Cell Differentiation; Female; Humans; Mesenchymal Stem Cells; Neurogenesi | 2017 |
In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation.
Topics: Acetylation; Animals; Anticonvulsants; Apoptosis; Brain; Cell Cycle; Cell Differentiation; Cell Prol | 2016 |
Women are unaware of pregnancy risks linked with sodium valproate.
Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Health Knowledge, Attitudes, Practice | 2016 |
Prenatal sonographic diagnosis of fetal valproate syndrome: a case report.
Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Infant, Newborn; Japan; Pregnancy; Pregnancy Com | 2016 |
The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Female; Frontal Lobe; Male; Maternal Exposure; | 2016 |
[Caution and warning: About valproate and pregnancy].
Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Epilepsy; Female; Humans; Pregnancy; Pre | 2016 |
Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects.
Topics: Amino Acids; Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Embryo, Mammalian; Fem | 2017 |
Status epilepticus in pregnant women with epilepsy after valproate adjustment: A case series.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Pregnancy; Retrospective S | 2016 |
Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats.
Topics: Amygdala; Animals; Autism Spectrum Disorder; Autoradiography; Azides; Benzodiazepines; Carbon Radioi | 2017 |
Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia.
Topics: Administration, Oral; Animals; Ataxia; Calbindins; Cell Size; Cerebellum; Developmental Disabilities | 2017 |
Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia.
Topics: Adult; Anticonvulsants; Child; Child Development; Child, Preschool; Cognition; Cohort Studies; Epile | 2017 |
Optimized logic rules reveal interferon-γ-induced modes regulated by histone deacetylases and protein tyrosine phosphatases.
Topics: Animals; Cell Line, Tumor; Choriocarcinoma; Computer Simulation; Epigenetic Repression; Female; Gene | 2017 |
Combining adverse pregnancy and perinatal outcomes for women exposed to antiepileptic drugs during pregnancy, using a latent trait model.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Florida; Humans; Infant, Low | 2017 |
Prenatal exposure to antiepileptic drugs and use of primary healthcare during childhood: a population-based cohort study in Denmark.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Denmark; Epilepsy; Femal | 2017 |
Valproate teratogenicity and epilepsy syndrome.
Topics: Abnormalities, Drug-Induced; Age of Onset; Analysis of Variance; Anticonvulsants; Dose-Response Rela | 2008 |
[Eclampsia at a teaching hospital in Ivory Coast: management, outcome and prognostic factors].
Topics: Adolescent; Adult; Anticonvulsants; Antihypertensive Agents; Cote d'Ivoire; Diazepam; Eclampsia; Fem | 2008 |
Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons.
Topics: Animals; Astrocytes; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral C | 2008 |
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cell Line, Tumor; Female; Folic Acid; Homocysteine; Hum | 2008 |
Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: evaluation of the teratogenic effects of its amide derivatives in NMRI mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Benzenesulfonamides; Cyclopropanes; D | 2008 |
Valproate and babies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Bipolar Disorder; Cross-Sectional Studies; Dose-Respon | 2008 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia].
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Brain Edema; Cesarean Section; Diazepam; Dru | 2008 |
Altered morphology of motor cortex neurons in the VPA rat model of autism.
Topics: Age Factors; Animals; Autistic Disorder; Dendrites; Disease Models, Animal; Female; Male; Motor Cort | 2008 |
Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation.
Topics: Acetylation; Analysis of Variance; Animals; Basic Helix-Loop-Helix Transcription Factors; Bromodeoxy | 2009 |
Fibular aplasia in a child exposed to sodium valproate in pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Female; Fibula; Humans; Infant; Maternal Exposu | 2009 |
[Valproate treatment during pregnancy: description of four cases with foetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E | 2009 |
A case of fetal valproate syndrome with new features expanding the phenotype.
Topics: Abnormalities, Multiple; Anticonvulsants; Epilepsy, Post-Traumatic; Female; Fetus; Humans; Infant; P | 2009 |
Changing trends in antiepileptic drug prescribing in girls of child-bearing potential.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Contraceptive Agents | 2009 |
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose | 2009 |
Dose-dependent memory effects and cerebral volume changes after in utero exposure to valproate in the rat.
Topics: Abnormalities, Drug-Induced; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvu | 2009 |
Observation of fetal brain in a rat valproate-induced autism model: a developmental neurotoxicity study.
Topics: Animals; Anticonvulsants; Autistic Disorder; Brain; Disease Models, Animal; Female; Fetus; Humans; M | 2009 |
Pregnancy, delivery, and outcome for the child in maternal epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Apgar Score; Birth Weight; Congenital Abnormali | 2009 |
Assessment of embryotoxicity using mouse embryo culture.
Topics: Animals; Anticonvulsants; Culture Media; Embryo, Mammalian; Female; Mice; Pregnancy; Signal Transduc | 2009 |
[Fetal malformations in women with epilepsy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Bulgaria; Carbamazepine; Epilepsy; Female; Humans; Inf | 2009 |
Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; DNA Damage; Female; Fructose; Histone Deacetylase Inhi | 2009 |
Cognitive outcome after exposure to antiepileptic drugs in utero.
Topics: Anticonvulsants; Child, Preschool; Cognition Disorders; Dose-Response Relationship, Drug; Female; Hu | 2009 |
Human decidual stromal cells protect lymphocytes from apoptosis.
Topics: Apoptosis; Cell Line; Cell Survival; Coculture Techniques; Decidua; Doxorubicin; Fas Ligand Protein; | 2009 |
Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice.
Topics: Animals; Autoradiography; Brain; Calcium-Binding Proteins; Cell Adhesion Molecules, Neuronal; Female | 2009 |
A case of fetal valproate syndrome with new features expanding the phenotype.
Topics: Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant; Phenotype; Pregna | 2009 |
Cognitive function after fetal exposure to antiepileptic drugs.
Topics: Anticonvulsants; Child, Preschool; Confounding Factors, Epidemiologic; Developmental Disabilities; E | 2009 |
Epilepsy: Should valproate be avoided during childbearing years?
Topics: Anticonvulsants; Brain; Child Development; Child, Preschool; Cognition Disorders; Female; Humans; Pr | 2009 |
Histologic and morphologic effects of valproic acid and oxcarbazepine on rat uterine and ovarian cells.
Topics: Animals; Anticonvulsants; Apoptosis; Carbamazepine; Cell Count; Cytoplasm; Embryo Implantation; Endo | 2010 |
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2010 |
Pregnancy treatment guidelines: throwing the baby out with the bath water.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Femal | 2009 |
Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat.
Topics: Age Factors; Animals; Autistic Disorder; Disease Models, Animal; Exploratory Behavior; Female; Inter | 2010 |
Unilateral lung agenesis: coincidence or association with maternal valproate therapy?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Lung; Male; | 2009 |
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential T | 2009 |
VPA-related axial skeletal defects and apoptosis: a proposed event cascade.
Topics: Abnormalities, Drug-Induced; Acetylation; Animals; Anticonvulsants; Apoptosis; Blotting, Western; Bo | 2010 |
A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy.
Topics: Analysis of Variance; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Creativity; Epile | 2009 |
Changing patterns of antiepileptic drug use in pregnant Australian women.
Topics: Anticonvulsants; Australia; Congenital Abnormalities; Epilepsy; Female; Humans; Linear Models; Pract | 2010 |
Valproic acid: long-term effects on children exposed in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose | 2009 |
Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Brain; Disease Models, Animal; Female; GABA Agents; Hi | 2010 |
Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment.
Topics: Age Factors; Animals; Animals, Newborn; Autistic Disorder; Brain; Brain Chemistry; Cell Count; Disea | 2010 |
[Valproate for treatment of women with epilepsy: recommendations of the German Society for Epileptology].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combin | 2010 |
Etiological heterogeneity and clinical characteristics of metopic synostosis: Evidence from a tertiary craniofacial unit.
Topics: Adolescent; Anticoagulants; Child; Child, Preschool; Chromosome Aberrations; Craniosynostoses; Enoxa | 2010 |
Role of parental risk factors in the aetiology of isolated non-syndromic metopic craniosynostosis.
Topics: Anticonvulsants; Chi-Square Distribution; Craniosynostoses; Epilepsy; Female; Fertility Agents, Fema | 2010 |
Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity.
Topics: Animal Testing Alternatives; Animals; Biomarkers; Embryonic Development; Female; Gene Expression Pro | 2010 |
Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid.
Topics: Animals; Anticonvulsants; Autistic Disorder; Behavior, Animal; Brain; Brain-Derived Neurotrophic Fac | 2010 |
Early cognitive development in children born to women with epilepsy: a prospective report.
Topics: Age Factors; Anticonvulsants; Child; Child of Impaired Parents; Cognition; Cognition Disorders; Deve | 2010 |
Does folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Case-Control Studies; Dietary Supplements; Female; Fol | 2010 |
Valproic acid transfer across human placental cotyledon during dual perfusion in vitro.
Topics: Anticonvulsants; Biological Transport; Female; Humans; Maternal-Fetal Exchange; Perfusion; Placenta; | 2010 |
Epigenetic modifications in valproic acid-induced teratogenesis.
Topics: Abnormalities, Drug-Induced; Acetylation; Animals; Epigenesis, Genetic; Female; Histones; Mice; Neur | 2010 |
Demethylation of specific Wnt/β-catenin pathway genes and its upregulation in rat brain induced by prenatal valproate exposure.
Topics: Animals; beta Catenin; Brain; DNA Methylation; Epigenesis, Genetic; Female; GABA Agents; Hippocampus | 2010 |
Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Congenital Abnormalities; Dose-Response Rel | 2010 |
Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts.
Topics: Acetylation; Animals; Apoptosis; Blotting, Western; Cell Differentiation; Cell Nucleus; Cell Prolife | 2010 |
Tibial developmental field defect in valproic acid embryopathy: Report on three cases.
Topics: Adolescent; Adult; Child; Child, Preschool; Comparative Genomic Hybridization; Female; Fetal Disease | 2010 |
Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort.
Topics: Adult; Animals; Animals, Newborn; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Infant, | 2010 |
Valproic acid use in pregnancy and congenital malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy | 2010 |
Effects of breastfeeding in children of women taking antiepileptic drugs.
