valproic acid has been researched along with Muscle Contraction in 14 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We included 43 patients with migraine without aura in a triple-blind, placebo- and dose-controlled, crossover study of the prophylactic effect of slow-release sodium valproate; 34 patients completed the trial." | 2.67 | Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo-controlled crossover study. ( Brinck, T; Jensen, R; Olesen, J, 1994) |
| "Pretreatment with bicuculline (GABAA antagonist) turned them to relaxation." | 2.67 | gamma-Aminobutyric acid enhances the tone of human internal anal sphincter. ( Fujita, S; Kusunoki, M; Sakanoue, Y; Shoji, Y; Utsunomiya, J; Yamamura, T; Yanagi, H, 1991) |
| "Skeletal muscles in animal models of Duchenne muscular dystrophy (DMD) are more susceptible to contraction-induced functional loss, which is not related to fatigue." | 1.91 | Valproic acid reduces muscle susceptibility to contraction-induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. ( Agbulut, O; Delacroix, C; Ferry, A; Furling, D; Lemaitre, M; Moutachi, D, 2023) |
| "Muscular dystrophies are debilitating neuromuscular disorders for which no cure exists." | 1.62 | Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner. ( Breuls, N; Carai, P; Deroose, C; Garrido, GM; Giarratana, N; Heymans, S; Ranga, A; Sampaolesi, M; Yedigaryan, L, 2021) |
| "The data suggest that this rat cardiac arrest model may be a valuable tool for investigating the pathophysiologic mechanisms of posthypoxic myoclonus and for developing new therapeutic strategies for treating the disorder." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "Orthostatic tremor, sometimes known as "shaky legs syndrome," is a disorder of middle-aged or elderly people characterized by feelings of unsteadiness in the legs and a fear of falling when standing." | 1.29 | Orthostatic tremor: clinical and electrophysiologic characteristics. ( McManis, PG; Sharbrough, FW, 1993) |
| "Isolated continuous lingual myoclonus is an exceptional entity, poorly documented and understood." | 1.28 | Isolated continuous rhythmic lingual myoclonus. ( De Blas, G; Galarreta, M; Gobernado, JM; Hernandez, A; Jimenez-Escrig, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Moutachi, D | 1 |
| Lemaitre, M | 1 |
| Delacroix, C | 1 |
| Agbulut, O | 1 |
| Furling, D | 1 |
| Ferry, A | 1 |
| Breuls, N | 1 |
| Giarratana, N | 1 |
| Yedigaryan, L | 1 |
| Garrido, GM | 1 |
| Carai, P | 1 |
| Heymans, S | 1 |
| Ranga, A | 1 |
| Deroose, C | 1 |
| Sampaolesi, M | 1 |
| Kissel, JT | 1 |
| Elsheikh, B | 1 |
| King, WM | 1 |
| Freimer, M | 1 |
| Scott, CB | 1 |
| Kolb, SJ | 1 |
| Reyna, SP | 1 |
| Crawford, TO | 1 |
| Simard, LR | 1 |
| Krosschell, KJ | 1 |
| Acsadi, G | 1 |
| Schroth, MK | 1 |
| D'Anjou, G | 1 |
| LaSalle, B | 1 |
| Prior, TW | 1 |
| Sorenson, S | 1 |
| Maczulski, JA | 1 |
| Swoboda, KJ | 1 |
| Gelfand, JM | 1 |
| Nelson, AB | 1 |
| Fross, RD | 1 |
| Glass, GA | 1 |
| Colussi, C | 1 |
| Scopece, A | 1 |
| Vitale, S | 1 |
| Spallotta, F | 1 |
| Mattiussi, S | 1 |
| Rosati, J | 1 |
| Illi, B | 1 |
| Mai, A | 1 |
| Castellano, S | 1 |
| Sbardella, G | 1 |
| Farsetti, A | 1 |
| Capogrossi, MC | 1 |
| Gaetano, C | 1 |
| Tokuoka, SM | 1 |
| Saiardi, A | 1 |
| Nurrish, SJ | 1 |
| Paredes, RG | 1 |
| Holmes, GM | 1 |
| Sachs, BD | 1 |
| Agmo, A | 1 |
| Jensen, R | 1 |
| Brinck, T | 1 |
| Olesen, J | 1 |
| Truong, DD | 1 |
| Matsumoto, RR | 1 |
| Schwartz, PH | 1 |
