valproic acid has been researched along with Nausea in 16 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of the study was to compare the antiaggressive efficacy of risperidone monotherapy versus risperidone plus valproate in patients with schizophrenia." | 9.12 | Risperidone alone versus risperidone plus valproate in the treatment of patients with schizophrenia and hostility. ( Citrome, L; Czobor, P; Nolan, KA; Shope, CB; Volavka, J, 2007) |
| " Compared to other active drugs, it only showed a lower significant effect compared with granisetron regarding headache change while it showed significantly higher effects only with placebo in both rescue medication needs and headache-free symptoms and valproate in only rescue medication need." | 5.41 | The efficacy and safety of metoclopramide in relieving acute migraine attacks compared with other anti-migraine drugs: a systematic review and network meta-analysis of randomized controlled trials. ( Abd-ElGawad, M; Abdelhay, HM; Abdelmonem, H; Abdelwadoud, GT; Ahmed, AE; Al-Dardery, NM; Alhosini, ANM; Kamel, MA; Mohamed, SW, 2023) |
| "The objective of the study was to compare the antiaggressive efficacy of risperidone monotherapy versus risperidone plus valproate in patients with schizophrenia." | 5.12 | Risperidone alone versus risperidone plus valproate in the treatment of patients with schizophrenia and hostility. ( Citrome, L; Czobor, P; Nolan, KA; Shope, CB; Volavka, J, 2007) |
| "Comparison of the change in median VAS scores over 60 minutes revealed that sodium valproate was significantly less effective than prochlorperazine in reducing pain or nausea (P <." | 5.10 | Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial. ( French, T; Miller, S; Riffenburgh, RH; Tanen, DA, 2003) |
| " On the other hand, patients with divalproex exhibited significantly higher risk of nausea compared to those with placebo, topiramate, propranolol, gabapentin and amitriptyline." | 4.95 | Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. ( He, A; Li, C; Song, D; Zhang, L, 2017) |
| "Migraine is a common and incapacitating neurologic disorder manifesting with episodic moderate to a severe headache and other symptoms such as photophobia, phonophobia, nausea, and vomiting." | 2.80 | Intravenous Valproate versus Subcutaneous Sumatriptan in Acute Migraine Attack. ( Ghaderibarmi, F; Tavakkoli, N; Togha, M, 2015) |
| "Patients with migraines have typically been given one group of medications for abortive treatment and another for preventative." | 1.31 | Use of intravenous valproate sodium in status migraine. ( Norton, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelmonem, H | 1 |
| Abdelhay, HM | 1 |
| Abdelwadoud, GT | 1 |
| Alhosini, ANM | 1 |
| Ahmed, AE | 1 |
| Mohamed, SW | 1 |
| Al-Dardery, NM | 1 |
| Abd-ElGawad, M | 1 |
| Kamel, MA | 1 |
| Ghaderibarmi, F | 1 |
| Tavakkoli, N | 1 |
| Togha, M | 1 |
| He, A | 1 |
| Song, D | 1 |
| Zhang, L | 1 |
| Li, C | 1 |
| Prakash, S | 1 |
| Shah, ND | 1 |
| Thibault, M | 1 |
| Blume, WT | 1 |
| Saint-Hilaire, JM | 1 |
| Zakhari, R | 1 |
| Sommerville, KW | 1 |
| Tanen, DA | 1 |
| Miller, S | 1 |
| French, T | 1 |
| Riffenburgh, RH | 1 |
| Parisi, P | 1 |
| Ferri, R | 1 |
| Pagani, J | 1 |
| Cecili, M | 1 |
| Montemitro, E | 1 |
| Villa, MP | 1 |
| Citrome, L | 1 |
| Shope, CB | 1 |
| Nolan, KA | 1 |
| Czobor, P | 1 |
| Volavka, J | 1 |
| Egger, J | 1 |
| Brett, EM | 1 |
| Kando, JC | 1 |
| Tohen, M | 1 |
| Castillo, J | 1 |
| Zarate, CA | 1 |
| Levine, J | 1 |
| Chengappa, KN | 1 |
| Parepally, H | 1 |
| Norton, J | 1 |
| Hassan, MN | 1 |
| Laljee, HC | 1 |
| Parsonage, MJ | 1 |
| Nasrallah, HA | 1 |
| Dunner, FJ | 1 |
| McCalley-Whitters, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130] | Phase 4 | 58 participants (Actual) | Interventional | 2017-05-16 | Completed | ||
| Risperidone Alone Vs. Risperidone Plus Valproate in the Treatment of Patients With Schizophrenia and Hostility[NCT00308360] | Phase 4 | 46 participants | Interventional | 1999-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
2 reviews available for valproic acid and Nausea
| Article | Year |
|---|---|
The efficacy and safety of metoclopramide in relieving acute migraine attacks compared with other anti-migraine drugs: a systematic review and network meta-analysis of randomized controlled trials.
