valproic acid has been researched along with Multiple Sclerosis in 17 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here in this study, we found significant demyelination in the hippocampus of the mouse cuprizone model, which is accompanied by reduced cholesterol biosynthesis and increased anxiety-like behavior." | 8.02 | Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis. ( Gan, G; He, Y; Hu, Y; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2021) |
| "We present a case of a patient with multiple sclerosis who was treated with plasmapheresis and valproic acid." | 7.79 | Removal of valproic acid by plasmapheresis in a patient treated for multiple sclerosis. ( Bastiaans, DE; de Jong, BA; Ruiterkamp, RA; van Uden, IW, 2013) |
| " Here in this study, we found significant demyelination in the hippocampus of the mouse cuprizone model, which is accompanied by reduced cholesterol biosynthesis and increased anxiety-like behavior." | 4.02 | Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis. ( Gan, G; He, Y; Hu, Y; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2021) |
| "We present a case of a patient with multiple sclerosis who was treated with plasmapheresis and valproic acid." | 3.79 | Removal of valproic acid by plasmapheresis in a patient treated for multiple sclerosis. ( Bastiaans, DE; de Jong, BA; Ruiterkamp, RA; van Uden, IW, 2013) |
| "In order to produce this demyelination model, LPC (1%, 2 μL) was injected into the rat optic chiasm." | 1.51 | Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm. ( Ghasemi-Kasman, M; Hashemian, M; Parsian, H; Sadeghi, F, 2019) |
| "Multiple sclerosis is a demyelinating disease with severe neurological symptoms due to blockage of signal conduction in affected axons." | 1.43 | Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice. ( Dehghan, S; Fathollahi, Y; Hesaraki, M; Javan, M; Mirnajafi-Zadeh, J; Soleimani, M, 2016) |
| "A 27-year-old woman was diagnosed with juvenile myoclonic epilepsy since the age of 13 and was on valproate therapy." | 1.40 | Juvenile myoclonic epilepsy with multiple sclerosis: is there a dual role for valproate? ( Acharya, M; Kumawat, BL; Parekh, J; Sharma, C, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, X | 1 |
| Yao, Y | 1 |
| Hu, Y | 1 |
| Yang, J | 1 |
| Zhang, C | 2 |
| He, Y | 1 |
| Zhang, A | 1 |
| Liu, X | 1 |
| Gan, G | 1 |
| Maghbooli, M | 2 |
| Jourahmad, Z | 2 |
| Golizadeh, M | 2 |
| Hashemian, M | 1 |
| Ghasemi-Kasman, M | 1 |
| Parsian, H | 1 |
| Sadeghi, F | 1 |
| Johnson, B | 1 |
| Nichols, S | 1 |
| Sharma, C | 1 |
| Parekh, J | 1 |
| Kumawat, BL | 1 |
| Acharya, M | 1 |
| Nielsen, NM | 1 |
| Svanström, H | 1 |
| Stenager, E | 1 |
| Magyari, M | 1 |
| Koch-Henriksen, N | 1 |
| Pasternak, B | 1 |
| Hviid, A | 1 |
| Anderson, G | 1 |
| Rodriguez, M | 1 |
| Dehghan, S | 1 |
| Hesaraki, M | 1 |
| Soleimani, M | 1 |
| Mirnajafi-Zadeh, J | 1 |
| Fathollahi, Y | 1 |
| Javan, M | 1 |
| Azuchi, Y | 1 |
| Kimura, A | 1 |
| Guo, X | 1 |
| Akiyama, G | 1 |
| Noro, T | 1 |
| Harada, C | 1 |
| Nishigaki, A | 1 |
| Namekata, K | 1 |
| Harada, T | 1 |
| Bittner, S | 1 |
| Höhn, K | 1 |
| Göbel, K | 1 |
| Kleinschnitz, C | 1 |
| Wiendl, H | 1 |
| Meuth, SG | 1 |
| Chabwine, JN | 1 |
| Rossetti, AR | 1 |
| Hirt, L | 1 |
| Kuntzer, T | 1 |
| Schluep, M | 1 |
| Michel, P | 1 |
| Démonet, JF | 1 |
| du Pasquier, RA | 1 |
| Vingerhoets, FG | 1 |
| Lv, J | 1 |
| Du, C | 1 |
| Wei, W | 1 |
| Wu, Z | 1 |
| Zhao, G | 1 |
| Li, Z | 1 |
| Xie, X | 1 |
| Bastiaans, DE | 1 |
| van Uden, IW | 1 |
| Ruiterkamp, RA | 1 |
| de Jong, BA | 1 |
| Lopez-Meza, E | 1 |
| Corona-Vazquez, T | 1 |
| Ruano-Calderon, LA | 1 |
| Ramirez-Bermudez, J | 1 |
| Stip, E | 1 |
| Daoust, L | 1 |
| Marazziti, D | 1 |
| Cassano, GB | 1 |
| Jacome, DE | 1 |
4 reviews available for valproic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Crying and suicidal, but not depressed. Pseudobulbar affect in multiple sclerosis successfully treated with valproic acid: Case report and literature review.
