valproic acid has been researched along with Neuroblastoma in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.35) | 18.7374 |
| 1990's | 10 (14.49) | 18.2507 |
| 2000's | 23 (33.33) | 29.6817 |
| 2010's | 22 (31.88) | 24.3611 |
| 2020's | 11 (15.94) | 2.80 |
| Authors | Studies |
|---|---|
| Andreu, S; Bello-Morales, R; López-Guerrero, JA; Praena, B; Ripa, I | 1 |
| Collu, M; Dedoni, S; Manconi, B; Olianas, A; Olianas, MC; Onali, P; Tuveri, B; Vincis, ME | 1 |
| Chen, J; Jiang, H; Jiang, X; Lin, Z; Liu, Y; Lu, J; Shang, H; Shi, J; Song, L; Wang, X; Wu, S; Yan, D; Zhang, H | 1 |
| Kitazawa, M; Marquez, FE; Subramanian, S; Subramanian, VS; Teafatiller, T | 1 |
| Ahlatcı, A; Bektaş, M; Tülüce, Y; Yıldızhan, K | 1 |
| Choi, J; Hwang, J; Jang, S; Jeong, HS; Ramalingam, M | 1 |
| Deng, YN; He, XL; Li, YF; Wang, LJ; Wang, T; Zhang, YH | 1 |
| Dedoni, S; Ingianni, A; Marras, L; Olianas, MC; Onali, P | 2 |
| Hira, D; Kakumoto, M; Okano, T; Shimokawa, K; Ueshima, S | 1 |
| Davletshin, AI; Garbuz, DG; Gaydukov, IO; Kondrakhin, EA; Kovalev, GI; Litvinova, SA; Vasileva, EV; Voronina, TA | 1 |
| Adam, V; Eckschlager, T; Gumulec, J; Heger, Z; Hrabeta, J; Kratochvilova, M; Krejcova, L; Masarik, M; Raudenska, M; Richtera, L; Stiborova, M | 1 |
| Arlt, VM; Cerna, T; Eckschlager, T; Frei, E; Hrabeta, J; Schmeiser, HH; Stiborová, M | 1 |
| Fang, E; Hong, M; Tong, Q; Wang, J; Zheng, L | 1 |
| Asai, T; Bundo, M; Ishigooka, J; Iwamoto, K; Kasai, K; Kato, T; Sugawara, H; Sunaga, F; Tanaka, G; Ueda, J | 1 |
| Farrelly, LA; O'Callaghan, C; Savage, NT; Toulouse, A; Yilmazer-Hanke, DM | 1 |
| Angelucci, F; Bernardini, S; Caltagirone, C; Croce, N | 1 |
| Greenberg, ML; Ye, C | 1 |
| Doktorova, H; Eckschlager, T; Groh, T; Hrabeta, J; Khalil, MA; Stiborova, M | 1 |
| Ng, YK; Ong, WY; Tan, CS | 1 |
| Cui, DX; Fu, HL; Gao, J; Jin, WL; Luo, Q; Ma, Y; Wang, Z; Xiao, YH; Yang, H | 1 |
| Kaushik, G; Thomas, MA; Xia, Y; Yang, L | 1 |
| Doktorová, H; Eckschlager, T; Groh, T; Hraběta, J; Khalil, MA; Procházka, P | 1 |
| Chen, G; Creson, TK; Manji, HK; Yuan, P | 1 |
| Anderson, E; Brown, R; Forster, S; Gibson, GG; Lyon, J; Plant, KE; Plant, N; Simecek, N; Spinks, J; Toms, N | 1 |
| Blake, KR; Cowell, RM; Meador-Woodruff, JH; Russell, JW; Talati, P | 1 |
| Alesci, S; Bachmann, RF; Du, J; Li, X; Manji, HK; Wang, Y; Yuan, P; Zhou, R | 1 |
| Dae, HM; Kim, CH; Kim, KS; Kwon, HY; Lee, YC; Song, NR | 1 |
| Qian, Y; Tiffany-Castiglioni, E; Zheng, Y | 1 |
