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valproic acid and Neurovisceral Storage Disease with Vertical Supranuclear Ophthalmoplegia

valproic acid has been researched along with Neurovisceral Storage Disease with Vertical Supranuclear Ophthalmoplegia in 4 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

ExcerptRelevanceReference
"Like valproic acid, treatment with primidone reduced free-C levels in LE/LY in NPC1-null/mutant cells."5.62Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice. ( Ashikawa, H; Honda, T; Mogi, H; Murayama, T; Nakamura, H, 2021)
"Like valproic acid, treatment with primidone reduced free-C levels in LE/LY in NPC1-null/mutant cells."1.62Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice. ( Ashikawa, H; Honda, T; Mogi, H; Murayama, T; Nakamura, H, 2021)
"Whilst post-ictal psychosis is rarely reported prior to the age of 16, NPC in adolescents and adults is particularly psychotogenic and may increase the risk for post-ictal psychosis in the pediatric population."1.36Post-ictal psychosis in adolescent Niemann-Pick disease type C. ( Adams, S; Fietz, M; Kornberg, A; Velakoulis, D; Walterfang, M, 2010)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's2 (50.00)2.80

Authors

AuthorsStudies
Lee, SE1
Shin, N1
Kook, MG1
Kong, D1
Kim, NG1
Choi, SW1
Kang, KS1
Ashikawa, H1
Mogi, H1
Honda, T1
Nakamura, H1
Murayama, T1
Probert, F1
Ruiz-Rodado, V1
Zhang, X1
te Vruchte, D1
Claridge, TD1
Edgar, M1
Tocchio, AZ1
Lachmann, RH1
Platt, FM1
Grootveld, M1
Walterfang, M1
Kornberg, A1
Adams, S1
Fietz, M1
Velakoulis, D1

Other Studies

4 other studies available for valproic acid and Neurovisceral Storage Disease with Vertical Supranuclear Ophthalmoplegia

ArticleYear
Human iNSC-derived brain organoid model of lysosomal storage disorder in Niemann-Pick disease type C.
    Cell death & disease, 2020, 12-12, Volume: 11, Issue:12

    Topics: Autophagy; Biomarkers; Brain; Cell Count; Cell Differentiation; Cell Line; Cell Proliferation; Gene

2020
Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice.
    European journal of pharmacology, 2021, Apr-05, Volume: 896

    Topics: Animals; Biological Transport; CHO Cells; Cholesterol; Cricetulus; Disease Models, Animal; Endoplasm

2021
Urinary excretion and metabolism of miglustat and valproate in patients with Niemann-Pick type C1 disease: One- and two-dimensional solution-state (1)H NMR studies.
    Journal of pharmaceutical and biomedical analysis, 2016, Jan-05, Volume: 117

    Topics: 1-Deoxynojirimycin; Animals; Cohort Studies; Enzyme Inhibitors; Humans; Magnetic Resonance Spectrosc

2016
Post-ictal psychosis in adolescent Niemann-Pick disease type C.
    Journal of inherited metabolic disease, 2010, Volume: 33 Suppl 3

    Topics: Adolescent; Age Factors; Anticonvulsants; Cells, Cultured; Cholesterol Esters; Esterification; Fibro

2010