valproic acid has been researched along with Muscle Relaxation in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A transverse myelopathy at the sixth cervical level developed in a 25-year-old woman after an overdose of valproic acid in a suicide attempt." | 7.71 | Cervical flexion myelopathy after valproic acid overdose. ( Kaye, KL; Ramsay, D; Young, GB, 2001) |
| "To evaluate the effect of valproic acid on transient lower oesophageal sphincter relaxation, lower oesophageal sphincter pressure and gastro-oesophageal reflux." | 5.10 | Effect of non-selective gamma-aminobutyric acid receptor stimulation on motor function of the lower oesophageal sphincter and gastro-oesophageal reflux in healthy human subjects. ( Allocca, M; Cantù, P; Carmagnola, S; Penagini, R; Savojardo, D, 2003) |
| "A transverse myelopathy at the sixth cervical level developed in a 25-year-old woman after an overdose of valproic acid in a suicide attempt." | 3.71 | Cervical flexion myelopathy after valproic acid overdose. ( Kaye, KL; Ramsay, D; Young, GB, 2001) |
| "Pretreatment with bicuculline (GABAA antagonist) turned them to relaxation." | 2.67 | gamma-Aminobutyric acid enhances the tone of human internal anal sphincter. ( Fujita, S; Kusunoki, M; Sakanoue, Y; Shoji, Y; Utsunomiya, J; Yamamura, T; Yanagi, H, 1991) |
| " Pharmacokinetic experiments with trans-2-en-VPA indicated non-linear kinetics with dose-dependent elimination rate and enterohepatic recirculation." | 1.28 | Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled rats. ( Hönack, D; Löscher, W; Rundfeldt, C, 1992) |
| " for 6 weeks, and anticonvulsant and adverse effects during this period were studied." | 1.28 | Valproic acid in amygdala-kindled rats: alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment. ( Fisher, JE; Hönack, D; Löscher, W; Nau, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cantù, P | 1 |
| Carmagnola, S | 1 |
| Savojardo, D | 1 |
| Allocca, M | 1 |
| Penagini, R | 1 |
| Kaye, KL | 1 |
| Ramsay, D | 1 |
| Young, GB | 1 |
| Hönack, D | 2 |
| Rundfeldt, C | 1 |
| Löscher, W | 2 |
| Kusunoki, M | 1 |
| Shoji, Y | 1 |
| Sakanoue, Y | 1 |
| Yanagi, H | 1 |
| Fujita, S | 1 |
| Yamamura, T | 1 |
| Utsunomiya, J | 1 |
| Fisher, JE | 1 |
| Nau, H | 1 |
2 trials available for valproic acid and Muscle Relaxation
| Article | Year |
|---|---|
Effect of non-selective gamma-aminobutyric acid receptor stimulation on motor function of the lower oesophageal sphincter and gastro-oesophageal reflux in healthy human subjects.
Topics: Adult; Aged; Aged, 80 and over; Deglutition; Esophagogastric Junction; Female; GABA Agents; Gastroes | 2003 |
gamma-Aminobutyric acid enhances the tone of human internal anal sphincter.
Topics: Anal Canal; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Humans; Muscimol; Muscle Contraction; Mu | 1991 |
3 other studies available for valproic acid and Muscle Relaxation
| Article | Year |
|---|---|
Cervical flexion myelopathy after valproic acid overdose.
Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Muscle Relaxation; Neck; Posture; Spinal Cord; Sp | 2001 |
Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled rats.
Topics: Amygdala; Animals; Epilepsy; Female; Injections, Intraperitoneal; Kindling, Neurologic; Muscle Relax | 1992 |
Valproic acid in amygdala-kindled rats: alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment.
Topics: Amygdala; Animals; Anticonvulsants; Body Temperature Regulation; Body Weight; Brain; Female; Kindlin | 1989 |