valproic acid has been researched along with Pain, Postoperative in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if the perioperative administration of valproic acid reduces the incidence of chronic pain three months after amputation or revision surgery." | 5.30 | The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial. ( Buchheit, T; Buckenmaier, CT; Cooter, M; Hsia, HJ; Kent, M; McDuffie, M; Shaw, A; Shortell, C; Van de Ven, T, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buchheit, T | 1 |
| Hsia, HJ | 1 |
| Cooter, M | 1 |
| Shortell, C | 1 |
| Kent, M | 1 |
| McDuffie, M | 1 |
| Shaw, A | 1 |
| Buckenmaier, CT | 1 |
| Van de Ven, T | 1 |
| Martin, C | 1 |
| Martin, A | 1 |
| Rud, C | 1 |
| Valli, M | 1 |
2 trials available for valproic acid and Pain, Postoperative
| Article | Year |
|---|---|
The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial.
Topics: Adult; Aged; Amputation, Surgical; Chronic Pain; Double-Blind Method; Endpoint Determination; Female | 2019 |
[Comparative study of sodium valproate and ketoprofen in the treatment of postoperative pain].
Topics: Adult; Baclofen; Clinical Trials as Topic; Double-Blind Method; Female; gamma-Aminobutyric Acid; Hum | 1988 |