| Chlenski, A; Cohn, SL; Godley, LA; Guerrero, LJ; Ostler, KR; Salwen, HR; Tian, Y; Yang, Q | 1 |
| Aguilera, D; Das, CM; Gopalakrishnan, V; Lee, D; Taylor, P; Wolff, JE; Zage, PE | 1 |
| Hu, JP; Teng, WP; Wang, CY; Wang, SL; Wang, T; Wang, X; Wang, ZY; Xie, JW | 1 |
| Chen, Y; Tsai, YH; Tseng, SH | 1 |
| Bagrova, DI; Belyaev, ND; Dubrovskaya, NM; Lewis, DI; Makova, NZ; Nalivaeva, NN; Pickles, AR; Plesneva, SA; Turner, AJ; Zhuravin, IA | 1 |
| Cipro, Š; Eckschlager, T; Hraběta, J; Hřebačková, J; Poljaková, J | 1 |
| Dvorakova, M; Eckschlager, T; Frei, E; Göttlicherova, M; Hrabeta, J; Hrebackova, J; Kizek, R; Kopejtkova, B; Moserova, M; Poljakova, J; Stiborova, M | 1 |
| Chlenski, A; Gu, S; Lu, Z; Raj, JU; Salwen, HR; Tian, Y; Yang, Q | 1 |
| Das, G; Jagtap, JC; Mruthyunjaya, S; Pujari, R; Shah, RD; Shastry, P; Shelke, GV | 1 |
| Eckschlager, T; Groh, T; Hrabeta, J; Poljakova, J; Stiborova, M | 1 |
| el-Mailakh, RS; el-Masri, MA; Hennion, JP; Huff, MO | 1 |
| Avraham, I; Engelstein, R; Gabizon, R; Rosenmann, H; Shaked, GM | 1 |
| Caron, HN; Ceelie, N; Hennekam, RC; Merks, JH | 1 |
| Cinatl, J; Driever, PH; Michaelis, M; Suhan, T | 1 |
| Axelson, H; Manetopoulos, C; Sjölund, J; Stockhausen, MT | 1 |
| Bianucci, F; Camerin, C; Ferreri, AM; Fronza, R; Guerra, F; Pession, A; Purgato, S; Rocchi, P; Tonelli, R | 1 |
| Chen, G; Chen, J; Damschroder-Williams, P; Du, J; Gray, NA; Li, X; Manji, HK; Yuan, P; Zhang, L; Zhou, R | 1 |
| Lai, JS; Li, PP; Warsh, JJ; Zhao, C | 1 |
| Frühwald, MC; Furchert, SE; Jung, M; Juürgens, H; Lanvers-Kaminsky, C; Loidl, A | 1 |
| Chlenski, A; Cohn, SL; Henkin, J; Liu, S; Salwen, HR; Tian, Y; Yang, Q; Zeine, R | 1 |
| Fujita, Y; Fujiwara, Y; Miyamoto, Y; Murabe, M; Murase, S; Sanbe, A; Tanoue, A; Yamauchi, J | 1 |
| Blaheta, RA; Cinatl, J; Doerr, HW; Hasenberg, C; Jonas, D; Michaelis, M; Natsheh, I; Relja, B; Weich, E | 1 |
| Andrieu, T; Casagrande, F; Clayette, P; Dormont, D; Legendre, C | 1 |
| Canonico, PL; Condorelli, F; Genazzani, AA; Gnemmi, I; Vallario, A | 1 |
| Chatterjie, N; Grundke-Iqbal, I; Iqbal, K; Wang, JZ; Wang, XC; Zhang, YC | 1 |
| Cinatl, J; Doerr, HW; Driever, PH; Henrich, D; Kabickova, H; Kornhuber, B; Scholz, M; Vogel, JU | 1 |
| Chen, G; Hawver, DB; Manji, HK; Potter, WZ; Yuan, P | 1 |
| Cinatl, J; Driever, PH; Kornhuber, B; Kotchetkov, R; Pouckova, P; Schwabe, D | 1 |
| Asghari, V; Reiach, JS; Wang, JF; Young, LT | 1 |
| Andriamampandry, C; Kemmel, V; Maitre, M; Mark, J; Perard, A; Siffert, JC; Taleb, O | 1 |
