valproic acid has been researched along with Microcephaly in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Microcephaly: A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a widely prescribed drug to treat epilepsy, bipolar disorder, and migraine." | 1.72 | Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects. ( Keyes, WM; Klein, A; Knauer-Meyer, T; Plassat, JL; Rhinn, M; Zapata-Bodalo, I, 2022) |
| "Focal seizures were more frequent during drowsiness and sleep." | 1.39 | Epilepsy in Mowat-Wilson syndrome: delineation of the electroclinical phenotype. ( Bianchi, P; Bonetti, S; Boni, A; Buoni, S; Cecconi, I; Cerruti Mainardi, P; Cordelli, DM; Della Giustina, E; Doz, M; Epifanio, R; Faravelli, F; Ferrari, AR; Franzoni, E; Garavelli, L; Gelmini, C; Giordano, L; Grasso, M; Grioni, D; Grosso, S; Guerra, A; Licata, F; Malbora, B; Mammi, I; Mari, F; Mazzanti, L; Mostardini, R; Pantaleoni, C; Pellicciari, A; Poch-Olivé, ML; Rivieri, F; Rosato, S; Savasta, S; Seri, M; Simonte, G; Sorge, G; Tarani, L; Terazzi, E; Wischmeijer, A; Zanotta, N; Zollino, M, 2013) |
| "Valproate exposed embryos have microcephaly and disrupted cardiovasculature with delayed vessel circulation, thrombus formation, and slow heart rate." | 1.38 | Valproate-induced teratogenesis in Japanese rice fish (Oryzias latipes) embryogenesis. ( Dasmahapatra, AK; Khan, IA; Wu, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ju, Y | 1 |
| Ji, TY | 1 |
| Rhinn, M | 1 |
| Zapata-Bodalo, I | 1 |
| Klein, A | 1 |
| Plassat, JL | 1 |
| Knauer-Meyer, T | 1 |
| Keyes, WM | 1 |
| Awa, HD | 1 |
| Chelo, D | 1 |
| Kinkela, MN | 1 |
| Ndombo, PO | 1 |
| Wu, M | 1 |
| Khan, IA | 1 |
| Dasmahapatra, AK | 1 |
| Cordelli, DM | 1 |
| Garavelli, L | 1 |
| Savasta, S | 1 |
| Guerra, A | 1 |
| Pellicciari, A | 1 |
| Giordano, L | 1 |
| Bonetti, S | 1 |
| Cecconi, I | 1 |
| Wischmeijer, A | 1 |
| Seri, M | 1 |
| Rosato, S | 1 |
| Gelmini, C | 1 |
| Della Giustina, E | 1 |
| Ferrari, AR | 1 |
| Zanotta, N | 1 |
| Epifanio, R | 1 |
| Grioni, D | 1 |
| Malbora, B | 1 |
| Mammi, I | 1 |
| Mari, F | 1 |
| Buoni, S | 1 |
| Mostardini, R | 1 |
| Grosso, S | 1 |
| Pantaleoni, C | 1 |
| Doz, M | 1 |
| Poch-Olivé, ML | 1 |
| Rivieri, F | 1 |
| Sorge, G | 1 |
| Simonte, G | 1 |
| Licata, F | 1 |
| Tarani, L | 1 |
| Terazzi, E | 1 |
| Mazzanti, L | 1 |
| Cerruti Mainardi, P | 1 |
| Boni, A | 1 |
| Faravelli, F | 1 |
| Grasso, M | 1 |
| Bianchi, P | 1 |
| Zollino, M | 1 |
| Franzoni, E | 1 |
| Gardner, RJ | 1 |
| Savarirayan, R | 1 |
| Dunne, KB | 1 |
| McLellan, JA | 1 |
| Coleman, LT | 1 |
| Suthers, GK | 1 |
6 other studies available for valproic acid and Microcephaly
| Article | Year |
|---|---|
[Clinical features of epilepsy in 5 children with Mowat-Wilson syndrome].
Topics: Child; Electroencephalography; Epilepsy; Facies; Female; Hirschsprung Disease; Humans; Intellectual | 2022 |
Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects.
Topics: Animals; Autism Spectrum Disorder; Cellular Senescence; Female; Mice; Microcephaly; Neural Tube Defe | 2022 |
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human | 2013 |
Valproate-induced teratogenesis in Japanese rice fish (Oryzias latipes) embryogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Cardiovascular Abnormalities; Cell Cycle Proteins; Embryo, Non | 2012 |
Epilepsy in Mowat-Wilson syndrome: delineation of the electroclinical phenotype.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; DNA Mutational Analysis; Electroencephalograph | 2013 |
Microlissencephaly with cardiac, spinal and urogenital defects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Brain; Fetal Diseases; Heart | 2001 |