valproic acid has been researched along with Parkinson Disease, Secondary in 20 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Parkinson Disease, Secondary: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Combination therapy with valproic acid plus quetiapine is recommended as one of the first-line approaches to treatment of manic or mixed episodes in patients with bipolar disorder." | 3.77 | Reversible parkinsonism and cognitive decline due to a possible interaction of valproic acid and quetiapine. ( De Dios, C; Fudio, S; Lorenzo, A, 2011) |
| "We describe two patients who developed levodopa-responsive parkinsonism without dementia at least 4 years after beginning chronic valproate (VPA) treatment for seizures." | 3.70 | Reversible parkinsonism induced by prolonged treatment with valproate. ( Onofrj, M; Paci, C; Thomas, A, 1998) |
| " Reduction in VPA dosage in the third patient produced no improvement." | 2.71 | Reversible parkinsonism with normal beta-CIT-SPECT in patients exposed to sodium valproate. ( Clough, P; Duncan, S; Easterford, K; Fallon, K; Kellett, M, 2004) |
| " We hypothesise that an increase in valproate dosage unmasked clinically silent Parkinson's disease." | 1.42 | Clinically silent idiopathic Parkinson's disease unmasked by valproate use: a brief report. ( Athauda, D; Batley, R; Ellis, C, 2015) |
| "Valproic acid is a drug used for the treatment of a variety of psychiatric and neurological disorders." | 1.39 | Valproic acid-induced parkinsonism: levodopa responsiveness with dyskinesia. ( Factor, SA; Silver, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, CL | 1 |
| Lu, CC | 1 |
| Lin, HC | 1 |
| Sung, YF | 1 |
| Wu, YP | 1 |
| Hong, JS | 1 |
| Peng, GS | 1 |
| Silver, M | 1 |
| Factor, SA | 1 |
| Athauda, D | 1 |
| Batley, R | 1 |
| Ellis, C | 1 |
| Salazar, Z | 1 |
| Tschopp, L | 1 |
| Calandra, C | 1 |
| Micheli, F | 1 |
| Schreur, L | 1 |
| Middeljans-Tijssen, CW | 1 |
| Hengstman, GJ | 1 |
| Olde Rikkert, MG | 1 |
| Monti, B | 1 |
| Gatta, V | 1 |
| Piretti, F | 1 |
| Raffaelli, SS | 1 |
| Virgili, M | 1 |
| Contestabile, A | 1 |
| Louter, M | 1 |
| Tromp, SC | 1 |
| Sleegers, MJ | 1 |
| Beutler, JJ | 1 |
| Hardon, WJ | 1 |
| Berden, JH | 1 |
| Verhave, JC | 1 |
| Conemans, JM | 1 |
| Hollander, DA | 1 |
| Dautzenberg, PL | 1 |
| Hoogeveen, EK | 1 |
| De Dios, C | 1 |
| Fudio, S | 1 |
| Lorenzo, A | 1 |
| Levin, OS | 1 |
| Shindriaeva, NN | 1 |
| Anikina, MA | 1 |
| Easterford, K | 1 |
| Clough, P | 1 |
| Kellett, M | 1 |
| Fallon, K | 1 |
| Duncan, S | 1 |
| Gaubert, ML | 1 |
| Cougnaud, A | 1 |
| Ghali, A | 1 |
| Bruhat, C | 1 |
| Diquet, B | 1 |
| Berrut, G | 1 |
| Ristić, AJ | 1 |
| Vojvodić, N | 1 |
| Janković, S | 1 |
| Sindelić, A | 1 |
| Sokić, D | 1 |
| Friis, T | 1 |
| Christensen, TR | 1 |
| Gerlach, J | 1 |
| Froomes, PR | 1 |
| Stewart, MR | 1 |
| Alvarez-Gomez, MJ | 1 |
| Vaamonde, J | 1 |
| Narbona, J | 1 |
| Barao, M | 1 |
| Barona, P | 1 |
| Brannan, T | 1 |
| Gudin, M | 1 |
| Ibañez, R | 1 |
| Wils, V | 1 |
| Golüke-Willemse, G | 1 |
| Park-Matsumoto, YC | 1 |
| Tazawa, T | 1 |
| Onofrj, M | 1 |
| Thomas, A | 1 |
| Paci, C | 1 |
| van der Zwan, A | 1 |
1 review available for valproic acid and Parkinson Disease, Secondary
| Article | Year |
|---|---|
[Valproate induced parkinsonism].
