valproic acid has been researched along with Morphine Abuse in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphine is a potent opioid analgesic." | 1.36 | Valproate attenuates the development of morphine antinociceptive tolerance. ( Aoe, T; Dobashi, T; Jin, H; Nishino, T; Tanabe, S, 2010) |
| "Kainic acid is an analog of glutamate." | 1.26 | Hippocampal involvement in the pharmacologic induction of withdrawal-like behaviors. ( Isaacson, RL; Lanthorn, TH, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dobashi, T | 1 |
| Tanabe, S | 1 |
| Jin, H | 1 |
| Nishino, T | 1 |
| Aoe, T | 1 |
| Mu, P | 1 |
| Yu, LC | 1 |
| van der Laan, JW | 2 |
| Jacobs, AW | 1 |
| Bruinvels, J | 2 |
| Cowan, A | 1 |
| Isaacson, RL | 1 |
| Lanthorn, TH | 1 |
| Mucha, RF | 1 |
| Fassos, FF | 1 |
| Perl, FM | 1 |
7 other studies available for valproic acid and Morphine Abuse
| Article | Year |
|---|---|
Valproate attenuates the development of morphine antinociceptive tolerance.
Topics: Analgesics; Animals; Drug Tolerance; GABA Agents; Glycogen Synthase Kinase 3; Glycogen Synthase Kina | 2010 |
Valproic acid sodium inhibits the morphine-induced conditioned place preference in the central nervous system of rats.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Classical; GABA Agents; Injections, Intraventricular | 2007 |
Effects of branched-chain fatty acids on GABA-degradation and behavior: further evidence for a role of GABA in quasi-morphine abstinence behavior.
Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Brain Chemistry; Caproates; Dose-Response R | 1980 |
RX 336-M, a new chemical tool in the analysis of the quasi-morphine withdrawal syndrome.
Topics: Animals; Codeine; Drug Tolerance; Humans; Hydroxamic Acids; Male; Morphine Dependence; Pyrimidinones | 1981 |
Hippocampal involvement in the pharmacologic induction of withdrawal-like behaviors.
Topics: Animals; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Escape Reaction; Ethylketocyc | 1981 |
A dual role for GABA in quasi-morphine abstinence behavior induced by di-n-propylacetate involving both initiation and termination.
Topics: Animals; Behavior, Animal; Drug Tolerance; gamma-Aminobutyric Acid; Humans; Hydroxylation; Male; Mor | 1981 |
Withdrawal-like effects of pentylenetetrazol and valproate in the naive organism: a model of motivation produced by opiate withdrawal?
Topics: Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Dose-Response Relation | 1995 |