Topics: Adult; Anticonvulsants; Breast Feeding; Carbamazepine; Child, Preschool; Cognition; Epilepsy; Female | 2010 |
Validating γ oscillations and delayed auditory responses as translational biomarkers of autism.
Topics: Animals; Animals, Newborn; Auditory Perception; Autistic Disorder; Behavior, Animal; Biomarkers; Bra | 2010 |
The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats.
Topics: Animals; Anticonvulsants; Autistic Disorder; Disease Models, Animal; Electroshock; Female; Fetus; Gl | 2011 |
Child development following in utero exposure: levetiracetam vs sodium valproate.
Topics: Anticonvulsants; Child Development; Child, Preschool; Cognition; Epilepsy; Female; Humans; Infant; L | 2011 |
Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal.
Topics: Anticonvulsants; Epilepsy; Female; Glucose; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, | 2010 |
Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Craniosynostoses; Fatal Outcome; Female; Heart | 2011 |
[Valproate and pregnancy].
Topics: Anticonvulsants; Contraindications; Female; Humans; Pregnancy; Risk Factors; Valproic Acid | 2011 |
Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child, Preschool; Developmental Disabilities; | 2011 |
Effect of the enucleation procedure on the reprogramming potential and developmental capacity of mouse cloned embryos treated with valproic acid.
Topics: Acetylation; Analysis of Variance; Animals; Birth Weight; Blastocyst; Cell Line; Cellular Reprogramm | 2011 |
Morphological abnormalities of embryonic cranial nerves after in utero exposure to valproic acid: implications for the pathogenesis of autism with multiple developmental anomalies.
Topics: Abnormalities, Multiple; Animals; Anticonvulsants; Autistic Disorder; Cranial Nerves; Disease Models | 2011 |
Final results from 18 years of the International Lamotrigine Pregnancy Registry.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Female; Humans; Infant; Lamotrigine; Pregnanc | 2011 |
Malformation of the superior olivary complex in an animal model of autism.
Topics: Animals; Auditory Pathways; Auditory Perceptual Disorders; Autistic Disorder; Disease Models, Animal | 2011 |
Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epile | 2011 |
Valproic acid-induced DNA damage increases embryonic p27(KIP1) and caspase-3 expression: a mechanism for valproic-acid induced neural tube defects.
Topics: Animals; Anticonvulsants; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cyclin-Dependent Kinase Inhi | 2011 |
Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL.
Topics: Animals; Apoptosis; bcl-X Protein; Cytoprotection; Female; Neural Stem Cells; Neurogenesis; NF-kappa | 2011 |
Antiepileptic drug use during pregnancy: perinatal outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Cohort Studies; Drug | 2011 |
Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States.
Topics: Anticonvulsants; Carbamazepine; Cleft Palate; Female; Humans; Pregnancy; Pregnancy Complications; Pr | 2011 |
Animal model of autism induced by prenatal exposure to valproate: behavioral changes and liver parameters.
Topics: Aging; Alanine Transaminase; Animals; Anticonvulsants; Aspartate Aminotransferases; Autistic Disorde | 2011 |
Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects.
Topics: Animals; Apoptosis; Dose-Response Relationship, Drug; Embryonic Development; Female; Mice; Neural Tu | 2011 |
Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex.
Topics: Aldehyde Dehydrogenase 1 Family; Amino Acids; Animals; Animals, Newborn; Calbindin 2; Calbindins; Ce | 2011 |
The prescribing of antiepileptic drugs for pregnant Australian women.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Fetus; Humans; Log | 2012 |
Synaptic and intrinsic balancing during postnatal development in rat pups exposed to valproic acid in utero.
Topics: Abnormalities, Drug-Induced; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Fema | 2011 |
Effects of the histone deacetylase inhibitor valproic acid on human pericytes in vitro.
Topics: Cell Culture Techniques; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; Col | 2011 |
Use of antiepileptic medications in pregnancy in relation to risks of birth defects.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hu | 2011 |
mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism.
Topics: Animals; Anti-Anxiety Agents; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; G | 2011 |
Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid.
Topics: Acetylation; Animals; Autistic Disorder; Cell Movement; Cerebral Cortex; Female; Histones; Interpers | 2013 |
Rare but real--the effects of sodium valproate in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Va | 2011 |
The effect of valproic acid and oxcarbazepine on the distribution of adhesion molecules in embryo implantation.
Topics: Animals; Anticonvulsants; Carbamazepine; Cell Adhesion Molecules; Collagen Type IV; Embryo Implantat | 2012 |
Early life stress exacerbates cognitive dysfunction induced by d-amphetamine: amelioration by valproic acid.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Body Weight; Central Nervous System S | 2012 |
Juvenile myoclonic epilepsy.
Topics: Adaptation, Psychological; Adult; Anticonvulsants; Female; Health Knowledge, Attitudes, Practice; Hu | 2012 |
Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats.
Topics: Animals; Autistic Disorder; Bacopa; Behavior, Animal; Biomarkers; Female; Male; Oxidative Stress; Pl | 2012 |
Prenatal exposure to valproic acid enhances synaptic plasticity in the medial prefrontal cortex and fear memories.
Topics: Analysis of Variance; Animals; Biophysics; Conditioning, Psychological; Disease Models, Animal; Elec | 2012 |
Valproate and the risk for congenital malformations: Is formulation and dosage regime important?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 2012 |
We must warn women about the risks of untreated, or ineffectively treated, epilepsy.
Topics: Anticonvulsants; Female; Health Knowledge, Attitudes, Practice; Humans; Myoclonic Epilepsy, Juvenile | 2012 |
Prenatal antiepileptic exposure associates with neonatal DNA methylation differences.
Topics: Anticonvulsants; Carbamazepine; CpG Islands; Depressive Disorder, Major; DNA Methylation; Drug Evalu | 2012 |
Effect of prenatal valproic acid exposure on cortical morphology in female mice.
Topics: Animals; Female; Male; Mice; Mice, Inbred ICR; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delay | 2012 |
Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Cost-Benefit Analysis; Epil | 2012 |
Gestational valproate alters BOLD activation in response to complex social and primary sensory stimuli.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Behavior, Animal; Female; | 2012 |
Epigenetic approaches and methods in developmental toxicology: role of HDAC inhibition in teratogenic events.
Topics: Acetylation; Animals; Blotting, Western; Embryo, Mammalian; Epigenesis, Genetic; Female; HeLa Cells; | 2012 |
An anomalous left superior venacava draining into left atrium in association with fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Female; Heart Atria; Humans; Infant, Newborn; Pregnancy; Valproic Acid; | 2013 |
Reduction in valproic acid-induced neural tube defects by maternal immune stimulation: role of apoptosis.
Topics: Animals; Apoptosis; Embryo, Mammalian; Female; Immunity; Interferon-gamma; Male; Maternal Exposure; | 2012 |
Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin pathway.
Topics: Animals; Anticonvulsants; Antimetabolites; beta Catenin; Blotting, Western; Bromodeoxyuridine; Cell | 2012 |
Teratogenesis in repeated pregnancies in antiepileptic drug-treated women.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Epilepsy; Female; Humans; Parity; Pregnancy | 2013 |
Effects of rat prenatal exposure to valproic acid on behaviour and neuro-anatomy.
Topics: Animals; Behavior, Animal; Brain; Dendritic Spines; Female; GABA Agents; Male; Maze Learning; Neuron | 2012 |
Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs.
Topics: Animals; Blotting, Western; Cells, Cultured; Chondrogenesis; Core Binding Factor Alpha 1 Subunit; Do | 2013 |
Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics.
Topics: Amniotic Fluid; Animals; Antigens, Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; | 2013 |
Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid.
Topics: Animals; Behavior, Animal; Child; Child Development Disorders, Pervasive; Disease Models, Animal; Fe | 2013 |
[Stigmata of dysembryogenesis and physical development in children born to mothers with epilepsy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child Development; Child, Preschool; Developmental Dis | 2011 |
Spirulina (arthrospira) protects against valproic acid-induced neural tube defects in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; Female; Fetus; Lipid Peroxidation; Mice; Mice, I | 2012 |
Valproic acid improved in vitro development of pig cloning embryos but did not improve survival of cloned pigs to adulthood.
Topics: Animals; Blastocyst; Cloning, Organism; Embryo Culture Techniques; Embryo Transfer; Embryonic Develo | 2013 |
Animal model of autism induced by prenatal exposure to valproate: altered glutamate metabolism in the hippocampus.
Topics: Animals; Anticonvulsants; Astrocytes; Autistic Disorder; Disease Models, Animal; Female; Glutamic Ac | 2013 |
Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism.
Topics: Animals; Antimanic Agents; Autistic Disorder; Biophysics; Disease Models, Animal; Electric Stimulati | 2013 |
Neuroprotective effects of valproic acid against hemin toxicity: possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathway.
Topics: Animals; Base Sequence; DNA Primers; Down-Regulation; Female; Heme Oxygenase-1; Hemin; Immunohistoch | 2013 |
Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Generalize | 2013 |
Antiepileptic drugs (AEDs) during pregnancy and risk of congenital jaw and oral malformation.
Topics: Abnormalities, Drug-Induced; Adverse Drug Reaction Reporting Systems; Amines; Anticonvulsants; Cyclo | 2013 |
Male-specific alteration in excitatory post-synaptic development and social interaction in pre-natal valproic acid exposure model of autism spectrum disorder.
Topics: Animals; Child; Child Development Disorders, Pervasive; Disease Models, Animal; Female; Humans; Inte | 2013 |
The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child Development Disorders, Per | 2013 |
The effects of prenatal exposure to valproic acid on the initial development of serotonergic neurons.
Topics: Animals; Female; Hedgehog Proteins; Male; Pregnancy; Prenatal Exposure Delayed Effects; Raphe Nuclei | 2013 |
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea | 2002 |
Nuchal edema as the first sign of fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Edema; Female; Gestational Age; Humans; Neck; P | 2002 |
Letter to the editor. Discordant twins for neural tube defect on treatment with sodium valproate.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Prenatal Exposure | 2002 |
Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism.
