valproic acid has been researched along with Ovarian Neoplasms in 15 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid did not increase PTX-induced α-tubulin acetylation." | 5.43 | Valproic Acid as a Promising Co-Treatment With Paclitaxel and Doxorubicin in Different Ovarian Carcinoma Cell Lines. ( Fiedor, E; Gregoraszczuk, EL; Grzyb, E; Kwiecińska, P; Ptak, A; Taubøll, E, 2016) |
| "Patients with platinum-resistant ovarian cancer (PROC) have limited therapeutic options and poor survival." | 3.11 | Phase II study of sodium valproate in combination with oral etoposide in platinum-resistant ovarian cancer. ( Barathi, D; Dahagama, S; Dubashi, B; Ganesan, P; Goenka, L; Kayal, S; Krishnamoorthy, N; Mathaiyan, J; Nakka, T; Thumaty, DB, 2022) |
| "Valproic acid (VPA) is a commonly used drug for clinical treatment of seizure disorders." | 1.48 | Valproic Acid Promotes Apoptosis and Cisplatin Sensitivity Through Downregulation of H19 Noncoding RNA in Ovarian A2780 Cells. ( Amini-Farsani, Z; Ghasemi-Dehkordi, P; Sajadpoor, Z; Sangtarash, MH; Shamsara, M; Teimori, H; Yadollahi, F, 2018) |
| "Valproic acid did not increase PTX-induced α-tubulin acetylation." | 1.43 | Valproic Acid as a Promising Co-Treatment With Paclitaxel and Doxorubicin in Different Ovarian Carcinoma Cell Lines. ( Fiedor, E; Gregoraszczuk, EL; Grzyb, E; Kwiecińska, P; Ptak, A; Taubøll, E, 2016) |
| "Notably, pretreatment of ovarian cancer cells expressing moderate to low levels of NKG2DLs with the histone deacetylase inhibitor sodium valproate (VPA) upregulated NKG2DL cell surface expression and consequently enhanced their immune recognition by chimeric NKG2D CAR T cells." | 1.39 | Chimeric NKG2D CAR-expressing T cell-mediated attack of human ovarian cancer is enhanced by histone deacetylase inhibition. ( Best, A; Fang, C; Powell, DJ; Santoro, S; Song, DG; Ye, Q, 2013) |
| "A human ovarian cancer model transplanted subcutaneously in nude mice was established, and the efficacy of VPA used alone and in combination with diammine dichloroplatinum (DDP) to inhibit the growth of tumors was also assessed." | 1.38 | Effects of valproic acid on proliferation, apoptosis, angiogenesis and metastasis of ovarian cancer in vitro and in vivo. ( Feng-Nian, R; Jie, G; Shan, Z; Ting, Z, 2012) |
| "Phenytoin levels were reduced to 37% of the original values, although the drug was given intravenously." | 1.27 | An interaction between cytostatic and anticonvulsant drugs. ( de Voogd-van der Straaten, I; Neef, C, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 11 (73.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Nakka, T | 1 |
| Goenka, L | 1 |
| Dubashi, B | 1 |
| Kayal, S | 1 |
| Mathaiyan, J | 1 |
| Barathi, D | 1 |
| Krishnamoorthy, N | 1 |
| Thumaty, DB | 1 |
| Dahagama, S | 1 |
| Ganesan, P | 1 |
| Sajadpoor, Z | 1 |
| Amini-Farsani, Z | 1 |
| Teimori, H | 1 |
| Shamsara, M | 1 |
| Sangtarash, MH | 1 |
| Ghasemi-Dehkordi, P | 1 |
| Yadollahi, F | 1 |
| Booth, L | 1 |
| Roberts, JL | 1 |
| Rais, R | 1 |
| Cutler, RE | 1 |
| Diala, I | 1 |
| Lalani, AS | 1 |
| Poklepovic, A | 1 |
| Dent, P | 1 |
| Yan, HC | 1 |
| Zhang, J | 1 |
| Kwiecińska, P | 4 |
| Wróbel, A | 1 |
| Taubøll, E | 4 |
| Gregoraszczuk, EŁ | 1 |
| Barnhorst, A | 1 |
| Xiong, GL | 1 |
| Novohradsky, V | 1 |
| Zerzankova, L | 1 |
| Stepankova, J | 1 |
| Vrana, O | 1 |
| Raveendran, R | 1 |
| Gibson, D | 1 |
| Kasparkova, J | 1 |
| Brabec, V | 1 |
| Grzyb, E | 1 |
| Fiedor, E | 1 |
| Ptak, A | 1 |
| Gregoraszczuk, EL | 3 |
| Shan, Z | 1 |
| Feng-Nian, R | 1 |
