valproic acid has been researched along with Myocardial Ischemia in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Svennerholm, K | 1 |
| Bergh, N | 1 |
| Larsson, P | 1 |
| Jern, S | 1 |
| Johansson, G | 1 |
| Biber, B | 1 |
| Haney, M | 1 |
| Kuai, Q | 1 |
| Wang, C | 1 |
| Wang, Y | 2 |
| Li, W | 1 |
| Zhang, G | 1 |
| Qiao, Z | 1 |
| He, M | 1 |
| Wang, X | 1 |
| Jiang, X | 1 |
| Su, L | 1 |
| He, Y | 1 |
| Ren, S | 1 |
| Yu, Q | 1 |
| Ferrari, R | 1 |
| Merli, E | 1 |
| Cicchitelli, G | 1 |
| Mele, D | 1 |
| Fucili, A | 1 |
| Ceconi, C | 1 |
| Meerson, FZ | 1 |
| Gimrikh, EO | 1 |
| Gutsol, LIa | 1 |
| Popov, SV | 1 |
| Plekhanov, IG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940] | Phase 3 | 120 participants (Actual) | Interventional | 2018-05-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review.
Topics: Cardiotonic Agents; Cardiovascular Diseases; Carnitine; Humans; Kidney Failure, Chronic; Liver; Myoc | 2004 |
3 other studies available for valproic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model.
Topics: Animals; Disease Models, Animal; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Myocardial Isc | 2014 |
Energy metabolism regulated by HDAC inhibitor attenuates cardiac injury in hemorrhagic rat model.
Topics: Animals; Cell Line; Disease Models, Animal; Energy Metabolism; Hemorrhage; Histone Deacetylase Inhib | 2016 |
[The anti-arrhythmic efficacy of sodium valproate].
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Evaluation; Electrocar | 1992 |