valproic acid has been researched along with Polycystic Ovarian Syndrome in 66 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy." | 9.13 | Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. ( Adams, JM; Bhatt, M; Hayes, FJ; Isojärvi, J; Morrell, MJ; Ozkara, C; Sluss, PM; Warnock, CR, 2008) |
| "The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied." | 7.75 | Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. ( Dogan, EA; Genc, BO; Genc, E; Gorkemli, H; Ozdemir, S, 2009) |
| "Valproic acid (VPA) treatment in female patients is suggested to be associated with the occurrence of a variety of endocrine side effects that include many characteristic symptoms of polycystic ovary syndrome (PCOS)." | 7.72 | Valproic acid fails to induce polycystic ovary syndrome in female rats. ( Lagace, DC; Nachtigal, MW, 2003) |
| "In order to investigate the possible role of valproic acid therapy in the development of obesity, hyperinsulinism and polycystic ovaries (PCOs), we have studied metabolic parameters and ovarian morphology in epileptic women." | 7.71 | Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women. ( Abraham, I; Alge, A; Bauer, G; Haslinger, M; Lechleitner, M; Luef, G; Seppi, K; Trinka, E; Unterberger, I; Windisch, J, 2002) |
| "To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy." | 5.27 | Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study. ( Sadhotra, A; Sidhu, HS; Srinivasa, R, 2018) |
| "To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy." | 5.13 | Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. ( Adams, JM; Bhatt, M; Hayes, FJ; Isojärvi, J; Morrell, MJ; Ozkara, C; Sluss, PM; Warnock, CR, 2008) |
| " Recent data suggest that valproic acid, a commonly prescribed mood stabilizer, may be associated with polycystic ovarian syndrome (PCOS)." | 5.10 | Valproate, bipolar disorder and polycystic ovarian syndrome. ( Kennedy, SH; Mancini, DA; McCann, S; McIntyre, RS; Srinivasan, J, 2003) |
| "Twenty-two female outpatients with a DSM-IV diagnosis of bipolar disorder who were between the ages of 18 and 45 years (inclusive) and who were taking lithium and/or divalproex (10, divalproex monotherapy; 10, lithium monotherapy; 2, divalproex/lithium combination therapy) were evaluated." | 5.09 | Medication status and polycystic ovary syndrome in women with bipolar disorder: a preliminary report. ( Altshuler, LL; Burt, VK; Gudeman, D; Hendrick, V; Korenman, S; Rasgon, NL; Tanavoli, S, 2000) |
| "Valproic acid (2-n-propylpentanoic acid, VPA) is well-established as a mood-stabilizer for bipolar disorder, in addition to its application as a treatment in neurological disorders such as epilepsy, migraine headaches, and chronic neuropathic pain." | 4.84 | Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review. ( Rasgon, NL; Reynolds, MF; Sisk, EC, 2007) |
| "The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied." | 3.75 | Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. ( Dogan, EA; Genc, BO; Genc, E; Gorkemli, H; Ozdemir, S, 2009) |
| "Valproic acid (VPA) is an anti-epileptic drug that has been associated with polycystic ovary syndrome (PCOS)-like symptoms, including increased ovarian androgen production." | 3.73 | Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects. ( Jansen, E; McAllister, JM; Mosselman, S; Nelson-Degrave, VL; Strauss, JF; Wood, JR, 2005) |
