valproic acid has been researched along with Polyneuropathies in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is used in first case as an antiepileptic; own clinical observance and references from the literature show other indication-fields outside of the group of cerebral fits; so Convulex was employed successfully also in the therapy of perioral dyskinesia of variable etiology and in the medical treatment of therapy-resistant pains within the bounds of Polyneuropathy-Polyneuritis Syndrome." | 3.67 | [Further therapeutic possibilities with valproic acid (Convulex)]. ( Auff, E; Holzner, F; Wessely, P, 1985) |
| "Primary Sjogren syndrome is considered as the most frequent connective tissue disease." | 1.33 | [Sjögren's syndrome with autonomic failure and epilepsy]. ( Attout, H; Guez, S; Martre, A; Series, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chabwine, JN | 1 |
| Rossetti, AR | 1 |
| Hirt, L | 1 |
| Kuntzer, T | 1 |
| Schluep, M | 1 |
| Michel, P | 1 |
| Démonet, JF | 1 |
| du Pasquier, RA | 1 |
| Vingerhoets, FG | 1 |
| Otto, M | 2 |
| Bach, FW | 2 |
| Jensen, TS | 2 |
| Sindrup, SH | 2 |
| Attout, H | 1 |
| Martre, A | 1 |
| Guez, S | 1 |
| Series, C | 1 |
| Auff, E | 1 |
| Holzner, F | 1 |
| Wessely, P | 1 |
2 trials available for valproic acid and Polyneuropathies
| Article | Year |
|---|---|
Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middl | 2004 |
Health-related quality of life and its predictive role for analgesic effect in patients with painful polyneuropathy.
Topics: Adult; Aged; Aged, 80 and over; Analgesia; Analgesics; Cross-Over Studies; Cyclohexanols; Drug Resis | 2007 |
3 other studies available for valproic acid and Polyneuropathies
| Article | Year |
|---|---|
[Neurology].
Topics: Antibodies, Monoclonal; Anticonvulsants; Atrial Fibrillation; Carbamates; Chronic Disease; Deep Brai | 2012 |
[Sjögren's syndrome with autonomic failure and epilepsy].
Topics: Aged; Anti-Inflammatory Agents; Anticonvulsants; Autonomic Nervous System Diseases; Electromyography | 2005 |
[Further therapeutic possibilities with valproic acid (Convulex)].
Topics: Aged; Blepharospasm; Dyskinesia, Drug-Induced; Female; Foot Diseases; Humans; Male; Middle Aged; Myo | 1985 |