| Bacon, CL; Berezin, V; Bock, E; Bojic, U; Ehlers, K; Ellerbeck, U; Kawa, A; Lepekhin, E; Nau, H; O'Connell, C; O'Driscoll, E; Regan, CM | 1 |
| Chen, G; Huang, LD; Jiang, YM; Manji, HK; Yuan, PX | 1 |
| Asghari, V; Rockel, C; Wang, JF; Young, LT | 1 |
| Grimes, CA; Jope, RS | 1 |
| Jope, RS; Pacheco, MA | 1 |
| El-Mallahk, RS; Li, R | 1 |
| Blaheta, R; Cinatl, J; Driever, PH; Kotchetkov, R; Vogel, JU | 1 |
| Ciesielski, L; Gensburger, C; Mandel, P; Simler, S | 1 |
| Arienti, G; Binaglia, L; Bocchini, V; Corazzi, L; Freysz, L; Porcellati, F; Roberti, R; Vecchini, A | 1 |
| Regan, CM | 1 |
69 other study(ies) available for valproic acid and Neuroblastoma
| Article | Year |
|---|---|
The Valproic Acid Derivative Valpromide Inhibits Pseudorabies Virus Infection in Swine Epithelial and Mouse Neuroblastoma Cell Lines.
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Herpesvirus 1, Suid; Mice; Neuroblastoma; Pseudorabies; Swine; Swine Diseases; Valproic Acid | 2021 |
Upregulation of p75NTR by Histone Deacetylase Inhibitors Sensitizes Human Neuroblastoma Cells to Targeted Immunotoxin-Induced Apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Histone Deacetylase Inhibitors; Humans; Immunotoxins; Mice; Neuroblastoma; Receptors, Nerve Growth Factor; Saporins; Up-Regulation; Valproic Acid | 2022 |
Alterations of serine racemase expression determine proliferation and differentiation of neuroblastoma cells.
Topics: Animals; Cell Differentiation; Cell Proliferation; Mice; Mice, Nude; Neuroblastoma; Racemases and Epimerases; RNA, Small Interfering; Serine; Valproic Acid | 2022 |
Valproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells.
Topics: Animals; Ascorbic Acid; Histone Deacetylase Inhibitors; Humans; Mice; Neuroblastoma; Protein Isoforms; RNA, Heterogeneous Nuclear; RNA, Messenger; Sodium-Coupled Vitamin C Transporters; Transcription Factors; Valproic Acid; Vitamins | 2022 |
Valproic Acid Attenuated PTZ-induced Oxidative Stress, Inflammation, and Apoptosis in the SH-SY5Y Cells via Modulating the TRPM2 Channel.
Topics: Apoptosis; Humans; Inflammation; Neuroblastoma; Oxidative Stress; Pentylenetetrazole; TRPM Cation Channels; Valproic Acid | 2022 |
Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway.
Topics: Cell Differentiation; Cell Line, Tumor; Histone Deacetylase Inhibitors; Humans; Neuroblastoma; Neurons; Tretinoin; Valproic Acid; Wnt Signaling Pathway | 2023 |
N-acetylcysteine improves autism-like behavior by recovering autophagic deficiency and decreasing Notch-1/Hes-1 pathway activity.
