valproic acid has been researched along with Pituitary Neoplasms in 22 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Di-n-propylacetic acid (valproic acid) has been reported to lower plasma ACTH concentration after both acute and chronic administration of the drug." | 5.27 | Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma. ( Choi, B; Elias, AN; Gwinup, G, 1984) |
| "Fifteen patients with prolactinomas, 8 patients with non-tumoral hyperprolactinemia and 10 healthy subjects were studied: in non consecutive days, all subjects received placebo and SV at the dose of 400 and 800 mg po." | 2.68 | Different sensitivity to sodium valproate in healthy, non-tumoral and tumoral hyperprolactinemic subjects. ( Colao, A; Di Sarno, A; Di Somma, C; Ferone, D; Landi, ML; Lombardi, G; Merola, B; Sarnacchiaro, F; Tolino, A, 1997) |
| " Neither a single dose nor long term administration of sodium valproate resulted in a significant decrease of plasma ACTH levels in patients with Cushing's disease and Nelson's syndrome." | 2.66 | The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease. ( Allolio, B; Jaursch-Hancke, C; Kaulen, D; Reincke, M; Winkelmann, W, 1988) |
| " The effect of a long term administration of sodium valproate (600-1000 mg/day) was evaluated in 2 patients with active Cushing's disease and in 1 patient with Nelson's syndrome (3 weeks, 3, 9 months respectively); in the 2 patients with Cushing's disease ACTH and cortisol secretion, 17-hydroxy-corticosteroids (17-OHCS) urinary excretion did not change during DPA treatment." | 2.65 | Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion. ( Berselli, ME; Frascatani, F; Loli, P; Muratori, F; Tagliaferri, M, 1984) |
| "The toxicity of an agent or the therapeutic effect of a drug may be assessed by a dose-response study." | 1.29 | Exact power computation for dose-response studies. ( Hirji, KF; Tang, ML; Vollset, SE, 1995) |
| "Di-n-propylacetic acid (valproic acid) has been reported to lower plasma ACTH concentration after both acute and chronic administration of the drug." | 1.27 | Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma. ( Choi, B; Elias, AN; Gwinup, G, 1984) |
| "We describe herein the reduction in the size of an ACTH-secreting pituitary macroadenoma in a patient with Nelson's syndrome during chronic administration of sodium valproate, and the changes in tumour volume after withdrawal and re-institution of treatment." | 1.27 | Size reduction of an ACTH-secreting pituitary macroadenoma in Nelson's syndrome by sodium valproate: effect of withdrawal and re-institution of treatment. ( Berselli, ME; De Grandi, C; Loli, P; Tagliaferri, M; Vignati, F, 1988) |
| "189 patients with secretory pituitary adenomas underwent medical therapy for the hypersecretory state." | 1.27 | The medical treatment of the hypersecreting pituitary gland. ( Corenblum, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (86.36) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, P | 1 |
| Tundup, T | 1 |
| Singh, J | 1 |
| Deb, KS | 1 |
| Verma, R | 1 |
| Kumar, N | 1 |
| Koppeschaar, HP | 1 |
| Croughs, RJ | 1 |
| van't Verlaat, JW | 1 |
| Hendriks, MJ | 1 |
| Arts, CJ | 1 |
| Thijssen, JH | 1 |
| Schwarz, F | 1 |
| Jones, MT | 2 |
| Gillham, B | 2 |
| Beckford, U | 2 |
| Dornhorst, A | 2 |
| Abraham, RR | 2 |
| Seed, M | 1 |
| Wynn, V | 2 |
| Elias, AN | 3 |
| Gwinup, G | 3 |
| Valenta, LJ | 1 |
| Jenkins, JS | 1 |
| Lamberts, SW | 2 |
| Verleun, T | 1 |
| Bons, EG | 1 |
| Uitterlinden, P | 1 |
| Oosterom, R | 1 |
| Ambrosi, B | 1 |
| Bochicchio, D | 1 |
| Riva, E | 1 |
| Faglia, G | 1 |
| Choi, B | 1 |
| Loli, P | 2 |
| Berselli, ME | 2 |
| Frascatani, F | 1 |
| Muratori, F | 1 |
| Tagliaferri, M | 2 |
| Melis, GB | 1 |
| Paoletti, AM | 1 |
| Mais, V | 1 |
| Mastrapasqua, NM | 1 |
| Strigini, F | 1 |
| Fruzzetti, F | 1 |
| Guarnieri, G | 1 |
| Gambacciani, M | 1 |
| Fioretti, P | 1 |
| Tang, ML | 1 |
| Hirji, KF | 1 |
| Vollset, SE | 1 |
| Sarnacchiaro, F | 1 |
| Colao, A | 1 |
| Merola, B | 1 |
| Di Sarno, A | 1 |
| Landi, ML | 1 |
| Di Somma, C | 1 |
| Ferone, D | 1 |
| Tolino, A | 1 |
| Lombardi, G | 1 |
| Kelly, W | 1 |
| Adams, JE | 1 |
| Laing, I | 1 |
| Longson, D | 1 |
| Davies, D | 1 |
| Reincke, M | 1 |
| Allolio, B | 1 |
| Kaulen, D | 1 |
| Jaursch-Hancke, C | 1 |
| Winkelmann, W | 1 |
| Vignati, F | 1 |
| De Grandi, C | 1 |
| Kasperlik-Załuska, A | 1 |
| Drac-Kaniewska, J | 1 |
| Migdalska, B | 1 |
| Jeske, W | 1 |
| Wiśniewska-Woźniak, T | 1 |
| Corenblum, B | 1 |
| Gomi, M | 1 |
| Iida, S | 1 |
| Itoh, Y | 1 |
| Moriwaki, K | 1 |
| Kanayama, S | 1 |
| Namba, M | 1 |
| Tarui, S | 1 |
| Yoshida, H | 1 |
| Takeda, F | 1 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
| Shukla, S | 1 |
| Turner, WJ | 1 |
| Newman, G | 1 |
| Burch, WM | 1 |
2 reviews available for valproic acid and Pituitary Neoplasms
| Article | Year |
|---|---|
[Drug and radiotherapy of pituitary tumors].
