valproic acid has been researched along with Muscle Weakness in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy and bipolar disorder." | 3.88 | [Valproic acid toxicity due to misinterpretation of plasma levels: increase in unbound fraction caused by hypoalbuminaemia and renal dysfunction]. ( Dols, A; Jacobs, GE; Nauta, KJ; Ruiter-Visser, R; Smulders, YM, 2018) |
| " Seizures were controlled in a few weeks with intramuscular synthetic ACTH, followed by valproic acid." | 3.81 | LAMA2-related congenital muscular dystrophy complicated by West syndrome. ( Camacho, A; de Aragón, AM; Dekomien, G; Hernández-Laín, A; Núñez, N; Simón, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruiter-Visser, R | 1 |
| Dols, A | 1 |
| Smulders, YM | 1 |
| Jacobs, GE | 1 |
| Nauta, KJ | 1 |
| Camacho, A | 1 |
| Núñez, N | 1 |
| Dekomien, G | 1 |
| Hernández-Laín, A | 1 |
| de Aragón, AM | 1 |
| Simón, R | 1 |
| Hanley, P | 1 |
| Cunningham, RJ | 1 |
| Lou, L | 1 |
| Vog, B | 1 |
| Raina, R | 1 |
| Al-sharefi, A | 1 |
| Bilous, R | 1 |
| Tsai, LK | 1 |
| Yang, CC | 1 |
| Hwu, WL | 1 |
| Li, H | 1 |
5 other studies available for valproic acid and Muscle Weakness
| Article | Year |
|---|---|
[Valproic acid toxicity due to misinterpretation of plasma levels: increase in unbound fraction caused by hypoalbuminaemia and renal dysfunction].
Topics: Aged; Anticonvulsants; Bipolar Disorder; Humans; Hypoalbuminemia; Male; Mobility Limitation; Muscle | 2018 |
LAMA2-related congenital muscular dystrophy complicated by West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Electroencephalography; Human | 2015 |
Muscle Weakness and Pain With Profound Hypophosphatemia: Mystery Revealed.
Topics: Adolescent; Epilepsy; Fanconi Syndrome; Humans; Hypophosphatemia; Male; Muscle Weakness; Valproic Ac | 2015 |
Reversible weakness and encephalopathy while on long-term valproate treatment due to carnitine deficiency.
Topics: Adult; Antimanic Agents; Brain Diseases; Cardiomyopathies; Carnitine; Female; Humans; Hyperammonemia | 2015 |
Valproic acid treatment in six patients with spinal muscular atrophy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship | 2007 |