valproic acid has been researched along with Poisoning in 34 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning." | 8.91 | Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. ( Ghannoum, M; Gosselin, S; Hoffman, RS; Laliberté, M; Lavergne, V; MacTier, R; Nolin, TD, 2015) |
| "Valproic acid (VPA) is an antiepileptic drug that is now used for a variety of neurological and psychiatric indications." | 6.45 | Extracorporeal elimination in acute valproic acid poisoning. ( Thanacoody, RH, 2009) |
| " This guideline applies to the acute ingestion and acute-on-chronic ingestion of immediate-release and extended-release dosage forms of valproic acid, divalproex, and valproate sodium alone." | 6.44 | Valproic acid poisoning: an evidence-based consensus guideline for out-of-hospital management. ( Booze, LL; Caravati, EM; Christianson, G; Chyka, PA; Cobaugh, DJ; Erdman, AR; Manoguerra, AS; Nelson, LS; Scharman, EJ; Troutman, WG; Woolf, AD, 2008) |
| "He presented coma requiring tracheal intubation and mechanical ventilation at 11 hours and central diabetes insipidus." | 5.33 | [Transient central diabetes insipidus during a valproic acid poisoning]. ( Corne, P; Jonquet, O; Lemaire, X, 2006) |
| "The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning." | 4.91 | Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. ( Ghannoum, M; Gosselin, S; Hoffman, RS; Laliberté, M; Lavergne, V; MacTier, R; Nolin, TD, 2015) |
| " There were more dialysis treatments for poisonings with valproate and acetaminophen in 2001-2005 than for methanol and theophylline, although hemodialysis for acetaminophen removal is generally not recommended." | 3.74 | Use of hemodialysis and hemoperfusion in poisoned patients. ( Goldfarb, DS; Hoffman, RS; Holubek, WJ; Nelson, LS, 2008) |
| "The termination time of seizure, doses of diazepam, mental symptoms and the continual time of mental symptoms were not significantly different among these three groups." | 2.71 | [Evaluation of therapeutic project on acute tetramethylene disulphotetramine poisoning and effect on intelligence in children]. ( Bai, H; Bai, YW; Ding, MB; Ji, JT; Lu, XR; Ma, PB; Sun, CY; Wang, HS; Zhang, HS; Zhang, SL; Zhou, XR, 2005) |
| "Valproic acid (VPA) is an antiepileptic drug that is now used for a variety of neurological and psychiatric indications." | 2.45 | Extracorporeal elimination in acute valproic acid poisoning. ( Thanacoody, RH, 2009) |
| " This guideline applies to the acute ingestion and acute-on-chronic ingestion of immediate-release and extended-release dosage forms of valproic acid, divalproex, and valproate sodium alone." | 2.44 | Valproic acid poisoning: an evidence-based consensus guideline for out-of-hospital management. ( Booze, LL; Caravati, EM; Christianson, G; Chyka, PA; Cobaugh, DJ; Erdman, AR; Manoguerra, AS; Nelson, LS; Scharman, EJ; Troutman, WG; Woolf, AD, 2008) |
| "Valproic acid is a widely used anticonvulsant that has recently been approved for stabilization of manic episodes in patients with bipolar disorder." | 2.44 | Carnitine as an antidote for acute valproate toxicity in children. ( Russell, S, 2007) |
| "Valproic acid (VPA) has been used as an anticonvulsant for the treatment of epilepsy." | 1.37 | An UPLC-MS/MS method for the determination of valproic acid in blood of a fatal intoxication case. ( Corte-Real, F; Franco, JM; Marcos, M; Mustra, C; Pereira, AR; Proença, P; Vieira, DN, 2011) |
| "A 32-year-old comatose woman was admitted to the ICU at our hospital; she suffered from hypotension, respiratory depression, hypoglycaemia, sinus bradycardia, hyperammonaemia, metabolic acidosis, and her core body temperature was 33." | 1.35 | Severe valproic acid intoxication: case study on the unbound fraction and the applicability of extracorporeal elimination. ( Meulenbelt, J; Sikma, MA; van den Broek, MP; Ververs, TF, 2009) |
