valproic acid has been researched along with Muscle Spasticity in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Selected examples from three series of isomeric (alkylthio)-1,2,4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice." | 3.69 | 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. ( Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA, 1994) |
| "Treatment with valproic acid greatly diminished the frequency of myoclonic jerks with minimal side effects." | 1.30 | Spinal myoclonus complicating spasticity in spinal cord injury: a case study. ( Andary, MT; Green, DF; Hulce, VD; Pysh, JJ, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kane, JM | 1 |
| Staeger, MA | 1 |
| Dalton, CR | 1 |
| Miller, FP | 1 |
| Dudley, MW | 1 |
| Ogden, AM | 1 |
| Kehne, JH | 1 |
| Ketteler, HJ | 1 |
| McCloskey, TC | 1 |
| Senyah, Y | 1 |
| Rüegg, SJ | 1 |
| Steck, AJ | 1 |
| Fuhr, P | 1 |
| Sandyk, R | 1 |
| Zachariah, SB | 1 |
| Borges, EF | 1 |
| Varghese, R | 1 |
| Cruz, AR | 1 |
| Ross, GS | 1 |
| Andary, MT | 1 |
| Green, DF | 1 |
| Hulce, VD | 1 |
| Pysh, JJ | 1 |
| Finke, J | 1 |
| Gerstenbrand, F | 1 |
| Harrer-Kuhnert, G | 1 |
| Mamoli, G | 1 |
| Watanabe, K | 1 |
1 review available for valproic acid and Muscle Spasticity
| Article | Year |
|---|---|
[The stiff-man syndrome].
Topics: Baclofen; Diazepam; Humans; Muscle Rigidity; Muscle Spasticity; Syndrome; Valproic Acid | 1987 |
7 other studies available for valproic acid and Muscle Spasticity
| Article | Year |
|---|---|
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mi | 1994 |
Levetiracetam improves paroxysmal symptoms in a patient with stiff-person syndrome.
Topics: Female; GABA Agonists; Humans; Immunoglobulins, Intravenous; Levetiracetam; Middle Aged; Muscle Spas | 2004 |
Treatment of writer's cramp with sodium valproate and baclofen. A case report.
Topics: Adult; Baclofen; Drug Therapy, Combination; Handwriting; Humans; Male; Muscle Spasticity; Valproic A | 1983 |
Positive response to oral divalproex sodium (Depakote) in patients with spasticity and pain.
Topics: Adult; Humans; Male; Middle Aged; Muscle Spasticity; Pain; Valproic Acid | 1994 |
Spinal myoclonus complicating spasticity in spinal cord injury: a case study.
Topics: Activities of Daily Living; Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalograph | 1997 |
[Therapy of spasticity using sodium valproinate].
Topics: Humans; Muscle Spasticity; Valproic Acid | 1978 |
[Augmented indication field for Convulex therapy (author's transl)].
Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Child, Preschool; Electroencephalography; Enceph | 1976 |