Topics: Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Parkinson Disease, Secondary; Valproic Acid | 1998 |
1 trial available for valproic acid and Parkinson Disease, Secondary
| Article | Year |
|---|---|
Reversible parkinsonism with normal beta-CIT-SPECT in patients exposed to sodium valproate.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Incidence; Male; Middle Aged; | 2004 |
18 other studies available for valproic acid and Parkinson Disease, Secondary
| Article | Year |
|---|---|
Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: A potential role of BDNF up-regulation.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dopaminergic Neurons; Mal | 2019 |
Valproic acid-induced parkinsonism: levodopa responsiveness with dyskinesia.
Topics: Adult; Aged; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Diseas | 2013 |
Clinically silent idiopathic Parkinson's disease unmasked by valproate use: a brief report.
Topics: Aged; Humans; Male; Parkinson Disease, Secondary; Valproic Acid | 2015 |
Pisa syndrome and parkinsonism secondary to valproic acid in Huntington's disease.
Topics: Aged; Anticonvulsants; Humans; Huntington Disease; Male; Parkinson Disease, Secondary; Sensation Dis | 2008 |
[Cognitive impairment and parkinsonism due to use of sodium valproate].
Topics: Aged; Anticonvulsants; Cognition Disorders; Epilepsy; Humans; Male; Parkinson Disease, Secondary; Re | 2009 |
Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Brain; Cell Death; Chromatography, High Pressure Liq | 2010 |
[Parkinsonism due to the medication].
Topics: Aged; Aged, 80 and over; Cinnarizine; Female; Humans; Parkinson Disease, Secondary; Valproic Acid | 2009 |
Reversible rapidly progressive dementia with parkinsonism induced by valproate in a patient with systemic lupus erythematosus.
Topics: Aged; Anticonvulsants; Dementia; Diagnosis, Differential; Disease Progression; Epilepsy, Generalized | 2010 |
Reversible parkinsonism and cognitive decline due to a possible interaction of valproic acid and quetiapine.
Topics: Aged; Antimanic Agents; Bipolar Disorder; Cognition Disorders; Cytochrome P-450 CYP3A; Dibenzothiaze | 2011 |
[Drug-induced parkinsonism].
Topics: Anticonvulsants; Antipsychotic Agents; Calcium Channel Blockers; Cinnarizine; Diagnosis, Differentia | 2012 |
Loss of autonomy related to valproic acid intake.
Topics: Aged, 80 and over; Cognition Disorders; Humans; Male; Parkinson Disease, Secondary; Valproic Acid | 2006 |
The frequency of reversible parkinsonism and cognitive decline associated with valproate treatment: a study of 364 patients with different types of epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cognition Disorders; Drug Administration Schedule; Drug Th | 2006 |
Sodium valproate and biperiden in neuroleptic-induced akathisia, parkinsonism and hyperkinesia. A double-blind cross-over study with placebo.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Biperiden; Double-Blind Method; Drug Therapy, Combina | 1983 |
A reversible parkinsonian syndrome and hepatotoxcity following addition of carbamazepine to sodium valproate.
Topics: Aged; Carbamazepine; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Interactions; Drug Th | 1994 |
Parkinsonian syndrome in childhood after sodium valproate administration.
Topics: Child; Female; Humans; Parkinson Disease, Secondary; Valproic Acid | 1993 |
Extrapyramidal syndrome due to valproate administration as an adjunct to lithium in an elderly manic patient.
Topics: Aged; Antimanic Agents; Basal Ganglia Diseases; Bipolar Disorder; Drug Therapy, Combination; Female; | 1997 |
Reversible parkinsonism induced by prolonged treatment with valproate.
Topics: Aged; Anticonvulsants; Antiparkinson Agents; Carbidopa; Female; Humans; Levodopa; Male; Middle Aged; | 1998 |
[Transient Parkinson syndrome and tremor caused by the use of sodium valproate].
Topics: Aged; Epilepsy; Female; Humans; Male; Middle Aged; Parkinson Disease, Secondary; Valproic Acid | 1989 |