Topics: Acetylcysteine; Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; Neuroblastoma; Prenatal Exposure Delayed Effects; Rats; Valproic Acid | 2023 |
Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Apoptosis; Cell Line, Tumor; DNA-Binding Proteins; Gene Expression Regulation; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; LDL-Receptor Related Proteins; Membrane Transport Proteins; Mice; Nerve Growth Factor; Nerve Tissue Proteins; Neuroblastoma; Neurons; Primary Cell Culture; Receptors, Nerve Growth Factor; Transcription Factors; Valproic Acid | 2020 |
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Humans; Lamotrigine; NAV1.1 Voltage-Gated Sodium Channel; Neuroblastoma; Neuronal Outgrowth; Neurons; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Valproic Acid | 2021 |
ERK1/2 kinases and dopamine D2 receptors participate in the anticonvulsant effects of a new derivative of benzoylpyridine oxime and valproic acid.
Topics: Animals; Anticonvulsants; Cell Line, Tumor; Corpus Striatum; Electroshock; Extracellular Signal-Regulated MAP Kinases; Humans; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroblastoma; Phosphorylation; Receptors, Dopamine D2; Seizures; Synapsins; Valproic Acid | 2021 |
The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid.
Topics: Anticonvulsants; Apoptosis; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Neuroblastoma; Receptor, trkC; Tumor Cells, Cultured; Valproic Acid | 2021 |
VPA does not enhance platinum binding to DNA in cisplatin-resistant neuroblastoma cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; DNA; Drug Resistance, Neoplasm; Drug Synergism; Humans; Neuroblastoma; Oxidative Stress; Platinum Compounds; Valproic Acid | 2017 |
The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells.
Topics: Apoptosis; Cell Line, Tumor; Drug Synergism; Ellipticines; Histone Deacetylase Inhibitors; Humans; Mutagens; Neuroblastoma; Neurons; Valproic Acid | 2018 |
Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma.
Topics: Aerobiosis; Animals; Antineoplastic Agents; Child; Cytokines; Disease Progression; Down-Regulation; E2F1 Transcription Factor; Female; Glucose-6-Phosphate Isomerase; Glycolysis; Histone Deacetylase Inhibitors; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Neuroblastoma; Phosphoglycerate Kinase; Valproic Acid; Xenograft Model Antitumor Assays | 2019 |
Effect of mood stabilizers on DNA methylation in human neuroblastoma cells.
Topics: Antimanic Agents; Brain-Derived Neurotrophic Factor; Carbamazepine; Cell Line, Tumor; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Lithium Compounds; Neuroblastoma; Promoter Regions, Genetic; Serotonin Plasma Membrane Transport Proteins; Valproic Acid | 2013 |
Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line.
Topics: Amitriptyline; Anticonvulsants; Cell Line, Tumor; Cell Survival; Gene Expression; Humans; Neuroblastoma; Neuropeptide Y; Tetradecanoylphorbol Acetate; Valproic Acid | 2013 |
Lithium/Valproic acid combination and L-glutamate induce similar pattern of changes in the expression of miR-30a-5p in SH-SY5Y neuroblastoma cells.
Topics: Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Drug Synergism; Gene Expression Regulation; Glutamic Acid; Humans; In Vitro Techniques; Lithium; MicroRNAs; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Neurotoxins; Real-Time Polymerase Chain Reaction; Up-Regulation; Valproic Acid | 2014 |
Inositol synthesis regulates the activation of GSK-3α in neuronal cells.
Topics: Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Glycogen Synthase Kinase 3; Heat-Shock Proteins; Humans; Inositol; Intracellular Fluid; Intramolecular Lyases; Neuroblastoma; RNA, Messenger; Symporters; Valproic Acid | 2015 |
The synergistic effects of DNA-damaging drugs cisplatin and etoposide with a histone deacetylase inhibitor valproate in high-risk neuroblastoma cells.
Topics: Acetylation; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cisplatin; DNA Damage; DNA, Neoplasm; Drug Synergism; Etoposide; Histone Deacetylase Inhibitors; Histones; Humans; Neuroblastoma; Valproic Acid | 2015 |
Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells.
Topics: Anacardic Acids; Anilides; Benzamides; Cell Line, Tumor; Chromatin Immunoprecipitation; Deoxyadenosines; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Group IV Phospholipases A2; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; L-Lactate Dehydrogenase; Lysine; Neuroblastoma; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thionucleosides; Valproic Acid | 2016 |
Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells.
