valproic acid has been researched along with Metabolic Acidosis in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first report of mixed respiratory alkalosis and metabolic acidosis in a child treated with sulthiame." | 7.76 | Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame. ( Garty, BZ; Hoffer, V; Scheuerman, O; Tirosh, I; Weissbach, A, 2010) |
| " He was found to have high anion gap metabolic acidosis with significantly elevated lactate along with an elevated osmolal gap and calcium oxalate crystals in his urine." | 3.85 | Two gaps too many, three clues too few? Do elevated osmolal and anion gaps with crystalluria always mean ethylene glycol poisoning? ( Abu Sitta, E; Gaddam, M; Kanzy, A; Velagapudi, RK, 2017) |
| "This is the first report of mixed respiratory alkalosis and metabolic acidosis in a child treated with sulthiame." | 3.76 | Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame. ( Garty, BZ; Hoffer, V; Scheuerman, O; Tirosh, I; Weissbach, A, 2010) |
| "Valproic acid (VPA) is a histone deacetylase inhibitor that may decrease cellular metabolic needs following traumatic injury." | 1.39 | Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury. ( Alam, H; Causey, MW; Hempel, J; Hoffer, Z; Jin, G; Martin, M; Miller, S; Stallings, JD, 2013) |
| " Adverse events and reasons for terminating the diet were tabulated." | 1.33 | Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy. ( Ghosh, S; Lyczkowski, DA; Pfeifer, HH; Thiele, EA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaddam, M | 1 |
| Velagapudi, RK | 1 |
| Abu Sitta, E | 1 |
| Kanzy, A | 1 |
| Causey, MW | 1 |
| Miller, S | 1 |
| Hoffer, Z | 1 |
| Hempel, J | 1 |
| Stallings, JD | 1 |
| Jin, G | 1 |
| Alam, H | 1 |
| Martin, M | 1 |
| Vannaprasaht, S | 1 |
| Tiamkao, S | 1 |
| Sirivongs, D | 1 |
| Piyavhatkul, N | 1 |
| Weissbach, A | 1 |
| Tirosh, I | 1 |
| Scheuerman, O | 1 |
| Hoffer, V | 1 |
| Garty, BZ | 1 |
| Lyczkowski, DA | 1 |
| Pfeifer, HH | 1 |
| Ghosh, S | 1 |
| Thiele, EA | 1 |
| Riche, H | 2 |
| Salord, F | 2 |
| Jourdan, C | 2 |
| Wertheimer, P | 1 |
| Marti-Flich, J | 1 |
| Dumoulin, A | 1 |
| Lapostolle, F | 1 |
| Adnet, F | 1 |
| Muzynski, J | 1 |
| Baud, FJ | 1 |
| Frey, HH | 1 |
| Löscher, W | 1 |
| Böhles, H | 1 |
| Rengel-Aranda, M | 1 |
| Gougoux, A | 1 |
| Vinay, P | 1 |
| Lopez-Novoa, JM | 1 |
11 other studies available for valproic acid and Metabolic Acidosis
| Article | Year |
|---|---|
Two gaps too many, three clues too few? Do elevated osmolal and anion gaps with crystalluria always mean ethylene glycol poisoning?
Topics: Acid-Base Equilibrium; Acidosis; Anticonvulsants; Brain Diseases; Calcium Oxalate; Cognitive Dysfunc | 2017 |
Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury.
Topics: Acidosis; Animals; Disease Models, Animal; Epinephrine; Hemorrhage; Histone Deacetylase Inhibitors; | 2013 |
Acute valproic acid overdose: enhance elimination with multiple-doses activated charcoal.
Topics: Acidosis; Acute Disease; Adult; Antidotes; Charcoal; Drug Overdose; Female; Glasgow Coma Scale; Huma | 2009 |
Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Anticonvulsants; Carbamazepine; Child; Confusion; Dose-R | 2010 |
Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy.
Topics: Acidosis; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Dietary Fats; Epileps | 2005 |
Neurological side effects related to valproate after neurosurgery.
Topics: Acidosis; Adult; Aged; Akathisia, Drug-Induced; Anesthesia Recovery Period; Craniotomy; Epilepsy, Ge | 1994 |
[Metabolic acidosis caused by injectable sodium valproate. 6 postoperative cases in neurosurgery].
Topics: Acidosis; Aged; Anticonvulsants; Female; Humans; Male; Middle Aged; Postoperative Period; Valproic A | 1996 |
[Acidosis and hyperlactatemia in acute sodium valproate poisoning].
Topics: Acidosis; Acute Disease; Adult; Female; Humans; Intensive Care Units; Lactates; Male; Retrospective | 1997 |
Distribution of valproate across the interface between blood and cerebrospinal fluid.
Topics: Acidosis; Animals; Dogs; Drug Interactions; Female; Kinetics; Male; Phenylbutazone; Probenecid; Prot | 1978 |
[When is parenteral carnitine administration indicated?].
Topics: Acidosis; Adult; Ammonia; Carnitine; Fat Emulsions, Intravenous; Humans; Infant, Newborn; Infant, Pr | 1986 |
Effect of valproate on renal metabolism in the intact dog.
Topics: Acid-Base Equilibrium; Acidosis; Ammonia; Animals; Biological Transport; Dogs; Kidney; Kidney Tubule | 1988 |