Topics: Animals; Autistic Disorder; Biogenic Monoamines; Brain; Female; Pregnancy; Rats; Rats, Sprague-Dawle | 2002 |
Outcome of pregnancy in women attending an outpatient epilepsy clinic: adverse features associated with higher doses of sodium valproate.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Rel | 2002 |
Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Chromosome Aberrations | 2003 |
Major malformations in offspring of women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Comorbidity; Educational Status; | 2003 |
Congenital nasolacrimal duct obstruction requiring external dacryocystorhinostomies in a child with foetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Dacryocystorhinostomy; Female; Humans; Infant; Lacrima | 2003 |
Postimplantation whole embryo culture assay for hamsters: an alternative to rat and mouse.
Topics: Abnormalities, Drug-Induced; Animals; Cadmium Chloride; Cricetinae; Culture Techniques; Diethylstilb | 2001 |
Successful pregnancy in a patient with hyperoxaluria and combined liver and renal transplant.
Topics: Adult; Epilepsy; Female; Humans; Hyperoxaluria; Infant, Newborn; Kidney Transplantation; Liver Trans | 2003 |
Posterior reversible encephalopathy syndrome (PRES) in critically ill obstetric patients.
Topics: Adult; Fatal Outcome; Female; Humans; Magnetic Resonance Imaging; Nervous System Diseases; Postpartu | 2003 |
The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months.
Topics: Abortion, Induced; Anticonvulsants; Australia; Carbamazepine; Cohort Studies; Congenital Abnormaliti | 2003 |
[Fetal valproate syndrome].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complicatio | 2003 |
Patent ductus arteriosus in fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Arm; Ductus Arteriosus, Patent; Female; Head; Humans; Infant, Ne | 2003 |
[Influence of valproic acid (depakine I.V.) on human placenta metabolism--experimental model].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Glucose; Embryo, Mammalian; Embryonic and Fetal | 2003 |
Evidence-based mental health use of anticonvulsants during pregnancy.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Clinical Trials as Topic; Evidence-Based Medicine; Female; | 2003 |
Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero.
Topics: Abnormalities, Multiple; Anticonvulsants; Dermatoglyphics; Epilepsy; Fatal Outcome; Female; Gingiva; | 2003 |
[Fetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pre | 2003 |
The influence of developmental periods of sodium valproate exposure on synaptic plasticity in the CA1 region of rat hippocampus.
Topics: Animals; Animals, Newborn; Excitatory Postsynaptic Potentials; Female; Hippocampus; In Vitro Techniq | 2003 |
Axial skeletal and Hox expression domain alterations induced by retinoic acid, valproic acid, and bromoxynil during murine development.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Gene Expression Regu | 2003 |
Neurobehavioral teratogenicity in antiepileptic drugs: the new Pandora's box.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Developmental Disabilities; Dose-Respons | 2004 |
Normal intelligence in children with prenatal exposure to carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; | 2004 |
Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats.
Topics: Androgen Antagonists; Animals; Anticonvulsants; Female; Flutamide; Humans; Hypospadias; Male; Pregna | 2004 |
Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carrier Proteins; Diet; Disease Models, Anima | 2003 |
Interaction between anticonvulsants and human placental carnitine transporter.
Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techn | 2004 |
Teratogenicity of valproate conjugates with anticonvulsant activity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Female; Lethal Dose 50; Male; Mice; Pregnancy | 2003 |
Effects of valproic acid on longitudinal bone growth.
Topics: Animals; Anticonvulsants; Apoptosis; Body Height; Bone Development; Chondrocytes; Culture Techniques | 2004 |
Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.
Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases; Hu | 2004 |
Detection of Purkinje cell loss following drug exposures to developing rat pups using reverse transcriptase-polymerase chain reaction (RT-PCR) analysis for calbindin-D28k mRNA expression.
Topics: Administration, Oral; Animals; Animals, Newborn; Calbindin 1; Calbindins; Cell Count; Dose-Response | 2004 |
Etiological heterogeneity of familial periventricular heterotopia and hydrocephalus.
Topics: Adult; Anticonvulsants; Blotting, Western; Brain; Child; Child, Preschool; Choristoma; Contractile P | 2004 |
Mapping a chromosomal locus for valproic acid-induced exencephaly in mice.
Topics: Animals; Anticonvulsants; Chromosome Mapping; Crosses, Genetic; Female; Genetic Predisposition to Di | 2004 |
Neuroblastoma, maternal valproic acid use, in-vitro fertilization and family history of mosaic chromosome 22: coincidence or causal relationship?
Topics: Adult; Anticonvulsants; Child; Chromosomes, Human, Pair 22; Female; Fertilization in Vitro; Humans; | 2004 |
Effect of valproic acid on fetal and maternal organs in the mouse: a morphological study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Female; Fetus; Gestational Age; Growt | 2004 |
Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Attention; Autistic Disorder; Behavior, Animal; Disc | 2005 |
Navigating toward fetal and maternal health: the challenge of treating epilepsy in pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Child; Cohort Studies; Confoundi | 2004 |
Longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema | 2004 |
The longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Child; Child, Preschool; Cognition Disorde | 2004 |
Australian pregnancy registry of women taking antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Drug Therapy, Combination; Epilepsy; Female | 2004 |
Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Dose-Response Relationship, Drug; Epilepsy; | 2004 |
Polycomb homologs are involved in teratogenicity of valproic acid in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Bone and Bones; DNA-Binding Proteins; | 2004 |
Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure.
Topics: Abortion, Induced; Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Female; Heart Defects, | 2005 |
Baller-Gerold syndrome after fetal exposure to sodium valproate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Craniosynostoses; Female; Hum | 2005 |
What can we say to women of reproductive age with epilepsy?
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; E | 2005 |
Neuropsychological effects of exposure to anticonvulsant medication in utero.
Topics: Adolescent; Anticonvulsants; Brain; Child; Cognition Disorders; Cohort Studies; Epilepsy; Female; Hu | 2005 |
Increased rate of major malformations in offspring exposed to valproate during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Inte | 2005 |
Fetal exposure to sodium valproate associated with Baller-Gerold syndrome: case report and review of the literature.
Topics: Craniosynostoses; Female; Humans; Infant; Pregnancy; Prenatal Exposure Delayed Effects; Radiography; | 2006 |
Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.
Topics: Analysis of Variance; Animals; Animals, Newborn; CD11b Antigen; Cell Count; Cells, Cultured; Dopamin | 2005 |
Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Embryo, Mammalian; Female; Gene Expression; Gene Expre | 2005 |
Valproic acid binding to human serum and human placenta in vitro.
Topics: Blood Proteins; Female; Humans; Male; Maternal-Fetal Exchange; Placenta; Pregnancy; Protein Binding; | 2005 |
Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism.
Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Behavior, Animal; Environment; Exploratory Beh | 2006 |
Potential risks associated with high-dose valproate in pregnancy in psychiatric patients.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Depressive Disorder, Major; Dose-Response Relationship, D | 2005 |
Antiepileptic drug use of women with epilepsy and congenital malformations in offspring.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cardiovascular Abnormalities; Cleft Palate; Coh | 2005 |
Split-hand/split-foot malformation associated with maternal valproate consumption.
Topics: Adult; Anticonvulsants; Female; Foot Deformities, Congenital; Hand Deformities, Congenital; Humans; | 2005 |
Children exposed to valproate in utero--population based evaluation of risks and confounding factors for long-term neurocognitive development.
Topics: Adolescent; Adult; Anticonvulsants; Child; Cognition Disorders; Confounding Factors, Epidemiologic; | 2005 |
Maternal valproate dosage and foetal malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Logistic Models; Pregnancy; | 2005 |
Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Dose-Response Relationship, Drug; Female; Feta | 2006 |
Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity.
Topics: Abnormalities, Drug-Induced; Acetylation; Animals; Bone and Bones; Cartilage; Enzyme Inhibitors; Fem | 2005 |
Valproic acid-induced skeletal malformations: associated gene expression cascades.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Dose-Response Relationship, D | 2005 |
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Child | 2006 |
S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates an
Topics: Abnormalities, Drug-Induced; Animals; Blood-Brain Barrier; Disease Models, Animal; Dose-Response Rel | 2006 |
Myo-inositol enhances teratogenicity of valproic acid in the mouse.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anticonvulsants; Drug Synergism; Embryo | 2006 |
Ultrastructural investigation of the protective role of folic acid and vitamin E against toxic effects of valproic acid on maternal liver tissue during period of gestation.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Injections, Su | 2006 |
The effects of valproic acid, vitamin E and folic acid on ribs of rat fetuses in the prenatal period.
Topics: Animals; Bone and Bones; Female; Fetal Development; Folic Acid; Models, Animal; Pregnancy; Rats; Rat | 2006 |
An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms.
Topics: Animals; Anticonvulsants; Female; Gene Expression Profiling; Glucose; Humans; Liver; Male; Mice; Oli | 2006 |
A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate.
Topics: Animals; Animals, Newborn; Anticonvulsants; Attention; Autistic Disorder; Disease Models, Animal; Do | 2006 |
A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases | 2006 |
Prenatal exposure to antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cognition Disorders; Diethylcarbamazine; Face; Female; | 2006 |
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Dru | 2006 |
Antiepileptic drug use and birth rate in patients with epilepsy--a population-based cohort study in Finland.
Topics: Adolescent; Adult; Anticonvulsants; Birth Rate; Carbamazepine; Cohort Studies; Epilepsy; Female; Fin | 2006 |
Teratology study of derivatives of tetramethylcyclopropyl amide analogues of valproic acid in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Body Weight; Cesarean Section; Cyclopropanes; Female; | 2006 |
Immunogold study of effects of prenatal exposure to lipopolysaccharide and/or valproic acid on the rat blood-brain barrier vessels.
Topics: Albumins; Animals; Blood-Brain Barrier; Brain Ischemia; Cell Membrane; Cerebral Arteries; Child; Dev | 2005 |
The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition; Education, Special; Epilepsy; Female; Humans; Ment | 2006 |
Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma.
Topics: Abnormalities, Drug-Induced; Adjuvants, Immunologic; Animals; Anticonvulsants; Dose-Response Relatio | 2006 |
Fetal valproate syndrome.
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; | 2006 |
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Homocystein | 2007 |
Discrimination learning and reversal of the conditioned eyeblink reflex in a rodent model of autism.
Topics: Analysis of Variance; Animals; Autistic Disorder; Conditioning, Eyelid; Discrimination Learning; Fem | 2007 |
Abnormality of circadian rhythm accompanied by an increase in frontal cortex serotonin in animal model of autism.
Topics: Animals; Animals, Newborn; Autistic Disorder; Behavior, Animal; Chronobiology Disorders; Disease Mod | 2007 |
Medroxyprogesterone - valproic acid - aspirin. MVA regime to reduce transfusion associated mortality in late-term hemoglobinopathies. Hypothesis and rationale.
Topics: Aspirin; Blood Transfusion, Intrauterine; Dose-Response Relationship, Drug; Drug Therapy, Combinatio | 2007 |
Observations on juvenile myoclonic epilepsy amongst ethnic Bengalees in West Bengal--an Eastern Indian State.
Topics: Abnormalities, Drug-Induced; Age of Onset; Anticonvulsants; Benzodiazepines; Clobazam; Electroenceph | 2007 |
Boric acid inhibits embryonic histone deacetylases: a suggested mechanism to explain boric acid-related teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Blotting, Western; Bone and Bones; Boric Acids; Cell Nucleus; | 2007 |
A survey of antiepileptic prescribing to women of childbearing potential in psychiatry.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Prescriptions; England; Epilepsy; Female; Ho | 2007 |
Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Female; Fetus | 2007 |
Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism.
Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Basal Ganglia; Conditioning, Classical; Diseas | 2007 |
Abnormal fear conditioning and amygdala processing in an animal model of autism.
Topics: Amygdala; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Autistic Disorder; Behav | 2008 |
Phenytoin but not valproate directly affected in vitro trophoblast differentiation.
Topics: Anticonvulsants; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Epilepsy; | 2008 |
Psychopharmacology news. New side effects of agents.
Topics: Benzodiazepines; Bupropion; Female; Humans; Olanzapine; Pregnancy; Propranolol; Psychotropic Drugs; | 2007 |
Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid.
Topics: Animals; Anticonvulsants; Autistic Disorder; Cell Count; Disease Models, Animal; Female; Male; Neoco | 2008 |
Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium; Female; Long-Term Potentiation; Maternal Expos | 2007 |
Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature.
Topics: Adult; Anticonvulsants; Brain; Female; Genetic Counseling; Heart Neoplasms; Humans; Infant, Newborn; | 2008 |
Early intervention for the ocular and neurodevelopmental sequelae of Fetal Valproate Syndrome.
Topics: Abnormalities, Drug-Induced; Amblyopia; Anticonvulsants; Autistic Disorder; Child, Preschool; Cranio | 2007 |
Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cell Cycle; Cells, Cultured; Dopamine; Dose-Response Re | 2007 |
Valproate-induced developmental neurotoxicity is affected by maternal conditions including shipping stress and environmental change during early pregnancy.
Topics: Animal Husbandry; Animals; Anticonvulsants; Antimanic Agents; Brain; Female; Fetal Weight; Fetus; Ma | 2007 |
The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies.
Topics: Anticonvulsants; Australia; Birth Weight; Epilepsy; Female; Fetus; Humans; Pregnancy; Pregnancy Comp | 2007 |
Trigonocephaly and valproate: a case report and review of literature.
Topics: Adult; Anticonvulsants; Craniosynostoses; Female; Gestational Age; Humans; Magnetic Resonance Imagin | 2008 |
Posterior reversible encephalopathy syndrome (PRES).
Topics: Adult; Anticonvulsants; Cesarean Section; Female; Humans; Magnetic Resonance Imaging; Patient Readmi | 2008 |
Contraindications to phenytoin in emergency department patients with seizures.
Topics: Anticonvulsants; Contraindications; Emergency Service, Hospital; Epilepsy; Female; Humans; Levetirac | 2009 |
Congenital gingival hyperplasia in a neonate with foetal valproate syndrome.
Topics: Adult; Anticonvulsants; Apgar Score; Craniofacial Abnormalities; Dose-Response Relationship, Drug; E | 2007 |
Pregnancy outcome after in utero exposure to valproate : evidence of dose relationship in teratogenic effect.
Topics: Abnormalities, Drug-Induced; Antimanic Agents; Dose-Response Relationship, Drug; Female; Humans; Pre | 2008 |
Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; Immunity, Innate; Male | 2008 |
Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition.
Topics: Acetylation; Animals; Apoptosis; Blotting, Western; Caspases; Cell Survival; Cells, Cultured; Embryo | 2008 |
Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility.
Topics: Adult; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; In Vitro Techniques; Oxytoc | 2008 |
Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain.
Topics: Anticonvulsants; Case-Control Studies; Epilepsy; Female; Humans; Hypospadias; Infant, Newborn; Logis | 2008 |
Teratogenic potential of valproic acid.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Mice; Pregnancy; Val | 1980 |
Valproic acid during pregnancy.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Valproic Acid | 1980 |
Maternal valproic acid and congenital neural tube defects.
Topics: Epilepsy; Female; Humans; Maternal-Fetal Exchange; Neural Tube Defects; Pregnancy; Valproic Acid | 1982 |
Valproic acid and spina bifida.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregn | 1982 |
Sodium valproate and neural tube defects.
Topics: Adult; Epilepsy, Tonic-Clonic; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meningocele | 1982 |
Valproate and malformations.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pre | 1982 |
Valproate, birth defects, and zinc.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Va | 1983 |
Embryotoxicity testing of valproic acid.
Topics: Animals; Drug Evaluation, Preclinical; Embryo, Mammalian; Female; Fetal Diseases; Humans; Methods; P | 1983 |
Valproic acid and spina bifida.
Topics: Adult; Anencephaly; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; S | 1983 |
Valproate and birth defects.
Topics: Abnormalities, Drug-Induced; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Valproic Acid | 1983 |
Pharmacokinetics of antiepileptic drugs.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1983 |
Spina bifida and in-utero exposure to valproate.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Spina Bif | 1984 |
Valproate and spina bifida.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Epilepsy; Female; Humans; Middle Aged; Pregnancy; Pr | 1984 |
[Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance].
Topics: Adult; Amylases; Body Weight; Drug Tolerance; Epilepsy; Female; Humans; Male; Middle Aged; Pregnancy | 1983 |
[Absence of effects of sodium valproate on the estrous cycle of the rat].
Topics: Animals; Estrus; Female; gamma-Aminobutyric Acid; Pregnancy; Rats; Rats, Inbred Strains; Valproic Ac | 1982 |
Valproic acid and fetal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Clinical pharmacokinetics of drugs used in the treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Female; Humans; Kinetics; Models, Biologica | 1983 |
Spina bifida and sodium valproate.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Spina Bifida Occulta; | 1983 |
Valproic acid in pregnancy--association with spina bifida: a preliminary report.
Topics: Female; Humans; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects; Spina Bifida Occulta; | 1983 |
Valproate link to spina bifida.
Topics: Abnormalities, Drug-Induced; Female; Humans; Pregnancy; Risk; Spina Bifida Occulta; Valproic Acid | 1983 |
[Spina bifida caused by valproic acid?].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1983 |
Teratogenic effects of valproic acid and diphenylhydantoin on mouse embryos in culture.
Topics: Animals; Culture Media; Embryo, Mammalian; Female; Mice; Mice, Inbred ICR; Organ Culture Techniques; | 1983 |
Transplacental passage and half-life of sodium valproate in infants born to epileptic mothers.
Topics: Epilepsy; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnanc | 1983 |
Spina bifida and anencephaly: fewer patients, more problems.
Topics: Abnormalities, Drug-Induced; Anencephaly; Female; Humans; Infant, Newborn; Neural Tube Defects; Preg | 1983 |
Valproate teratogenicity.
Topics: Female; Humans; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects; Spina Bifida Occulta; | 1983 |
Valproate: a new cause of birth defects--report from Italy and follow-up from France.
Topics: Abnormalities, Drug-Induced; Female; France; Humans; Infant, Newborn; Italy; Pregnancy; Spina Bifida | 1983 |
Treatment of epilepsy in women of child-bearing age: patients' opinion of teratogenic potential of valproate.
Topics: Adolescent; Adult; Attitude; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant, Newborn; M | 1983 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
[Case of congenital anomalies born to an epileptic woman treated with valproic acid and phenobarbital].
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Esotropia; Female; Humans; Infant; Phenobarbit | 1983 |
Delayed effects of drug exposure during pregnancy: reproductive function.
Topics: Animals; Anticonvulsants; Estrus; Female; Fertility; Luteinizing Hormone; Male; Phenobarbital; Pheny | 1983 |
[Is valproic acid teratogenic?].
Topics: Abnormalities, Drug-Induced; Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infa | 1983 |
Pharmacological activation of gamma-aminobutyric acid-system blunts prolactin response to mechanical breast stimulation in puerperal women.
Topics: Adult; Breast; Female; gamma-Aminobutyric Acid; Humans; Physical Stimulation; Postpartum Period; Pre | 1984 |
Possible teratogenic effect of valproate during pregnancy.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pre | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Anticonvulsant activity and embryotoxicity of valproic acid.
Topics: Animals; Female; Fetal Diseases; Humans; Muridae; Pregnancy; Valproic Acid | 1984 |
Protein binding of valproic acid in maternal and umbilical cord serum.
Topics: Adolescent; Adult; Blood Proteins; Epilepsy; Female; Fetal Blood; Humans; Pregnancy; Pregnancy Compl | 1984 |
Valproic acid in the perinatal period: decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites.
Topics: Blood Proteins; Epilepsy; Fatty Acids, Nonesterified; Female; Fetal Blood; Fetus; Humans; Infant, Ne | 1984 |
Mechanism of altered drug binding to serum proteins in pregnant women: studies with valproic acid.