Topics: Animals; Catalytic Domain; Cell Differentiation; Cell Line, Tumor; DNA-Binding Proteins; Enzyme Inhibitors; GTPase-Activating Proteins; Immunohistochemistry; Mice; Microscopy, Fluorescence; Neuroblastoma; Protein Isoforms; Proto-Oncogene Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Valproic Acid | 2016 |
Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders.
Topics: Animals; Autistic Disorder; Carbamazepine; Cell Line, Tumor; Environmental Pollutants; Fluoxetine; Gene Expression Profiling; Humans; Nervous System Diseases; Neuroblastoma; Psychotropic Drugs; Transcriptome; Valproic Acid; Venlafaxine Hydrochloride | 2016 |
Valproic Acid Increases CD133 Positive Cells that Show Low Sensitivity to Cytostatics in Neuroblastoma.
Topics: AC133 Antigen; Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Caspase 3; Cell Cycle; Cell Line, Tumor; Cytostatic Agents; Flow Cytometry; Fluorescent Antibody Technique; Humans; Neuroblastoma; Valproic Acid | 2016 |
Evidence for involvement of ERK, PI3K, and RSK in induction of Bcl-2 by valproate.
Topics: Anticonvulsants; Cell Line, Tumor; Dose-Response Relationship, Drug; Genes, Reporter; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroblastoma; Neurons; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Ribosomal Protein S6 Kinases, 90-kDa; Valproic Acid | 2009 |
The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1.
Topics: Antimanic Agents; Apoptosis; Cell Line, Tumor; Gene Expression Profiling; Gene Silencing; Homeodomain Proteins; Humans; Lithium Chloride; Neuroblastoma; Staurosporine; Up-Regulation; Valproic Acid | 2009 |
Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells.
Topics: Apoptosis; Biological Transport; Caspase 3; Cell Line, Tumor; Enzyme Inhibitors; Fatty Acids; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Heat-Shock Proteins; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Huntington Disease; Hydrogen Peroxide; Hydroxamic Acids; Neuroblastoma; Neurons; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Transcription Factors; Valproic Acid | 2009 |
Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage.
Topics: Aldehydes; Analysis of Variance; Animals; Antimanic Agents; bcl-2-Associated X Protein; Brain; Cell Line, Tumor; Central Nervous System Stimulants; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Electron Transport Complex IV; Gene Expression Regulation; Humans; Lithium; Male; Methamphetamine; Mitochondria; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Organic Chemicals; Oxygen Consumption; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred WKY; RNA, Small Interfering; Time Factors; Transfection; Tyrosine 3-Monooxygenase; Valproic Acid | 2009 |
Valproic acid induces transcriptional activation of human GD3 synthase (hST8Sia I) in SK-N-BE(2)-C human neuroblastoma cells.
Topics: Cell Line, Tumor; Gangliosides; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Neuroblastoma; Response Elements; RNA, Messenger; Sialyltransferases; Transcriptional Activation; Valproic Acid | 2009 |
Valproate reversibly reduces neurite outgrowth by human SY5Y neuroblastoma cells.
Topics: Animals; Antimanic Agents; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cytoskeleton; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Humans; Nerve Growth Factor; Neurites; Neuroblastoma; Neurofilament Proteins; Parkinsonian Disorders; PC12 Cells; Rats; RNA, Messenger; Substantia Nigra; Valproic Acid | 2009 |
Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines.
Topics: Acetylation; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cell Shape; Chromatin Immunoprecipitation; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genotype; Histone Deacetylase Inhibitors; Histones; Humans; Neuroblastoma; Phenotype; Polymerase Chain Reaction; Promoter Regions, Genetic; Thrombospondin 1; Transfection; Valproic Acid | 2010 |
Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Synergism; Epigenomics; Etoposide; Histone Deacetylase Inhibitors; Humans; Inhibitory Concentration 50; Neuroblastoma; Valproic Acid | 2010 |
Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways.
