valproic acid has been researched along with Metabolic Diseases in 20 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Metabolic Diseases: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is an anticonvulsant and mood-stabilizing drug for the long-term treatment." | 5.37 | Valproic Acid related metabolic syndrome in patients with epilepsy. ( Kasradze, S; Mania, M; Okujava, N, 2011) |
| "A pregnant woman with epilepsy receiving VPA and ethosuximide (ESM) was given high-dose multivitamins from 13 to 28 weeks' gestation." | 3.70 | Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report. ( Baggot, PJ; Kalamarides, JA; Shoemaker, JD, 1999) |
| " Endocrine and metabolic adverse effects are among the most concerning adverse effects of commonly used psychotropic medications." | 2.43 | Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. ( Carlson, HE; Correll, CU, 2006) |
| "Valproic acid (VPA) is an anticonvulsant and mood-stabilizing drug for the long-term treatment." | 1.37 | Valproic Acid related metabolic syndrome in patients with epilepsy. ( Kasradze, S; Mania, M; Okujava, N, 2011) |
| "The effect of comorbid substance use on the likelihood of response differed significantly according to baseline BMI." | 1.36 | Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome. ( Calabrese, JR; Chan, PK; Findling, RL; Ganocy, SJ; Gao, K; Kemp, DE, 2010) |
| "Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies." | 1.33 | Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003. ( Borusiak, P; Boxtermann, W; Brückner, R; Buesing, D; Degen, I; Degenhardt, V; Fitzek, S; Gerstner, T; Haensch, CA; Hanusch, R; Hartmann, M; Häussermann, P; Hoppen, T; Jungck, A; Kasper, JM; Kluger, G; Knapp, R; Koenig, SA; Korenke, GC; Kuhn, H; Lindmayer, F; Longin, E; Müller-Deile, A; Oehring, R; Richard, HH; Samii, K; Seitz, R; Specht, U; Weber, Y; Weidner, B, 2006) |
| " We performed a cross-sectional surveillance study on pediatric patients taking valproate to evaluate the relationship between carnitine levels and demographic data including age, daily dosage of valproate, number of antiepileptic drugs, body mass index, and feeding problems." | 1.32 | Carnitine level in Chinese epileptic patients taking sodium valproate. ( Fok, TF; Fung, EL; Ho, CS; Lam, CW; Tang, NL, 2003) |
| " In both group A and group B patients, plasma ammonia levels were correlated with the valproic acid dosage (r = 0." | 1.30 | Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. ( Chiarelli, F; Greco, R; Morgese, G; Verrotti, A, 1999) |
| "Women with heterozygous ornithine transcarbamylase deficiency may have no symptoms or have episodic, symptomatic hyperammonemia, which can be fatal." | 1.28 | Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonemia during initiation of valproate therapy. ( Callahan, K; Evans, B; Honeycutt, D; Rutledge, L, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mampilly, GT | 1 |
| Mampilly, TK | 1 |
| Christopher, R | 1 |
| Chandramohan, N | 1 |
| Janaki, V | 1 |
| Zhang, L | 1 |
| Li, H | 1 |
| Li, S | 1 |
| Zou, X | 1 |
| Li, R | 1 |
| Liang, L | 1 |
| Wu, X | 1 |
| Ma, X | 1 |
| Su, M | 1 |
| Kemp, DE | 2 |
| Gao, K | 1 |
| Chan, PK | 1 |
| Ganocy, SJ | 1 |
| Findling, RL | 1 |
| Calabrese, JR | 2 |
| Mania, M | 1 |
| Kasradze, S | 1 |
| Okujava, N | 1 |
| Karayal, ON | 1 |
| Sachs, GS | 1 |
| Pappadopulos, E | 1 |
| Ice, KS | 1 |
| Siu, CO | 1 |
| Vieta, E | 1 |
| Aldemir, E | 1 |
| Akdeniz, F | 2 |
| Altay, AB | 1 |
| Arıcı, Ş | 1 |
| Umul, M | 1 |
| Aydın, HH | 1 |
| Çelebisoy, M | 1 |
| Vahip, S | 2 |
| Kreher, U | 1 |
| Darius, J | 1 |
| Wien, F | 1 |
| Taneli, F | 1 |
| Noyan, A | 1 |
| Yüncü, Z | 1 |
| Fung, EL | 1 |
| Tang, NL | 1 |
| Ho, CS | 1 |
| Lam, CW | 1 |
| Fok, TF | 1 |
| Correll, CU | 1 |
| Carlson, HE | 1 |
| Koenig, SA | 1 |
| Buesing, D | 1 |
| Longin, E | 1 |
| Oehring, R | 1 |
| Häussermann, P | 1 |
| Kluger, G | 1 |
| Lindmayer, F | 1 |
| Hanusch, R | 1 |
| Degen, I | 1 |
| Kuhn, H | 1 |
| Samii, K | 1 |
| Jungck, A | 1 |
| Brückner, R | 1 |
| Seitz, R | 1 |
| Boxtermann, W | 1 |
| Weber, Y | 1 |
| Knapp, R | 1 |
| Richard, HH | 1 |
| Weidner, B | 1 |
| Kasper, JM | 1 |
| Haensch, CA | 1 |
| Fitzek, S | 1 |
| Hartmann, M | 1 |
| Borusiak, P | 1 |
| Müller-Deile, A | 1 |
| Degenhardt, V | 1 |
| Korenke, GC | 1 |
| Hoppen, T | 1 |
| Specht, U | 1 |
| Gerstner, T | 1 |
| Schmidt, D | 1 |
| Kulick, SK | 1 |
| Kramer, DA | 1 |
| Baggot, PJ | 1 |
| Kalamarides, JA | 1 |
| Shoemaker, JD | 1 |
| Verrotti, A | 1 |
| Greco, R | 1 |
| Morgese, G | 1 |
| Chiarelli, F | 1 |
| Kamoun, P | 1 |
| Parvy, P | 1 |
| Debray-Ritzen, P | 1 |
| Bratton, SL | 1 |
| Garden, AL | 1 |
| Bohan, TP | 1 |
| French, JW | 1 |
| Clarke, WR | 1 |
| Honeycutt, D | 1 |
| Callahan, K | 1 |
| Rutledge, L | 1 |
| Evans, B | 1 |
| Morgan, HB | 1 |
| Swaiman, KF | 1 |
| Johnson, BD | 1 |
2 reviews available for valproic acid and Metabolic Diseases
| Article | Year |
|---|---|
Reproductive and metabolic abnormalities in women taking valproate for bipolar disorder: a meta-analysis.
