valproic acid has been researched along with Osteomalacia in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Osteomalacia: Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a wide spread anticonvulsant and mood-stabilizing agent, the use of which is associated with hepatotoxicity, bone marrow suppression and osteomalacia." | 7.77 | Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia? ( Bachleda, P; Bitman, M; Doricakova, A; Dvorak, Z; Novotna, A; Pavek, P; Vrzal, R, 2011) |
| "Valproic acid (VPA) is a wide spread anticonvulsant and mood-stabilizing agent, the use of which is associated with hepatotoxicity, bone marrow suppression and osteomalacia." | 3.77 | Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia? ( Bachleda, P; Bitman, M; Doricakova, A; Dvorak, Z; Novotna, A; Pavek, P; Vrzal, R, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vrzal, R | 1 |
| Doricakova, A | 1 |
| Novotna, A | 1 |
| Bachleda, P | 1 |
| Bitman, M | 1 |
| Pavek, P | 1 |
| Dvorak, Z | 1 |
| Tillmann, F | 1 |
| Kruppa, E | 1 |
| Grün, R | 1 |
| Blaschke, S | 1 |
| Delling, G | 1 |
| Karaaslan, Y | 1 |
| Haznedaroğlu, S | 1 |
| Oztürk, M | 1 |
| Pedrera, JD | 1 |
| Canal, ML | 1 |
| Carvajal, J | 1 |
| Postigo, S | 1 |
| Villa, LF | 1 |
| Hernández, ER | 1 |
| Rico, H | 1 |
1 trial available for valproic acid and Osteomalacia
| Article | Year |
|---|---|
Influence of vitamin D administration on bone ultrasound measurements in patients on anticonvulsant therapy.
Topics: 25-Hydroxyvitamin D 2; Adult; Aged; Anticonvulsants; Bone and Bones; Calcifediol; Carbamazepine; Epi | 2000 |
3 other studies available for valproic acid and Osteomalacia
| Article | Year |
|---|---|
Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia?
Topics: Anticonvulsants; Blotting, Western; Cholecalciferol; Dose-Response Relationship, Drug; Extracellular | 2011 |
[Increased fracture risk in a 67-year-old patient with hypocalcemia of unknown etiology].
Topics: Aged; Anticonvulsants; Biopsy; Bone and Bones; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Fe | 1999 |
Osteomalacia associated with carbamazepine/valproate.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Humans; Osteomalacia; Valproic Acid | 2000 |