valproic acid has been researched along with Myasthenia Gravis in 1 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Myasthenia Gravis: A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Five years later she developed myasthenia gravis, and phenytoin was replaced by valproic acid and phenobarbital." | 3.68 | Epilepsy, myasthenia gravis, and effect of plasmapheresis on antiepileptic drug concentrations. ( Jenkins, DC; Lai, CW; Leppik, IE; Sood, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, CW | 1 |
| Leppik, IE | 1 |
| Jenkins, DC | 1 |
| Sood, P | 1 |
1 other study available for valproic acid and Myasthenia Gravis
| Article | Year |
|---|---|
Epilepsy, myasthenia gravis, and effect of plasmapheresis on antiepileptic drug concentrations.
Topics: Adult; Anticonvulsants; Combined Modality Therapy; Drug Therapy, Combination; Epilepsy, Temporal Lob | 1990 |