valproic acid has been researched along with Paraparesis, Tropical Spastic in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Paraparesis, Tropical Spastic: A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conclude that long-term treatment with VPA is safe in HAM/TSP." | 2.76 | Safety of long-term treatment of HAM/TSP patients with valproic acid. ( Asquith, B; Bangham, C; Belrose, G; Boxus, M; Césaire, R; Gillet, N; Lezin, A; Olindo, S; Rodriguez, S; Signaté, A; Smadja, D; Verlaeten, O; Willems, L, 2011) |
| "Importantly, HTLV-1 does not cause ATLL through insertional mutagenesis." | 2.47 | [Virological aspects of HTLV-1 infection and new therapeutical concepts]. ( Mahieux, R, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Afonso, PV | 1 |
| Mekaouche, M | 1 |
| Mortreux, F | 1 |
| Toulza, F | 1 |
| Moriceau, A | 1 |
| Wattel, E | 1 |
| Gessain, A | 1 |
| Bangham, CR | 1 |
| Dubreuil, G | 1 |
| Plumelle, Y | 1 |
| Hermine, O | 1 |
| Estaquier, J | 1 |
| Mahieux, R | 2 |
| Belrose, G | 3 |
| Gross, A | 1 |
| Olindo, S | 3 |
| Lézin, A | 3 |
| Dueymes, M | 1 |
| Komla-Soukha, I | 1 |
| Smadja, D | 3 |
| Tanaka, Y | 1 |
| Willems, L | 3 |
| Mesnard, JM | 1 |
| Peloponese, JM | 1 |
| Césaire, R | 3 |
| Gillet, N | 2 |
| Rodriguez, S | 1 |
| Boxus, M | 1 |
| Verlaeten, O | 2 |
| Asquith, B | 2 |
| Bangham, C | 1 |
| Signaté, A | 2 |
| Grandvaux, N | 1 |
| de Carvalho Bittencourt, M | 1 |
| Hiscott, J | 1 |
| Burny, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Label Study of the Clinical and Laboratory Effects of Valproic Acid In HAM/TSP[NCT00519181] | 19 participants (Actual) | Interventional | 2006-03-31 | Terminated | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Paraparesis, Tropical Spastic
| Article | Year |
|---|---|
[Virological aspects of HTLV-1 infection and new therapeutical concepts].
Topics: Animals; Anti-Retroviral Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Genome, Vir | 2011 |
1 trial available for valproic acid and Paraparesis, Tropical Spastic
| Article | Year |
|---|---|
Safety of long-term treatment of HAM/TSP patients with valproic acid.
Topics: Adult; Aged; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytophagocytosis; Enzyme Inhibi | 2011 |
3 other studies available for valproic acid and Paraparesis, Tropical Spastic
| Article | Year |
|---|---|
Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors.
Topics: Animals; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD8-Positive T-Lymphocytes; Deltar | 2010 |
Effects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes.
Topics: Antisense Elements (Genetics); Apoptosis; Asymptomatic Diseases; Basic-Leucine Zipper Transcription | 2011 |
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients.
Topics: Enzyme Inhibitors; Gene Expression Regulation, Viral; HeLa Cells; Histone Deacetylase Inhibitors; Hi | 2007 |