Topics: Bipolar Disorder; Female; Humans; Hyperandrogenism; Menstruation Disturbances; Metabolic Diseases; P | 2016 |
Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents.
Topics: Adolescent; Antipsychotic Agents; Child; Dibenzothiazepines; Drug Administration Schedule; Endocrine | 2006 |
1 trial available for valproic acid and Metabolic Diseases
| Article | Year |
|---|---|
Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles.
Topics: Adjuvants, Immunologic; Antipsychotic Agents; Bipolar Disorder; Body Weight; Double-Blind Method; Dr | 2012 |
17 other studies available for valproic acid and Metabolic Diseases
| Article | Year |
|---|---|
Challenges in diagnosing a metabolic disorder: error of pyruvate metabolism or drug induced?
Topics: Anticonvulsants; Female; Fructose; Humans; Infant; Metabolic Diseases; Pyruvic Acid; Topiramate; Val | 2014 |
Valproate acid (VPA)-induced dysmetabolic function in clinical and animal studies.
Topics: Adipose Tissue; Adult; Anticonvulsants; Epilepsy; Fatty Acid-Binding Proteins; Female; Gene Expressi | 2017 |
Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome.
Topics: Adult; Bipolar Disorder; Body Mass Index; Comorbidity; Endocrine System Diseases; Female; Humans; Li | 2010 |
Valproic Acid related metabolic syndrome in patients with epilepsy.
Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Carbamazepine; Cholesterol, HDL; Epilepsy; F | 2011 |
Valproate-associated reproductive hormone abnormalities: do bipolar men have the same risk as epileptic men?
Topics: Adolescent; Adult; Animals; Anticonvulsants; Bipolar Disorder; Disease Models, Animal; Endocrine Sys | 2012 |
Abnormal alterations in the metabolic patterns of patients on valproate therapy.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Humans; Infant; Liver Diseases; Male; Metab | 2002 |
Valproate-associated reproductive and metabolic abnormalities: are epileptic women at greater risk than bipolar women?
Topics: Adult; Antimanic Agents; Bipolar Disorder; Cross-Sectional Studies; Endocrine System; Epilepsy; Fema | 2003 |
Carnitine level in Chinese epileptic patients taking sodium valproate.
Topics: Adolescent; Anticonvulsants; Asian People; Carnitine; Child; Epilepsy; Female; Humans; Male; Metabol | 2003 |
Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Chil | 2006 |
Adverse effects of valproate.
Topics: Gastrointestinal Diseases; Hematologic Diseases; Humans; Mental Disorders; Metabolic Diseases; Nervo | 1984 |
Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.
Topics: Adult; Ammonia; Epilepsy, Complex Partial; Humans; Male; Metabolic Diseases; Valproic Acid | 1993 |
Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report.
Topics: Adult; Anticonvulsants; Epilepsy; Ethosuximide; Female; Humans; Metabolic Diseases; Pantothenic Acid | 1999 |
Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs.
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; H | 1999 |
[Hyperglycinuria induced by n-dipropylacetate. Possible model of propionic acidemia].
Topics: Child; Child, Preschool; Glycine; Humans; Infant; Metabolic Diseases; Models, Biological; Propionate | 1977 |
A child with valproic acid-associated carnitine deficiency and carnitine-responsive cardiac dysfunction.
Topics: Carnitine; Child; Developmental Disabilities; Heart Diseases; Humans; Male; Metabolic Diseases; Myoc | 1992 |
Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonemia during initiation of valproate therapy.
Topics: Adult; Ammonia; Female; Heterozygote; Humans; Metabolic Diseases; Ornithine Carbamoyltransferase Def | 1992 |
Diagnosis of argininosuccinic aciduria after valproic acid-induced hyperammonemia.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Argininosuccinic Acid; F | 1987 |