| "He presented coma requiring tracheal intubation and mechanical ventilation at 11 hours and central diabetes insipidus." | 1.33 | [Transient central diabetes insipidus during a valproic acid poisoning]. ( Corne, P; Jonquet, O; Lemaire, X, 2006) |
| "The methemoglobinemia was readily reversed with the administration of methylene blue." | 1.30 | Acute valproate ingestion induces symptomatic methemoglobinemia. ( Lynch, A; Tobias, JD, 1998) |
| "To evaluate an animal model of multiple-dose activated charcoal (MDAC) therapy and correlate the pharmacokinetic properties of four drugs with the efficacy of MDAC." | 1.29 | Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy. ( Chyka, PA; Holley, JE; Mandrell, TD; Sugathan, P, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (17.65) | 18.2507 |
| 2000's | 20 (58.82) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghannoum, M | 1 |
| Laliberté, M | 1 |
| Nolin, TD | 1 |
| MacTier, R | 1 |
| Lavergne, V | 1 |
| Hoffman, RS | 2 |
| Gosselin, S | 1 |
| Manoguerra, AS | 1 |
| Erdman, AR | 1 |
| Woolf, AD | 1 |
| Chyka, PA | 2 |
| Caravati, EM | 1 |
| Scharman, EJ | 1 |
| Booze, LL | 1 |
| Christianson, G | 1 |
| Nelson, LS | 2 |
| Cobaugh, DJ | 1 |
| Troutman, WG | 1 |
| Churchwell, MD | 1 |
| Pasko, DA | 1 |
| Smoyer, WE | 1 |
| Mueller, BA | 1 |
| Holubek, WJ | 1 |
| Goldfarb, DS | 2 |
| van den Broek, MP | 1 |
| Sikma, MA | 2 |
| Ververs, TF | 1 |
| Meulenbelt, J | 2 |
| Licari, E | 1 |
| Calzavacca, P | 1 |
| Warrillow, SJ | 1 |
| Bellomo, R | 1 |
| Thanacoody, RH | 1 |
| Deras, P | 1 |
| Gignon, L | 1 |
| Toumi, M | 1 |
| Louart, G | 1 |
| Muller, L | 1 |
| Boyer, JC | 1 |
| Lefrant, JY | 1 |
| Gonçalves, JA | 1 |
| Santos, C | 1 |
| Montalbán, JM | 1 |
| Filipe, RA | 1 |
| Chorão, R | 1 |
| Freixo, J | 1 |
| Ramalheiro, A | 1 |
| Bernardo, A | 1 |
| Iglesias, AB | 1 |
| Rocha, E | 1 |
| Bayliss, G | 1 |
| Mégarbane, B | 1 |
| Jacobs, F | 1 |
| Garlich, FM | 1 |
| Proença, P | 1 |
| Franco, JM | 1 |
| Mustra, C | 1 |
| Marcos, M | 1 |
| Pereira, AR | 1 |
| Corte-Real, F | 1 |
| Vieira, DN | 1 |
| Deng, X | 1 |
| Li, G | 1 |
| Mei, R | 1 |
| Sun, S | 1 |
| Sztajnkrycer, MD | 1 |
| Imbenotte, M | 3 |
| Azaroual, N | 2 |
| Cartigny, B | 3 |
| Vermeersch, G | 3 |
| Lhermitte, M | 3 |
| Bai, H | 1 |
| Zhang, SL | 1 |
| Zhang, HS | 1 |
| Ji, JT | 1 |
| Ma, PB | 1 |
| Wang, HS | 1 |
| Bai, YW | 1 |
| Zhou, XR | 1 |
| Ding, MB | 1 |
| Lu, XR | 1 |
| Sun, CY | 1 |
| Dhondt, A | 1 |
| Verstraete, A | 1 |
| Vandewoude, K | 1 |
| Segers, H | 1 |
| Eloot, S | 1 |
| Decruyenaere, J | 1 |
| Vanholder, R | 1 |
| Bebarta, VS | 1 |
| Kostic, MA | 1 |
| Gonzalez, MG | 1 |
| Lemaire, X | 1 |
| Corne, P | 1 |
| Jonquet, O | 1 |
| Russell, S | 1 |
| Thanacoody, HK | 1 |
| Katiyar, A | 1 |
| Aaron, C | 1 |
| Mier, JC | 1 |
| Holley, JE | 1 |
| Mandrell, TD | 1 |
| Sugathan, P | 1 |
| Guieu, R | 1 |
| Kopeyan, C | 1 |
| Rochat, H | 1 |
| Lynch, A | 1 |
| Tobias, JD | 1 |
| Johnson, LZ | 1 |
| Martinez, I | 1 |
| Fernández, MC | 1 |
| Davis, CP | 1 |
| Kasinath, BS | 1 |
| Vallée, L | 1 |
| Rengstorff, DS | 1 |
| Milstone, AP | 1 |
| Seger, DL | 1 |
| Meredith, TJ | 1 |
| Espinoza, O | 1 |
| Maradei, I | 1 |
| Ramírez, M | 1 |
| Pascuzzo-Lima, C | 1 |
| Hicks, LK | 1 |
| McFarlane, PA | 1 |
| Dharnidharka, VR | 1 |
| Fennell, RS | 1 |
| Richard, GA | 1 |
10 reviews available for valproic acid and Poisoning
| Article | Year |
|---|---|
Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup.