| "Valproic acid (VPA) treatment in female patients is suggested to be associated with the occurrence of a variety of endocrine side effects that include many characteristic symptoms of polycystic ovary syndrome (PCOS)." | 3.72 | Valproic acid fails to induce polycystic ovary syndrome in female rats. ( Lagace, DC; Nachtigal, MW, 2003) |
| "A group of 105 women (54 of whom were, and had only ever been, taking valproate for at least a year, and 51 who had only ever taken either lamotrigine or carbamazepine, for at least a year) were compared with a group of 50 women who did not have epilepsy: any oral contraceptive taken at the time of testing was recorded and blood levels of follicle stimulating hormone (FSH), luteinising hormone (LH), testosterone and prolactin were estimated from days 2 to 6 of the menstrual cycle (day 1 being the first day of bleeding) and an MRI scan made of their pelvis." | 3.72 | A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy. ( Betts, T; Dutton, N; Greenhill, L; Rolfe, T; Yarrow, H, 2003) |
| " Anthropometric measurements, staging of pubertal maturation, and clinical manifestations of hyperandrogenism were assessed, as well as measurement of serum levels of testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), and free androgen index (FAI)." | 3.72 | Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy. ( Abd El-Basset, FZ; El Barbary, NS; El-Khayat, HA; Hakky, SM; Mohamed, MS; Nassef, NM; Tohamy, SM; Tomoum, HY; Zaky, AA, 2004) |
| "In order to investigate the possible role of valproic acid therapy in the development of obesity, hyperinsulinism and polycystic ovaries (PCOs), we have studied metabolic parameters and ovarian morphology in epileptic women." | 3.71 | Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women. ( Abraham, I; Alge, A; Bauer, G; Haslinger, M; Lechleitner, M; Luef, G; Seppi, K; Trinka, E; Unterberger, I; Windisch, J, 2002) |
| "Valproic acid (VPA) was the first recognized AED to cause disturbances potentially due to metabolic changes and increasing weight." | 2.66 | Reproductive health in patients with epilepsy. ( Chatzistefanidis, D; Georgiou, I; Keramida, A; Kyritsis, AP; Markoula, S; Siarava, E; Zikopoulos, A, 2020) |
| "Epilepsy is one of the commonest chronic neurological disorders in developing countries." | 2.50 | [Epilepsy, antiepileptic drugs and disorders of reproductive functions of women]. ( Gregoraszczuk, EL; Grzyb, E; Kwiecińska, P, 2014) |
| "Women with untreated epilepsy are more likely to have irregular menstrual cycles than are nonepileptic controls, indicating that the disease itself plays a role in the etiology of these reproductive abnormalities." | 2.44 | Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents. ( Hayes, FJ; Joffe, H, 2008) |
| " Endocrine and metabolic adverse effects are among the most concerning adverse effects of commonly used psychotropic medications." | 2.43 | Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. ( Carlson, HE; Correll, CU, 2006) |
| " No correlation was found between duration or dosage of treatment and BMI-SDS, height-SDS, or androgen level." | 1.34 | Endocrine effects of valproate in adolescent girls with epilepsy. ( de Vries, L; Goldberg-Stern, H; Karasik, A; Kiviti, S; Landau, Z; Phillip, M, 2007) |
