valproic acid has been researched along with Nerve Pain in 15 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 5.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Neuropathic pain is often insensitive to morphine." | 5.42 | Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. ( Araki, K; Matsushita, Y; Mukae, T; Uchida, H; Ueda, H, 2015) |
| "Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action." | 3.70 | Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain. ( Alves, ND; de Carvalho, AM; de Castro-Costa, CM; Santos, FJ; Silveira, DG, 1999) |
| "Post-herpetic neuralgia is difficult to treat." | 2.71 | Divalproex sodium in the management of post-herpetic neuralgia: a randomized double-blind placebo-controlled study. ( Beniwal, R; Bumb, RA; Garg, P; Kochar, DK; Kochar, SK; Mehta, RD; Rawat, N, 2005) |
| "Spinal inflammation is a pathophysiological state of neuropathic pain (NP)." | 1.62 | Valproic acid mitigates spinal nerve ligation-induced neuropathic pain in rats by modulating microglial function and inhibiting neuroinflammatory response. ( Chen, C; Feng, X; Guo, A; Ke, J; Li, J; Lu, Q; Luo, L, 2021) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 1.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "We report four patients with neuropathic pain who responded very well to the initiation of low-dose oral sodium valproate." | 1.43 | The use of low-dose sodium valproate in the management of neuropathic pain: illustrative case series. ( Aggarwal, A; Pirapakaran, K, 2016) |
| "Neuropathic pain is often insensitive to morphine." | 1.42 | Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. ( Araki, K; Matsushita, Y; Mukae, T; Uchida, H; Ueda, H, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| King, AM | 1 |
| Salomé, C | 1 |
| Dinsmore, J | 1 |
| Salomé-Grosjean, E | 1 |
| De Ryck, M | 1 |
| Kaminski, R | 1 |
| Valade, A | 1 |
| Kohn, H | 1 |
| Bai, Y | 2 |
| He, X | 1 |
| Sun, Y | 1 |
| Zhao, Z | 1 |
| Chen, X | 1 |
| Li, B | 1 |
| Xie, J | 1 |
| Li, Y | 1 |
| Jia, P | 1 |
| Meng, X | 1 |
| Zhao, Y | 2 |
| Ding, Y | 1 |
| Xiao, C | 1 |
| Wang, S | 1 |
| Yu, J | 1 |
| Liao, S | 1 |
| Zhang, Y | 2 |
| Zhu, Z | 1 |
| Zhang, Q | 1 |
| Qin, F | 1 |
| Wei, X | 1 |
| Zeng, M | 1 |
| Liang, J | 1 |
| Cuan, Y | 1 |
| Shan, G | 1 |
| Fan, TP | 1 |
| Wu, B | 1 |
| Zheng, X | 1 |
| Chu, Z | 1 |
| Liu, P | 1 |
| Li, X | 1 |
| Liu, Y | 1 |
| Liu, F | 1 |
| Lei, G | 1 |
| Yang, L | 1 |
| Deng, L | 1 |
| Dang, Y | 1 |
| Guo, A | 1 |
| Li, J | 1 |
| Luo, L | 1 |
| Chen, C | 1 |
| Lu, Q | 1 |
| Ke, J | 1 |
| Feng, X | 1 |
| Chen, JY | 1 |
| Chu, LW | 1 |
| Cheng, KI | 1 |
| Hsieh, SL | 1 |
| Juan, YS | 1 |
| Wu, BN | 1 |
| Elsherbiny, NM | 1 |
| Ahmed, E | 1 |
| Kader, GA | 1 |
| Abdel-Mottaleb, Y | 1 |
| ElSayed, MH | 1 |
| Youssef, AM | 1 |
| Zaitone, SA | 1 |
| Uchida, H | 1 |
| Matsushita, Y | 1 |
| Araki, K | 1 |
| Mukae, T | 1 |
| Ueda, H | 1 |
| Pirapakaran, K | 1 |
| Aggarwal, A | 1 |
| Kaufmann, D | 1 |
| West, PJ | 1 |
| Smith, MD | 1 |
| Yagen, B | 1 |
| Bialer, M | 1 |
| Devor, M | 1 |
| White, HS | 1 |
| Brennan, KC | 1 |
| Otto, M | 1 |
| Bach, FW | 1 |
| Jensen, TS | 1 |
| Sindrup, SH | 1 |
| Kochar, DK | 1 |
| Garg, P | 1 |
| Bumb, RA | 1 |
| Kochar, SK | 1 |
| Mehta, RD | 1 |
| Beniwal, R | 1 |
| Rawat, N | 1 |
| Alves, ND | 1 |
| de Castro-Costa, CM | 1 |
| de Carvalho, AM | 1 |
| Santos, FJ | 1 |
| Silveira, DG | 1 |
| Davies, AN | 1 |
| Covington, EC | 1 |
| Bowsher, D | 1 |
| Lahuerta, J | 1 |
1 review available for valproic acid and Nerve Pain
| Article | Year |
|---|---|
Anticonvulsants for neuropathic pain and detoxification.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Acids; Gabapenti | 1998 |
2 trials available for valproic acid and Nerve Pain
| Article | Year |
|---|---|
Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middl | 2004 |
Divalproex sodium in the management of post-herpetic neuralgia: a randomized double-blind placebo-controlled study.
Topics: Adult; Aged; Double-Blind Method; Female; GABA Agents; Herpes Zoster; Humans; Male; Middle Aged; Neu | 2005 |
12 other studies available for valproic acid and Nerve Pain
| Article | Year |
|---|---|
Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Convulsants; Electroshock; Formaldehyde; Male; Mi | 2011 |
Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study.
Topics: Allosteric Regulation; Animals; Anisoles; Anticonvulsants; Carbamazepine; Cinnamates; Dioxolanes; Dr | 2019 |
Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antinociceptive effect in a rat of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agents; Male; Mi | 2020 |
Valproic acid mitigates spinal nerve ligation-induced neuropathic pain in rats by modulating microglial function and inhibiting neuroinflammatory response.
Topics: Animals; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylases; Inflammation; J | 2021 |
Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cell Death; Cytokines; Disease Models, Animal; Glycog | 2018 |
Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators.
Topics: Analgesics; Animals; Behavior, Animal; Cells, Cultured; Cytokines; Diabetes Complications; Disease M | 2019 |
Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury.
Topics: Acetylation; Analgesia; Analgesics; Animals; Down-Regulation; Drug Resistance; Ganglia, Spinal; Gene | 2015 |
The use of low-dose sodium valproate in the management of neuropathic pain: illustrative case series.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Australia; Female; Humans; Middle Aged; Neuralgia; Treatme | 2016 |
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain.
Topics: Amides; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin | 2017 |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain.
Topics: Analgesics; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Neuralgia; Phenytoin; Rats; Ra | 1999 |
Re: Sodium valproate in cancer-related neuropathic pain.
Topics: Anticonvulsants; Humans; Neoplasms; Neuralgia; Valproic Acid | 2002 |
A case of tabes dorsalis with tonic pupils and lightning pains relieved by sodium valproate.
Topics: Aged; Female; Humans; Neuralgia; Reflex, Pupillary; Tabes Dorsalis; Valproic Acid | 1987 |