valproic acid has been researched along with Porphyria in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jackson, R | 1 |
| Toubia, N | 1 |
| Dhaliwal, G | 1 |
| Bottomley, SS | 1 |
| Bronze, MS | 1 |
| Gorchein, A | 1 |
| Garcia-Merino, JA | 1 |
| Lopez-Lozano, JJ | 1 |
| Doss, M | 1 |
| Becker, U | 1 |
| Peter, HJ | 1 |
| Kaffarnik, H | 1 |
| Bonkowsky, HL | 1 |
| Sinclair, PR | 1 |
| Emery, S | 1 |
| Sinclair, JF | 1 |
| Jalil, P | 1 |
| Vergara, F | 1 |
| Flueckiger, F | 1 |
| Steiner, H | 1 |
| Leitinger, G | 1 |
| Hoedl, S | 1 |
| Deu, E | 1 |
| Herrick, AL | 1 |
| McColl, KE | 1 |
| Moore, MR | 2 |
| Brodie, MJ | 2 |
| Adamson, AR | 1 |
| Goldberg, A | 1 |
| McGuire, GM | 1 |
| Macphee, GJ | 1 |
| Thompson, GG | 1 |
1 trial available for valproic acid and Porphyria
| Article | Year |
|---|---|
Effects of sodium valproate on haem biosynthesis in man: implications for seizure management in the porphyric patient.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Drug Administration Schedule; Epilepsy; Female; Hem | 1988 |
8 other studies available for valproic acid and Porphyria
| Article | Year |
|---|---|
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, R | 2008 |
Drug safety in porphyria.
Topics: Animals; Disease Models, Animal; Furosemide; Humans; Porphyrias; Rats; Rifampin; Risk; Valproic Acid | 1980 |
Risks of valproate in porphyria.
Topics: Acute Disease; Adult; Epilepsy, Temporal Lobe; Female; Humans; Porphyrias; Valproic Acid | 1980 |
Drug safety in porphyria: risks of valproate and metoclopramide.
Topics: Adolescent; Epilepsy; Female; Humans; Metoclopramide; Porphyrias; Valproic Acid | 1981 |
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo; | 1980 |
[Porphyria induced by valproic acid: clinical case].
Topics: Female; Humans; Middle Aged; Porphyrias; Valproic Acid | 1991 |
Nodular focal fatty infiltration of the liver in acquired porphyria cutanea tarda.
Topics: Adult; Fatty Liver; Humans; Liver; Male; Porphyrias; Radiography; Skin Diseases; Ultrasonography; Va | 1991 |
Acute intermittent porphyria in two patients on anticonvulsant therapy and with normal erythrocyte porphobilinogen deaminase activity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Ammonia-Lyases; Anticonvulsants; Er | 1989 |