valproic acid has been researched along with Nervous System Disorders in 39 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 8.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| "Valproic acid (VPA) is a known human teratogen." | 6.45 | Valproic acid in pregnancy: how much are we endangering the embryo and fetus? ( Ornoy, A, 2009) |
| "Valproic acid-treated animals demonstrated significantly less neurologic impairment on PID 1 and returned to baseline faster (PID 1 mean neurologic severity score, control = 22 ± 3 vs." | 5.62 | Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Chtraklin, K; Kemp, MT; O'Connell, RL; Pai, MP; Siddiqui, AZ; Srinivasan, A; Vercruysse, CA; Wakam, GK; Williams, AM, 2021) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 5.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 4.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| " Reversible dystonia may occasionally be precipitated by phenytoin or carbamazepine; asterixis by phenytoin, barbiturates or carbamazepine; and, more commonly, tremor by valproate." | 4.77 | Adverse neuropsychiatric effects of anticonvulsant drugs. ( Reynolds, EH; Trimble, MR, 1985) |
| "Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy and bipolar disorder." | 3.88 | [Valproic acid toxicity due to misinterpretation of plasma levels: increase in unbound fraction caused by hypoalbuminaemia and renal dysfunction]. ( Dols, A; Jacobs, GE; Nauta, KJ; Ruiter-Visser, R; Smulders, YM, 2018) |
| " We differentiated and treated human SK-N-SH neuroblastoma cells with a mixture (fluoxetine, carbamazepine and venlafaxine) and valproate (used as a positive control to induce autism-associated profiles), followed by transcriptome analysis with RNA-Seq approach." | 3.83 | Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders. ( Kaushik, G; Thomas, MA; Xia, Y; Yang, L, 2016) |
| " The anticonvulsant activity of all of the synthesized compounds was evaluated against maximal electrical shock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizures." | 3.76 | Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives. ( Abd El-Latif, HA; Abu Yossef, HA; Hassan, GS; Ragab, FA; Yahya, TA, 2010) |
| "Pain was assessed using a pain scale based on the Brief Pain Inventory at days 0, 8 and 15." | 2.70 | A phase II study to establish the efficacy and toxicity of sodium valproate in patients with cancer-related neuropathic pain. ( A'Hern, R; Broadley, K; Gwilliam, B; Hardy, JR; Ling, J; Rees, EA, 2001) |
| "Valproic acid (VPA) is a known human teratogen." | 2.45 | Valproic acid in pregnancy: how much are we endangering the embryo and fetus? ( Ornoy, A, 2009) |
| "Valproic acid-treated animals demonstrated significantly less neurologic impairment on PID 1 and returned to baseline faster (PID 1 mean neurologic severity score, control = 22 ± 3 vs." | 1.62 | Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Chtraklin, K; Kemp, MT; O'Connell, RL; Pai, MP; Siddiqui, AZ; Srinivasan, A; Vercruysse, CA; Wakam, GK; Williams, AM, 2021) |
| "We studied an observational cohort of comatose subjects treated at a single academic medical center after cardiac arrest from September 2010 to January 2018." | 1.51 | Association of antiepileptic drugs with resolution of epileptiform activity after cardiac arrest. ( Baldwin, MA; Callaway, CW; Coppler, PJ; Elmer, J; Kvaløy, JT; Solanki, P, 2019) |
| "Tremor is a known side-effect of anticonvulsants, particularly of valproate." | 1.46 | The clinical features and functional impact of valproate-induced tremor. ( Alonso-Juarez, M; Baizabal-Carvallo, JF; Crespo-Morfin, P; Torres-Russotto, D, 2017) |
