valproic acid has been researched along with Metastase in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we performed combination treatment of caffeine and valproic acid on osteosarcoma cell lines in vitro and in spontaneous and experimental lung metastasis mouse models of osteosarcoma." | 7.85 | Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice. ( Hayashi, K; Hoffman, RM; Igarashi, K; Kawaguchi, K; Kimura, H; Kiyuna, T; Miwa, S; Murakami, T; Tsuchiya, H; Yamamoto, N, 2017) |
| "Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage." | 6.82 | Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial. ( Aversa, C; Botti, G; Bruzzese, F; Budillon, A; Calogero, E; Caponigro, F; Cavalcanti, E; D'Aniello, R; Daponte, A; De Cecio, R; De Feo, G; Di Gennaro, E; Di Marzo, M; Ionna, F; Longo, F; Losito, NS; Maglione, MG; Maiolino, P; Montano, M; Muto, P; Pavone, E; Perri, F; Petrillo, A; Pontone, M; Sandomenico, F; Scala, S; Trotta, A; Zotti, AI, 2016) |
| "In this study, we performed combination treatment of caffeine and valproic acid on osteosarcoma cell lines in vitro and in spontaneous and experimental lung metastasis mouse models of osteosarcoma." | 3.85 | Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice. ( Hayashi, K; Hoffman, RM; Igarashi, K; Kawaguchi, K; Kimura, H; Kiyuna, T; Miwa, S; Murakami, T; Tsuchiya, H; Yamamoto, N, 2017) |
| "Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage." | 2.82 | Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial. ( Aversa, C; Botti, G; Bruzzese, F; Budillon, A; Calogero, E; Caponigro, F; Cavalcanti, E; D'Aniello, R; Daponte, A; De Cecio, R; De Feo, G; Di Gennaro, E; Di Marzo, M; Ionna, F; Longo, F; Losito, NS; Maglione, MG; Maiolino, P; Montano, M; Muto, P; Pavone, E; Perri, F; Petrillo, A; Pontone, M; Sandomenico, F; Scala, S; Trotta, A; Zotti, AI, 2016) |
| "Twenty-six patients with advanced cancer (14 men/12 women), median age of 56 years (range 38-70 years), and a median number of two prior therapies (range 0-12) were enrolled." | 2.80 | Phase I trial of valproic acid and lenalidomide in patients with advanced cancer. ( Abdelrahim, M; Bilen, MA; Erguvan-Dogan, B; Falchook, GS; Fu, S; Hong, DS; Kurzrock, R; Naing, A; Ng, CS; Tsimberidou, AM; Wheler, JJ, 2015) |
| "A human ovarian cancer model transplanted subcutaneously in nude mice was established, and the efficacy of VPA used alone and in combination with diammine dichloroplatinum (DDP) to inhibit the growth of tumors was also assessed." | 1.38 | Effects of valproic acid on proliferation, apoptosis, angiogenesis and metastasis of ovarian cancer in vitro and in vivo. ( Feng-Nian, R; Jie, G; Shan, Z; Ting, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kiweler, N | 1 |
| Wünsch, D | 1 |
| Wirth, M | 1 |
| Mahendrarajah, N | 1 |
| Schneider, G | 1 |
| Stauber, RH | 1 |
| Brenner, W | 1 |
| Butter, F | 1 |
| Krämer, OH | 1 |
| Igarashi, K | 1 |
| Kawaguchi, K | 1 |
| Kiyuna, T | 1 |
| Murakami, T | 1 |
| Yamamoto, N | 1 |
| Hayashi, K | 1 |
| Kimura, H | 1 |
| Miwa, S | 1 |
| Tsuchiya, H | 1 |
| Hoffman, RM | 1 |
| Qi, G | 1 |
| Lu, G | 1 |
| Yu, J | 1 |
| Zhao, Y | 1 |
| Wang, C | 1 |
| Zhang, H | 1 |
| Xia, Q | 1 |
| Bilen, MA | 1 |
| Fu, S | 1 |
| Falchook, GS | 1 |
| Ng, CS | 1 |
| Wheler, JJ | 1 |
| Abdelrahim, M | 1 |
| Erguvan-Dogan, B | 1 |
| Hong, DS | 1 |
| Tsimberidou, AM | 1 |
| Kurzrock, R | 1 |
| Naing, A | 1 |
| Caponigro, F | 1 |
| Di Gennaro, E | 1 |
| Ionna, F | 1 |
| Longo, F | 1 |
| Aversa, C | 1 |
| Pavone, E | 1 |
| Maglione, MG | 1 |
| Di Marzo, M | 1 |
| Muto, P | 1 |
| Cavalcanti, E | 1 |
| Petrillo, A | 1 |
| Sandomenico, F | 1 |
| Maiolino, P | 1 |
| D'Aniello, R | 1 |
| Botti, G | 1 |
| De Cecio, R | 1 |
| Losito, NS | 1 |
| Scala, S | 1 |
| Trotta, A | 1 |
| Zotti, AI | 1 |
| Bruzzese, F | 1 |
| Daponte, A | 1 |
| Calogero, E | 1 |
| Montano, M | 1 |
| Pontone, M | 1 |
| De Feo, G | 1 |
| Perri, F | 1 |
| Budillon, A | 1 |
| Shan, Z | 1 |
| Feng-Nian, R | 1 |
| Jie, G | 1 |
| Ting, Z | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preclinical and Clinical Study of Valproic Acid Plus Cisplatin and Cetuximab in Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck[NCT02624128] | Phase 2 | 39 participants (Anticipated) | Interventional | 2015-02-23 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for valproic acid and Metastase
| Article | Year |
|---|---|
Phase I trial of valproic acid and lenalidomide in patients with advanced cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; L | 2015 |
Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cetu | 2016 |
4 other studies available for valproic acid and Metastase
| Article | Year |
|---|---|
Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes.
Topics: Animals; Benzamides; Cell Plasticity; Cisplatin; DNA Repair; DNA Repair Enzymes; DNA-Binding Protein | 2020 |
Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Cell Death; Cell | 2017 |
Up-regulation of TIF1γ by valproic acid inhibits the epithelial mesenchymal transition in prostate carcinoma through TGF-β/Smad signaling pathway.
Topics: Animals; Cell Proliferation; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Ge | 2019 |
Effects of valproic acid on proliferation, apoptosis, angiogenesis and metastasis of ovarian cancer in vitro and in vivo.
Topics: Animals; Anticonvulsants; Apoptosis; Blotting, Western; Cell Adhesion; Cell Cycle; Cell Movement; Ce | 2012 |