Topics: Amyloid beta-Protein Precursor; Animals; Brain; Calpain; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Mice; Mice, Transgenic; Neuroblastoma; Phosphorylation; Presenilin-1; Signal Transduction; tau Proteins; Threonine; Valproic Acid | 2011 |
Combined valproic acid and celecoxib treatment induced synergistic cytotoxicity and apoptosis in neuroblastoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Celecoxib; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Drug Synergism; G1 Phase; Humans; Neuroblastoma; Pyrazoles; Resting Phase, Cell Cycle; Sulfonamides; Valproic Acid | 2011 |
Effect of sodium valproate administration on brain neprilysin expression and memory in rats.
Topics: Alzheimer Disease; Animals; Anticonvulsants; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Male; Memory; Memory Disorders; Neprilysin; Neuroblastoma; Rats; Rats, Wistar; Valproic Acid | 2012 |
Valproic acid overcomes hypoxia-induced resistance to apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Caspase 8; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Histone Deacetylase Inhibitors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Neuroblastoma; Time Factors; Valproic Acid | 2012 |
Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; DNA Damage; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ellipticines; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Microsomes, Liver; Models, Biological; Neuroblastoma; Rats; Treatment Outcome; Tumor Cells, Cultured; Valproic Acid | 2011 |
Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma.
Topics: Acetylation; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; DNA Methylation; G1 Phase; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Neuroblastoma; Promoter Regions, Genetic; Valproic Acid | 2012 |
Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Inhibitor of Apoptosis Proteins; Isoenzymes; Neuroblastoma; Proteolysis; Proto-Oncogene Proteins c-akt; Pyridines; Staurosporine; Survivin; Valproic Acid | 2013 |
Impact of histone deacetylase inhibitor valproic acid on the anticancer effect of etoposide on neuroblastoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bone Marrow Neoplasms; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Etoposide; Histone Deacetylase Inhibitors; Humans; Neuroblastoma; Risk Factors; Valproic Acid | 2012 |
Evaluation of neuroprotection by lithium and valproic acid against ouabain-induced cell damage.
Topics: Antimanic Agents; Apoptosis; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Lithium; Neuroblastoma; Neurons; Neuroprotective Agents; Ouabain; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured; Valproic Acid | 2002 |
Valproic acid treatment results in increased accumulation of prion proteins.
Topics: Animals; Anticonvulsants; Contraindications; Cricetinae; Culture Media; Dose-Response Relationship, Drug; Neuroblastoma; Prions; PrPC Proteins; PrPSc Proteins; Scrapie; Tumor Cells, Cultured; Valproic Acid | 2002 |
Neuroblastoma, maternal valproic acid use, in-vitro fertilization and family history of mosaic chromosome 22: coincidence or causal relationship?
Topics: Adult; Anticonvulsants; Child; Chromosomes, Human, Pair 22; Female; Fertilization in Vitro; Humans; Karyotyping; Male; Maternal Exposure; Mosaicism; Neuroblastoma; Pregnancy; Seizures; Valproic Acid | 2004 |
Valproic acid and interferon-alpha synergistically inhibit neuroblastoma cell growth in vitro and in vivo.
Topics: Animals; Cell Nucleus; Drug Interactions; Enzyme Inhibitors; Humans; Interferon-alpha; Mice; Mice, Nude; Neuroblastoma; Transplantation, Heterologous; Tumor Cells, Cultured; Valproic Acid | 2004 |
Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells.
Topics: Anticonvulsants; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Blotting, Northern; Blotting, Western; Cell Line, Tumor; DNA-Binding Proteins; DNA, Complementary; Enzyme Inhibitors; Flow Cytometry; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Luciferases; Membrane Proteins; Neuroblastoma; Phenotype; Receptor, Notch1; Receptors, Cell Surface; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Transcription Factor HES-1; Transcription Factors; Valproic Acid | 2005 |
p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells.