Topics: Chlorpromazine; Granisetron; Headache; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Nausea | 2023 |
Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis.
Topics: Adult; Amines; Amitriptyline; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizziness; Female; Fruct | 2017 |
5 trials available for valproic acid and Nausea
| Article | Year |
|---|---|
Intravenous Valproate versus Subcutaneous Sumatriptan in Acute Migraine Attack.
Topics: Adult; Female; Humans; Male; Middle Aged; Migraine Disorders; Nausea; Recurrence; Sumatriptan; Valpr | 2015 |
Divalproex extended-release versus the original divalproex tablet: results of a randomized, crossover study of well-controlled epileptic patients with primary generalized seizures.
Topics: Adolescent; Adult; Analysis of Variance; Asthenia; Child; Cross-Over Studies; Delayed-Action Prepara | 2002 |
Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Anticonvulsants; Antiemetics; Double-Blind Method; Emergency | 2003 |
Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Anticonvulsants; Antiemetics; Double-Blind Method; Emergency | 2003 |
Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Anticonvulsants; Antiemetics; Double-Blind Method; Emergency | 2003 |
Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Anticonvulsants; Antiemetics; Double-Blind Method; Emergency | 2003 |
Risperidone alone versus risperidone plus valproate in the treatment of patients with schizophrenia and hostility.
Topics: Adult; Aggression; Anticonvulsants; Antipsychotic Agents; Diarrhea; Drug Therapy, Combination; Femal | 2007 |
A placebo-controlled trial of valproate in tardive dyskinesia.
Topics: Adult; Aged; Clinical Trials as Topic; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; | 1985 |
9 other studies available for valproic acid and Nausea
| Article | Year |
|---|---|
Migrainous vertigo responsive to intravenous methylprednisolone: case reports.
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Female; Humans; Injections, Intravenous; Male; Met | 2009 |
Ictal video-polysomnography and EEG spectral analysis in a child with severe Panayiotopoulos syndrome.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Partial; Eye Movements; Hallucinations; | 2005 |
Effects of sodium valproate in 100 children with special reference to weight.
Topics: Adolescent; Appetite; Body Weight; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; | 1981 |
The use of valproate in an elderly population with affective symptoms.
Topics: Affective Disorders, Psychotic; Age Factors; Aged; Antimanic Agents; Comorbidity; Depressive Disorde | 1996 |
Drugs for psychiatric disorders.
Topics: Aged; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety; Benzodi | 1997 |
Side effect profile of enteric-coated divalproex sodium versus valproic acid.
Topics: Humans; Male; Middle Aged; Nausea; Platelet Count; Tablets, Enteric-Coated; Thrombocytopenia; Valpro | 2000 |
Use of intravenous valproate sodium in status migraine.
Topics: Acute Disease; Adult; Female; Humans; Infusions, Intravenous; Migraine Disorders; Nausea; Pain, Intr | 2000 |
Valproate and other anticonvulsants for psychiatric disorders.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Bipolar | 2000 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |