valproic acid has been researched along with Pervasive Child Development Disorders in 28 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using the prenatal valproic acid (VPA)-injection model of autism spectrum disorder (ASD) in rats, which produces social impairrment and altered seizure susceptibility as in human ASD patients as well as mild neural tube defects like crooked tail phenotype, we examined whether chronic administration of red ginseng extract may rescue the social impairment and crooked tail phenotype in prenatally VPA-exposed rat offspring." | 7.79 | Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. ( Han, SH; Kim, HJ; Kim, HY; Kim, KC; Kim, P; Kwon, KJ; Lee, JM; Park, JH; Shin, CY, 2013) |
| "Valproic acid (VPA) is a blocker of histone deacetylase widely used to treat epilepsy, bipolar disorders, and migraine; its administration during pregnancy increases the risk of autism spectrum disorder (ASD) in the child." | 3.79 | Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder. ( Atzori, M; Bringas, ME; Carvajal-Flores, FN; Flores, G; López-Ramírez, TA, 2013) |
| " Using the prenatal valproic acid (VPA)-injection model of autism spectrum disorder (ASD) in rats, which produces social impairrment and altered seizure susceptibility as in human ASD patients as well as mild neural tube defects like crooked tail phenotype, we examined whether chronic administration of red ginseng extract may rescue the social impairment and crooked tail phenotype in prenatally VPA-exposed rat offspring." | 3.79 | Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. ( Han, SH; Kim, HJ; Kim, HY; Kim, KC; Kim, P; Kwon, KJ; Lee, JM; Park, JH; Shin, CY, 2013) |
| "9)), with a dose-response relationship." | 1.56 | Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. ( Blotière, PO; Coste, J; Dray-Spira, R; Mahmoud, Z; Mikaeloff, Y; Miranda, S; Peyre, H; Ramus, F; Weill, A, 2020) |
| " Our previous studies have demonstrated the social cognition deficits observed in this model, a major core symptom of ASD, to be ameliorated following chronic administration of histone deacetylase (HDAC) inhibitors." | 1.40 | Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders. ( Cassidy, AW; Foley, AG; Regan, CM, 2014) |
| "Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential." | 1.39 | Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. ( Christensen, J; Grønborg, TK; Parner, ET; Pedersen, LH; Schendel, D; Sørensen, MJ; Vestergaard, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 24 (85.71) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Blotière, PO | 1 |
| Miranda, S | 1 |
| Weill, A | 1 |
| Mikaeloff, Y | 1 |
| Peyre, H | 1 |
| Ramus, F | 1 |
| Mahmoud, Z | 1 |
| Coste, J | 1 |
| Dray-Spira, R | 1 |
| Bringas, ME | 2 |
| Carvajal-Flores, FN | 1 |
| López-Ramírez, TA | 1 |
| Atzori, M | 2 |
| Flores, G | 2 |
| Christensen, J | 1 |
| Grønborg, TK | 1 |
| Sørensen, MJ | 1 |
| Schendel, D | 1 |
| Parner, ET | 1 |
| Pedersen, LH | 1 |
| Vestergaard, M | 1 |
| Meador, KJ | 2 |
| Loring, DW | 2 |
| Bachmann, CJ | 1 |
| Manthey, T | 1 |
| Kamp-Becker, I | 1 |
| Glaeske, G | 1 |
| Hoffmann, F | 1 |
| Wood, A | 1 |
| Singh, S | 1 |
| Lucchina, L | 1 |
| Depino, AM | 1 |
| Jacob, J | 1 |
| Ribes, V | 1 |
| Moore, S | 1 |
| Constable, SC | 1 |
| Sasai, N | 1 |
