Page last updated: 2024-10-26

valproic acid and Pancytopenia

valproic acid has been researched along with Pancytopenia in 13 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.

Research Excerpts

ExcerptRelevanceReference
"We present a patient who developed pancytopenia while taking valproic acid for bipolar illness."7.77Successful reintroduction of valproic acid after the occurrence of pancytopenia. ( Stewart, JT, 2011)
" 58 years old female with pancytopenia in the course of acute valproic acid intoxication was described."7.77[Pancytopenia in the course of acute valproic acid poisoning--case report]. ( Klimaszyk, D; Łukasik-Głebocka, M, 2011)
"We present a patient who developed pancytopenia while taking valproic acid for bipolar illness."3.77Successful reintroduction of valproic acid after the occurrence of pancytopenia. ( Stewart, JT, 2011)
" 58 years old female with pancytopenia in the course of acute valproic acid intoxication was described."3.77[Pancytopenia in the course of acute valproic acid poisoning--case report]. ( Klimaszyk, D; Łukasik-Głebocka, M, 2011)
"Pancytopenia was recovered after discontinuation of valproate but panhypogammaglobulinemia has been persisting."1.39Valproate-induced panhypogammaglobulinemia. ( Eom, TH; Jang, PS; Kim, YH; Lee, HS, 2013)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's4 (30.77)18.2507
2000's3 (23.08)29.6817
2010's4 (30.77)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Lhamu, T1
Sadh, K1
Dahale, AB1
Mohan, V1
Loganathan, S1
Dumas, C1
Jamilloux, Y1
Bienvenu, AL1
Stewart, JT1
Klimaszyk, D1
Łukasik-Głebocka, M1
Eom, TH1
Lee, HS1
Jang, PS1
Kim, YH1
Chae, BJ1
Kang, BJ1
Keown, P1
McAllister-Williams, H1
Young, A1
Robinson, D1
Langer, A1
Casso, D1
Fenn, H1
Yesavage, J1
Taniguchi, Y1
Hattori, H1
Higuchi, Y1
Maihara, T1
Jung, EY1
Furusho, K1
Oluboka, OJ1
Haslam, D1
Gardner, DM1
Boutillier, L1
de Lumley, L1
Saura, R1
Boulesteix, J1
Rajantie, J1
Kajosaari, M1
Ylitalo, V1
Kaya, IS1
Dilmen, U1
Toppare, M1
Senses, DA1
Prentice, HG1

Other Studies

13 other studies available for valproic acid and Pancytopenia

ArticleYear
Valproate-Induced Pancytopenia and Phenytoin Toxicity in a Young Adult With Intellectual Disability and Mesial Temporal Lobe Sclerosis.
    The primary care companion for CNS disorders, 2021, Dec-23, Volume: 23, Issue:6

    Topics: Humans; Intellectual Disability; Pancytopenia; Phenytoin; Sclerosis; Temporal Lobe; Valproic Acid; Y

2021
Sodium valproate and dysmegakaryocytopoiesis.
    British journal of haematology, 2019, Volume: 186, Issue:2

    Topics: Adult; Bone Marrow Cells; Female; Humans; Megakaryocytes; Pancytopenia; Thrombopoiesis; Valproic Aci

2019
Successful reintroduction of valproic acid after the occurrence of pancytopenia.
    The American journal of geriatric pharmacotherapy, 2011, Volume: 9, Issue:5

    Topics: Aged; Antimanic Agents; Bipolar Disorder; Drug Administration Schedule; Drug Monitoring; Humans; Mal

2011
[Pancytopenia in the course of acute valproic acid poisoning--case report].
    Przeglad lekarski, 2011, Volume: 68, Issue:8

    Topics: Epistaxis; Female; Humans; Middle Aged; Mood Disorders; Pancytopenia; Valproic Acid

2011
Valproate-induced panhypogammaglobulinemia.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013, Volume: 34, Issue:6

    Topics: Agammaglobulinemia; Anticonvulsants; Female; Humans; Infant; Pancytopenia; Status Epilepticus; Valpr

2013
A case of delirium and subsequent pancytopenia associated with the oral loading of valproic acid.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:6

    Topics: Administration, Oral; Anticonvulsants; Delirium; Dose-Response Relationship, Drug; Drug Administrati

2005
A case of pancytopenia.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:5

    Topics: Adult; Anticonvulsants; Folic Acid; Humans; Male; Pancytopenia; Schizophrenia; Schizophrenic Psychol

2006
Pancytopenia and valproic acid--a possible association.
    Journal of the American Geriatrics Society, 1995, Volume: 43, Issue:2

    Topics: Aged; Humans; Male; Pancytopenia; Valproic Acid

1995
[Valproate-induced pancytopenia in a patient with infantile spasms].
    No to hattatsu = Brain and development, 1997, Volume: 29, Issue:1

    Topics: Anticonvulsants; Humans; Infant; Male; Pancytopenia; Spasms, Infantile; Valproic Acid

1997
Pancytopenia and valproic acid: a dose-related association.
    Journal of the American Geriatrics Society, 2000, Volume: 48, Issue:3

    Topics: Aged; Antimanic Agents; Bipolar Disorder; Dose-Response Relationship, Drug; Humans; Male; Pancytopen

2000
[Transitory medullary hypoplasia induced by sodium dipropylacetate (author's transl)].
    La Nouvelle presse medicale, 1979, Feb-17, Volume: 8, Issue:8

    Topics: Bone Marrow; Child; Epilepsy; Humans; Male; Pancytopenia; Purpura, Thrombocytopenic; Remission, Spon

1979
Fatal pancytopenia during high-dose valproate monotherapy.
    European journal of pediatrics, 1992, Volume: 151, Issue:8

    Topics: Child, Preschool; Epilepsy; Female; Humans; Pancytopenia; Valproic Acid

1992
Valproic-acid-induced pancytopenia and Coombs test positivity.
    Lancet (London, England), 1991, May-18, Volume: 337, Issue:8751

    Topics: Adolescent; Coombs Test; Epilepsy; Female; Humans; Pancytopenia; Valproic Acid

1991