valproic acid has been researched along with Porphyrias in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jackson, R | 1 |
| Toubia, N | 1 |
| Dhaliwal, G | 1 |
| Bottomley, SS | 1 |
| Bronze, MS | 1 |
| Gorchein, A | 1 |
| Garcia-Merino, JA | 1 |
| Lopez-Lozano, JJ | 1 |
| Doss, M | 1 |
| Becker, U | 1 |
| Peter, HJ | 1 |
| Kaffarnik, H | 1 |
| Bonkowsky, HL | 1 |
| Sinclair, PR | 1 |
| Emery, S | 1 |
| Sinclair, JF | 1 |
| Jalil, P | 1 |
| Vergara, F | 1 |
| Flueckiger, F | 1 |
| Steiner, H | 1 |
| Leitinger, G | 1 |
| Hoedl, S | 1 |
| Deu, E | 1 |
| Herrick, AL | 1 |
| McColl, KE | 1 |
| Moore, MR | 2 |
| Brodie, MJ | 2 |
| Adamson, AR | 1 |
| Goldberg, A | 1 |
| McGuire, GM | 1 |
| Macphee, GJ | 1 |
| Thompson, GG | 1 |
1 trial available for valproic acid and Porphyrias
| Article | Year |
|---|---|
Effects of sodium valproate on haem biosynthesis in man: implications for seizure management in the porphyric patient.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Drug Administration Schedule; Epilepsy; Female; Hem | 1988 |
8 other studies available for valproic acid and Porphyrias
| Article | Year |
|---|---|
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, R | 2008 |
Drug safety in porphyria.
Topics: Animals; Disease Models, Animal; Furosemide; Humans; Porphyrias; Rats; Rifampin; Risk; Valproic Acid | 1980 |
Risks of valproate in porphyria.
Topics: Acute Disease; Adult; Epilepsy, Temporal Lobe; Female; Humans; Porphyrias; Valproic Acid | 1980 |
Drug safety in porphyria: risks of valproate and metoclopramide.
Topics: Adolescent; Epilepsy; Female; Humans; Metoclopramide; Porphyrias; Valproic Acid | 1981 |
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo; | 1980 |
[Porphyria induced by valproic acid: clinical case].
Topics: Female; Humans; Middle Aged; Porphyrias; Valproic Acid | 1991 |
Nodular focal fatty infiltration of the liver in acquired porphyria cutanea tarda.
Topics: Adult; Fatty Liver; Humans; Liver; Male; Porphyrias; Radiography; Skin Diseases; Ultrasonography; Va | 1991 |
Acute intermittent porphyria in two patients on anticonvulsant therapy and with normal erythrocyte porphobilinogen deaminase activity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Ammonia-Lyases; Anticonvulsants; Er | 1989 |