| "Polycystic ovary syndrome was more common in patients on medication (38%; in 63% on VPA, in 25% on other medication) than in patients off medication (6%) or in controls (11%) (p = 0." | 1.32 | Long-term reproductive endocrine health in young women with epilepsy during puberty. ( Isojärvi, JI; Järvelä, IY; Knip, M; Mikkonen, K; Pakarinen, AJ; Tapanainen, JS; Vainionpää, LK, 2004) |
| " As increasing numbers of bipolar patients are in long-term treatment with valproate, there is an important need for further research that clarifies the relationship between long-term administration of valproate and other mood stabilizers and the potential development of reproductive endocrinologic abnormalities, and for increased awareness among clinicians and patients of the unknown potential for these worrisome side-effects." | 1.31 | Valproate treatment and the risk of hyperandrogenism and polycystic ovaries. ( Soares, JC, 2000) |
| "A possible role of the seizure disorder or, alternatively, of the use of antiepileptic drugs (AEDs) has been suggested as the pathogenic mechanism." | 1.31 | Characterization of reproductive endocrine disorders in women with epilepsy. ( Bilo, L; Di Carlo, C; Meo, R; Nappi, C; Striano, S; Valentino, R, 2001) |
| "Oligomenorrhea occurred in 16 patients, polymenorrhea in 2." | 1.30 | Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy. ( Copello, F; Deagatone, C; Ferrari, E; Galimberti, CA; Gazzerro, E; Gianelli, MV; Magri, F; Manni, R; Murialdo, G; Polleri, A; Rollero, A; Sampaolo, P; Tartara, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (16.67) | 18.2507 |
| 2000's | 44 (66.67) | 29.6817 |
| 2010's | 9 (13.64) | 24.3611 |
| 2020's | 2 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Teng, Z | 1 |
| Xie, H | 1 |
| Yuan, H | 1 |
| Liu, M | 1 |
| Chen, J | 1 |
| Tang, H | 1 |
| Xiang, H | 1 |
| Wu, H | 1 |
| Huang, J | 1 |
| Markoula, S | 1 |
| Siarava, E | 1 |
| Keramida, A | 1 |
| Chatzistefanidis, D | 1 |
| Zikopoulos, A | 1 |
| Kyritsis, AP | 1 |
| Georgiou, I | 1 |
| Gotlib, D | 1 |
| Ramaswamy, R | 1 |
| Kurlander, JE | 1 |
| DeRiggi, A | 1 |
| Riba, M | 1 |
| Sidhu, HS | 1 |
| Srinivasa, R | 1 |
| Sadhotra, A | 1 |
| Kawakami, Y | 1 |
| Fujii, S | 1 |
| Ishikawa, G | 1 |
| Sekiguchi, A | 1 |
| Nakai, A | 1 |
| Takase, M | 1 |
| Minagawa, K | 1 |
| Watanabe, T | 1 |
| Oyanagi, R | 1 |
| Grzyb, E | 1 |
| Kwiecińska, P | 1 |
| Gregoraszczuk, EL | 1 |
| Zhang, L | 1 |
| Li, H | 1 |
| Li, S | 1 |
| Zou, X | 1 |
| Joffe, H | 3 |
| Hayes, FJ | 2 |
| Morrell, MJ | 1 |
| Sluss, PM | 1 |
| Adams, JM | 2 |
| Bhatt, M | 1 |
| Ozkara, C | 1 |
| Warnock, CR | 1 |
| Isojärvi, J | 2 |
| Bilo, L | 4 |
| Meo, R | 4 |
| Gorkemli, H | 1 |
| Genc, BO | 1 |
| Dogan, EA | 1 |
| Genc, E | 1 |
| Ozdemir, S | 1 |
| Kenna, HA | 1 |
| Jiang, B | 1 |
| Rasgon, NL | 4 |
| Hu, X | 1 |
| Wang, J | 1 |
| Dong, W | 1 |
| Fang, Q | 1 |
| Hu, L | 1 |
| Liu, C | 1 |
| Zhou, JQ | 1 |
| Zhou, LM | 1 |
| Chen, LJ | 1 |
| Han, JD | 1 |
| Wang, Q | 1 |
| Fang, ZY | 1 |
| Chen, ZY | 1 |
| Ling, S | 1 |
| Krępuła, K | 1 |
| Bidzińska-Speichert, B | 1 |
| Lenarcik, A | 1 |
| Tworowska-Bardzińska, U | 1 |
| Luef, G | 2 |
