valproic acid has been researched along with Multiple System Atrophy in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borroni, B | 1 |
| Rosati, A | 1 |
| Costanzi, C | 1 |
| Zulli, R | 1 |
| Mardighian, D | 1 |
| Gasparotti, R | 1 |
| Padovani, A | 1 |
| Shill, HA | 1 |
| Fife, TD | 1 |
| Manto, MU | 1 |
| Moore, J | 1 |
3 other studies available for valproic acid and Multiple System Atrophy
| Article | Year |
|---|---|
Multiple system atrophy due to prolonged valproic acid treatment.
Topics: Anticonvulsants; Brain; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Multiple | 2007 |
Valproic acid toxicity mimicking multiple system atrophy.
Topics: Aged; Diagnosis, Differential; Female; Humans; Multiple System Atrophy; Valproic Acid | 2000 |
Valproic acid toxicity mimicking multiple system atrophy.
Topics: Humans; Multiple System Atrophy; Valproic Acid | 2001 |