valproic acid has been researched along with Optic Neuritis in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Optic Neuritis: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects." | 5.46 | Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis. ( Li, H; Liu, Q; Niu, X; Wang, Z; Yang, J; Zhao, C; Zhao, L, 2017) |
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects." | 1.46 | Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis. ( Li, H; Liu, Q; Niu, X; Wang, Z; Yang, J; Zhao, C; Zhao, L, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Q | 1 |
| Li, H | 1 |
| Yang, J | 1 |
| Niu, X | 1 |
| Zhao, C | 1 |
| Zhao, L | 1 |
| Wang, Z | 1 |
| Azuchi, Y | 1 |
| Kimura, A | 1 |
| Guo, X | 1 |
| Akiyama, G | 1 |
| Noro, T | 1 |
| Harada, C | 1 |
| Nishigaki, A | 1 |
| Namekata, K | 1 |
| Harada, T | 1 |
| Abbas, A | 1 |
| Styra, R | 1 |
3 other studies available for valproic acid and Optic Neuritis
| Article | Year |
|---|---|
Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis.
Topics: Animals; Apoptosis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; In Situ Nic | 2017 |
Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; MAP Kinase Kin | 2017 |
Valproate prophylaxis against steroid induced psychosis.
Topics: Adult; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans | 1994 |