| "Individuals treated with combined valproate-lamotrigine rarely present late adverse effects (unrelated to introduction and titration)." | 1.38 | Late adverse effects of the coadministration of valproate and lamotrigine. ( Moreira, B; Thome-Souza, S; Valente, KD, 2012) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 1.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| " We monitor free and total VPA at minimum and maximum along with evaluation of side effects and seizures for better interpretation of dosage requirements." | 1.27 | Variable free and total valproic acid concentrations in sole- and multi-drug therapy. ( Bennett, DM; Cramer, JA; Mattson, RH; Swick, CT, 1986) |
| "This syndrome consists of sustained seizures, resembling amygdaloid kindled seizures, and acute destruction of neural elements in limbic brain regions (amygdala, olfactory cortex, hippocampus, lateral septum and several thalamic nuclei)." | 1.26 | Only certain anticonvulsants protect against kainate neurotoxicity. ( Fuller, TA; Olney, JW, 1981) |
| "Only 21% of those with myoclonic astatic epilepsy have become free from seizures." | 1.26 | Sodium valproate: monotherapy and polytherapy. ( Covanis, A; Gupta, AK; Jeavons, PM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (28.21) | 18.7374 |
| 1990's | 6 (15.38) | 18.2507 |
| 2000's | 9 (23.08) | 29.6817 |
| 2010's | 11 (28.21) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| De Fazio, C | 1 |
| Goffin, M | 1 |
| Franchi, F | 1 |
| Ferlini, L | 1 |
| Orinckx, C | 1 |
| Spadaro, S | 1 |
| Brasseur, A | 1 |
| Gaspard, N | 1 |
| Antonucci, E | 1 |
| Khattar, L | 1 |
| Peluso, L | 1 |
| Romeo, I | 1 |
| Creteur, J | 1 |
| Legros, B | 1 |
| Taccone, FS | 1 |
| Wakam, GK | 1 |
| Biesterveld, BE | 1 |
| Pai, MP | 1 |
| Kemp, MT | 1 |
| O'Connell, RL | 1 |
| Williams, AM | 1 |
| Srinivasan, A | 1 |
| Chtraklin, K | 1 |
| Siddiqui, AZ | 1 |
| Bhatti, UF | 1 |
| Vercruysse, CA | 1 |
| Alam, HB | 1 |
| Alonso-Juarez, M | 1 |
| Torres-Russotto, D | 1 |
| Crespo-Morfin, P | 1 |
| Baizabal-Carvallo, JF | 1 |
| Ruiter-Visser, R | 1 |
| Dols, A | 1 |
| Smulders, YM | 1 |
| Jacobs, GE | 1 |
| Nauta, KJ | 1 |
| Solanki, P | 1 |
| Coppler, PJ | 1 |
| Kvaløy, JT | 1 |
| Baldwin, MA | 1 |
| Callaway, CW | 1 |
| Elmer, J | 1 |
| Adedinsewo, DA | 1 |
| Thurman, DJ | 1 |
| Luo, YH | 1 |
| Williamson, RS | 1 |
| Odewole, OA | 1 |
| Oakley, GP | 1 |
| Kaushik, G | 1 |
| Xia, Y | 1 |
| Yang, L | 1 |
| Thomas, MA | 1 |
| Hill, EJ | 1 |
| Woehrling, EK | 1 |
| Prince, M | 1 |
| Coleman, MD | 1 |
| Feng, HL | 1 |
| Leng, Y | 1 |
| Ma, CH | 1 |
| Zhang, J | 1 |
| Ren, M | 1 |
| Chuang, DM | 1 |
| Ornoy, A | 1 |
| Ragab, FA | 1 |
| Hassan, GS | 1 |
| Abu Yossef, HA | 1 |
| Yahya, TA | 1 |
| Abd El-Latif, HA | 1 |
| Thome-Souza, S | 1 |
| Moreira, B | 1 |
| Valente, KD | 1 |
| Huang, L | 1 |
| Yu, CY | 1 |
| Wang, BN | 1 |
| Zhang, HM | 1 |
| Li, LY | 1 |
| Wang, Y | 1 |
| Wang, X | 1 |
| Cabrera, RM | 1 |
| Li, Y | 1 |
| Miller, DS | 1 |
| Finnell, RH | 1 |
| Servillo, G | 1 |
| Striano, P | 1 |
| Striano, S | 1 |
| Tortora, F | 1 |
| Boccella, P | 1 |
| De Robertis, E | 1 |
| Rossano, F | 1 |
| Briganti, F | 1 |
| Tufano, R | 1 |
| Tariot, PN | 1 |
| Hirsch, LJ | 1 |
| Weintraub, D | 1 |
| Du, Y | 1 |
| Buchsbaum, R | 1 |
| Spencer, HT | 1 |
| Hager, M | 1 |
| Straka, T | 1 |
| Bazil, CW | 1 |
| Adams, DJ | 1 |
| Resor, SR | 1 |
| Morrell, MJ | 1 |
| Hammond, EJ | 1 |
| Wilder, BJ | 1 |
| Bruni, J | 1 |
| Escorihuela, R | 1 |
| Sandiumenge, J | 1 |