Topics: Adult; Blood Proteins; Fatty Acids, Nonesterified; Female; Gestational Age; Humans; Pregnancy; Prote | 1984 |
Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Arousal; Benzodiazepinones; Carbamazepine; Chemical and Drug Induced Li | 1983 |
Non-dose-related side effects of valproate.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Fat Necrosi | 1984 |
Valproic acid and congenital malformations. A case report.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Female; Humans; Infant, Newbo | 1984 |
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsatur | 1984 |
Enzyme induction in neonates after fetal exposure to antiepileptic drugs.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Anticonvulsants; Breath Tests; Carbamazepine; Carbon Radiois | 1983 |
Differential transplacental binding of valproic acid: influence of free fatty acids.
Topics: Dialysis; Fatty Acids, Nonesterified; Female; Fetal Blood; Humans; Maternal-Fetal Exchange; Oxytocin | 1984 |
Congenital liver damage after treatment of mother with valproic acid and phenytoin?
Topics: Adult; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Liver; Liver Diseases; Maternal-Fetal Exchang | 1984 |
Teratogenic effects of dosage levels and time of administration of carbamazepine, sodium valproate, and diphenylhydantoin on craniofacial development in the CD-1 mouse fetus.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Dr | 1984 |
The fetal valproate syndrome.
Topics: Epilepsy; Face; Female; Heart Defects, Congenital; Humans; Infant, Low Birth Weight; Infant, Newborn | 1984 |
[Fertile women and valproate. Reactions to information about the possible teratogenic effect].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Female; Humans; Neural Tube Defects; Pregnancy; Risk | 1984 |
[Use of valproic acid in pregnancy: an indication for prenatal diagnosis of spina bifida].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1984 |
[Use of valproic acid by pregnant women with epilepsy and the risk of congenital abnormalities in the child].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1984 |
Studies on the involvement of GABA in the aggression directed by groups of intact or gonadectomized male and female mice towards lactating intruders.
Topics: Aggression; Animals; Brain Chemistry; Castration; Dose-Response Relationship, Drug; Female; gamma-Am | 1980 |
Teratogenicity of valproic acid.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Se | 1980 |
Teratogenic effects of anticonvulsants.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cleft Palate; Eyelid Diseases; | 1981 |
Possible teratogenicity of valproic acid.
Topics: Abnormalities, Drug-Induced; Adolescent; Female; Humans; Infant, Newborn; Male; Meningocele; Pregnan | 1981 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Altered drug binding to serum proteins in pregnant women: therapeutic relevance.
Topics: Adult; Blood Proteins; Diazepam; Female; Humans; In Vitro Techniques; Phenytoin; Pregnancy; Pregnanc | 1981 |
Recent advances in the treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Huma | 1980 |
Possible teratogenic effect of valproic acid.
Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Valproic Aci | 1981 |
Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.
Topics: Abnormalities, Drug-Induced; Aminopyrine; Breath Tests; Epilepsy; Female; Fetal Blood; Half-Life; Hu | 1981 |
Sodium valproate in pregnancy.
Topics: Adult; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid | 1981 |
A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations.
Topics: Animals; Blood Proteins; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fetus; Half-L | 1981 |
Materno-fetal pharmacokinetics and fetal distribution of valproic acid in a pregnant rhesus monkey.
Topics: Amniotic Fluid; Animals; Female; Fetus; Kinetics; Macaca mulatta; Maternal-Fetal Exchange; Pregnancy | 1980 |
Placental transfer of anticonvulsants (phenobarbital, phenytoin, valproic acid) and the elimination from neonates.
Topics: Anticonvulsants; Bilirubin; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Male; Maternal- | 1981 |
Brain maturation following administration of phenobarbital, phenytoin, and sodium valproate to developing rats or to their dams: effects on synthesis of brain myelin and other subcellular membrane proteins.
Topics: Animals; Anticonvulsants; Brain; Female; Intracellular Membranes; Membrane Proteins; Myelin Proteins | 1982 |
Valproic acid and spina bifida: a preliminary report--France.
Topics: Epilepsy; Female; France; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Spina Bifida | 1982 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; | 1982 |
Sodium valproate: monotherapy and polytherapy.
Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsies, Part | 1982 |
[Human teratogenicity of valproic acid containing antiepileptic drugs].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 1982 |
[Valproate and congenital abnormalities].
Topics: Abnormalities, Drug-Induced; Carbamazepine; Female; Humans; Pregnancy; Valproic Acid | 1982 |
Erythrocyte antioxidant enzyme activities in children with myelomeningocele.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; Glutathione Peroxidase; | 1995 |
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.
Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family | 1994 |
Juvenile myoclonic epilepsy.
Topics: Adolescent; Age of Onset; Animals; Anticonvulsants; Child; Circadian Rhythm; Clonazepam; Cricetinae; | 1995 |
Benzodiazepine amplification of valproate teratogenic effects in children of mothers with absence epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Benzodiazepines; Brain; Child; Child, Preschool; Developmental D | 1993 |
Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids.
Topics: Abnormalities, Drug-Induced; Acids; Administration, Oral; Animals; Caproates; Caprylates; Dose-Respo | 1994 |
Trans-2-ene-valproic acid is less behaviorally teratogenic than an equivalent dose of valproic acid in rats.
Topics: Animals; Behavior, Animal; Fatty Acids, Monounsaturated; Female; Maze Learning; Motor Activity; Preg | 1994 |
Omphalocele in a newborn baby exposed to sodium valproate in utero.
Topics: Face; Female; Hernia, Umbilical; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Diagnosis; Prena | 1995 |
Partial hydranencephaly in a child coincidental with intrauterine exposure to sodium valproate.
Topics: Brain; Female; Humans; Hydranencephaly; Infant; Male; Maternal Welfare; Pregnancy; Prenatal Exposure | 1994 |
Validation of an in vitro teratology system using chiral substances: stereoselective teratogenicity of 4-yn-valproic acid in cultured mouse embryos.
Topics: Animals; Embryo, Mammalian; Embryonic and Fetal Development; Female; Mice; Mice, Inbred Strains; Org | 1995 |
Lithium: the present and the future.
Topics: Acute Disease; Bipolar Disorder; Carbamazepine; Depressive Disorder; Drug Interactions; Female; Huma | 1995 |
Neonatal fibrinogen depletion caused by sodium valproate.
Topics: Afibrinogenemia; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy | 1994 |
Carnitine affects octanoate oxidation to carbon dioxide and dicarboxylic acids in colostrum-deprived piglets: in vivo analysis of mechanisms involved based on CoA- and carnitine-ester profiles.
Topics: Animals; Animals, Newborn; Caprylates; Carbon Dioxide; Carnitine; Chromatography, High Pressure Liqu | 1995 |
Prevention of neural tube defects.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Female; Folic Acid; Humans; Neural Tube Defects; Pregnan | 1994 |
Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero.
Topics: Abnormalities, Drug-Induced; Adult; Causality; Epilepsy; Female; Humans; Infant, Newborn; Male; Preg | 1994 |
Developmental toxicity and structure-activity relationships of aliphatic acids, including dose-response assessment of valproic acid in mice and rats.
Topics: Acids; Animals; Behavior, Animal; Body Weight; Female; Male; Mice; Pregnancy; Rats; Rats, Sprague-Da | 1994 |
Evaluation of the rat embryo culture system as a predictive test for human teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Captopril; Diphenhydramine; DNA; Embryo, Mammalian; False Nega | 1994 |
Radial ray aplasia in utero: a prenatal finding associated with valproic acid exposure.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Carbamazepine; Epilepsy, Absence; Female; Huma | 1994 |
Pregnancy, epilepsy, management and outcome: a 10-year perspective.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Carbamazepine; Cohort Studies; Drug Ther | 1993 |
Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus: peak sensitivity of gestational day and dose-dependent effect.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Fetal Resorption; Fetus; Heart Defec | 1993 |
Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero.
Topics: Drug Administration Schedule; Epilepsy; Female; Heart Defects, Congenital; Humans; Infant, Newborn; | 1993 |
Teratogenicity of antiepileptic drugs and drug specific malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug | 1993 |
Preaxial ray reduction defects as part of valproic acid embryofetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Therapeutic; Adolescent; Adult; Extr | 1993 |
Vitamins to prevent neural-tube defects.
Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pantothenic Acid; Pregnancy; Pregnancy Complications; | 1993 |
Treating epilepsy--when, with what and by whom?
Topics: Adult; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Seizures; Valproic Acid | 1993 |
Valproate and sodium currents in cultured hippocampal neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Choline; Electrophysiology; Female; Hippocampus; Membra | 1993 |
Lack of concordance between heat shock proteins and the development of tolerance to teratogen-induced neural tube defects.
Topics: Animals; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; Gene | 1993 |
Fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Human | 1995 |
Exact power computation for dose-response studies.
Topics: Adenoma; Algorithms; Animals; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Fem | 1995 |
Acute manic episodes in pregnancy.
Topics: Adult; Bipolar Disorder; Chlorpromazine; Comorbidity; Diabetes Mellitus, Type 1; Drug Therapy, Combi | 1996 |
Placental transfer of valproic acid after liposome encapsulation during in vitro human placenta perfusion.
Topics: Anticonvulsants; Biological Transport; Drug Carriers; Female; Humans; Liposomes; Maternal-Fetal Exch | 1996 |
Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I).
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Embryo, Mammalian; Eyelids; F | 1995 |
Circadian rhythm of embryotoxicity induced by sodium valproate in mice.
Topics: Animals; Anticonvulsants; Chronobiology Phenomena; Circadian Rhythm; Drug Administration Schedule; E | 1995 |
The pharmacokinetics of valproic acid in pregnant sheep after maternal and fetal intravenous bolus administration.
Topics: Amniotic Fluid; Animals; Anticonvulsants; Blood Gas Analysis; Female; Fetus; Half-Life; Injections, | 1995 |
Effect of supplemental folic acid on valproic acid-induced embryotoxicity and tissue zinc levels in vivo.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Drug Interactions; Embryo, Mammalian; Embryonic and Feta | 1995 |
Arnold-Chiari-like malformation associated with a valproate model of spina bifida in the rat.
Topics: Animals; Arnold-Chiari Malformation; Brain; Disease Models, Animal; Female; Fetus; Litter Size; Lumb | 1995 |
Radiological case of the month. In utero ultrasonographic demonstration of a lymphangioma.
