valproic acid has been researched along with Opioid-Related Disorders in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Opioid-Related Disorders: Disorders related to or resulting from abuse or misuse of OPIOIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Overall, the combination of Buprenorphine and Valproate seems to be a safe and promising method for treating multiple drug withdrawal symptoms." | 5.12 | Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment. ( Clausen, T; Isaksen, A; Kristensen, Ø; Lølandsmo, T; Vederhus, JK, 2006) |
| "In this preliminary report from a placebo-controlled, double-blind, dose-response study on the use of pergolide mesylate for cocaine dependence in outpatients 8 out of 235 subjects noted adverse events requiring breaking of the blind." | 2.68 | Pergolide mesylate. Adverse events occurring in the treatment of cocaine dependence. ( Cochrane, CE; Kajdasz, DK; Malcolm, R; Moore, JW, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tesone-Coelho, C | 1 |
| Morel, LJ | 1 |
| Bhatt, J | 1 |
| Estevez, L | 1 |
| Naudon, L | 1 |
| Giros, B | 1 |
| Zwiller, J | 1 |
| Daugé, V | 1 |
| Sheng, Y | 1 |
| Filichia, E | 1 |
| Shick, E | 1 |
| Preston, KL | 1 |
| Phillips, KA | 1 |
| Cooperman, L | 1 |
| Lin, Z | 1 |
| Tesar, P | 1 |
| Hoffer, B | 1 |
| Luo, Y | 1 |
| Kristensen, Ø | 1 |
| Lølandsmo, T | 1 |
| Isaksen, A | 1 |
| Vederhus, JK | 1 |
| Clausen, T | 1 |
| Mucha, RF | 1 |
| Fassos, FF | 1 |
| Perl, FM | 1 |
| Malcolm, R | 1 |
| Moore, JW | 1 |
| Kajdasz, DK | 1 |
| Cochrane, CE | 1 |
| Espinoza, O | 1 |
| Maradei, I | 1 |
| Ramírez, M | 1 |
| Pascuzzo-Lima, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Polydrug-Using Opiate Dependents During Withdrawal[NCT00367874] | Phase 4 | 12 participants | Interventional | 2003-02-28 | Completed | ||
| Dose Response Trial of Pergolide for Cocaine Dependence[NCT00000248] | Phase 3 | 0 participants | Interventional | 1996-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for valproic acid and Opioid-Related Disorders
| Article | Year |
|---|---|
Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Buprenorphine; Carbamazepine; Clonidi | 2006 |
Pergolide mesylate. Adverse events occurring in the treatment of cocaine dependence.
Topics: Adult; Antimanic Agents; Cardiovascular Physiological Phenomena; Cardiovascular System; Cocaine; Dop | 1997 |
4 other studies available for valproic acid and Opioid-Related Disorders
| Article | Year |
|---|---|
Vulnerability to opiate intake in maternally deprived rats: implication of MeCP2 and of histone acetylation.
Topics: Acetylation; Analgesics, Opioid; Animals; Behavior, Animal; Epigenesis, Genetic; Gene-Environment In | 2015 |
Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.
Topics: Adult; Cell Differentiation; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Enzy | 2016 |
Withdrawal-like effects of pentylenetetrazol and valproate in the naive organism: a model of motivation produced by opiate withdrawal?
Topics: Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Dose-Response Relation | 1995 |
An unusual presentation of opioid-like syndrome in pediatric valproic acid poisoning.
Topics: Child, Preschool; Diagnosis, Differential; Drug Overdose; Gastric Lavage; Humans; Male; Naloxone; Op | 2001 |