| Abraham, I | 2 |
| Haslinger, M | 1 |
| Trinka, E | 2 |
| Seppi, K | 2 |
| Unterberger, I | 2 |
| Alge, A | 2 |
| Windisch, J | 2 |
| Lechleitner, M | 2 |
| Bauer, G | 2 |
| McIntyre, RS | 1 |
| Mancini, DA | 1 |
| McCann, S | 1 |
| Srinivasan, J | 1 |
| Kennedy, SH | 1 |
| Lagace, DC | 1 |
| Nachtigal, MW | 1 |
| Betts, T | 2 |
| Yarrow, H | 1 |
| Dutton, N | 1 |
| Greenhill, L | 1 |
| Rolfe, T | 1 |
| Nelson-DeGrave, VL | 2 |
| Wickenheisser, JK | 1 |
| Cockrell, JE | 1 |
| Wood, JR | 2 |
| Legro, RS | 1 |
| Strauss, JF | 2 |
| McAllister, JM | 2 |
| Mikkonen, K | 2 |
| Vainionpää, LK | 1 |
| Pakarinen, AJ | 6 |
| Knip, M | 5 |
| Järvelä, IY | 1 |
| Tapanainen, JS | 6 |
| Isojärvi, JI | 8 |
| El-Khayat, HA | 1 |
| Abd El-Basset, FZ | 1 |
| Tomoum, HY | 1 |
| Tohamy, SM | 1 |
| Zaky, AA | 1 |
| Mohamed, MS | 1 |
| Hakky, SM | 1 |
| El Barbary, NS | 1 |
| Nassef, NM | 1 |
| Karlov, VA | 1 |
| Jansen, E | 1 |
| Mosselman, S | 1 |
| Flück, CE | 1 |
| Yaworsky, DC | 1 |
| Miller, WL | 1 |
| Altshuler, LL | 2 |
| Fairbanks, L | 1 |
| Elman, S | 1 |
| Bitran, J | 1 |
| Labarca, R | 1 |
| Saad, M | 1 |
| Kupka, R | 1 |
| Nolen, WA | 1 |
| Frye, MA | 1 |
| Suppes, T | 2 |
| McElroy, SL | 1 |
| Keck, PE | 1 |
| Leverich, G | 1 |
| Grunze, H | 1 |
| Walden, J | 1 |
| Post, R | 1 |
| Mintz, J | 1 |
| Klipstein, KG | 1 |
| Goldberg, JF | 1 |
| Seki, A | 1 |
| Inoue, T | 1 |
| Maegaki, Y | 1 |
| Sugiura, C | 1 |
| Toyoshima, M | 1 |
| Akaboshi, S | 1 |
| Ohno, K | 1 |
| Correll, CU | 1 |
| Carlson, HE | 1 |
| Cohen, LS | 1 |
| Hwang, CH | 1 |
| Molay, F | 1 |
| Sachs, GS | 1 |
| Hall, JE | 2 |
| Löfgren, E | 1 |
| Tolonen, U | 1 |
| Pakarinen, A | 1 |
| Koivunen, R | 3 |
| Myllyla, VV | 5 |
| de Vries, L | 1 |
| Karasik, A | 1 |
| Landau, Z | 1 |
| Phillip, M | 1 |
| Kiviti, S | 1 |
| Goldberg-Stern, H | 1 |
| Prabhakar, S | 1 |
| Sahota, P | 1 |
| Kharbanda, PS | 1 |
| Siali, R | 1 |
| Jain, V | 1 |
| Lal, V | 1 |
| Khurana, D | 1 |
| Reynolds, MF | 1 |
| Sisk, EC | 1 |
| Popovic, V | 1 |
| Spremovic, S | 1 |
| Laatikainen, TJ | 3 |
| Juntunen, KT | 2 |
| Garland, EJ | 1 |
| Behr, R | 1 |
| Murialdo, G | 1 |
| Galimberti, CA | 1 |
| Magri, F | 1 |
| Sampaolo, P | 1 |
| Copello, F | 1 |
| Gianelli, MV | 1 |
| Gazzerro, E | 1 |
| Rollero, A | 1 |
| Deagatone, C | 1 |
| Manni, R | 1 |
| Ferrari, E | 1 |
| Polleri, A | 1 |
| Tartara, A | 1 |
| Sharma, S | 1 |
| Jacobs, HS | 1 |
| Irwin, M | 1 |
| Masand, P | 1 |
| Rättyä, J | 2 |
| Tekay, A | 1 |
| Eberle, AJ | 1 |
| Johnston, HF | 1 |
| Piontek, CM | 1 |
| Wisner, KL | 1 |
| Gudeman, D | 1 |
| Burt, VK | 1 |
| Tanavoli, S | 1 |
| Hendrick, V | 1 |
| Korenman, S | 1 |
| Bauer, J | 3 |
| Jarre, A | 1 |
| Klingmüller, D | 1 |
| Elger, CE | 1 |
| Soares, JC | 1 |
| Genton, P | 1 |
| Duncan, S | 2 |
| Taylor, AE | 2 |
| Balen, AH | 1 |
| Eberle, A | 1 |
| Pedersen, B | 1 |
| Salas-Puig, X | 1 |
| Sauer, MV | 1 |
| Taubøll, E | 2 |
| Herzog, AG | 1 |
| Schachter, SC | 1 |
| Valentino, R | 1 |
| Di Carlo, C | 1 |
| Striano, S | 1 |
| Nappi, C | 1 |
| Stephen, LJ | 1 |
| Kwan, P | 1 |
| Shapiro, D | 1 |
| Dominiczak, M | 1 |
| Brodie, MJ | 1 |
| van Parys, J | 1 |
| Harbo, HF | 1 |
| Dale, PO | 1 |
| Fauser, BC | 1 |
| Gjerstad, L | 1 |
| Daxenbichler, G | 1 |
| Krämer, G | 1 |