| Hussong, MJ | 1 |
| Wasterlain, CG | 1 |
| McManis, PG | 1 |
| Sharbrough, FW | 1 |
| Kristev, A | 1 |
| Peichev, L | 1 |
| Zaprianov, G | 1 |
| Lukanov, J | 1 |
| Sevrin, C | 1 |
| Moulin, T | 1 |
| Tatu, L | 1 |
| Monnier, G | 1 |
| Rumbach, L | 1 |
| Sevrin, P | 1 |
| Gobernado, JM | 1 |
| Galarreta, M | 1 |
| De Blas, G | 1 |
| Jimenez-Escrig, A | 1 |
| Hernandez, A | 1 |
| Kusunoki, M | 1 |
| Shoji, Y | 1 |
| Sakanoue, Y | 1 |
| Yanagi, H | 1 |
| Fujita, S | 1 |
| Yamamura, T | 1 |
| Utsunomiya, J | 1 |
3 trials available for valproic acid and Muscle Contraction
| Article | Year |
|---|---|
SMA valiant trial: a prospective, double-blind, placebo-controlled trial of valproic acid in ambulatory adults with spinal muscular atrophy.
Topics: Adult; Ambulatory Care; Cohort Studies; Cross-Over Studies; Dose-Response Relationship, Drug; Double | 2014 |
Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo-controlled crossover study.
Topics: Adult; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Muscle Contraction; Placebos | 1994 |
gamma-Aminobutyric acid enhances the tone of human internal anal sphincter.
Topics: Anal Canal; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Humans; Muscimol; Muscle Contraction; Mu | 1991 |
11 other studies available for valproic acid and Muscle Contraction
| Article | Year |
|---|---|
Valproic acid reduces muscle susceptibility to contraction-induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy.
Topics: Animals; Desmin; Disease Models, Animal; Female; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle, | 2023 |
Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner.
Topics: Animals; Cell Differentiation; Cell Lineage; Cells, Cultured; Coculture Techniques; Disease Models, | 2021 |
Speech-activated myoclonus masquerading as stuttering.
Topics: Anticonvulsants; Electromyography; Encephalitis, Varicella Zoster; Facial Muscles; Humans; Magnetic | 2009 |
P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins.
Topics: Acetylation; Actins; Animals; Aorta; Benzamides; Cyclic GMP; Histone Deacetylase Inhibitors; Hydroxa | 2012 |
The mood stabilizer valproate inhibits both inositol- and diacylglycerol-signaling pathways in Caenorhabditis elegans.
Topics: Acetylcholine; Animals; Antimanic Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; C | 2008 |
Electromyographic activity of rat ischiocavernosus muscles during copulation after treatment with a GABA-transaminase inhibitor.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Copulation; Ejaculation; Electromyography; Female; Inj | 1993 |
Novel rat cardiac arrest model of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Clonazepam; Disease Models, Ani | 1994 |
Orthostatic tremor: clinical and electrophysiologic characteristics.
Topics: Acceleration; Arm; Clonazepam; Electroencephalography; Electromyography; Electrophysiology; Evoked P | 1993 |
Effect of sodium valproate on the spontaneous contractile and bioelectric activity of smooth muscle fibres isolated from experimental animals.
Topics: Animals; Anticonvulsants; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rats | 1994 |
["Stiff-man" syndrome treated with intravenous immunoglobulins].
Topics: Diazepam; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Muscle Contraction; Stiff-Person | 1998 |
Isolated continuous rhythmic lingual myoclonus.
Topics: Electroencephalography; Electromyography; Female; Humans; Middle Aged; Muscle Contraction; Myoclonus | 1992 |