valproic acid has been researched along with Nelson Syndrome in 16 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Nelson Syndrome: A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Neither a single dose nor long term administration of sodium valproate resulted in a significant decrease of plasma ACTH levels in patients with Cushing's disease and Nelson's syndrome." | 2.66 | The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease. ( Allolio, B; Jaursch-Hancke, C; Kaulen, D; Reincke, M; Winkelmann, W, 1988) |
| " The effect of a long term administration of sodium valproate (600-1000 mg/day) was evaluated in 2 patients with active Cushing's disease and in 1 patient with Nelson's syndrome (3 weeks, 3, 9 months respectively); in the 2 patients with Cushing's disease ACTH and cortisol secretion, 17-hydroxy-corticosteroids (17-OHCS) urinary excretion did not change during DPA treatment." | 2.65 | Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion. ( Berselli, ME; Frascatani, F; Loli, P; Muratori, F; Tagliaferri, M, 1984) |
| "We describe herein the reduction in the size of an ACTH-secreting pituitary macroadenoma in a patient with Nelson's syndrome during chronic administration of sodium valproate, and the changes in tumour volume after withdrawal and re-institution of treatment." | 1.27 | Size reduction of an ACTH-secreting pituitary macroadenoma in Nelson's syndrome by sodium valproate: effect of withdrawal and re-institution of treatment. ( Berselli, ME; De Grandi, C; Loli, P; Tagliaferri, M; Vignati, F, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (87.50) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasperlik-Załuska, AA | 1 |
| Zgliczyński, W | 1 |
| Jeske, W | 3 |
| Zdunowski, P | 1 |
| Jones, MT | 3 |
| Gillham, B | 3 |
| Beckford, U | 2 |
| Dornhorst, A | 2 |
| Abraham, RR | 2 |
| Seed, M | 1 |
| Wynn, V | 2 |
| Elias, AN | 2 |
| Gwinup, G | 2 |
| Altaher, AR | 1 |
| Nicholson, SA | 1 |
| Campbell, EA | 1 |
| Watts, SM | 1 |
| Thody, A | 1 |
| Valenta, LJ | 1 |
| Jenkins, JS | 1 |
| Lamberts, SW | 2 |
| Verleun, T | 1 |
| Bons, EG | 1 |
| Uitterlinden, P | 1 |
| Oosterom, R | 1 |
| Ambrosi, B | 1 |
| Bochicchio, D | 1 |
| Riva, E | 1 |
| Faglia, G | 1 |
| Loli, P | 2 |
| Berselli, ME | 2 |
| Frascatani, F | 1 |
| Muratori, F | 1 |
| Tagliaferri, M | 2 |
| Mercado-Asis, LB | 1 |
| Yanovski, JA | 1 |
| Tracer, HL | 1 |
| Chik, CL | 1 |
| Cutler, GB | 1 |
| Kasperlik-Załuska, A | 2 |
| Migdalska, B | 2 |
| Drac-Kaniewska, J | 2 |
| Wiśniewska-Woźniak, T | 2 |
| Kelly, W | 1 |
| Adams, JE | 1 |
| Laing, I | 1 |
| Longson, D | 1 |
| Davies, D | 1 |
| Reincke, M | 1 |
| Allolio, B | 1 |
| Kaulen, D | 1 |
| Jaursch-Hancke, C | 1 |
| Winkelmann, W | 1 |
| Vignati, F | 1 |
| De Grandi, C | 1 |
| Gomi, M | 1 |
| Iida, S | 1 |
| Itoh, Y | 1 |
| Moriwaki, K | 1 |
| Kanayama, S | 1 |
| Namba, M | 1 |
| Tarui, S | 1 |
5 trials available for valproic acid and Nelson Syndrome
| Article | Year |
|---|---|
ACTH responses to somatostatin, valproic acid and dexamethasone in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Dexamethasone; Down-Regulation; Female; Humans; Hydrocortisone; | 2005 |
Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion.
Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans | 1984 |
Acute effects of bromocriptine, cyproheptadine, and valproic acid on plasma adrenocorticotropin secretion in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Bromocriptine; Cyproheptadine; Drug Combinations; Drug Synergism | 1997 |
The effect of magnesium valproate on plasma ACTH concentrations in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged | 1989 |
The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease.
Topics: Addison Disease; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hydrocortisone; Lypressin; N | 1988 |
11 other studies available for valproic acid and Nelson Syndrome
| Article | Year |
|---|---|
Effect of treatment with sodium valproate and diazepam on plasma corticotropin in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Depression, Chemical; Diazepam; Female; gamma-Aminobutyric Acid; | 1981 |
Sodium valproate and Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Humans; Nelson Syndrome; Pituitary Neoplasms; Secretory Rate; Valproic | 1981 |
Clinical and experimental studies on the role of GABA in the regulation of ACTH secretion: a review.
Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Cushing Syndrome; gamma-Aminobutyric A | 1984 |
Effects of valproic acid, naloxone and hydrocortisone in Nelson's syndrome and cushing's disease.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; | 1981 |
The evaluation of sodium valproate in the treatment of Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Evaluat | 1983 |
Effect of cyproheptadine, desmethylcyproheptadine, gamma-amino-butyric acid and sodium valproate on adrenocorticotrophin secretion by cultured pituitary tumour cells from three patients with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Cyproheptadine; Female; gamma-Aminobutyric Acid; Humans; Nelson Syndrom | 1983 |
Effects of sodium-valproate administration on plasma ACTH levels in patients with ACTH hypersecretion.
Topics: Addison Disease; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Male; Nelson Syndrom | 1983 |
Long-term treatment of Nelson's syndrome with sodium valproate.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Female; Humans; Hydrocortisone; Male; Middle Aged; N | 1988 |
Size reduction of an ACTH-secreting pituitary macroadenoma in Nelson's syndrome by sodium valproate: effect of withdrawal and re-institution of treatment.
Topics: Adenoma; Adrenocorticotropic Hormone; Brain; Humans; Middle Aged; Nelson Syndrome; Pituitary Neoplas | 1988 |
The effect of sodium valproate on plasma ACTH and cortisol concentrations in Cushing's disease and Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Hormone Antagonists; Humans; Hydrocort | 1988 |
Unaltered stimulation of pituitary adrenocorticotrophin secretion by corticotrophin-releasing factor following sodium valproate administration in a patient with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Female; Humans; Middle Aged; Nelson Sy | 1985 |