Page last updated: 2024-10-26

valproic acid and Migraine with Aura

valproic acid has been researched along with Migraine with Aura in 18 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Migraine with Aura: A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Research Excerpts

ExcerptRelevanceReference
" In a post-hoc comparison, responders to levetiracetam had significantly less migraine attacks at baseline and had significantly more often migraine with aura."4.12Levetiracetam in the prophylactic treatment of episodic migraine: A prospective open label study. ( Evers, S; Frese, A; Husstedt, IW; Marziniak, M; Summ, O, 2022)
"We examined the effect of standard migraine prophylaxis with sodium valproate on repeated measures of occipital excitability using transcranial magnetic stimulation (TMS)."2.70Visual cortex excitability in migraine before and after valproate prophylaxis: a pilot study using TMS. ( Chronicle, EP; Koehler, PJ; Mulleners, WM; Vredeveld, JW, 2002)
"Impaired consciousness or coma can occur in such patients."1.37Basilar-type migraine with coma: case reports and literature review. ( Li, Q; Tan, G; Zhou, J, 2011)
"Chorea is a rare and dose dependent side effect of valproate."1.37Acute chorea caused by valproate in an elderly. ( Cras, P; Helsen, G; van de Velde, K, 2011)
"We report a case of familial hemiplegic migraine with prolonged aura where multimodality imaging showed hemispheric cytotoxic edema along with evidence of hypometabolism in the affected hemisphere while there was no evidence of hypoperfusion of the affected hemisphere demonstrating that neuronal depression is a more plausible explanation in its pathogenesis."1.35Familial hemiplegic migraine with prolonged aura and multimodality imaging: a case report. ( Kumar, G; Maytal, J; Topper, L, 2009)
" They have been controlled after increasing her dosage to 600mg/day."1.34The efficacy of sodium valproate and a MRA finding in confusional migraine. ( Fujita, M; Fujiwara, J; Maki, T; Shibasaki, K; Shigeta, M; Takahashi, M; Takahashi, N, 2007)
"A diagnosis of classic migraine with hypomanic aura was made."1.33Hypomania as an aura in migraine. ( Datta, SS; Kumar, S, 2006)
"In Study 1, 12 migraine with aura patients (MA), 12 age-matched migraine without aura patients (MO) and 12 age- and sex-matched headache-free control subjects (C) were compared using the metacontrast test."1.31Cortical hyperexcitability is cortical under-inhibition: evidence from a novel functional test of migraine patients. ( Chronicle, EP; Mulleners, WM; Palmer, JE; Rolan, P, 2000)
"A 60-year-old woman with secondary chronic cluster headache had increased serum ferritin and serum transferrin saturation and was homozygous for the C282Y mutation in the HFE gene, which is indicative of hereditary haemochromatosis."1.31Hereditary haemochromatosis in two cousins with cluster headache. ( Bjerve, KS; Hagen, K; Stovner, LJ; Waage, A, 2002)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (55.56)29.6817
2010's7 (38.89)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Evers, S1
Frese, A1
Summ, O1
Husstedt, IW1
Marziniak, M1
Xu, JH1
Mi, HY1
Ilik, F1
Ilik, K1
Budhdeo, S1
Marquette, M1
Singh, D1
Rajagopal, V1
Kawamura, S1
Sakai, A1
Endo, T1
Maruta, M1
Kumar, G1
Topper, L1
Maytal, J1
Palermo, A1
Fierro, B1
Giglia, G1
Cosentino, G1
Puma, AR1
Brighina, F1
Li, Q1
Tan, G1
Zhou, J1
van de Velde, K1
Cras, P1
Helsen, G1
Rovers, JM1
Roks, G1
Huang, L1
Yu, CY1
Wang, BN1
Zhang, HM1
Li, LY1
Wang, Y1
Maggioni, F1
Ruffatti, S1
Dainese, F1
Mainardi, F1
Zanchin, G1
Datta, SS1
Kumar, S1
Fujita, M1
Fujiwara, J1
Maki, T1
Shigeta, M1
Shibasaki, K1
Takahashi, N1
Takahashi, M1
Palmer, JE1
Chronicle, EP2
Rolan, P1
Mulleners, WM2
Vredeveld, JW1
Koehler, PJ1
Smith, M1
Cros, D1
Sheen, V1
Stovner, LJ1
Hagen, K1
Waage, A1
Bjerve, KS1

Trials

3 trials available for valproic acid and Migraine with Aura

ArticleYear
A randomized controlled trial of acupressure as an adjunctive therapy to sodium valproate on the prevention of chronic migraine with aura.
    Medicine, 2017, Volume: 96, Issue:27

    Topics: Acupressure; Adult; Analgesics; Central Nervous System Agents; Combined Modality Therapy; Female; Fo

