valproic acid has been researched along with Mitochondrial Diseases in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid." | 7.71 | Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. ( Glocker, FX; Jaksch, M; Ketelsen, UP; Kottlors, M; Lücking, CH; Weiner, S, 2001) |
| "A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid." | 3.71 | Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. ( Glocker, FX; Jaksch, M; Ketelsen, UP; Kottlors, M; Lücking, CH; Weiner, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Finsterer, J | 1 |
| Vantroys, E | 1 |
| Smet, J | 1 |
| Vanlander, AV | 1 |
| Vergult, S | 1 |
| De Bruyne, R | 1 |
| Roels, F | 1 |
| Stepman, H | 1 |
| Roeyers, H | 1 |
| Menten, B | 1 |
| Van Coster, R | 1 |
| Komulainen, T | 1 |
| Lodge, T | 1 |
| Hinttala, R | 1 |
| Bolszak, M | 1 |
| Pietilä, M | 1 |
| Koivunen, P | 1 |
| Hakkola, J | 1 |
| Poulton, J | 1 |
| Morten, KJ | 1 |
| Uusimaa, J | 1 |
| Ono, H | 1 |
| Kottlors, M | 1 |
| Jaksch, M | 1 |
| Ketelsen, UP | 1 |
| Weiner, S | 1 |
| Glocker, FX | 1 |
| Lücking, CH | 1 |
| Yamanouchi, H | 1 |
| Imataka, G | 1 |
1 review available for valproic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
[Mitochondrial diseases due to drug toxicity].
Topics: Animals; Antibiotics, Antineoplastic; Aspirin; Humans; Mitochondria; Mitochondrial Diseases; Reye Sy | 2002 |
5 other studies available for valproic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Valproic acid for myoclonic epilepsy in POLG1 carriers can be fatal.
Topics: Acute Disease; Anticonvulsants; Child; Diffuse Cerebral Sclerosis of Schilder; DNA Polymerase gamma; | 2021 |
Severe hepatopathy and neurological deterioration after start of valproate treatment in a 6-year-old child with mitochondrial tryptophanyl-tRNA synthetase deficiency.
Topics: Amino Acyl-tRNA Synthetases; Blotting, Western; Child; DNA Polymerase gamma; Electron Transport Comp | 2018 |
Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model.
Topics: Adenosine Triphosphate; Anticonvulsants; Cell Death; Cell Proliferation; Cell Respiration; Chemical | 2015 |
[Correlation between renal tubular dysfunction and serum carnitine deficiency in cases with valproate therapy].
Topics: Adult; Anticonvulsants; Carnitine; Child; Child, Preschool; Fanconi Syndrome; Female; Humans; Male; | 2009 |
Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency.
Topics: Acetylcarnitine; Acute Disease; Antimanic Agents; Bipolar Disorder; Carnitine O-Palmitoyltransferase | 2001 |