valproic acid has been researched along with Neuroleptic Malignant Syndrome in 18 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serotonin syndrome and neuroleptic malignant syndrome are two drug toxidromes that have often overlapping and confusing clinical pictures." | 2.50 | Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary. ( Ambaliya, A; Dosi, R; Joshi, H; Patell, R, 2014) |
| "A diagnosis of neuroleptic malignant syndrome was made and the patient continued to receive aggressive supportive care." | 2.41 | Neuroleptic malignant syndrome and severe thrombocytopenia: case report and literature review. ( Ahmed, W; Ghani, SO; Marco, LA, 2000) |
| "BACKGROUND Considering the ongoing coronavirus disease 2019 (COVID-19) pandemic, sufficient information about common and serious adverse events is needed to rapidly distribute COVID-19 vaccines worldwide." | 1.72 | Neuroleptic Malignant Syndrome with Adrenal Insufficiency After BNT162b2 COVID-19 Vaccination in a Man Taking Valproate: A Case Report. ( Kamiyama, T; Mizuno, T; Suzuki, A; Suzuki, M; Takahashi, R, 2022) |
| "Weight gain was found to be lower in the elderly for antipsychotic drugs, in particular for olanzapine." | 1.39 | Age and adverse drug reactions from psychopharmacological treatment: data from the AMSP drug surveillance programme in Switzerland. ( Baumann, P; Greil, W; Grohmann, R; Häberle, A; Schuhmann, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mizuno, T | 1 |
| Takahashi, R | 1 |
| Kamiyama, T | 1 |
| Suzuki, A | 1 |
| Suzuki, M | 1 |
| Uvais, NA | 1 |
| Moideen, S | 1 |
| Anver, PC | 1 |
| Lindeman, S | 1 |
| Kolari, T | 1 |
| Tiihonen, J | 1 |
| Das, S | 1 |
| Purushothaman, ST | 1 |
| Bc, M | 1 |
| Chatterjee, SS | 1 |
| Kartha, A | 1 |
| Rajan, V | 1 |
| Greil, W | 1 |
| Häberle, A | 1 |
| Schuhmann, T | 1 |
| Grohmann, R | 1 |
| Baumann, P | 1 |
| Verma, R | 1 |
| Junewar, V | 1 |
| Rathaur, BP | 1 |
| Dosi, R | 1 |
| Ambaliya, A | 1 |
| Joshi, H | 1 |
| Patell, R | 1 |
| Nabih, FO | 1 |
| Benali, A | 1 |
| Adali, I | 1 |
| Manoudi, F | 1 |
| Asri, F | 1 |
| Menon, V | 1 |
| Rajkumar, RP | 1 |
| Thamizh, JS | 1 |
| Selvakumar, N | 1 |
| Ladds, B | 1 |
| Thomas, P | 1 |
| Mejia, C | 1 |
| Hauser, D | 1 |
| Tanii, H | 1 |
| Saka, K | 1 |
| Inoue, K | 1 |
| Okada, M | 1 |
| Crosby, D | 1 |
| Peterson, J | 1 |
| Carroll, BT | 1 |
| Chungh, DS | 1 |
| Kim, BN | 1 |
| Cho, SC | 1 |
| Tadke, RR | 1 |
| Suryavanshi, P | 1 |
| Harter, C | 1 |
| Obier, C | 1 |
| Druschky, KF | 1 |
| Eikelmann, B | 1 |
| Brazelton, T | 1 |
| Blanc, PD | 1 |
| Olson, KR | 1 |
| Ghani, SO | 1 |
| Ahmed, W | 1 |
| Marco, LA | 1 |
| Roffe, C | 1 |
2 reviews available for valproic acid and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary.
Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Clonazepam; Diagnosis, Differential; GABA M | 2014 |
Neuroleptic malignant syndrome and severe thrombocytopenia: case report and literature review.
Topics: Adult; Antipsychotic Agents; Drug Therapy, Combination; Haloperidol; Humans; Male; Neuroleptic Malig | 2000 |
16 other studies available for valproic acid and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Neuroleptic Malignant Syndrome with Adrenal Insufficiency After BNT162b2 COVID-19 Vaccination in a Man Taking Valproate: A Case Report.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; BNT162 Vaccine; Bromocriptine; COVID-19; Dantrol | 2022 |
Confusion, Rigidity, and Elevated Creatine Phosphokinase: Atypical Neuroleptic Malignant Syndrome Possibly Associated With Clozapine and Sodium Valproate Use.
Topics: Antipsychotic Agents; Clozapine; Creatine Kinase; Humans; Neuroleptic Malignant Syndrome; Valproic A | 2022 |
Valproate and Neuroleptic Malignant Syndrome in an Elderly Patient With Schizoaffective Disorder.
Topics: Aged; Humans; Male; Neuroleptic Malignant Syndrome; Psychotic Disorders; Tranquilizing Agents; Valpr | 2020 |
Oral Asenapine overdose leading to Neuroleptic Malignant Syndrome (NMS).
Topics: Administration, Oral; Adult; Antipsychotic Agents; Bromocriptine; Diagnosis, Differential; Dibenzocy | 2017 |
Age and adverse drug reactions from psychopharmacological treatment: data from the AMSP drug surveillance programme in Switzerland.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; An | 2013 |
An atypical case of neuroleptic malignant syndrome precipitated by valproate.
Topics: Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Benzothiazoles; Dopamine Agonists; Drug Ther | 2014 |
[Association of atypical neuroleptics with anticonvulsants and malignant syndrome. Report of 2 cases].
Topics: Adolescent; Adult; Amisulpride; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Carbamazepin | 2014 |
Atypical neuroleptic malignant syndrome in a young male precipitated by oral sodium valproate.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Humans; Male; Neuroleptic Malignant Syndrome; Valproic Ac | 2016 |
Extreme elevation of creatinine phosphokinase levels in neuroleptic malignant syndrome associated with atypical antipsychotics.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Clozapine; Creatine Kinase; Dose-Response Relationship, D | 2009 |
Neuroleptic malignant syndrome following levomepromazine discontinuation.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Humans; Male; Methotrimeprazine; Neuroleptic Malignan | 2010 |
Atypical neuroleptic malignant syndrome in H1N1 pneumonia.
Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Creatine Kinase; Haloperidol; Humans; Influ | 2013 |
Neuroleptic malignant syndrome due to three atypical antipsychotics in a child.
Topics: Aggression; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Body Temperature; Child; Dibenz | 2005 |
Use of intravenous valproate in a patient with neuroleptic malignant syndrome.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Creatine Kinase; Diagnosis, Differen | 2006 |
[Malignant neuroleptic syndrome associated with amisulpride].
Topics: Affective Disorders, Psychotic; Amisulpride; Anticonvulsants; Antipsychotic Agents; Creatine Kinase; | 2008 |
Toxic effects of nefazodone.
Topics: Adult; Antidepressive Agents, Second-Generation; Antimanic Agents; Bipolar Disorder; Female; Humans; | 1997 |
Nonconvulsive status epilepticus causing acute confusion.
Topics: Aged; Anti-Anxiety Agents; Diazepam; Female; Humans; Neuroleptic Malignant Syndrome; Status Epilepti | 2001 |