Topics: Crying; Female; Humans; Middle Aged; Multiple Sclerosis; Pseudobulbar Palsy; Suicidal Ideation; Valp | 2015 |
Multiple sclerosis: the role of melatonin and N-acetylserotonin.
Topics: Fingolimod Hydrochloride; Glatiramer Acetate; Humans; Immunologic Factors; Immunosuppressive Agents; | 2015 |
[Pregabalin and gabapentin in multiple sclerosis: clinical experiences and therapeutic implications].
Topics: Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Antineoplastic Agents; Carbamazepine; Cohor | 2011 |
1 trial available for valproic acid and Multiple Sclerosis
| Article | Year |
|---|---|
The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis.
Topics: Animals; Anticonvulsants; Caspase 3; Caspase 8; Drug Evaluation, Preclinical; Encephalomyelitis, Aut | 2012 |
12 other studies available for valproic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis.
Topics: Animals; Anxiety; Cholesterol; Cuprizone; Demyelinating Diseases; Hippocampus; Male; Mice; Mice, Inb | 2021 |
Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Histone Deacetyla | 2019 |
Juvenile myoclonic epilepsy with multiple sclerosis: is there a dual role for valproate?
Topics: Adult; Anticonvulsants; Brain; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; | 2014 |
The use of valproic acid and multiple sclerosis.
Topics: Adolescent; Adult; Cohort Studies; Denmark; Female; Histone Deacetylase Inhibitors; Humans; Male; Mi | 2015 |
Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice.
Topics: Animals; Cell Differentiation; Cell Transdifferentiation; Demyelinating Diseases; Male; Mice, Inbred | 2016 |
Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; MAP Kinase Kin | 2017 |
[Neurology].
Topics: Antibodies, Monoclonal; Anticonvulsants; Atrial Fibrillation; Carbamates; Chronic Disease; Deep Brai | 2012 |
Removal of valproic acid by plasmapheresis in a patient treated for multiple sclerosis.
Topics: Anticonvulsants; Drug Monitoring; Humans; Male; Middle Aged; Multiple Sclerosis; Plasmapheresis; Val | 2013 |
Severe impulsiveness as the primary manifestation of multiple sclerosis in a young female.
Topics: Adolescent; Adult; Antimanic Agents; Antipsychotic Agents; Child; Clozapine; Female; Homicide; Human | 2005 |
Valproate in the treatment of mood disorder due to multiple sclerosis.
Topics: Adult; Female; Humans; Male; Middle Aged; Mood Disorders; Multiple Sclerosis; Valproic Acid | 1995 |
Valproic acid for panic disorder associated with multiple sclerosis.
Topics: Adult; Female; Humans; Multiple Sclerosis; Panic Disorder; Treatment Outcome; Valproic Acid | 1996 |
La toux diabolique: neurogenic tussive crisis.
Topics: Carbamazepine; Cough; Female; Humans; Middle Aged; Multiple Sclerosis; Valproic Acid | 1985 |