| Keränen, T | 1 |
| Sivenius, J | 1 |
| Sáenz-Lope, E | 1 |
| Herranz-Tanarro, FJ | 1 |
| Masdeu, JC | 1 |
| Chacón Peña, JR | 1 |
| Schmidt, D | 1 |
| Fuller, TA | 1 |
| Olney, JW | 1 |
| Herranz, JL | 1 |
| Arteaga, R | 1 |
| Armijo, JA | 1 |
| Covanis, A | 1 |
| Gupta, AK | 1 |
| Jeavons, PM | 1 |
| Elmazar, MM | 1 |
| Hauck, RS | 1 |
| Nau, H | 2 |
| Park, BK | 1 |
| Pirmohamed, M | 1 |
| Kitteringham, NR | 1 |
| Koch, S | 1 |
| Jäger-Roman, E | 1 |
| Lösche, G | 1 |
| Rating, D | 1 |
| Helge, H | 1 |
| Roks, G | 1 |
| Deckers, CL | 1 |
| Meinardi, H | 1 |
| Dirksen, R | 1 |
| van Egmond, J | 1 |
| van Rijn, CM | 1 |
| Jennings, HR | 1 |
| Romanelli, F | 1 |
| Hardy, JR | 1 |
| Rees, EA | 1 |
| Gwilliam, B | 1 |
| Ling, J | 1 |
| Broadley, K | 1 |
| A'Hern, R | 1 |
| Sobaniec, W | 1 |
| Kułak, W | 1 |
| Boćkowski, L | 1 |
| Smigielska-Kuzia, J | 1 |
| Sobaniec-Łotowska, M | 1 |
| Sołowiej, E | 1 |
| Sobaniec, H | 1 |
| Artemowicz, B | 1 |
| Yagi, K | 1 |
| Watanabe, M | 1 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Reynolds, EH | 1 |
| Trimble, MR | 1 |
| Cramer, JA | 1 |
| Mattson, RH | 1 |
| Bennett, DM | 1 |
| Swick, CT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Clinical Trial, Double Blind, Placebo-controlled of Lithium and Valproate in Amyotrophic Lateral Sclerosis.[NCT03204500] | Phase 2 | 43 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641] | 20 participants (Anticipated) | Observational | 2018-12-03 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for valproic acid and Nervous System Disorders
| Article | Year |
|---|---|
Valproic acid in pregnancy: how much are we endangering the embryo and fetus?
Topics: Abnormalities, Drug-Induced; Adolescent; Animals; Anticonvulsants; Autistic Disorder; Child; Child D | 2009 |
Valproate use in neuropsychiatric disorders in the elderly.
Topics: Aged; Animals; Anticonvulsants; Clinical Trials as Topic; Humans; Mental Disorders; Nervous System D | 2003 |
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Drug Interactions; Drug Therapy, | 2004 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; | 1981 |
[Use of phenobarbital in febrile convulsive crisis].
Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr | 1983 |
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 1995 |
[Studies of damaged processes in the nervous system and possibilities of neuroprotection].
Topics: Adult; Animals; Biomarkers; Calcium Channel Blockers; Child; Epilepsy; Evoked Potentials; Humans; Li | 2001 |
[Neurotoxicity of antiepileptic drugs].
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Ethosuximide; Humans; Male; Nervous S | 1992 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
Adverse neuropsychiatric effects of anticonvulsant drugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Biogenic Amines; Carba | 1985 |
2 trials available for valproic acid and Nervous System Disorders
| Article | Year |
|---|---|
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
A phase II study to establish the efficacy and toxicity of sodium valproate in patients with cancer-related neuropathic pain.
Topics: Adult; Aged; Anticonvulsants; Female; Humans; Male; Middle Aged; Neoplasms; Nervous System Diseases; | 2001 |
27 other studies available for valproic acid and Nervous System Disorders
| Article | Year |
|---|---|
Hyperammonemia during treatment with valproate in critically ill patients.
Topics: Aged; Critical Care; Critical Illness; Enzyme Inhibitors; Female; Humans; Hyperammonemia; Incidence; | 2022 |
Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury.
Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Dose-Response Relationship, Drug; | 2021 |
The clinical features and functional impact of valproate-induced tremor.
Topics: Adult; Aged; Anticonvulsants; Cohort Studies; Female; Humans; Male; Middle Aged; Nervous System Dise | 2017 |
[Valproic acid toxicity due to misinterpretation of plasma levels: increase in unbound fraction caused by hypoalbuminaemia and renal dysfunction].
Topics: Aged; Anticonvulsants; Bipolar Disorder; Humans; Hypoalbuminemia; Male; Mobility Limitation; Muscle | 2018 |
Association of antiepileptic drugs with resolution of epileptiform activity after cardiac arrest.
Topics: Anticonvulsants; Cohort Studies; Coma; Combined Modality Therapy; Electroencephalography; Female; He | 2019 |
Valproate prescriptions for nonepilepsy disorders in reproductive-age women.
Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Congenital Abnormalities; Drug Prescriptions; | 2013 |
[Valproic acid during pregnancy lowers IQ in children].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Intellectual Disability; Maternal-Fetal Exchange; Nervous | 2013 |
[The reports of the collaborative studies supported by the Japanese Society of Child Neurology].
Topics: Child; Humans; Multicenter Studies as Topic; Nervous System Diseases; Prognosis; Societies, Medical; | 2016 |
Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders.
Topics: Animals; Autistic Disorder; Carbamazepine; Cell Line, Tumor; Environmental Pollutants; Fluoxetine; G | 2016 |
Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing.
Topics: Acrylamides; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Densitometry; | 2008 |
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model.
Topics: Adjuvants, Immunologic; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Anticonvulsants; Behavi | 2008 |
Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives.
Topics: Animals; Anticonvulsants; Benzopyrans; Electroshock; Indicators and Reagents; Lethal Dose 50; Male; | 2010 |
Late adverse effects of the coadministration of valproate and lamotrigine.
Topics: Adolescent; Anticonvulsants; Ataxia; Child; Drug Therapy, Combination; Epilepsy; Female; Headache; H | 2012 |
Vertebrobasilar dolichoectasia causing a presentation resembling basilar-type migraine.
Topics: Anticonvulsants; Dilatation, Pathologic; Humans; Magnetic Resonance Angiography; Magnetic Resonance | 2013 |
Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transp | 2013 |
Posterior reversible encephalopathy syndrome (PRES) in critically ill obstetric patients.
Topics: Adult; Fatal Outcome; Female; Humans; Magnetic Resonance Imaging; Nervous System Diseases; Postpartu | 2003 |
Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Arousal; Benzodiazepinones; Carbamazepine; Chemical and Drug Induced Li | 1983 |
Hyperekplexia: a syndrome of pathological startle responses.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Child; Female; Humans; Male; Nervous System Diseases; Pirace | 1984 |
Adverse effects of valproate.
Topics: Gastrointestinal Diseases; Hematologic Diseases; Humans; Mental Disorders; Metabolic Diseases; Nervo | 1984 |
Only certain anticonvulsants protect against kainate neurotoxicity.
Topics: Animals; Anticonvulsants; Diazepam; Kainic Acid; Male; Nervous System Diseases; Phenobarbital; Pheny | 1981 |
Side effects of sodium valproate in monotherapy controlled by plasma levels: a study in 88 pediatric patients.
Topics: Child; Child Behavior Disorders; Child, Preschool; Digestive System Diseases; Epilepsy; Female; Hair | 1982 |
Sodium valproate: monotherapy and polytherapy.
Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsies, Part | 1982 |
Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nervou | 1993 |
[Injectionable valproate: experiences in neurology pediatrics and psychiatry. Workshop at Hamburg, 8 November 1997].
Topics: Analgesics; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Child; Critical Care; Female; Human | 1998 |
Effects of polytherapy compared with monotherapy in antiepileptic drugs: an animal study.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interacti | 1999 |
Comment: potential risk of valproic acid therapy in patients who are HIV-positive.
Topics: Anticonvulsants; Cytomegalovirus; Drug Interactions; HIV Seropositivity; Humans; Nervous System Dise | 2000 |
Variable free and total valproic acid concentrations in sole- and multi-drug therapy.
Topics: Adult; Drug Therapy, Combination; Humans; Nervous System Diseases; Valproic Acid | 1986 |