valproic acid has been researched along with Mitochondrial Myopathies in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Mitochondrial Myopathies: A group of muscle diseases associated with abnormal mitochondria function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "He developed coma and acute liver failure that were attributed to VPA toxicity, and underwent emergency orthotopic liver transplantation (OLTx)." | 1.31 | Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure. ( Camboulives, J; Delarue, A; Guys, JM; Lethel, V; Montfort, MF; Paut, O; Pellissier, JF; Roquelaure, B; Sarles, J, 2000) |
| "The brother has suffered from CPEO since early childhood but has had so far no other symptoms of a mitochondrial disease." | 1.31 | Mitochondrial diseases represent a risk factor for valproate-induced fulminant liver failure. ( Brandner, S; Kleinle, S; Krähenbühl, S; Liechti, S; Straumann, D, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hadzić, N | 1 |
| Vara, R | 1 |
| Raiman, J | 1 |
| Mieli-Vergani, G | 1 |
| Delarue, A | 1 |
| Paut, O | 1 |
| Guys, JM | 1 |
| Montfort, MF | 1 |
| Lethel, V | 1 |
| Roquelaure, B | 1 |
| Pellissier, JF | 1 |
| Sarles, J | 1 |
| Camboulives, J | 1 |
| Kelly, DA | 1 |
| Krähenbühl, S | 1 |
| Brandner, S | 1 |
| Kleinle, S | 1 |
| Liechti, S | 1 |
| Straumann, D | 1 |
4 other studies available for valproic acid and Mitochondrial Myopathies
| Article | Year |
|---|---|
Old versus new antiepileptic drugs: the SANAD study.
Topics: Adolescent; Anticonvulsants; Diagnostic Errors; Female; Humans; Kearns-Sayre Syndrome; Liver Failure | 2007 |
Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure.
Topics: Anticonvulsants; Brain; Child, Preschool; Diagnosis, Differential; Diagnostic Errors; Diffuse Cerebr | 2000 |
Liver transplantation: to do or not to do?
Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Epilepsy; Female; | 2000 |
Mitochondrial diseases represent a risk factor for valproate-induced fulminant liver failure.
Topics: Adult; Anticonvulsants; Contraindications; DNA, Mitochondrial; Fatal Outcome; Female; Humans; Liver | 2000 |