2017
Weight variations in the prophylactic therapy of primary headaches: 6-month follow-up.
    The journal of headache and pain, 2005, Volume: 6, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants

2005
Visual cortex excitability in migraine before and after valproate prophylaxis: a pilot study using TMS.
    European journal of neurology, 2002, Volume: 9, Issue:1

    Topics: Anticonvulsants; Electromagnetic Fields; gamma-Aminobutyric Acid; Humans; Longitudinal Studies; Migr

2002

Other Studies

15 other studies available for valproic acid and Migraine with Aura

ArticleYear
Levetiracetam in the prophylactic treatment of episodic migraine: A prospective open label study.
    Cephalalgia : an international journal of headache, 2022, Volume: 42, Issue:11-12

    Topics: Adult; Anticonvulsants; Double-Blind Method; Humans; Levetiracetam; Migraine Disorders; Migraine wit

2022
Alice in Wonderland syndrome as aura of migraine.
    Neurocase, 2014, Volume: 20, Issue:4

    Topics: Adolescent; Alice in Wonderland Syndrome; Anticonvulsants; Hallucinations; Humans; Male; Migraine wi

2014
Normoammonemic encephalopathy: solely valproate induced or multiple mechanisms?
    BMJ case reports, 2014, Mar-10, Volume: 2014

    Topics: Aged; Aggression; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Brain Diseases; Confusion; Delusi

2014
Atypical depression as a premonitory symptom of migraine managed by an oral contraceptive.
    Psychiatry and clinical neurosciences, 2008, Volume: 62, Issue:3

    Topics: Adult; Alprazolam; Borderline Personality Disorder; Calcium Channel Blockers; Contraceptives, Oral,

2008
Familial hemiplegic migraine with prolonged aura and multimodality imaging: a case report.
    Headache, 2009, Volume: 49, Issue:1

    Topics: Adrenal Cortex Hormones; Anticonvulsants; Child; Electroencephalography; Female; Humans; Magnetic Re

2009
Modulation of visual cortex excitability in migraine with aura: effects of valproate therapy.
    Neuroscience letters, 2009, Dec-18, Volume: 467, Issue:1

    Topics: Adult; Analysis of Variance; Female; GABA Agents; Humans; Male; Middle Aged; Migraine with Aura; Pho

2009
Basilar-type migraine with coma: case reports and literature review.
    Pain medicine (Malden, Mass.), 2011, Volume: 12, Issue:4

    Topics: Adolescent; Anticonvulsants; Antihypertensive Agents; Asian People; Coma; Female; Humans; Male; Migr

2011
Acute chorea caused by valproate in an elderly.
    Acta neurologica Belgica, 2011, Volume: 111, Issue:3

    Topics: Acute Disease; Aged, 80 and over; Anticonvulsants; Chorea; Dose-Response Relationship, Drug; Female;

2011
Electroconvulsive therapy-induced migraine successfully treated with valproic acid.
    The journal of ECT, 2012, Volume: 28, Issue:1

    Topics: Aged, 80 and over; Depressive Disorder, Major; Electroconvulsive Therapy; GABA Agents; Humans; Male;

2012
Vertebrobasilar dolichoectasia causing a presentation resembling basilar-type migraine.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:6

    Topics: Anticonvulsants; Dilatation, Pathologic; Humans; Magnetic Resonance Angiography; Magnetic Resonance

2013
Hypomania as an aura in migraine.
    Neurology India, 2006, Volume: 54, Issue:2

    Topics: Adult; Antimanic Agents; Bipolar Disorder; Electroencephalography; Humans; Male; Migraine with Aura;

2006
The efficacy of sodium valproate and a MRA finding in confusional migraine.
    Brain & development, 2007, Volume: 29, Issue:3

    Topics: Anticonvulsants; Child; Confusion; Electroencephalography; Female; Humans; Magnetic Resonance Angiog

2007
Cortical hyperexcitability is cortical under-inhibition: evidence from a novel functional test of migraine patients.
    Cephalalgia : an international journal of headache, 2000, Volume: 20, Issue:6

    Topics: Adult; Aged; Analgesics; Cortical Spreading Depression; Female; GABA-A Receptor Agonists; gamma-Amin

2000
Hyperperfusion with vasogenic leakage by fMRI in migraine with prolonged aura.
    Neurology, 2002, Apr-23, Volume: 58, Issue:8

    Topics: Aged; Anti-Inflammatory Agents; Anticonvulsants; Cerebrovascular Circulation; Contrast Media; Electr

2002
Hereditary haemochromatosis in two cousins with cluster headache.
    Cephalalgia : an international journal of headache, 2002, Volume: 22, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brain Stem; Calcium Channel Blockers; Cluster Headac

2002