valproic acid has been researched along with Osteoporosis, Postmenopausal in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Secondary osteoporosis is the major concern associated with long term intake of antiepileptic drugs (AEDs)." | 1.48 | The anti-epileptic drugs valproate, carbamazepine and levetiracetam cause bone loss and modulate Wnt inhibitors in normal and ovariectomised rats. ( Chattopadhyay, N; Jain, M; Pal, S; Parveen, B; Tiwari, AK; Tripathi, M; Vohora, D, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tao, ZS | 1 |
| Zhou, WS | 1 |
| Xu, HG | 1 |
| Yang, M | 1 |
| Parveen, B | 1 |
| Tiwari, AK | 1 |
| Jain, M | 1 |
| Pal, S | 1 |
| Chattopadhyay, N | 1 |
| Tripathi, M | 1 |
| Vohora, D | 1 |
2 other studies available for valproic acid and Osteoporosis, Postmenopausal
| Article | Year |
|---|---|
Intermittent administration sodium valproate has a protective effect on bone health in ovariectomized rats.
Topics: Animals; Bone Density; Cancellous Bone; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; | 2021 |
The anti-epileptic drugs valproate, carbamazepine and levetiracetam cause bone loss and modulate Wnt inhibitors in normal and ovariectomised rats.
Topics: Animals; Anticonvulsants; Bone and Bones; Bone Density; Carbamazepine; Female; Humans; Levetiracetam | 2018 |