valproic acid has been researched along with Muscle Rigidity in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We applied valproic acid (VPA) on the rigidity of three parkinsonian patients, two with Parkinson disease and one with striatonigral degeneration." | 3.70 | [Valproic acid relieved marked rigidity in three patients with end-stage parkinsonism]. ( Fujimoto, K; Nakano, I; Sayama, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spehlmann, R | 1 |
| Norcross, K | 1 |
| Rasmus, SC | 1 |
| Schlageter, NL | 1 |
| Seghieri, G | 1 |
| De Giorgio, LA | 1 |
| Innocenti, F | 1 |
| Pettiná, G | 1 |
| Zolfanelli, F | 1 |
| Apicella, P | 1 |
| Sayama, S | 1 |
| Fujimoto, K | 1 |
| Nakano, I | 1 |
| Watanabe, K | 1 |
1 review available for valproic acid and Muscle Rigidity
| Article | Year |
|---|---|
[The stiff-man syndrome].
Topics: Baclofen; Diazepam; Humans; Muscle Rigidity; Muscle Spasticity; Syndrome; Valproic Acid | 1987 |
3 other studies available for valproic acid and Muscle Rigidity
| Article | Year |
|---|---|
Improvement of stiff-man syndrome with sodium valproate.
Topics: Humans; Male; Middle Aged; Muscle Rigidity; Syndrome; Valproic Acid | 1981 |
[Description of a case of a syndrome similar to Reye's syndrome in a male adult undergoing treatment with valproic acid and phenobarbital].
Topics: Adult; Brain Diseases; Coma; Epilepsy, Tonic-Clonic; Fever; Humans; Male; Muscle Rigidity; Phenobarb | 1982 |
[Valproic acid relieved marked rigidity in three patients with end-stage parkinsonism].
Topics: Aged; Female; GABA Agents; Humans; Middle Aged; Muscle Rigidity; Parkinson Disease; Treatment Outcom | 1998 |