Topics: Acetylation; Acetylcholinesterase; Butyrates; Carrier Proteins; Cell Cycle Proteins; Cell Differentiation; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; Fatty Acids; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Intracellular Signaling Peptides and Proteins; Neurites; Neuroblastoma; Triglycerides; Tumor Cells, Cultured; Valproic Acid | 2005 |
The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers.
Topics: Alkaline Phosphatase; Animals; Antimanic Agents; Behavior, Animal; Blotting, Western; Cell Line, Tumor; Dexamethasone; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression; Hippocampus; Humans; Immunohistochemistry; Indoles; Lithium; Male; Molecular Weight; Neuroblastoma; Rats; Rats, Wistar; Receptors, Glucocorticoid; RNA, Small Interfering; Time Factors; Transcription Factors; Transfection; Valproic Acid | 2005 |
Cytoprotection by lithium and valproate varies between cell types and cellular stresses.
Topics: Antimanic Agents; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cytochromes c; Cytoprotection; Electron Transport Complex I; Endoplasmic Reticulum; Enzyme Activation; Enzyme Inhibitors; Glioma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hydrogen Peroxide; Lithium Compounds; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rotenone; Thapsigargin; Up-Regulation; Valproic Acid | 2006 |
Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood.
Topics: Acetylation; Annexin A5; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Medulloblastoma; Neuroblastoma; Polymerase Chain Reaction; Rhabdoid Tumor; Risk Factors; Valproic Acid | 2007 |
Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Capillary Permeability; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Down-Regulation; Endothelial Cells; Female; Fibroblast Growth Factor 2; Humans; Mice; Neovascularization, Pathologic; Neuroblastoma; Oligopeptides; Valproic Acid; Xenograft Model Antitumor Assays | 2007 |
Gadd45a, the gene induced by the mood stabilizer valproic acid, regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells.
Topics: Animals; Antimanic Agents; Cell Cycle Proteins; Cell Differentiation; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 4; Mice; Nerve Growth Factors; Neurites; Neuroblastoma; Neurons; Neuroprotective Agents; Nuclear Proteins; Paxillin; Phosphorylation; RNA Interference; Signal Transduction; Up-Regulation; Valproic Acid | 2007 |
Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium.
Topics: Antigens, Surface; Antineoplastic Agents; Cell Adhesion; Cisplatin; Drug Resistance, Neoplasm; Endothelium, Vascular; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Neural Cell Adhesion Molecules; Neuroblastoma; RNA, Messenger; Tumor Cells, Cultured; Valproic Acid; Vincristine | 2007 |
Sodium valproate does not augment Prpsc in murine neuroblastoma cells.
Topics: Animals; Cell Line, Tumor; Chlorpromazine; Dopamine Antagonists; Enzyme Inhibitors; Gene Expression Regulation; Mice; Neuroblastoma; Prions; Scrapie; Time Factors; Valproic Acid | 2007 |
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells.
Topics: Acetylation; Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Butyrates; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Lysine; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Suppressor Protein p53; Up-Regulation; Valproic Acid | 2008 |
Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Melatonin; Mice; Neuroblastoma; Neurofilament Proteins; Valproic Acid | 2008 |
Antitumor activity of sodium valproate in cultures of human neuroblastoma cells.
Topics: Cell Adhesion Molecules; Cell Differentiation; Cell Division; Drug Screening Assays, Antitumor; Humans; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Microscopy, Electron; Neoplasm Proteins; Neural Cell Adhesion Molecules; Neuroblastoma; Neurons; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured; Valproic Acid | 1996 |
Increase in AP-1 transcription factor DNA binding activity by valproic acid.
Topics: Activating Transcription Factor 2; Animals; Anticonvulsants; Brain; Cyclic AMP Response Element-Binding Protein; Cycloheximide; DNA, Neoplasm; Dose-Response Relationship, Drug; Glioma; Humans; Indoles; Maleimides; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Time Factors; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured; Valproic Acid | 1997 |
Sodium valproate inhibits in vivo growth of human neuroblastoma cells.