Topics: Anticonvulsants; Drug Overdose; Hemoperfusion; Humans; Poisoning; Renal Dialysis; Treatment Outcome; | 2015 |
Valproic acid poisoning: an evidence-based consensus guideline for out-of-hospital management.
Topics: Ambulatory Care; Antidotes; Charcoal; Drug Overdose; Humans; Poison Control Centers; Poisoning; Prac | 2008 |
Life-threatening sodium valproate overdose: a comparison of two approaches to treatment.
Topics: Adult; Antimanic Agents; Drug Overdose; Emergency Treatment; Female; Humans; Poisoning; Valproic Aci | 2009 |
Extracorporeal elimination in acute valproic acid poisoning.
Topics: Acute Disease; Anticonvulsants; Databases, Bibliographic; Drug Overdose; Half-Life; Hemoperfusion; H | 2009 |
Dialysis in the poisoned patient.
Topics: Analgesics; Ethylene Glycol; Female; Humans; Lithium; Methanol; Middle Aged; Poisoning; Renal Dialys | 2010 |
Have advances in extracorporeal removal techniques changed the indications for their use in poisonings?
Topics: Carbamazepine; Hemodiafiltration; Hemodynamics; Hemoperfusion; Humans; Insulin; Membranes, Artificia | 2011 |
Valproic acid toxicity: overview and management.
Topics: Animals; Anticonvulsants; Antidotes; Biotransformation; Humans; Poisoning; Renal Dialysis; United St | 2002 |
Managing adverse reactions to psychotropic medications.
Topics: Adolescent; Anticonvulsants; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivit | 2005 |
Carnitine as an antidote for acute valproate toxicity in children.
Topics: Anticonvulsants; Antidotes; Carnitine; Child; Humans; Poisoning; Valproic Acid; Vitamin B Complex | 2007 |
Valproic acid overdose and haemodialysis.
Topics: Bipolar Disorder; Female; Glasgow Coma Scale; Humans; Middle Aged; Naloxone; Poisoning; Renal Dialys | 2001 |
1 trial available for valproic acid and Poisoning
| Article | Year |
|---|---|
[Evaluation of therapeutic project on acute tetramethylene disulphotetramine poisoning and effect on intelligence in children].
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Antidotes; Bridged-Ring Compounds; Child; Female; | 2005 |
23 other studies available for valproic acid and Poisoning
| Article | Year |
|---|---|
Enhanced clearance of highly protein-bound drugs by albumin-supplemented dialysate during modeled continuous hemodialysis.
Topics: Albumins; Animals; Carbamazepine; Cattle; Drug-Related Side Effects and Adverse Reactions; Hemodialy | 2009 |
Use of hemodialysis and hemoperfusion in poisoned patients.
Topics: Acetaminophen; Carbamazepine; Ethylene Glycol; Hemoperfusion; Humans; Lithium; Poisoning; Poisons; R | 2008 |
Severe valproic acid intoxication: case study on the unbound fraction and the applicability of extracorporeal elimination.
