valproic acid has been researched along with Postoperative Complications in 28 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure appears to vary from 3% to 92% over a five-year period." | 2.66 | Antiepileptic drugs as prophylaxis for postcraniotomy seizures. ( Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J, 2020) |
| "Postoperative seizures can precipitate the development of epilepsy; seizures are most likely to occur within the first month of cranial surgery." | 2.58 | Antiepileptic drugs as prophylaxis for postcraniotomy seizures. ( Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J, 2018) |
| " Hyperammonemic coma is determined through a complicated differential diagnosis, and although it can also be induced as a side effect of valproate (VPA), this cause is frequently unrecognized or confused with upper gastrointestinal hemorrhage (UGH)-induced hepatic encephalopathy." | 2.55 | Hyperammonemic coma after craniotomy: Hepatic encephalopathy from upper gastrointestinal hemorrhage or valproate side effect?: Case report and literature review. ( Gao, L; Guo, X; Wei, J; Xing, B; Xu, Z, 2017) |
| "Chronic post-hypoxic myoclonus is a condition in which the predominant clinical picture is myoclonus following hypoxic brain damage, usually due to cardiorespiratory arrest." | 1.62 | [Response to perampanel in a patient with chronic post-hypoxic myoclonus]. ( de Toledo, M; Muro-García, I; Pastor, J; Vega, L; Vieira, A, 2021) |
| "Postcranioplasty seizures, especially early seizures, are common and associated with poor outcomes and longer hospital stays." | 1.51 | A Novel Protocol to Reduce Early Seizures After Cranioplasty: A Single-Center Experience. ( Chen, CC; Chen, CT; Hsieh, PC; Lai, HY; Lee, CY; Liu, YT; Liu, ZH; Tu, PH; Wu, CT; Yeap, MC, 2019) |
| "Valproic acid (VPA) has been associated with coagulation factors deficiency, platelet dysfunction and hemorrhagic complications." | 1.43 | Valproic acid as an antiepileptic drug: Is there a clinical relevance for the epilepsy surgeon? ( Arora, A; Chandra, PS; Garg, K; Kurwale, N; Tripathi, M, 2016) |
| "Alcohol withdrawal delirium is associated with significant morbidity and mortality." | 1.42 | Alcohol withdrawal delirium manifested by manic symptoms in an elderly patient. ( Chan, HY; Lee, KI, 2015) |
| "Valproate-induced hyperammonemic encephalopathy is an uncommon but serious effect of valproate treatment." | 1.40 | Valproate-induced hyperammonemic encephalopathy in a renal transplanted patient. ( Boletis, JN; Darema, M; Efthimiou, A; Marinaki, S; Melexopoulou, C; Skalioti, C; Zavos, G, 2014) |
| "Headache is a significant problem with the suboccipital approach for acoustic tumor removal." | 1.30 | Medical treatment of headache after suboccipital acoustic tumor removal. ( Brandes, JL; Glasscock, ME; Hanson, MB; Jackson, CG, 1998) |
| "When phenytoin was discontinued, valproate levels increased, and he progressively improved." | 1.30 | Exceptionally long absence status: multifactorial etiology, drug interactions and complications. ( Andermann, F; Bastos, A; D'Agostino, MD; Dubeau, F; Fedi, M, 1999) |
| " All these patients were receiving the usual dosage (1000 to 1500 mg per day) of Valproic acid (VPA)." | 1.29 | Impairment of consciousness induced by valproate treatment following neurosurgical operation. ( Baulac, M; de Billy, A; Durand, G; Landau, J; Philippon, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 13 (46.43) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Greenhalgh, J | 2 |
| Weston, J | 2 |
| Dundar, Y | 2 |
| Nevitt, SJ | 2 |
| Marson, AG | 2 |
| Muro-García, I | 1 |
| Vieira, A | 1 |