| Chakravarty, A | 1 |
| O'Donovan, C | 1 |
| Kusumakar, V | 1 |
| Graves, GR | 1 |
| Bird, DC | 1 |
19 reviews available for valproic acid and Polycystic Ovarian Syndrome
| Article | Year |
|---|---|
Reproductive health in patients with epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Gonadal Steroid Hormones; Humans; Infertility, Female; Infertilit | 2020 |
Valproic Acid in Women and Girls of Childbearing Age.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Antimanic Agents; Europe; Female; H | 2017 |
[Epilepsy, antiepileptic drugs and disorders of reproductive functions of women].
Topics: Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infertility, Female; Polycystic Ovary Syn | 2014 |
Reproductive and metabolic abnormalities in women taking valproate for bipolar disorder: a meta-analysis.
Topics: Bipolar Disorder; Female; Humans; Hyperandrogenism; Menstruation Disturbances; Metabolic Diseases; P | 2016 |
Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents.
Topics: Adolescent; Amenorrhea; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Bone and Bones; Epi | 2008 |
Polycystic ovary syndrome in women using valproate: a review.
Topics: Antimanic Agents; Bipolar Disorder; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Prevalence; | 2008 |
Reproductive and metabolic abnormalities associated with bipolar disorder and its treatment.
Topics: Bipolar Disorder; Dyslipidemias; Endocrine System Diseases; Female; Humans; Hypogonadism; Hypothalam | 2009 |
A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Incidence; Polycystic Ovary Syndrome; Risk Factors; Valpr | 2011 |
Psychiatric disorders related to polycystic ovary syndrome.
Topics: Antimanic Agents; Bipolar Disorder; Depression; Feeding and Eating Disorders; Female; Hirsutism; Hor | 2012 |
Polycystic ovary syndrome and epilepsy: a review of the evidence.
Topics: Adolescent; Adult; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Female; Humans; Menstruation | 2003 |
[Therapy of epilepsy: current strategy and tactics].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; | 2004 |
Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents.
Topics: Adolescent; Antipsychotic Agents; Child; Dibenzothiazepines; Drug Administration Schedule; Endocrine | 2006 |
Epilepsy and polycystic ovary syndrome: where is the link?
Topics: Epilepsy; Female; History, 20th Century; History, 21st Century; Humans; Models, Biological; Polycyst | 2006 |
Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Contraceptives, Oral; Epilepsy; Female; Hormone | 2007 |
Epilepsy therapy: issues for women and men.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Infert | 2001 |
On the association between valproate and polycystic ovary syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Humans; Hyperinsulinism; Insulin | 2001 |
On the association between valproate and polycystic ovary syndrome: a response and an alternative view.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Comorbidity; Epilepsy; Female; Fertility; Humans | 2001 |
Polycystic ovarian syndrome--relationship to epilepsy and antiepileptic drug therapy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Risk Factors; Valproic Acid | 2001 |
Polycystic ovarian syndrome in women with epilepsy: a review.