Topics: Animals; Antineoplastic Agents; Cell Division; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neuroblastoma; Transplantation, Heterologous; Tumor Cells, Cultured; Valproic Acid | 1997 |
Differential effects of mood stabilizers on Fos/Jun proteins and AP-1 DNA binding activity in human neuroblastoma SH-SY5Y cells.
Topics: Antimanic Agents; Base Sequence; Binding Sites; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Lithium Chloride; Neuroblastoma; Nuclear Proteins; Oligodeoxyribonucleotides; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Time Factors; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid | 1998 |
Neurochemical and electrophysiological evidence for the existence of a functional gamma-hydroxybutyrate system in NCB-20 neurons.
Topics: Animals; Binding Sites; Biological Transport; Brain; Calcium; Calcium Channels; Cell Line; Cricetinae; Cricetulus; Hybridomas; Hydroxybutyrate Dehydrogenase; Immunohistochemistry; Kinetics; Membrane Potentials; Mice; Neuroblastoma; Neurons; Patch-Clamp Techniques; Rats; Sodium Oxybate; Valproic Acid | 1998 |
Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre.
Topics: Animals; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Female; Glioma; Male; Mice; Neural Cell Adhesion Molecules; Neuroblastoma; Rats; Structure-Activity Relationship; Teratogens; Tumor Cells, Cultured; Valproic Acid | 1998 |
Valproate robustly enhances AP-1 mediated gene expression.
Topics: Animals; Anticonvulsants; Bipolar Disorder; DNA-Binding Proteins; Gene Expression Regulation; Genes, Reporter; Glioma; Humans; Luciferases; Molecular Sequence Data; Mutation; Neuroblastoma; Neurons; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Sequence Homology, Amino Acid; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Valproic Acid | 1999 |
Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells.
Topics: Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Humans; Kinetics; Lithium Chloride; Neuroblastoma; Phosphorylation; Signal Transduction; Tumor Cells, Cultured; Valproic Acid | 1999 |
Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; DNA-Binding Proteins; DNA, Neoplasm; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Immediate-Early Proteins; Indoles; Kinetics; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Transcription Factors; Tumor Cells, Cultured; Valproic Acid | 1999 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calcium Signaling; Carbachol; Carbamazepine; Chelating Agents; DNA; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Gene Expression Regulation; Humans; Indoles; Ionomycin; Ionophores; Lithium; Muscarinic Agonists; Nerve Tissue Proteins; Neuroblastoma; Neurons; Phosphatidylinositols; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid | 1999 |
A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: caspase-3 dependency.
Topics: Antimanic Agents; Apoptosis; Caspase 3; Caspases; Humans; Ionophores; L-Lactate Dehydrogenase; Lithium Chloride; Neuroblastoma; Tumor Cells, Cultured; Valinomycin; Valproic Acid | 2000 |
Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: enhancement by combination with interferon-alpha.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Cell Differentiation; Cell Division; DNA Primers; Drug Synergism; Drug Therapy, Combination; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunoenzyme Techniques; Interferon-alpha; Neoplasm Proteins; Neuroblastoma; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Valproic Acid | 2002 |
[Effect of sodium n-dipropylacetate (sodium valproate) on GABA level of neuronal and glial cells in culture].
Topics: Animals; Astrocytoma; Bucladesine; Cell Line; gamma-Aminobutyric Acid; Kinetics; Neuroblastoma; Rats; Valproic Acid | 1978 |
Effect of pyridoxal 5'-phosphate and valproic acid on phospholipid synthesis in neuroblastoma NA.
Topics: Energy Metabolism; Lipid Bilayers; Neuroblastoma; Permeability; Phospholipids; Pyridoxal Phosphate; Tumor Cells, Cultured; Valproic Acid | 1989 |
Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin.
Topics: Animals; Cell Adhesion; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Glioma; Mitosis; Mitotic Index; Neuroblastoma; Thymidine; Time Factors; Valproic Acid | 1985 |