| Vega, L | 1 |
| Pastor, J | 1 |
| de Toledo, M | 1 |
| Ragland, JT | 1 |
| Lee, K | 1 |
| Guo, X | 1 |
| Wei, J | 1 |
| Gao, L | 1 |
| Xing, B | 1 |
| Xu, Z | 1 |
| Gawad, NA | 1 |
| Kohner, A | 1 |
| Ali, T | 1 |
| Hofstetter, W | 1 |
| Valentine, A | 1 |
| Li, C | 1 |
| Su, L | 1 |
| Lao, M | 1 |
| Zhu, S | 1 |
| Ding, M | 1 |
| Chen, CC | 1 |
| Yeap, MC | 1 |
| Liu, ZH | 1 |
| Hsieh, PC | 1 |
| Chen, CT | 1 |
| Liu, YT | 1 |
| Lee, CY | 1 |
| Lai, HY | 1 |
| Wu, CT | 1 |
| Tu, PH | 1 |
| Melexopoulou, C | 1 |
| Marinaki, S | 1 |
| Darema, M | 1 |
| Skalioti, C | 1 |
| Efthimiou, A | 1 |
| Zavos, G | 1 |
| Boletis, JN | 1 |
| Chan, HY | 1 |
| Lee, KI | 1 |
| Sánchez-Yáñez, E | 1 |
| Estaún-Martínez, C | 1 |
| Ojeda Burgos, G | 1 |
| Kurwale, N | 1 |
| Garg, K | 1 |
| Arora, A | 1 |
| Chandra, PS | 1 |
| Tripathi, M | 1 |
| Habets, JGV | 1 |
| Leentjens, AFG | 1 |
| Schijns, OEMG | 1 |
| Domínguez-Fuentes, B | 1 |
| García-Gil, D | 1 |
| Romero-Palacios, A | 1 |
| Sánchez-Crespo, JM | 1 |
| García-Arjona, R | 1 |
| Navarro-Navarro, J | 1 |
| Nadkarni, A | 1 |
| Oldham, M | 1 |
| Howard, M | 1 |
| Lazar, HL | 1 |
| Berenbaum, I | 1 |
| García-Ramos, R | 1 |
| Moreno Ramos, T | 1 |
| Villarejo Galende, A | 1 |
| Porta Etessam, J | 1 |
| Bumb, A | 1 |
| Diederich, N | 1 |
| Beyenburg, S | 1 |
| Patel, R | 1 |
| Jha, S | 1 |
| Kikuta, K | 1 |
| Takagi, Y | 1 |
| Arakawa, Y | 1 |
| Miyamoto, S | 1 |
| Hashimoto, N | 1 |
| Notani, M | 1 |
| Kawamura, H | 1 |
| Amano, K | 1 |
| Tanikawa, T | 1 |
| Kawabatake, H | 1 |
| Iseki, H | 1 |
| Shiwaku, T | 1 |
| Nagao, T | 1 |
| Kakinoki, Y | 1 |
| Kitamura, K | 1 |
| Hendler, N | 1 |
| Cashen, A | 1 |
| Morrison, C | 1 |
| Long, D | 1 |
| Holliday, M | 1 |
| Landau, J | 1 |
| Baulac, M | 1 |
| Durand, G | 1 |
| de Billy, A | 1 |
| Philippon, J | 1 |
| Hanson, MB | 1 |
| Glasscock, ME | 1 |
| Brandes, JL | 1 |
| Jackson, CG | 1 |
| Diehl, B | 1 |
| Wyllie, E | 1 |
| Rothner, AD | 1 |
| Bingaman, W | 1 |
| Hayashi, T | 1 |
| Hadeishi, H | 1 |
| Kawamura, S | 1 |
| Nonoyama, Y | 1 |
| Suzuki, A | 1 |
| Yasui, N | 1 |
| D'Agostino, MD | 1 |
| Andermann, F | 1 |
| Dubeau, F | 1 |
| Fedi, M | 1 |
| Bastos, A | 1 |
| Sutor, AH | 1 |
| Jesdinsky-Buscher, C | 1 |
| Kusunoki, M | 1 |
| Shoji, Y | 1 |
| Ikeuchi, H | 1 |
| Yamagata, K | 1 |
| Yamamura, T | 1 |
| Utsunomiya, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease[NCT04660019] | 43 participants (Actual) | Interventional | 2020-08-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for valproic acid and Postoperative Complications
| Article | Year |
|---|---|
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt | 2020 |
Chronic Subdural Hematoma ICU Management.
Topics: Adrenal Cortex Hormones; Craniotomy; Female; Hematoma, Subdural, Chronic; Humans; Intensive Care Uni | 2017 |
Hyperammonemic coma after craniotomy: Hepatic encephalopathy from upper gastrointestinal hemorrhage or valproate side effect?: Case report and literature review.
Topics: Anticonvulsants; Coma; Craniotomy; Diagnosis, Differential; Female; Gastrointestinal Hemorrhage; Hep | 2017 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt | 2018 |
1 trial available for valproic acid and Postoperative Complications
| Article | Year |
|---|---|
Usefulness of valproate sodium for treatment of incontinence after ileoanal anastomosis.
Topics: Adult; Anal Canal; Anastomosis, Surgical; Fecal Incontinence; Female; Humans; Ileum; Male; Middle Ag | 1990 |
23 other studies available for valproic acid and Postoperative Complications
| Article | Year |
|---|---|
[Response to perampanel in a patient with chronic post-hypoxic myoclonus].