| Gerety, SS | 1 |
| Martin, DJ | 1 |
| Sergeant, CP | 1 |
| Wilkinson, DG | 1 |
| Briscoe, J | 1 |
| de Theije, CG | 2 |
| Koelink, PJ | 1 |
| Korte-Bouws, GA | 1 |
| Lopes da Silva, S | 1 |
| Korte, SM | 1 |
| Olivier, B | 1 |
| Garssen, J | 2 |
| Kraneveld, AD | 2 |
| Wopereis, H | 1 |
| Ramadan, M | 1 |
| van Eijndthoven, T | 1 |
| Lambert, J | 1 |
| Knol, J | 1 |
| Oozeer, R | 1 |
| Foley, AG | 1 |
| Cassidy, AW | 1 |
| Regan, CM | 1 |
| Chomiak, T | 1 |
| Hung, J | 1 |
| Cihal, A | 1 |
| Dhaliwal, J | 1 |
| Baghdadwala, MI | 1 |
| Dzwonek, A | 1 |
| Podgorny, P | 1 |
| Hu, B | 1 |
| Smith, V | 1 |
| Brown, N | 1 |
| Sosa-Díaz, N | 1 |
| Ahn, Y | 1 |
| Narous, M | 1 |
| Tobias, R | 1 |
| Rho, JM | 1 |
| Mychasiuk, R | 1 |
| Cusmano, DM | 1 |
| Mong, JA | 1 |
| Mowery, TM | 1 |
| Wilson, SM | 1 |
| Kostylev, PV | 1 |
| Dina, B | 1 |
| Buchholz, JB | 1 |
| Prieto, AL | 1 |
| Garraghty, PE | 1 |
| Wong, IC | 1 |
| Hsia, Y | 1 |
| Solignac, I | 1 |
| Hollander, E | 2 |
| Chaplin, W | 1 |
| Soorya, L | 1 |
| Wasserman, S | 1 |
| Novotny, S | 2 |
| Rusoff, J | 1 |
| Feirsen, N | 1 |
| Pepa, L | 1 |
| Anagnostou, E | 1 |
| Kim, P | 2 |
| Park, JH | 2 |
| Kwon, KJ | 1 |
| Kim, KC | 2 |
| Kim, HJ | 2 |
| Lee, JM | 1 |
| Kim, HY | 1 |
| Han, SH | 2 |
| Shin, CY | 2 |
| Go, HS | 1 |
| Choi, CS | 1 |
| Jeon, SJ | 1 |
| Dela Pena, IC | 1 |
| Cheong, JH | 1 |
| Ryu, JH | 1 |
| Bromley, RL | 1 |
| Mawer, GE | 1 |
| Briggs, M | 1 |
| Cheyne, C | 1 |
| Clayton-Smith, J | 1 |
| García-Fiñana, M | 1 |
| Kneen, R | 1 |
| Lucas, SB | 1 |
| Shallcross, R | 1 |
| Baker, GA | 1 |
| Hellings, JA | 1 |
| Weckbaugh, M | 1 |
| Nickel, EJ | 1 |
| Cain, SE | 1 |
| Zarcone, JR | 1 |
| Reese, RM | 1 |
| Hall, S | 1 |
| Ermer, DJ | 1 |
| Tsai, LY | 1 |
| Schroeder, SR | 1 |
| Cook, EH | 1 |
| Dolgoff-Kaspar, R | 1 |
| Cartwright, C | 1 |
| Rawitt, R | 1 |
| Nass, R | 1 |
| Petrucha, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Infant MiND Study: An Examination of Infants' Microbiome, Nutrition, and Development Study.[NCT03229863] | 102 participants (Actual) | Interventional | 2017-04-18 | Active, not recruiting | |||
| A 12-weeks, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Related Mechanism of Sulforaphane in Treatment of Autism Spectrum Disorder[NCT02879110] | 110 participants (Actual) | Interventional | 2016-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for valproic acid and Pervasive Child Development Disorders
| Article | Year |
|---|---|
Divalproex sodium vs placebo for the treatment of irritability in children and adolescents with autism spectrum disorders.
Topics: Adolescent; Antimanic Agents; Child; Child Behavior Disorders; Child Development Disorders, Pervasiv | 2010 |
A double-blind, placebo-controlled study of valproate for aggression in youth with pervasive developmental disorders.
Topics: Adolescent; Adult; Aggression; Anticonvulsants; Child; Child Development Disorders, Pervasive; Doubl | 2005 |
An open trial of divalproex sodium in autism spectrum disorders.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Antipsychotic Agents; Asperger Syndrome; Autistic D | 2001 |
25 other studies available for valproic acid and Pervasive Child Development Disorders
| Article | Year |
|---|---|
Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study.