Topics: Adult; Epilepsy; Female; Fetal Diseases; Humans; Infant, Newborn; Liver Neoplasms; Lymphangioma, Cys | 1996 |
Teratogenic effects of sodium valproate in mice and rats at midgestation and at term.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Brain; Embryonic and Fetal De | 1996 |
Chronotoxicity of sodium valproate in pregnant mouse and embryo.
Topics: Animals; Circadian Rhythm; Embryo, Mammalian; Female; Mice; Mortality; Pregnancy; Teratogens; Valpro | 1996 |
[Example of teratogen detection using a birth defects registry: depakine and spina bifida].
Topics: Anticonvulsants; Drug Utilization; Female; France; Humans; Population Surveillance; Pregnancy; Prena | 1996 |
[Embryofetopathy due to valproate: a pathology only little known. Apropos of 4 cases].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Epilepsy; Face; Female; F | 1996 |
Valproate-induced developmental modifications maybe partially prevented by coadministration of folinic acid and S-adenosylmethionine.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Female; Fetus; Leucovorin; Li | 1996 |
A risk assessment of topical tretinoin as a potential human developmental toxin based on animal and comparative human data.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Female; Humans; Isotretinoin; Keratol | 1997 |
Fetal valproate embryopathy in twins: genetic modification of the response to a teratogen.
Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Diseases in Twins; Epilepsy; Female; Humans; Infant | 1996 |
[Embryo-fetopathy due to valproate].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Central Nervous System; Female; Fetal Diseases; Humans | 1997 |
Gene expression domains as markers in developmental toxicity studies using mammalian embryo culture.
Topics: Animals; Culture Techniques; DNA-Binding Proteins; Embryo, Mammalian; Embryonic and Fetal Developmen | 1997 |
Postimplantation mouse embryos cultured in vitro. Assessment with whole-mount immunostaining and in situ hybridization.
Topics: Animals; Congenital Abnormalities; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Develo | 1997 |
Effect of multifactorial genetic liability to exencephaly on the teratogenic effect of valproic acid in mice.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Susceptibility; Female; Fetal Death; Mice; Mice | 1997 |
A male with fetal valproate syndrome and autism.
Topics: Anticonvulsants; Audiology; Autistic Disorder; Child, Preschool; Developmental Disabilities; Female; | 1997 |
Polycystic ovary syndrome associated with treatment with the anticonvulsant sodium valproate.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Pregnancy; Valproic Aci | 1997 |
Lung hypoplasia--a possible teratogenic effect of valproate. Case report.
Topics: Anticonvulsants; Fatal Outcome; Female; Humans; Infant, Newborn; Lung; Pregnancy; Prenatal Exposure | 1998 |
Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Body Weight; Embryo, Mammalian; Femal | 1998 |
Teratogenic effects of antiepileptic drugs: what do we advise patients?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Patient Advoc | 1997 |
Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid.
Topics: Animals; Caproates; Crown-Rump Length; Encephalocele; Female; Hexanols; Hydrocephalus; Liver; Metall | 1998 |
[Prenatal ultrasonographic diagnosis in the epileptic mother on valproic acid. Retrospective study of 161 cases in the central eastern France register of congenital malformations].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; France; Humans; Population Surveilla | 1998 |
VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur amino acids and glutathione.
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Anticonvulsants; Female; Folic Acid; Glutathione; | 1998 |
Anomalous right pulmonary artery origins in association with the fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Female; Humans; Infant; Male; Pregna | 1999 |
Morphological alterations induced by sodium valproate on somites and spinal nerves in rat embryos.
Topics: Animals; Bone and Bones; Crown-Rump Length; Dose-Response Relationship, Drug; Female; Immunohistoche | 1999 |
Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report.
Topics: Adult; Anticonvulsants; Epilepsy; Ethosuximide; Female; Humans; Metabolic Diseases; Pantothenic Acid | 1999 |
Status epilepticus during pregnancy. A case report.
Topics: Anticonvulsants; Epilepsies, Myoclonic; Female; Humans; Obstetric Labor Complications; Pregnancy; Pr | 1999 |
Safe use of valproic acid during pregnancy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complica | 1999 |
Case-control studies using only malformed infants: are we interpreting the results correctly?
Topics: Abnormalities, Drug-Induced; Case-Control Studies; Congenital Abnormalities; Data Interpretation, St | 1999 |
Failure of periconceptual folic acid to prevent a neural tube defect in the offspring of a mother taking sodium valproate.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Folic Acid; Huma | 1999 |
Malformations in offspring of women with epilepsy: a prospective study.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Comorbidity; Congenital Abnormalities; | 1999 |
Stereoselective pharmacokinetics and pharmacodynamics of propylisopropyl acetamide, a CNS-active chiral amide analog of valproic acid.
Topics: Allylisopropylacetamide; Animals; Anticonvulsants; Blood Proteins; Chromatography, Gas; Dogs; Epoxid | 1999 |
[A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Fatal Outcome; Female; Humans; Infant; Infant, | 1999 |
A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Carcinoma, Embryonal | 2000 |
Blepharoptosis and central nervous system abnormalities in combined valproate and hydantoin embryopathy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Blepharoptosis; Brain; Drug Therapy, Combinatio | 2000 |
Carrier-mediated transport of valproic acid in BeWo cells, a human trophoblast cell line.
Topics: Anticonvulsants; Biological Transport; Carboxylic Acids; Choriocarcinoma; Female; Humans; Hydrogen-I | 2000 |
Prenatal exposure to valproic acid during pregnancy and limb deficiencies: a case-control study.
Topics: Anticonvulsants; Case-Control Studies; Female; Humans; Infant; Infant, Newborn; Limb Deformities, Co | 2000 |
Ribonucleotide reductase subunit R1: a gene conferring sensitivity to valproic acid-induced neural tube defects in mice.
Topics: Animals; Anticonvulsants; Embryonic and Fetal Development; Female; Gene Expression Regulation, Devel | 2000 |
A child with a DIC (15p; 22p) centric fusion and fetal Valproate syndrome.
Topics: Abnormalities, Multiple; Adult; Chromosome Aberrations; Chromosomes, Human, Pair 15; Chromosomes, Hu | 1999 |
Serum valproate levels in 6 breastfeeding mother-infant pairs.
Topics: Age Factors; Animals; Bipolar Disorder; Breast Feeding; Female; Humans; Infant; Infant, Newborn; Pos | 2000 |
Post-axial limb defects with maternal sodium valproate exposure.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Humans; Infant; Limb Deformities, Congenital; | 2000 |
Effects of valproic acid on fertility and reproductive organs in male rats.
Topics: Animals; Anticonvulsants; Body Weight; Female; Fertility; Genitalia, Male; Male; Organ Size; Pregnan | 2000 |
Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance.
Topics: Animals; Animals, Newborn; Anticonvulsants; Blood Proteins; Female; Fetus; Maternal-Fetal Exchange; | 2000 |
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
Topics: Animals; Animals, Newborn; Anticonvulsants; Female; Fetus; Humans; Kidney; Maternal-Fetal Exchange; | 2000 |
A clinical study of 57 children with fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2000 |
Prognosis of seizures occurring in the first year.
Topics: Anticonvulsants; Brain; Child, Preschool; Developmental Disabilities; Diagnosis, Differential; Elect | 2000 |
Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue.
Topics: Adult; Anticonvulsants; Astrocytes; Carrier Proteins; Cells, Cultured; Female; Fetus; GABA Plasma Me | 1999 |
Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Hypoglycemia; I | 2000 |
Developmental toxicity of valproic acid during embryonic chick vertebral chondrogenesis.
Topics: Abnormalities, Drug-Induced; Age Factors; Aggrecans; Animals; Cell Survival; Chick Embryo; Chondroge | 2000 |
Population based, prospective study of the care of women with epilepsy in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Death; Guidelin | 2000 |
Vitamin E decreases valproic acid induced neural tube defects in mice.
Topics: Administration, Oral; Animals; Crown-Rump Length; Dose-Response Relationship, Drug; Female; Fetal We | 2000 |
Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adjuvants, Immunologic; Animals; BCG Vaccine; | 2000 |
Fetal valproate syndrome and autism: additional evidence of an association.
Topics: Autistic Disorder; Child; Child, Preschool; Developmental Disabilities; Epilepsy; Female; Follow-Up | 2001 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).
Topics: 3-O-Methylglucose; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Alanine; Anticonvulsants; Biolo | 2001 |
[Hyperammonia, hypoglycemia and thrombocytopenia in a newborn after materanl treatment with valproate].
Topics: Adult; Ammonia; Anticonvulsants; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis | 2001 |
Valproic acid sodium-induced spina bifida occulta in the rat.
Topics: Animals; Brain; Female; Gestational Age; Lumbar Vertebrae; Male; Pregnancy; Rats; Rats, Wistar; Risk | 2001 |
Prediction of embryotoxic effects of valproic acid-derivatives with molecular in vitro methods.
Topics: Animals; Anticonvulsants; Cell Differentiation; Drug Evaluation, Preclinical; Female; Humans; Pregna | 2001 |
Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Genetic Predisposition to Disease; Gravidity; Humans; Neur | 2001 |
[Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report].
Topics: Adult; Anticonvulsants; Cranial Sutures; Craniosynostoses; Female; Humans; Infant; Phenobarbital; Pr | 2001 |
Selection bias in Teratology Information Service pregnancy outcome studies.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; California; Carbamazepine; Drug Information Ser | 2001 |
Septo-optic dysplasia as a manifestation of valproic acid embryopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Antimanic Agents; Child, Preschool | 2001 |
Craniosynostosis and fetal exposure to sodium valproate.
Topics: Anticonvulsants; Child; Child, Preschool; Craniosynostoses; Epilepsy; Female; Fetus; Humans; Infant; | 2001 |
Reduced corneal sensation and severe dry eyes in a child with fetal valproate syndrome.
Topics: Anticonvulsants; Corneal Diseases; Female; Humans; Hypesthesia; Infant, Newborn; Pregnancy; Prenatal | 2001 |
Fatal cardiac malformation in fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Fatal Outcome; Female; Heart Defects, | 2001 |
'Foetal valproate syndrome and autism: additional evidence of an association'.
