valproic acid has been researched along with Osteoporosis in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bipolar disorder and treatment with lithium, antipsychotics, valproate, and lamotrigine." | 8.12 | Association of Lithium Treatment With the Risk of Osteoporosis in Patients With Bipolar Disorder. ( Köhler-Forsberg, O; Nierenberg, AA; Rohde, C; Østergaard, SD, 2022) |
| "Bipolar disorder and treatment with lithium, antipsychotics, valproate, and lamotrigine." | 4.12 | Association of Lithium Treatment With the Risk of Osteoporosis in Patients With Bipolar Disorder. ( Köhler-Forsberg, O; Nierenberg, AA; Rohde, C; Østergaard, SD, 2022) |
| "Axial (second, third, and fourth lumbar vertebrae) and appendicular (distal third of radius) bone mineral density was measured by dual-energy x-ray absorptiometry in 27 healthy children and 26 children with uncomplicated idiopathic epilepsy treated with either carbamazepine (n = 13) or valproate (n = 13) for more than 18 months." | 3.69 | Effect of carbamazepine and valproate on bone mineral density. ( Bodensteiner, JB; Hobbs, GR; Jacob, JC; Penney, S; Riggs, JE; Sheth, RD; Wesolowski, CA, 1995) |
| "For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0." | 1.40 | Vitamin D levels in children and adolescents with antiepileptic drug treatment. ( Baek, JH; Eun, BL; Kim, GH; Kim, MK; Seo, YH, 2014) |
| "We evaluated the cross-sectional relationship of duration and dosage of valproate monotherapy on bone mineral density (BMD) in adult patients with epilepsy." | 1.36 | Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy. ( Antoniou, A; Armeni, E; Boufidou, F; Evangelopoulos, EM; Lambrinoudaki, I; Triantafyllou, N; Tsivgoulis, G, 2010) |
| "Epilepsy is a major public health problem affecting nearly 50 million people world wide." | 1.35 | Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats. ( El Elshamy, KA; Elwakkad, AS; Sibaii, H, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Tao, ZS | 2 |
| Li, TL | 1 |
| Xu, HG | 2 |
| Yang, M | 2 |
| Köhler-Forsberg, O | 1 |
| Rohde, C | 1 |
| Nierenberg, AA | 1 |
| Østergaard, SD | 1 |
| Zhou, WS | 1 |
| Baek, JH | 1 |
| Seo, YH | 1 |
| Kim, GH | 1 |
| Kim, MK | 1 |
| Eun, BL | 1 |
| Triantafyllou, N | 1 |
| Lambrinoudaki, I | 1 |
| Armeni, E | 1 |
| Evangelopoulos, EM | 1 |
| Boufidou, F | 1 |
| Antoniou, A | 1 |
| Tsivgoulis, G | 1 |
| Seymour, HM | 1 |
| Glendenning, P | 1 |
| Elwakkad, AS | 1 |
| El Elshamy, KA | 1 |
| Sibaii, H | 1 |
| Sheth, RD | 1 |
| Wesolowski, CA | 1 |
| Jacob, JC | 1 |
| Penney, S | 1 |
| Hobbs, GR | 1 |
| Riggs, JE | 1 |
| Bodensteiner, JB | 1 |
| Gilles, P | 1 |
| Alliët, P | 1 |
| Bruneel, E | 1 |
| Raes, M | 1 |
9 other studies available for valproic acid and Osteoporosis
| Article | Year |
|---|---|
Hydrogel contained valproic acid accelerates bone-defect repair via activating Notch signaling pathway in ovariectomized rats.
Topics: Animals; Bone Regeneration; Calcification, Physiologic; Cells, Cultured; Disease Models, Animal; Fem | 2021 |
Association of Lithium Treatment With the Risk of Osteoporosis in Patients With Bipolar Disorder.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Female; Humans; Lamotrigine; Lithiu | 2022 |
Simvastatin can enhance the osseointegration of titanium rods in ovariectomized rats maintenance treatment with valproic acid.
Topics: 3T3 Cells; Animals; Anticonvulsants; Female; Gene Expression Regulation; Mice; Osseointegration; Ost | 2020 |
Vitamin D levels in children and adolescents with antiepileptic drug treatment.
Topics: Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Carbamazepine; Child; Child, Pr | 2014 |
Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy.
Topics: Absorptiometry, Photon; Adult; Anticonvulsants; Biomarkers; Bone and Bones; Bone Density; Bone Disea | 2010 |
Fit for a fracture.
Topics: Anticonvulsants; Epilepsy; Ergocalciferols; Female; Femoral Neck Fractures; Follow-Up Studies; Fract | 2005 |
Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats.
Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Atropine; Biomarkers; Bone Resorption; Disease Model | 2008 |
Effect of carbamazepine and valproate on bone mineral density.
Topics: Absorptiometry, Photon; Adolescent; Bone Density; Calcium, Dietary; Carbamazepine; Case-Control Stud | 1995 |
Effect of valproate on bone mineral density.
Topics: Adolescent; Anticonvulsants; Bone Density; Epilepsy, Tonic-Clonic; Humans; Male; Osteoporosis; Spina | 1996 |