| Jie, G | 1 |
| Ting, Z | 1 |
| Song, DG | 1 |
| Ye, Q | 1 |
| Santoro, S | 1 |
| Fang, C | 1 |
| Best, A | 1 |
| Powell, DJ | 1 |
| Takai, N | 1 |
| Kawamata, N | 1 |
| Gui, D | 1 |
| Said, JW | 1 |
| Miyakawa, I | 1 |
| Koeffler, HP | 1 |
| Lin, CT | 1 |
| Lai, HC | 1 |
| Lee, HY | 1 |
| Lin, WH | 1 |
| Chang, CC | 1 |
| Chu, TY | 1 |
| Lin, YW | 1 |
| Lee, KD | 1 |
| Yu, MH | 1 |
| Neef, C | 1 |
| de Voogd-van der Straaten, I | 1 |
1 trial available for valproic acid and Ovarian Neoplasms
| Article | Year |
|---|---|
Phase II study of sodium valproate in combination with oral etoposide in platinum-resistant ovarian cancer.
Topics: Carcinoma, Ovarian Epithelial; Communicable Disease Control; COVID-19; Cytotoxins; Etoposide; Female | 2022 |
14 other studies available for valproic acid and Ovarian Neoplasms
| Article | Year |
|---|---|
Valproic Acid Promotes Apoptosis and Cisplatin Sensitivity Through Downregulation of H19 Noncoding RNA in Ovarian A2780 Cells.
Topics: Apoptosis; Cell Line, Tumor; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans | 2018 |
Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Female; Histone Deacetylase | 2019 |
Effects of sodium valproate on the growth of human ovarian cancer cell line HO8910.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Female; G1 Phase; Gene Expressi | 2012 |
Valproic acid, but not levetiracetam, selectively decreases HDAC7 and HDAC2 expression in human ovarian cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Female; Histone Deacetylase 2; Histone Deacetylase Inhibito | 2014 |
Pulmonary embolism in a psychiatric patient.
Topics: Adult; Aggression; Antipsychotic Agents; Autopsy; Benzodiazepines; Bipolar Disorder; Catatonia; Deat | 2014 |
New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells.
Topics: Acetylation; Cell Line, Tumor; Epigenesis, Genetic; Female; Glutathione; Histone Deacetylases; Histo | 2015 |
Valproic Acid as a Promising Co-Treatment With Paclitaxel and Doxorubicin in Different Ovarian Carcinoma Cell Lines.
Topics: Acetylation; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Caspa | 2016 |
Effects of valproic acid and levetiracetam on viability and cell cycle regulatory genes expression in the OVCAR-3 cell line.
Topics: Anticonvulsants; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female | 2012 |
Comparison of the effects of valproic acid and levetiracetam on apoptosis in the human ovarian cancer cell line OVCAR-3.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Far-Western; Caspase 3; Caspase 8; Caspase 9; Cell Line, | 2012 |
Effects of valproic acid on proliferation, apoptosis, angiogenesis and metastasis of ovarian cancer in vitro and in vivo.
Topics: Animals; Anticonvulsants; Apoptosis; Blotting, Western; Cell Adhesion; Cell Cycle; Cell Movement; Ce | 2012 |
Chimeric NKG2D CAR-expressing T cell-mediated attack of human ovarian cancer is enhanced by histone deacetylase inhibition.
Topics: Cell Line; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Order; Genetic Vect | 2013 |
Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis.
Topics: Acetylation; Animals; Apoptosis; Cadherins; Caspase 3; Caspases; Cell Cycle; Cell Cycle Proteins; Ce | 2004 |
Valproic acid resensitizes cisplatin-resistant ovarian cancer cells.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Ataxia Telangiectasia Muta | 2008 |
An interaction between cytostatic and anticonvulsant drugs.
Topics: Adenocarcinoma, Papillary; Adult; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carba | 1988 |