valproic acid has been researched along with Peripheral Nerve Injury in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuropathic pain is often insensitive to morphine." | 5.42 | Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. ( Araki, K; Matsushita, Y; Mukae, T; Uchida, H; Ueda, H, 2015) |
| "Neuropathic pain is often insensitive to morphine." | 1.42 | Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. ( Araki, K; Matsushita, Y; Mukae, T; Uchida, H; Ueda, H, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandez, L | 1 |
| Komatsu, DE | 1 |
| Gurevich, M | 1 |
| Hurst, LC | 1 |
| Yoshizumi, M | 1 |
| Eisenach, JC | 2 |
| Hayashida, K | 2 |
| Uchida, H | 1 |
| Matsushita, Y | 1 |
| Araki, K | 1 |
| Mukae, T | 1 |
| Ueda, H | 1 |
| Hobo, S | 1 |
1 review available for valproic acid and Peripheral Nerve Injury
| Article | Year |
|---|---|
Emerging Strategies on Adjuvant Therapies for Nerve Recovery.
Topics: Absorbable Implants; Allografts; Autografts; Calcium Channel Blockers; Erythropoietin; Gabapentin; H | 2018 |
3 other studies available for valproic acid and Peripheral Nerve Injury
| Article | Year |
|---|---|
Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Down-Regulation; Excitatory Amino Acid Transp | 2013 |
Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury.
Topics: Acetylation; Analgesia; Analgesics; Animals; Down-Regulation; Drug Resistance; Ganglia, Spinal; Gene | 2015 |
Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Transp | 2011 |