Topics: Anticonvulsants; Carcinoma, Papillary; Clonazepam; Drug Therapy, Combination; Electroencephalography | 2021 |
Valproic Acid Attenuates Postoperative Psychosis Following Aggressive Resection of an Intracardiac Carcinoid Neuroendocrine Tumor: A Case Report.
Topics: Carcinoid Tumor; Female; GABA Agents; Heart Neoplasms; Humans; Middle Aged; Postoperative Complicati | 2018 |
Anemia secondary to the use of sodium valproate for preventing postoperative seizures in a 79-year-old man: A case report.
Topics: Aged; Anemia; Anticonvulsants; Erythrocyte Transfusion; Humans; Liver Function Tests; Male; Neurosur | 2018 |
A Novel Protocol to Reduce Early Seizures After Cranioplasty: A Single-Center Experience.
Topics: Adult; Anticonvulsants; Clinical Protocols; Decompressive Craniectomy; Drug Administration Schedule; | 2019 |
Valproate-induced hyperammonemic encephalopathy in a renal transplanted patient.
Topics: Adolescent; Anticonvulsants; Brain Diseases; Female; Humans; Hyperammonemia; Kidney Transplantation; | 2014 |
Alcohol withdrawal delirium manifested by manic symptoms in an elderly patient.
Topics: Alcohol Withdrawal Delirium; Alcoholic Intoxication; Bipolar Disorder; Drug Therapy, Combination; He | 2015 |
[Meropenem and valproic acid: A clinically relevant drug-drug interaction].
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; Fructose; Humans | 2016 |
Valproic acid as an antiepileptic drug: Is there a clinical relevance for the epilepsy surgeon?
Topics: Adolescent; Anticonvulsants; Blood Loss, Surgical; Clinical Decision-Making; Drug Resistant Epilepsy | 2016 |
Serious and reversible levetiracetam-induced psychiatric symptoms after resection of frontal low-grade glioma: two case histories.
Topics: Anticonvulsants; Brain Neoplasms; Craniotomy; Epilepsy; Frontal Lobe; Humans; Levetiracetam; Magneti | 2017 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia].
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Brain Edema; Cesarean Section; Diazepam; Dru | 2008 |
Detrimental effects of divalproex on warfarin therapy following mechanical valve replacement.
Topics: Adult; Anticoagulants; Antimanic Agents; Bipolar Disorder; Drug Interactions; Drug Therapy, Combinat | 2011 |
Phenytoin-induced acute orofacial dyskinesia.
Topics: Aged, 80 and over; Anticonvulsants; Epilepsy, Tonic-Clonic; Hematoma, Subdural; Humans; Male; Moveme | 2013 |
Adding topiramate to valproate therapy may cause reversible hepatic failure.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsies, Part | 2003 |
Intravenous valproate in post-anoxic myoclonic status epilepticus: a report of ten patients.
Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; H | 2004 |
Absence epilepsy associated with moyamoya disease. Case report.
Topics: Anticonvulsants; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Cerebral Angiography; Cerebral | 2006 |
[The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm].
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; In | 1984 |
Divalproex sodium and other medications for headache following craniotomy for acoustic neuroma.
Topics: Anticonvulsants; Craniotomy; Female; Headache; Humans; Male; Middle Aged; Neuroma, Acoustic; Postope | 1995 |
Impairment of consciousness induced by valproate treatment following neurosurgical operation.
Topics: Adolescent; Adult; Arousal; Brain Neoplasms; Cerebral Hemorrhage; Coma; Consciousness Disorders; Del | 1993 |
Medical treatment of headache after suboccipital acoustic tumor removal.
Topics: Adult; Cerebellar Neoplasms; Cerebellopontine Angle; Craniotomy; Drug Therapy, Combination; Female; | 1998 |
Worsening seizures after surgery for focal epilepsy due to emergence of primary generalized epilepsy.
Topics: Adolescent; Anticonvulsants; Disease Progression; Electroencephalography; Epilepsies, Partial; Epile | 1998 |
Postoperative anticonvulsant prophylaxis for patients treated for cerebral aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Craniotomy; Drug Administration Schedule; Epilepsy; | 1999 |
Exceptionally long absence status: multifactorial etiology, drug interactions and complications.
Topics: Aged; Anticonvulsants; Brain Ischemia; Dementia, Vascular; Drug Interactions; Epilepsy, Generalized; | 1999 |
[Changes in hemostasis during epilespy treatment using dipropyl acetate. Extended study].
Topics: Adolescent; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Epilepsy; Factor IX; Female; | 1976 |