valproic acid has been researched along with Ph 1 Chromosome in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A particular VPA/ATRA responsiveness of Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) was confirmed in a therapy-refractory patient in vivo." | 1.33 | FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment. ( Barth, PJ; Burchert, A; Cai, D; Neubauer, A; Ottmann, OG; Wang, Y, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kircher, B | 1 |
| Schumacher, P | 1 |
| Petzer, A | 1 |
| Hoflehner, E | 1 |
| Haun, M | 1 |
| Wolf, AM | 1 |
| Nachbaur, D | 1 |
| Gastl, G | 1 |
| Cai, D | 1 |
| Wang, Y | 1 |
| Ottmann, OG | 1 |
| Barth, PJ | 1 |
| Neubauer, A | 1 |
| Burchert, A | 1 |
2 other studies available for valproic acid and Ph 1 Chromosome
| Article | Year |
|---|---|
Anti-leukemic activity of valproic acid and imatinib mesylate on human Ph+ ALL and CML cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; Benzamides; Case-Control Studies; Cell Line, Tumor; | 2009 |
FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Transformation, Neoplastic; Drug Resistance, Neopla | 2006 |