valproic acid has been researched along with Muscular Atrophy in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with valproic acid decreases muscle myostatin levels and enhances both follistatin expression and the inactivating phosphorylation of GSK-3beta, while these parameters are not affected by trichostatin-A." | 1.35 | Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice. ( Baccino, FM; Bonelli, G; Bonetto, A; Costelli, P; Minero, VG; Penna, F; Reffo, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawano, F | 1 |
| Nimura, K | 1 |
| Ishino, S | 1 |
| Nakai, N | 1 |
| Nakata, K | 1 |
| Ohira, Y | 1 |
| Sun, R | 1 |
| Zhang, S | 1 |
| Hu, W | 1 |
| Lu, X | 1 |
| Lou, N | 1 |
| Yang, Z | 1 |
| Chen, S | 1 |
| Zhang, X | 1 |
| Yang, H | 1 |
| Bonetto, A | 1 |
| Penna, F | 1 |
| Minero, VG | 1 |
| Reffo, P | 1 |
| Bonelli, G | 1 |
| Baccino, FM | 1 |
| Costelli, P | 1 |
3 other studies available for valproic acid and Muscular Atrophy
| Article | Year |
|---|---|
Differences in histone modifications between slow- and fast-twitch muscle of adult rats and following overload, denervation, or valproic acid administration.
Topics: Animals; Animals, Newborn; Denervation; Hindlimb Suspension; Histone Code; Male; Muscle Fibers, Fast | 2015 |
Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia.
Topics: Adenocarcinoma; Animals; Binding Sites; Cachexia; Carcinoma, Lewis Lung; CCAAT-Enhancer-Binding Prot | 2016 |
Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice.
Topics: Animals; Cachexia; Colonic Neoplasms; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme I | 2009 |