Topics: Abnormalities, Drug-Induced; Autistic Disorder; Child; Epilepsy, Generalized; Female; Humans; Male; | 2001 |
[Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment].
Topics: Abnormalities, Drug-Induced; Craniosynostoses; Diseases in Twins; Epilepsy, Generalized; Female; Hum | 2001 |
[Teratogenic action of antiepileptic drug: 2-propylpentanoic acid-effects on rat and hamster embryos cultured in vitro].
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cricetinae; Dose-Response Relationship, Drug; | 2001 |
Proton gradient-dependent transport of valproic acid in human placental brush-border membrane vesicles.
Topics: Adult; Algorithms; Anticonvulsants; Biological Transport, Active; Fatty Acids; Female; Humans; Hydro | 2002 |
A role for protein kinase C and its substrates in the action of valproic acid in the brain: implications for neural plasticity.
Topics: Animals; Anticonvulsants; Brain; Cell Differentiation; Cell Division; Cell Line, Transformed; Cytosk | 2002 |
Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases.
Topics: Acetylation; Acetyltransferases; Animals; beta-Galactosidase; Butyrates; Cell Nucleus; Cells, Cultur | 2002 |
Sodium valproate.
Topics: Adult; Animals; Brain; Child; Epilepsy; Epilepsy, Absence; Female; Hemostasis; Humans; Pregnancy; Va | 1979 |
Materno-fetal pharmacokinetics and fetal distribution of valproic acid in the monkey.
Topics: Amniotic Fluid; Animals; Female; Fetus; Haplorhini; Kinetics; Macaca mulatta; Maternal-Fetal Exchang | 1979 |
Sodium valproate, pregnancy, and neonatal hyperglycinaemia.
Topics: Adult; Epilepsy; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Pre | 1979 |
[Drug therapy of epilepsy].
Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol | 1977 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi | 1978 |
Sodium valproate and pregnancy.
Topics: Adult; Breast Feeding; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Mil | 1979 |
Transmission of valproic acid (Depakene) across the placenta: half-life of the drug in mother and baby.
Topics: Adult; Female; Fetus; Half-Life; Humans; Maternal-Fetal Exchange; Milk, Human; Placenta; Pregnancy; | 1979 |
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure.
Topics: Acetylcholinesterase; alpha-Fetoproteins; Amniotic Fluid; Female; Humans; Pregnancy; Pregnancy Trime | 1992 |
Valproic acid-induced placental and teratogenic effects in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetus; Placenta; Pregnancy; Rats; Rats, Sprague-D | 1992 |
Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice.
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Encephalocele; Female; Folic Acid; Methotrexat | 1992 |
A morphologic basis postulated for valproic acid's embryotoxic action in rats.
Topics: Animals; Decidua; Embryo, Mammalian; Embryonic and Fetal Development; Female; Homeostasis; Maternal- | 1992 |
Valproic acid-induced spina bifida: a mouse model.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Mice; Mice, Inbred Strains; Pr | 1992 |
The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida.
Topics: Amniocentesis; Amniotic Fluid; Drug Therapy, Combination; Epilepsy; Female; Gas Chromatography-Mass | 1992 |
Methionine decreases the embryotoxicity of sodium valproate in the rat: in vivo and in vitro observations.
Topics: Animals; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fetal Resor | 1992 |
Preaxial polydactyly in the fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Face; Female; Fingers; Humans; Infant, Newborn | 1992 |
Neural tube defects in association with epilepsy and its treatment.
Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Valproic Acid | 1992 |
The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats.
Topics: Administration, Cutaneous; Animals; Body Weight; Congenital Abnormalities; Dose-Response Relationshi | 1992 |
Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, | 1992 |
The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infant; Infant, Newborn; Male; Pre | 1992 |
Antiepileptic drug disposition during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Valproic | 1992 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe | 1992 |
Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis.
Topics: Animals; Circadian Rhythm; Fatty Acids, Monounsaturated; Female; Fetus; Folic Acid; Leucovorin; Mice | 1992 |
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
Effect of supplementation with folinic acid, vitamin B6, and vitamin B12 on valproic acid-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Drug Interactions; Embryo, Mammalian; | 1992 |
Valproic acid and spina bifida.
Topics: Case-Control Studies; Female; Humans; Infant; Pregnancy; Spain; Spinal Dysraphism; Time Factors; Val | 1991 |
Zinc concentrations in mouse embryo and maternal plasma. Effect of valproic acid and nonteratogenic metabolite.
Topics: Animals; Decidua; Embryo, Mammalian; Fatty Acids, Monounsaturated; Female; Mice; Pregnancy; Valproic | 1990 |
[The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combin | 1991 |
The effect of administration time on malformations induced by three anticonvulsant agents in C57BL/6J mice with emphasis on forelimb ectrodactyly.
Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Anticonvulsants; Dimethadione; Facial Bones; Fem | 1991 |
Sodium valproate, carbamazepine and spina bifida.
Topics: Carbamazepine; Female; Humans; Pregnancy; Spinal Dysraphism; Valproic Acid | 1991 |
Adaptation of postimplantation embryos to culture: membrane lipid synthesis and response to valproate.
Topics: Animals; Cholesterol; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Development; Female | 1991 |
Diurnal variation of folate concentrations in mouse embryo and plasma: the protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent.
Topics: Abnormalities, Drug-Induced; Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Decidu | 1991 |
Sodium valproate in pregnancy.
Topics: Epilepsy; Female; Fetal Diseases; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; V | 1991 |
Lack of attenuation of valproic acid-induced effects by folinic acid in rat embryos in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetal Death; In Vitro Techniqu | 1991 |
Lack of teratogenicity of trans-2-ene-valproic acid compared to valproic acid in rats.
Topics: Animals; Body Weight; Embryo, Mammalian; Embryonic and Fetal Development; Fatty Acids, Monounsaturat | 1991 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic
Topics: Animals; Anticonvulsants; Drug Design; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Femal | 1991 |
The fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child, Preschool; Face; Female; Humans; Male; | 1991 |
PIVKA-II (protein induced by vitamin K absence-II) status in newborns exposed to anticonvulsant drugs in utero.
Topics: Adult; Anticonvulsants; Biomarkers; Diazepam; Epilepsy; Factor VII; Factor X; Female; Humans; Infant | 1991 |
Transplacental distribution of weak acids in mice: accumulation in compartments of high pH.
Topics: Acids; Animals; Dimethadione; Female; Gestational Age; Hydrogen-Ion Concentration; Maternal-Fetal Ex | 1991 |
Effects of valproic acid, some of its metabolites and analogues on prenatal development of rats in vitro and comparison with effects in vivo.
Topics: Animals; Caproates; Culture Techniques; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryon | 1990 |
On the use of anticonvulsants for manic depression during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Bipolar Disorder; Carbamazepine; Female; Humans; Infan | 1990 |
Effect of pregnancy on the disposition of valproate in rats.
Topics: Animals; Blood Proteins; Female; Male; Pregnancy; Pregnancy, Animal; Protein Binding; Rats; Rats, In | 1990 |
Proximal phocomelia and radial ray aplasia in fetal valproic syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Ectromelia; Female; Humans; In | 1990 |
Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Dimethadione; Female; Fetal Death; Fetal Resorpt | 1990 |
Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to sodium valproate.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Electrophoresis, Gel, Two-Dimensional; Epithelium; Fema | 1990 |
Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Cerebellum; Drug Therapy, Combination; Epilepsy; Female; Humans; Nerve | 1990 |
Clinical manifestation of prenatal exposure to valproic acid using case reports and epidemiologic information.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Case-Control Studies; Face; Female; Humans; Infant, Ne | 1990 |
[Effects of Shosaiko-to-go-keishikashakuyaku-to (TJ-960) on the valproic acid induced anomalies of rat fetuses].
Topics: Abnormalities, Drug-Induced; Animals; Drug Interactions; Drugs, Chinese Herbal; Female; Fetus; Male; | 1990 |
Teratogenic effects of sodium valproate in the Jcl: ICR mouse fetus.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Gestational Age; Heart Defects, Congenital; Hum | 1990 |
Use of anticonvulsants for manic depression during pregnancy.
Topics: Bipolar Disorder; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Valproic | 1990 |
[Prenatal diagnosis of 4 cases of spina bifida in mothers treated with valproate].
Topics: Adult; alpha-Fetoproteins; Amniocentesis; Female; Fetal Diseases; Humans; Pregnancy; Pregnancy Trime | 1987 |
[The first case of a child born with fetal valproic acid syndrome in Hungary].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1989 |
The effect of valproic acid on 65Zn distribution in the pregnant rat.
Topics: Abnormalities, Drug-Induced; Animals; Carrier Proteins; Female; Fetus; Liver; Molecular Weight; Plac | 1989 |
Transplacental transfer and biotransformation studies of valproic acid and its glucuronide(s) in the perfused human placenta.
Topics: Biotransformation; Female; Humans; In Vitro Techniques; Metabolic Clearance Rate; Perfusion; Placent | 1989 |
Valproic acid disposition and protein binding in pregnancy.
Topics: Adult; Epilepsy; Female; Fetal Blood; Gestational Age; Humans; Pregnancy; Protein Binding; Valproic | 1989 |
Valpromide is a poor inhibitor of the cytosolic epoxide hydrolase.
Topics: Anticonvulsants; Cytosol; Epoxide Hydrolases; Female; Fetus; Humans; In Vitro Techniques; Liver; Pre | 1989 |
Fetal valproate phenotype is recognisable by mid pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Diseases; Humans; Meningomyelocele; Phenotype; Pre | 1989 |
Valproate and spina bifida.
Topics: Adult; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy; Pr | 1989 |
Epilepsy in women of childbearing age.
Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Co | 1989 |
[Valproate induced fetopathy and somatic and psychomotor development].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange; Preg | 1989 |
[Structural bases of the teratogenic effects of the antiepileptic valproic acid. 2-n-propyl-4-pentenic acid, the first structural analogue with significantly higher teratogenic action than VPA].
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Fetus; Mice; Organ Size; Pregnancy; | 1989 |
Valproate and spina bifida.
Topics: Adult; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Spina | 1989 |
Effects of sodium valproate and oxygen on the craniofacial skeletal pattern in the CD-1 mouse embryo.
Topics: Animals; Facial Bones; Female; Fetal Growth Retardation; Maternal-Fetal Exchange; Mice; Osteogenesis | 1989 |
Valproate, spina bifida, and birth defect registries.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Ireland; Pregnancy; Registries; Spina | 1989 |
Inhibition of epoxide hydrolase by anticonvulsants and risk of teratogenicity.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Interactions; Epoxide Hydrolases; Female; Humans; | 1989 |
Valproate and spina bifida.
Topics: Female; Humans; Pregnancy; Prenatal Diagnosis; Risk Factors; Spain; Spina Bifida Occulta; Valproic A | 1989 |
Lesions and repair of cells of maternal mice after valproic acid (VPA) treatment on day 8 of pregnancy: an enzyme histochemical analysis.
Topics: Alkaline Phosphatase; Aminopeptidases; Animals; CD13 Antigens; Cell Membrane; Dipeptidyl-Peptidases | 1989 |
Valpromide/carbamazepine and risk of teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Hu | 1985 |
In-utero exposure to valproate and neural tube defects.
Topics: Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neural T | 1986 |
An assessment of the effects of cyclophosphamide and sodium valproate on the viability of preimplantation mouse embryos using the fluorescein diacetate test.
Topics: Animals; Blastocyst; Cell Differentiation; Cell Survival; Cyclophosphamide; Ectogenesis; Embryonic D | 1986 |
Relationship between ossification and body weight of the CD-1 mouse fetus exposed in utero to anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Female; Fetu | 1986 |
Sodium valproate, pregnancy, and infantile fatal liver failure.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Epilepsy; Female; Humans; Infant; Infant, New | 1987 |
Valproate, spina bifida, and birth defect registries.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Registrie | 1988 |
[Maternal treatment with sodium valproate. An indication for amniocentesis].
Topics: Amniocentesis; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid | 1985 |
Enzymatic and morphological response of the thymus to drugs in normal and zinc-deficient pregnant rats and their fetuses.
Topics: Animals; Cell Membrane; Dexamethasone; Ethanol; Female; Fetus; Histocytochemistry; Microscopy, Elect | 1987 |
Effect of treatment with sodium valproate on plasma adrenocorticotropic hormone and cortisol concentrations in pregnancy.
Topics: Adrenocorticotropic Hormone; Adult; Epilepsies, Myoclonic; Female; Fetal Blood; Fetus; Humans; Hydro | 1985 |
Effects of valproic acid in cultured mammalian neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Drug Interactions; Electrophysiology; Female; gamma-Ami | 1986 |
Prenatal detection of a neural tube defect after fetal exposure to valproic acid.
Topics: Abortion, Therapeutic; Adolescent; Epilepsy; Female; Fetal Diseases; Humans; Hydrocephalus; Meningom | 1986 |
[Progressive myoclonus epilepsy and pregnancy].
Topics: Adult; Benzodiazepinones; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsies, | 1986 |
Valproic acid teratogenicity in whole embryo culture is not prevented by zinc supplementation.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Organ Culture Techniques; Pregnancy | 1986 |
Serum protein binding of valproic acid in fetus-mother pairs throughout pregnancy: correlation with oxytocin administration and albumin and free fatty acid concentrations.
Topics: Adolescent; Adult; Blood Proteins; Fatty Acids, Nonesterified; Female; Fetal Blood; Gestational Age; | 1986 |
Predicting the human teratogenic potential of the anticonvulsant, valproic acid, from a non-human primate model.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Female; Fetus; Gestational Age; Half-Lif | 1986 |
Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen.
Topics: Administration, Oral; Animals; Biotransformation; Female; Injections, Intraperitoneal; Injections, S | 1986 |
Pharmacologic evaluation of various metabolites and analogs of valproic acid: teratogenic potencies in mice.
Topics: Animals; Anticonvulsants; Female; Mice; Neural Tube Defects; Pregnancy; Protein Binding; Structure-A | 1986 |
Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Epilepsy; Female; Fetus; Growth; Humans; Infant, New | 1986 |
Prenatal antiepileptic drug exposure alters seizure susceptibility in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Female; Male; Motor Activity; Phenobarbital; | 1986 |
Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse.
Topics: Administration, Oral; Animals; Anticonvulsants; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturat | 1986 |
Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Animals, Newborn; Astrocytes; Cells, Cultured | 1986 |
Teratogenesis of calcium valproate in rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Female; Gestational Age; Maternal-Fetal Exchange; Pregnancy; R | 1986 |
[Combination of hydantoins and valproate. Evidence of its teratogenic effect in 4 consecutive gestations].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Drug Therapy, Combina | 1986 |
Species differences in pharmacokinetics and drug teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Blood Proteins; Cricetinae; Female; Half-Life; Haplorhini; Hum | 1986 |
Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Caproates; Diethylhexyl Phthalate; Drug Synergism; F | 1987 |
Prescribing in pregnancy.
Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Valproic Acid | 1987 |
Valproic acid-induced neural tube defects: reduction by folinic acid in the mouse.
Topics: Animals; Female; Leucovorin; Mice; Neural Tube Defects; Pregnancy; Teratogens; Valproic Acid | 1987 |
Sodium valproate: effects on maternal behaviour in the mouse.
Topics: Animals; Animals, Newborn; Behavior, Animal; Circadian Rhythm; Female; Lactation; Maternal Behavior; | 1987 |
Behavioral teratogenicity of valproic acid: selective effects on behavior after prenatal exposure to rats.
Topics: Animals; Behavior, Animal; Female; Kinetics; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rat | 1987 |
Teratogenicity and developmental toxicity of valproic acid in rats.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Dru | 1987 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |
Prognosis in fetal valproate syndrome.
Topics: Behavior; Child, Preschool; Female; Growth Disorders; Humans; Pregnancy; Prenatal Exposure Delayed E | 1987 |
Placental transfer and neonatal elimination of mono-unsaturated metabolites of valproic acid.
Topics: Adult; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Placenta; Pregnancy; Valproic Acid | 1987 |
The management of epilepsy in women of child-bearing age and the Australian experience of valproate in pregnancy.
Topics: Abnormalities, Drug-Induced; Australia; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregna | 1987 |
Fetal valproate syndrome: is there a recognisable phenotype?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy, Tonic-Clonic; Female; Humans; Infant | 1987 |
New animal model for the study of neural tube defects.
Topics: Animals; Disease Models, Animal; Female; Gestational Age; Lumbar Vertebrae; Macaca mulatta; Neural T | 1987 |
Mono-unsaturated metabolites of valproic acid in epileptic women and their neonates.
Topics: Adult; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Placenta; Pregnanc | 1987 |
Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro.
Topics: 2-Acetylaminofluorene; Animals; Cytochalasin D; Cytochalasins; Female; Glutathione; Hydroxyacetylami | 1988 |
Strain differences in the teratogenicity induced by sodium valproate in cultured mouse embryos.
Topics: Animals; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Injections, Intraperitoneal; M | 1988 |
Amniotic fluid cholinesterase of valproate-induced exencephaly in the mouse: an animal model for prenatal diagnosis of neural tube defects.
Topics: Amniotic Fluid; Animals; Brain; Cholinesterases; Disease Models, Animal; Female; Fetal Diseases; Mic | 1988 |
Effects of sodium valproate and oxygen on the CD-1 mouse fetus.
Topics: Animals; Female; Fetal Resorption; Fetus; Hematoma; Hypoxia; Mice; Mice, Inbred Strains; Oxygen; Pre | 1988 |
The role of ultrasound in the early diagnosis of fetal structural defects following maternal anticonvulsant therapy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Diazepam; Female; Humans; Infant, Newbo | 1988 |
Evaluation of valproic acid (VPA) developmental toxicity and pharmacokinetics in Sprague-Dawley rats.
Topics: Administration, Oral; Animals; Body Weight; Female; Fetal Death; Male; Pregnancy; Rats; Rats, Inbred | 1988 |
Congenital abnormalities in two sibs exposed to valproic acid in utero.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 1988 |
The fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Fetus; Humans; Infant, Newborn; Pregnancy; Syn | 1988 |
Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite.
Topics: Animals; Disease Susceptibility; Fatty Acids, Monounsaturated; Female; Fetal Resorption; Male; Mice; | 1988 |
Enzyme cytochemistry for the risk assessment of drug administration during pregnancy with special reference to proteases.
Topics: Animals; Female; Histocytochemistry; Maternal-Fetal Exchange; Mice; Peptide Hydrolases; Pregnancy; P | 1988 |
Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Electroshock; Female; Kinetics; Mice; Phenobarbital; Phenyt | 1985 |
Possible valproate teratogenicity.
Topics: Abnormalities, Multiple; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neural | 1985 |
Valproic acid therapy and neural tube defects.
Topics: Abortion, Induced; Adult; Amniocentesis; Female; Genetic Counseling; Humans; Neural Tube Defects; Pr | 1985 |
[Neural tube malformations in children of mothers treated with sodium valproate].
Topics: Abnormalities, Drug-Induced; Female; France; Humans; Infant, Newborn; Pregnancy; Risk; Spina Bifida | 1985 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol | 1985 |
Teratogenic valproic acid concentrations: infusion by implanted minipumps vs conventional injection regimen in the mouse.
Topics: Animals; Female; Fetal Resorption; Injections, Subcutaneous; Mice; Neural Tube Defects; Pregnancy; T | 1985 |
Teratogenic effects of valproate in the CD-1 mouse fetus.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Female; Fetal Diseases; Mice; Mice, Inbred Strains; Pre | 1985 |
Teratogenic potential of valproate.
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Valproic A | 1985 |
Valproic acid and liver damage.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Infant; Pregnancy; Prenatal Exposure Delayed | 1985 |
[Prenatal diagnosis of neural tube defects in use of valproic acid].
Topics: Female; Humans; Maternal-Fetal Exchange; Neural Tube Defects; Pregnancy; Prenatal Diagnosis; Valproi | 1985 |
Concentration of valproate during pregnancy, in the newborn and in breast milk.
Topics: Adult; Body Weight; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Maternal-Fetal Exchange; Milk, | 1985 |
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1985 |