Topics: Acromegaly; Adenoma; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; G | 1986 |
Cushing's disease. A review.
Topics: Adenoma; Adolescent; Adrenalectomy; Adult; Animals; Bromocriptine; Child; Combined Modality Therapy; | 1985 |
3 trials available for valproic acid and Pituitary Neoplasms
| Article | Year |
|---|---|
Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion.
Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans | 1984 |
Different sensitivity to sodium valproate in healthy, non-tumoral and tumoral hyperprolactinemic subjects.
Topics: Adolescent; Adult; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Hyperprolactinemia; Kinetic | 1997 |
The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease.
Topics: Addison Disease; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hydrocortisone; Lypressin; N | 1988 |
17 other studies available for valproic acid and Pituitary Neoplasms
| Article | Year |
|---|---|
Treatment complexities in psychosis associated with cabergoline treatment in patients having pituitary prolactinomas.
Topics: Adult; Cabergoline; Dopamine Agonists; Female; GABA Agents; Humans; Pituitary Neoplasms; Prolactinom | 2018 |
Successful treatment with sodium valproate of a patient with Cushing's disease and gross enlargement of the pituitary.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; H | 1984 |
Effect of treatment with sodium valproate and diazepam on plasma corticotropin in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Depression, Chemical; Diazepam; Female; gamma-Aminobutyric Acid; | 1981 |
Sodium valproate and Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Humans; Nelson Syndrome; Pituitary Neoplasms; Secretory Rate; Valproic | 1981 |
Effects of valproic acid, naloxone and hydrocortisone in Nelson's syndrome and cushing's disease.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; | 1981 |
The evaluation of sodium valproate in the treatment of Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Evaluat | 1983 |
Effect of cyproheptadine, desmethylcyproheptadine, gamma-amino-butyric acid and sodium valproate on adrenocorticotrophin secretion by cultured pituitary tumour cells from three patients with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Cyproheptadine; Female; gamma-Aminobutyric Acid; Humans; Nelson Syndrom | 1983 |
Effects of sodium-valproate administration on plasma ACTH levels in patients with ACTH hypersecretion.
Topics: Addison Disease; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Male; Nelson Syndrom | 1983 |
Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma.
Topics: Adenoma; Adrenocorticotropic Hormone; Cytoplasmic Granules; Drug Therapy, Combination; Female; Human | 1984 |
The effects of the gabaergic drug, sodium valproate, on prolactin secretion in normal and hyperprolactinemic subjects.
Topics: Adenoma; Adult; Female; Follicular Phase; gamma-Aminobutyric Acid; Humans; Kinetics; Male; Middle Ag | 1982 |
Exact power computation for dose-response studies.
Topics: Adenoma; Algorithms; Animals; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Fem | 1995 |
Long-term treatment of Nelson's syndrome with sodium valproate.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Female; Humans; Hydrocortisone; Male; Middle Aged; N | 1988 |
Size reduction of an ACTH-secreting pituitary macroadenoma in Nelson's syndrome by sodium valproate: effect of withdrawal and re-institution of treatment.
Topics: Adenoma; Adrenocorticotropic Hormone; Brain; Humans; Middle Aged; Nelson Syndrome; Pituitary Neoplas | 1988 |
The effect of sodium valproate on plasma ACTH and cortisol concentrations in Cushing's disease and Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Hormone Antagonists; Humans; Hydrocort | 1988 |
The medical treatment of the hypersecreting pituitary gland.
Topics: Adenoma; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Bromocriptine; Cyproheptadine; Ergoli | 1985 |
Unaltered stimulation of pituitary adrenocorticotrophin secretion by corticotrophin-releasing factor following sodium valproate administration in a patient with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Female; Humans; Middle Aged; Nelson Sy | 1985 |
Bromocriptine-related psychosis and treatment.
Topics: Adult; Bromocriptine; Female; Haloperidol; Humans; Pituitary Neoplasms; Prolactin; Psychoses, Substa | 1985 |