Topics: Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Finland; Follicle Stimulating Hormone; German | 2001 |
4 trials available for valproic acid and Polycystic Ovarian Syndrome
| Article | Year |
|---|---|
Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study.
Topics: Adolescent; Adult; Anticonvulsants; Endocrine System; Epilepsy; Female; Follow-Up Studies; Hormones; | 2018 |
Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine.
Topics: Adolescent; Adult; Anovulation; Epilepsy; Female; Humans; Hyperandrogenism; Internationality; Lamotr | 2008 |
Valproate, bipolar disorder and polycystic ovarian syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Cross-Sectional Studies; Female; Humans; Middl | 2003 |
Medication status and polycystic ovary syndrome in women with bipolar disorder: a preliminary report.
Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Drug Administration Schedule; Drug Therapy, Co | 2000 |
43 other studies available for valproic acid and Polycystic Ovarian Syndrome
| Article | Year |
|---|---|
Prevalence and characteristics of polycystic ovarian syndrome in patients with bipolar disorder.
Topics: Bipolar Disorder; Female; Humans; Insulin Resistance; Polycystic Ovary Syndrome; Prevalence; Valproi | 2023 |
Valproate-Induced Polycystic Ovary Syndrome in a Girl with Epilepsy: A Case Study.
Topics: Adolescent; Biomarkers; Epilepsy; Female; Humans; Luteinizing Hormone; Magnetic Resonance Imaging; P | 2018 |
[Characteristics of women with epilepsy who developed polycystic ovary syndrome owing to the therapy with valproate sodium].
Topics: Adolescent; Adult; Androstenedione; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Practice Gu | 2013 |
Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hype | 2009 |
Polycystic ovary syndrome in patients with epilepsy: a study in 102 Chinese women.
Topics: Adolescent; Adult; Asian People; Biomarkers; Child; Epilepsy; Female; Follicle Stimulating Hormone; | 2012 |
Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Insulin Resistance; Obesity; Polycy | 2002 |
Valproic acid fails to induce polycystic ovary syndrome in female rats.
Topics: Animals; Antimanic Agents; Disease Models, Animal; Estrus; Female; Ovarian Follicle; Polycystic Ovar | 2003 |
A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Follicle Stimulating Hormone | 2003 |
Valproate potentiates androgen biosynthesis in human ovarian theca cells.
Topics: 17-alpha-Hydroxyprogesterone; Acetylation; Adult; Androgens; Androstenedione; Cholesterol Side-Chain | 2004 |
Long-term reproductive endocrine health in young women with epilepsy during puberty.
Topics: Adolescent; Anticonvulsants; Child; Cohort Studies; Comorbidity; Epilepsy; Female; Finland; Follow-U | 2004 |
Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dehydroepiandrosterone; Epilepsy; Female; Growth; | 2004 |
Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects.
Topics: Anticonvulsants; Apoptosis; Base Sequence; Cell Cycle; DNA Primers; Female; Gene Expression Regulati | 2005 |
Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenal Cortex Hormones; Androgens; Anticonvulsants; Carbamazepine | 2005 |
Reproductive function and risk for PCOS in women treated for bipolar disorder.
Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Endocrine System Diseases; Female; Humans; Me | 2005 |
Screening for bipolar disorder in women with polycystic ovary syndrome: a pilot study.
Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Epilepsy; Female; Humans; Mass Screening; Midd | 2006 |
[Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman].
Topics: Adenoma, Liver Cell; Adult; Epilepsy; Female; Humans; Hyperandrogenism; Liver Neoplasms; Polycystic | 2006 |
Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary report.
Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Body Mass Index; Female; Follow-Up Studies; H | 2006 |
Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Epilepsy; Female; Humans; Hyperandrogenism | 2007 |
Endocrine effects of valproate in adolescent girls with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Body Height; Body Mass Index; Child; Comorbidity; Epilepsy; Fema | 2007 |
Sodium valproate, hyperandrogenism and altered ovarian function in Indian women with epilepsy: a prospective study.
Topics: Body Mass Index; Epilepsy; Female; Follow-Up Studies; Hirsutism; Humans; Hyperandrogenism; Indians, | 2007 |
The effect of sodium valproate on luteinizing hormone secretion in women with polycystic ovary disease.
Topics: Adult; Case-Control Studies; Dose-Response Relationship, Drug; Female; Follicular Phase; Gonadal Ste | 1995 |
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy.
Topics: Adolescent; Adult; Analysis of Variance; Carbamazepine; Cross-Sectional Studies; Epilepsies, Partial | 1993 |
Obesity and endocrine disorders in women taking valproate for epilepsy.
Topics: Adult; Body Weight; Carbamazepine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Endocrine | 1996 |
Hormonal effects of valproic acid?
Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Child; Female; Follow-Up Studies; Humans; Hyp | 1996 |
Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy.
Topics: Adolescent; Adult; Anovulation; Anticonvulsants; Corpus Luteum; Epilepsy; Female; Humans; Menstruati | 1997 |
Polycystic ovary syndrome associated with treatment with the anticonvulsant sodium valproate.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Pregnancy; Valproic Aci | 1997 |
Valproate and polycystic ovaries.
Topics: Adolescent; Antimanic Agents; Bipolar Disorder; Child; Female; Humans; Polycystic Ovary Syndrome; Va | 1998 |
Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy.
Topics: Analysis of Variance; Anticonvulsants; Cholesterol, HDL; Epilepsy; Female; Follow-Up Studies; Humans | 1998 |
Valproate and polycystic ovaries.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Hyperandrogenism; Polycystic Ov | 1998 |
More on valproate and polycystic ovaries.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Obesity; Polycystic Ovary Syndrome; Va | 1999 |
Appropriate clinical management of women taking valproate.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Epilepsy; Female; Humans; Hyperandrogenism; Insuli | 2000 |
Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Electroencephalography; Epilepsy; Female; Humans; H | 2000 |
Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women.
Topics: Adult; Amenorrhea; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Therapy, Combination; Epilep | 2000 |
Valproate treatment and the risk of hyperandrogenism and polycystic ovaries.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Hyperandrogenism; Polycystic Ovary Syndrome; Risk | 2000 |
Case reports.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Anticonvulsants; Child; Diagnosis, Differential; Epileps | 2001 |
Valproate and the polycystic ovarian syndrome: final thoughts.
Topics: Adolescent; Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Humans; Middle Aged; Polycystic O | 2001 |
Characterization of reproductive endocrine disorders in women with epilepsy.
Topics: Adolescent; Adult; Amenorrhea; Anticonvulsants; Endocrine System Diseases; Epilepsy; Female; Humans; | 2001 |
[The dangers of valproate in women].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cholesterol, HDL; Epilepsy; Female; Humans; Hyperandro | 1998 |
Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy.
Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Comorbidity; Dehydroepiandrosterone; Epileps | 2001 |
Altered ovarian function and cardiovascular risk factors in valproate-treated women.
Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Cardiovascular Diseases; Case-Control S | 2001 |
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate.
Topics: Adult; Anticonvulsants; Body Mass Index; Body Weight; Confidence Intervals; Cross-Sectional Studies; | 2002 |
Preliminary observations on valproate and cystic ovaries: letter to editor.
Topics: Adolescent; Adult; Anticonvulsants; Female; Humans; Polycystic Ovary Syndrome; Valproic Acid | 2002 |
Menstrual abnormalities and polycystic ovary syndrome in women taking valproate for bipolar mood disorder.
Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Anticonvulsants; Bipolar Disorder; Female; Health S | 2002 |