Topics: Anticonvulsants; Child; Child Development Disorders, Pervasive; Child, Preschool; Cohort Studies; Da | 2020 |
Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder.
Topics: Animals; Child Development Disorders, Pervasive; Dendrites; Disease Models, Animal; Exploratory Beha | 2013 |
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Child; Child Development Disorders, Pervasive | 2013 |
Risks of in utero exposure to valproate.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
Psychopharmacological treatment in children and adolescents with autism spectrum disorders in Germany.
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Central Nervous System Stimula | 2013 |
Prenatal valproate exposure is associated with autism spectrum disorder and childhood autism.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
Prenatal exposure to sodium valproate is associated with increased risk of childhood autism and autistic spectrum disorder.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2014 |
Valproate use during pregnancy was linked to autism spectrum disorder and childhood autism in offspring.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
Altered peripheral and central inflammatory responses in a mouse model of autism.
Topics: Animals; Cerebellum; Child Development Disorders, Pervasive; Corticosterone; Cytokines; Female; Hipp | 2014 |
Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Basic Helix-Loop-Helix Transcription Factors; | 2014 |
Intestinal inflammation in a murine model of autism spectrum disorders.
Topics: Animals; Brain; Child Development Disorders, Pervasive; Disease Models, Animal; Female; Ileitis; Ile | 2014 |
Altered gut microbiota and activity in a murine model of autism spectrum disorders.
Topics: Acetic Acid; Animals; Butyric Acid; Child Development Disorders, Pervasive; Disease Models, Animal; | 2014 |
Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders.
Topics: Acetylation; Animals; Behavior, Animal; Cerebellar Cortex; Child Development Disorders, Pervasive; C | 2014 |
Auditory-cued sensorimotor task reveals disengagement deficits in rats exposed to the autism-associated teratogen valproic acid.
Topics: Acoustic Stimulation; Animals; Anticipation, Psychological; Attention; Behavior, Animal; Child Devel | 2014 |
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2014 |
Prefrontal cortex, hippocampus, and basolateral amygdala plasticity in a rat model of autism spectrum.
Topics: Aging; Analysis of Variance; Animals; Basolateral Nuclear Complex; Child Development Disorders, Perv | 2014 |
The ketogenic diet modifies social and metabolic alterations identified in the prenatal valproic acid model of autism spectrum disorder.
Topics: Animals; Behavior, Animal; Child Development Disorders, Pervasive; Diet, Ketogenic; Disease Models, | 2014 |
In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism.
Topics: Aging; Animals; Arousal; Child Development Disorders, Pervasive; Circadian Rhythm; Disease Models, A | 2014 |
Embryological exposure to valproic acid disrupts morphology of the deep cerebellar nuclei in a sexually dimorphic way.
Topics: Animals; Animals, Newborn; Case-Control Studies; Cell Count; Cerebellar Nuclei; Child Development Di | 2015 |
Authors' response to Bachmann and Hoffman's comments on psychopharmacological prescriptions for people with autism spectrum disorder (ASD): a multinational study.
Topics: Child Development Disorders, Pervasive; Female; Humans; Male; Methylphenidate; Risperidone; Valproic | 2015 |
[A girl with foetal valproate syndrome and autism spectrum disorder].
Topics: Anticonvulsants; Autistic Disorder; Child; Child Development Disorders, Pervasive; Epilepsy; Female; | 2016 |
Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid.
Topics: Animals; Behavior, Animal; Child; Child Development Disorders, Pervasive; Disease Models, Animal; Fe | 2013 |
Male-specific alteration in excitatory post-synaptic development and social interaction in pre-natal valproic acid exposure model of autism spectrum disorder.
Topics: Animals; Child; Child Development Disorders, Pervasive; Disease Models, Animal; Female; Humans; Inte | 2013 |
The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child Development Disorders, Per | 2013 |
Acquired aphasia with convulsive disorder: a pervasive developmental disorder variant.
Topics: Aphasia; Child Development Disorders, Pervasive; Child, Preschool; Electroencephalography; Epilepsie | 1990 |