Topics: Adult; Anticonvulsants; Charcoal; Coma; Drug-Related Side Effects and Adverse Reactions; Female; Gla | 2009 |
[Lactic acidosis after voluntary intoxication with valproic acid].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Combined Modality Therapy; Depressive Disorder; Emerge | 2010 |
[Continuous venovenous haemodiafiltration as a solution for acute intoxication with sodium valproate].
Topics: Acute Disease; Antimanic Agents; Female; Hemodiafiltration; Humans; Middle Aged; Poisoning; Valproic | 2010 |
[Management of severe valproic acid poisoning: first optimize supportive treatments].
Topics: Humans; Poisoning; Renal Dialysis; Severity of Illness Index; Valproic Acid | 2010 |
An UPLC-MS/MS method for the determination of valproic acid in blood of a fatal intoxication case.
Topics: Anticonvulsants; Central Nervous System Depressants; Chromatography, Liquid; Ethanol; Female; Forens | 2011 |
Long term effects of tetramine poisoning: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anticonvulsants; Bridged-Ring Compounds; Charco | 2012 |
Detection and quantitation of xenobiotics in biological fluids by 1H NMR spectroscopy.
Topics: Acute Disease; Humans; Hydrogen; Magnetic Resonance Spectroscopy; Paraquat; Poisoning; Salicylates; | 2003 |
Efficiency of the Genius batch hemodialysis system with low serum solute concentrations: the case of lithium intoxication therapy.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Diffusion; Equipment Design; Equipment Failure; Female; H | 2005 |
[Transient central diabetes insipidus during a valproic acid poisoning].
Topics: Adult; Bipolar Disorder; Coma; Diabetes Insipidus; Fluid Therapy; Humans; Intubation, Intratracheal; | 2006 |
Chronic valproic acid intoxication: reversal by naloxone.
Topics: Aged; Antimanic Agents; Bipolar Disorder; Female; Humans; Naloxone; Narcotic Antagonists; Poisoning; | 2007 |
Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity.
Topics: Adult; Anticonvulsants; Antidotes; Carnitine; Charcoal; Humans; Male; Michigan; Poison Control Cente | 2007 |
Massive valproic acid overdose, a misleading case.
Topics: Adult; Ammonia; Anticonvulsants; Antidotes; Charcoal; Coma; Drug Overdose; Epilepsy; Humans; Male; P | 2008 |
Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy.
Topics: Acetaminophen; Animals; Charcoal; Digoxin; Disease Models, Animal; Drug Administration Schedule; Fem | 1995 |
Utilization of aspirin, quinine and verapamil in the prevention and treatment of scorpion venom intoxication.
Topics: Animals; Aspirin; Female; gamma-Aminobutyric Acid; Lethal Dose 50; Mice; Mice, Inbred C57BL; Poisoni | 1993 |
Acute valproate ingestion induces symptomatic methemoglobinemia.
Topics: Acute Disease; Antidotes; Charcoal; Child, Preschool; Female; Humans; Methemoglobinemia; Methylene B | 1998 |
Successful treatment of valproic acid overdose with hemodialysis.
Topics: Adult; Drug Overdose; Female; Humans; Hypotension; Poisoning; Renal Dialysis; Valproic Acid | 1999 |
[Analysis of two cases of valproic acid intoxication by 1H NMR spectroscopy and gas chromatography/mass spectrometry].
Topics: Acidosis, Lactic; Adolescent; Adult; Anticonvulsants; Gas Chromatography-Mass Spectrometry; Glucuron | 1999 |
[Identification and quantification of exogenous metabolites in biological liquids with new development in NMR spectroscopy in one and two dimensions].
Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Antimalarials; Aspirin; Chloroquine; Female; Humans; | 1999 |
Felbamate overdose complicated by massive crystalluria and acute renal failure.
Topics: Acute Kidney Injury; Adult; Anticonvulsants; Chromatography, Gas; Crystallization; Drug Interactions | 2000 |
An unusual presentation of opioid-like syndrome in pediatric valproic acid poisoning.
Topics: Child, Preschool; Diagnosis, Differential; Drug Overdose; Gastric Lavage; Humans; Male; Naloxone; Op | 2001 |
Extracorporeal removal of toxic valproic acid levels in children.
Topics: Adolescent; Female; Half-Life; Hemodiafiltration; Humans; Infant; Osmolar Concentration; Poisoning; | 2002 |